October 2024 PMID 39390760

Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment.

Xiaoqiang Wang, Shoubao Ma, Przemyslaw Twardowski, Clayton Lau, Yin S Chan, Kelly Wong, Sai Xiao, Jinhui Wang, Xiwei Wu, Paul Frankel, Timothy G Wilson, Timothy W Synold, Cary Presant, Tanya Dorff, Jianhua Yu

Mentions

81
Peak: 13 in Nov 2024
across 6 sources since Nov 2024

Extended reach

390,651
potential audience

Total likes

322

Video views

14,301

Mentions per month

Nov 2024 – Sep 2025

Where it's discussed

  • News35 articles
  • X / Twitter31 posts
  • Blogs6 articles
  • Facebook5 posts
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Several posts discuss how white button mushrooms may enhance immune responses and slow tumor growth, exemplified by phrases like 'suppresses tumor growth' and 'boosts immune responses.' The tone ranges from optimistic to informational, emphasizing potential biomedical impacts and interest in clinical results, which contributes to a generally positive outlook on the publication's significance.

AgreementModerate agreement

Most discussions positively highlight the potential benefits of white button mushroom in reducing suppressor cells and slowing prostate cancer progression, indicating general support for the research.

InterestHigh interest

Posts show high curiosity by referencing trial results and molecular mechanisms, suggesting readers find the topic relevant and promising.

EngagementModerate engagement

Many discussions mention specific findings such as decreased MDSCs and increased immune activity, reflecting a moderate level of detailed engagement.

ImpactModerate impact

Participants see potential for practical application, with some noting the importance of these findings for future cancer therapies, though the overall perception isn't overwhelmingly transformative.

Abstract in brief

  • White button mushroom (WBM) treatment reduced immunosuppressive myeloid-derived suppressor cells (MDSCs) and boosted immune responses in both prostate cancer (PCa) mice and patients.
  • In mouse models, WBM suppressed tumor growth by decreasing the number and activity of MDSCs, thus enhancing T cell and natural killer (NK) cell activity, and improved the effectiveness of anti-PD1 immunotherapy.
  • In patients, three months of WBM intake decreased circulating PMN-MDSCs and increased cytotoxic CD8 T and NK cells, with molecular changes indicating suppressed inflammatory and signaling pathways, supporting WBM as a potential nutraceutical to slow or prevent PCa progression.

Top posts

Most liked on X and Bluesky
Batya Cohen, PhD
@BatyaCohen1 · X

1/פטריית הכפתור הלבן (Agaricus bisporus) מוכרת כשמפיניון ופורטובלו, היא פטריית מאכל תרבותית מהנפוצות בעולם. למרות שהיא לא נחשבת 'כמזון תרופה', הרי שעדויות מעכברים ומבני אדם מצביעות על כך שהתמצית שלה עשויה להאט או אפילו למנוע את הצמיחה של סרטן הערמונית. https://t.co/TjJqLtwqji https://t.co/PLv3XreeA7

Dec 7, 2024 · 40 likes · 1 share · 5,056 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to act by depressing myeloid-derived suppressor cells. https://t.co/6YHakmx4kQ https://t.co/E3atVh8IqG https://t.co/zyJReBiwjO

Dec 14, 2024 · 22 likes · 9 shares · 145,345 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to act by depressing myeloid-derived suppressor cells. https://t.co/6YHakmx4kQ https://t.co/E3atVh8IqG https://t.co/2j36DleeC1

Sep 20, 2025 · 20 likes · 2 shares · 145,345 followers View post →
WeitzSportsChiro
@WeitzSportChiro · X

White button mushroom supplements were given to men w/prostate cancer & after 3 months there were less tumor-creating myeloid-derived suppressor cells and more anti-tumor T and natural killer cells, suggesting white button mushroom slowed cancer growth. https://t.co/OBDgugL21w

Nov 19, 2024 · 2 likes · 9,395 followers View post →
Celilcan Topçuoğlu
@celilcan · X

@drahmetrasim Kaynağı merak edenler : https://t.co/tbECakLL1i

May 7, 2025 · 2 likes · 4,798 followers View post →
Ciekawość.Nauka i Natura
@nauka_natura · X

#Pieczarka vs #rakProstaty Obiecujące badania https://t.co/iqtdVOoCGD

Dec 7, 2024 · 2 likes · 1,236 followers View post →

All mentions

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kippa777
@AuntiBee777 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Sep 21, 2025 · 2 shares · 3,114 followers View post →
Richard Suzuki
@RicSuzukiOpen · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Sep 20, 2025 · 2 shares · 32 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to act by depressing myeloid-derived suppressor cells. https://t.co/6YHakmx4kQ https://t.co/E3atVh8IqG https://t.co/2j36DleeC1

Sep 20, 2025 · 20 likes · 2 shares · 145,345 followers View post →
AteistAlbay
@AteistAlbay · X

Prostat kanseri tedavisinde Düğme Mantarı Tabletinin olumlu etkileri konulu makale. https://t.co/s272AUkOZQ

May 7, 2025 · 2,583 followers View post →
AteistAlbay
@AteistAlbay · X

@drahmetrasim Makalenin özgünü bu linkte. https://t.co/s272AUkOZQ

May 7, 2025 · 2,583 followers View post →
alans
@SumeyraAlan · X

@coskunomer23 @drahmetrasim https://t.co/myTjw6tcBF

May 7, 2025 · 251 followers View post →
Celilcan Topçuoğlu
@celilcan · X

@drahmetrasim Kaynağı merak edenler : https://t.co/tbECakLL1i

May 7, 2025 · 2 likes · 4,798 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 31,484 followers View post →
Ali
@AVancorbach · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 1,049 followers View post →
JCheri13053
@JCheri13053 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 826 followers View post →
Valdon Myers
@ValMeyers6 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 142 followers View post →
rabkadias
@rabkadias7 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 226 followers View post →
Dina Abbas
@dina4patients · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 15, 2024 · 9 shares · 14 followers View post →
Youssef Kassab
@MolKassab · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 14, 2024 · 9 shares · 7 followers View post →
Flim Flam Bim Bam
@BimFlim78128 · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 14, 2024 · 9 shares · 1,860 followers View post →
mary sue mccarty
@MccartySue · X

RT @robertlufkinmd: White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to…

Dec 14, 2024 · 9 shares · 1,783 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

White button mushroom treatment for prostate cancer early experience reported in animal and human trials. Appears to act by depressing myeloid-derived suppressor cells. https://t.co/6YHakmx4kQ https://t.co/E3atVh8IqG https://t.co/zyJReBiwjO

Dec 14, 2024 · 22 likes · 9 shares · 145,345 followers View post →
Ciekawość.Nauka i Natura
@nauka_natura · X

#Pieczarka vs #rakProstaty Obiecujące badania https://t.co/iqtdVOoCGD

Dec 7, 2024 · 2 likes · 1,236 followers View post →
Dr. Barak
@Barak1826 · X

RT @BatyaCohen1: 1/פטריית הכפתור הלבן (Agaricus bisporus) מוכרת כשמפיניון ופורטובלו, היא פטריית מאכל תרבותית מהנפוצות בעולם. למרות שהיא לא…

Dec 7, 2024 · 1 share · 509 followers View post →
Batya Cohen, PhD
@BatyaCohen1 · X

1/פטריית הכפתור הלבן (Agaricus bisporus) מוכרת כשמפיניון ופורטובלו, היא פטריית מאכל תרבותית מהנפוצות בעולם. למרות שהיא לא נחשבת 'כמזון תרופה', הרי שעדויות מעכברים ומבני אדם מצביעות על כך שהתמצית שלה עשויה להאט או אפילו למנוע את הצמיחה של סרטן הערמונית. https://t.co/TjJqLtwqji https://t.co/PLv3XreeA7

Dec 7, 2024 · 40 likes · 1 share · 5,056 followers View post →
CNELM
@CNELM1 · X

https://t.co/NLj99NPe1A

Nov 29, 2024 · 922 followers View post →
Saeed Doroudiani, MSc/PhD, PEng
@SaeedDoroudiani · X

new study on mushroom and #cancer --- Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment - Wang - 2024 - Clinical and Translational Medicine - Wiley Online Library https://t.co/kqJwY9DJKp

Nov 28, 2024 · 922 followers View post →
dnovatchev
@dnovatchev · X

Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment. Results: Provide a scientific foundation for WBM as a nutraceutical intervention to delay or prevent PCa progression. https://t.co/E6hsTC3Ka5

Nov 25, 2024 · 323 followers View post →
RCB
@rcb1point618 · X

https://t.co/jfOzqmLVt3 https://t.co/xpE3MO2WVQ

Nov 25, 2024 · 223 followers View post →
Tino Eberl
@tinoeberl.mastodon.online.ap.brid.gy · Bluesky

Weiße #Champignons zeigen beeindruckende Anti-Krebs-Wirkung. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.70048 Eine Studie des City of Hope-Instituts belegt, dass Extrakte dieser Pilze das #Tumorwachstum bei #Prostatakrebs verlangsamen und das #Immunsystem stärken. In klinischen Tests […]

Nov 25, 2024 · 1 share View post →
aaronshem
@aaronshem · X

@Rainmaker1973 https://t.co/qkZW8hJlfm

Nov 25, 2024 · 1 like · 1,350 followers View post →
WeitzSportsChiro
@WeitzSportChiro · X

White button mushroom supplements were given to men w/prostate cancer & after 3 months there were less tumor-creating myeloid-derived suppressor cells and more anti-tumor T and natural killer cells, suggesting white button mushroom slowed cancer growth. https://t.co/OBDgugL21w

Nov 19, 2024 · 2 likes · 9,395 followers View post →
Dr. Nick Mawani, BSc, RRT, CNPA, MPH, DrPH, FRSPH.
@orcdcanada · X

https://t.co/yMLWlBmhHe

Nov 18, 2024 · 353 followers View post →
サイエンスあれこれ
@sarekore · X

でしょう。シティ・オブ・ホープ病院では、マッシュルーム、ブドウ種子エキス、ザクロ、ブルーベリー、ジャムンと呼ばれる熟した紫色のベリーなどの食品の潜在的な薬効を調査し、将来的に伝統的ながん治療と予防法の補助に使用できる可能性があることが分かってきています。https://t.co/k8RRs7p3PC

Nov 18, 2024 · 922 followers View post →
Professor Erwin Loh
@erwinloh · X

White button #mushroom has #cancer-fighting abilities, according to the results of a human clinical trial on the use of #food as medicine. Not only does it slow #tumor growth, but it also allows cancer-fighting #immune cells to do their job effectively. https://t.co/F6aTW4sgLI https://t.co/PpAd9VfjbJ

Nov 18, 2024 · 10,266 followers View post →
SkinKiss Natural Body Bliss
@SkinKiss1 · X

https://t.co/VqcTDRSako

Nov 14, 2024 · 2,913 followers View post →
Vazquez, Ø
@VGO3696 · X

Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment https://t.co/N6XeqZnBtt https://t.co/n0ePccux3b

Nov 12, 2024 · 1 like · 321 followers View post →