September 2025 PMID 39393048

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females.

Sarah E Alexander, Briana Gatto, Olivia E Knowles, Ross M Williams, Kinga N Fiebig, Paul Jansons, Paul A Della Gatta, Andrew Garnham, Nir Eynon, Glenn D Wadley, Brad Aisbett, Danielle Hiam, Séverine Lamon

Mentions

59
Peak: 38 in Oct 2024
across 6 sources since Oct 2024

Extended reach

335,431
potential audience

Total likes

2,183

Video views

46,178

Mentions per month

Oct 2024 – Sep 2025

Where it's discussed

  • X / Twitter46 posts
  • Instagram4 posts
  • Facebook3 posts
  • Bluesky2 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Many discussions reiterate the study's core findings, emphasizing phrases like 'Forget total testosterone' to highlight the novelty of bioavailable testosterone's role in strength. Additionally, the use of hashtags such as #StrengthTraining and #WomenWhoLift illustrates a community-focused approach, enhancing the discussion's tone and signaling an active interest in practical applications of the research.

AgreementStrong agreement

The majority of posts express strong support for the study's findings and emphasize the importance of bioavailable testosterone over total testosterone.

InterestHigh interest

Many participants show high curiosity and relevance by referencing specific aspects of the study and its implications for women's strength training.

EngagementModerate engagement

While some posts summarize the study, the depth of engagement varies, with most being more informative rather than analytical or critical.

ImpactModerate impact

There is a moderate perception of impact; while the discussion recognizes the findings' significance, some voices suggest further inquiry is needed.

Abstract in brief

  • The study investigated the relationship between testosterone levels, muscle mass, and strength in pre-menopausal females undergoing a 12-week resistance training program, finding no link with total circulating testosterone.
  • Bioavailable testosterone and the localization of androgen receptors (AR) in the nucleus were positively associated with muscle mass and strength, suggesting a unique role of these factors in muscle development for females.
  • In vitro experiments indicated that high doses of testosterone increased muscle cell size without activating the previously assumed Akt/mTOR pathway, instead enhancing the nuclear presence of the AR.

Top posts

Most liked on X and Bluesky
Brad Schoenfeld, PhD
@BradSchoenfeld · X

A 100+ kg squat in untrained women at baseline? A 150+ squat after 12 wks???

Oct 12, 2024 · 113 likes · 1 share · 95,744 followers View post →
Daniel Berglind, PhD
@DanielBerglind · X

Bioavailable testosterone

Oct 16, 2024 · 83 likes · 19 shares · 7,876 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/U9y8daZYHt

Oct 12, 2024 · 31 likes · 4 shares · 3,941 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with muscle mass and strength in pre-menopausal females. AI-powered takeaway via @ConsensusNLP https://t.co/iP7CfVSjnm

Feb 4, 2025 · 23 likes · 6 shares · 22,233 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/0Cqd8O8rYN https://t.co/6NzDhRFS4h

Oct 14, 2024 · 23 likes · 5 shares · 5,479 followers View post →
CJ Cleary
@cleary_cj · X

@LagaceJc @BradSchoenfeld Estimated from a 5RM and here you go! https://t.co/5reo5hn7FH

Oct 12, 2024 · 3 likes · 96 followers View post →

All mentions

The Journal of Physiology
@jphysiol.bsky.social · Bluesky

In this study, Sarah E. Alexander of deakinuniversity.bsky.social et al. find that bioavailable #testosterone and androgen receptor activation, but not total testosterone, are associated with #muscle mass and strength in females

Sep 26, 2025 · 1 like View post →
Journal of Physiology
@JPhysiol · X

Sarah E. Alexander (@DeakinIPAN @BakerResearchAu) et al. find that bioavailable #testosterone and androgen receptor activation, but not total testosterone, are associated with #muscle mass and strength in females

Sep 26, 2025 · 2 likes · 32,619 followers View post →
John Paul Catanzaro
@catanzarogroup · X

Forget total testosterone—it’s what’s available that counts! This study shows that bioavailable testosterone and androgen receptor activation drive muscle mass and strength in women. #StrengthTraining #Testosterone #WomenWhoLift #TheEliteTrainer https://t.co/78vbImkAdm

Feb 6, 2025 · 1 like · 748 followers View post →
William Amaral
@_sempreguica · X

RT @JoseAntonioPhD: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with…

Feb 4, 2025 · 6 shares · 121 followers View post →
Mind Your Science!
@MindYourSci · X

RT @JoseAntonioPhD: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with…

Feb 4, 2025 · 6 shares · 132 followers View post →
John Paul Catanzaro
@catanzarogroup · X

RT @JoseAntonioPhD: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with…

Feb 4, 2025 · 6 shares · 748 followers View post →
Dr. Michael Sagner, MD
@DrMichaelSagner · X

RT @JoseAntonioPhD: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with…

Feb 4, 2025 · 6 shares · 5,360 followers View post →
Dr. Neil Paulvin
@NeilpDo · X

RT @JoseAntonioPhD: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with…

Feb 4, 2025 · 6 shares · 2,852 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are positively associated with muscle mass and strength in pre-menopausal females. AI-powered takeaway via @ConsensusNLP https://t.co/iP7CfVSjnm

Feb 4, 2025 · 23 likes · 6 shares · 22,233 followers View post →
Philipp Baumert
@baumert.bsky.social · Bluesky

Nice study: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jan 31, 2025 View post →
DSHB
@DSHB_antibodies · X

Oct 22, 2024 · 2,024 followers View post →
William Amaral
@_sempreguica · X

RT @DanielBerglind: Bioavailable testosterone

Oct 17, 2024 · 19 shares · 121 followers View post →
Cláudia
@claudianutri · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 136 followers View post →
YURI PAUCAR
@ypaucar · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 1,207 followers View post →
Dan Patrick
@mdpatrick · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 2,035 followers View post →
Meat Head
@markeatsmeat · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 46,163 followers View post →
Alex
@AlexViKu · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females - Alexander - The Journal of Physiology - Wiley Online Library https://t.co/sWvVKzYEf8

Oct 16, 2024 · 97 followers View post →
Mind Your Science!
@MindYourSci · X

RT @nick_krontiris: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass…

Oct 16, 2024 · 2 shares · 132 followers View post →
Andres Felipe
@Anferupu · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 51 followers View post →
Rafael Radaeli
@rfradaeli · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 382 followers View post →
Raul
@RaulM06 · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 849 followers View post →
Mind Your Science!
@MindYourSci · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 132 followers View post →
John Paul Catanzaro
@catanzarogroup · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 748 followers View post →
Colleen Griffith
@Griffith17431 · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 939 followers View post →
@Ap_Coach Amedio
@ap_coach · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 1,406 followers View post →
Markus Lehtonen
@MarkusLehtone14 · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 101 followers View post →
Niklas Virta
@NiklasVirta · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 691 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 22,233 followers View post →
Camille Goddard
@camillegoddard · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 135 followers View post →
Zack
@keychupkicap · X

RT @DanielBerglind: Bioavailable testosterone

Oct 16, 2024 · 19 shares · 389 followers View post →
Daniel Berglind, PhD
@DanielBerglind · X

Bioavailable testosterone

Oct 16, 2024 · 83 likes · 19 shares · 7,876 followers View post →
Javed Alam
@jalam1001 · X

RT @Jozo_Grgic: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and…

Oct 14, 2024 · 5 shares · 1,010 followers View post →
Guilherme Pussieldi, PhD
@GPussieldi · X

RT @Jozo_Grgic: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and…

Oct 14, 2024 · 5 shares · 260 followers View post →
paulo alvarez
@rpaulotovar · X

RT @nick_krontiris: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass…

Oct 14, 2024 · 2 shares · 439 followers View post →
Kristopher Mendes de Souza
@KristopherDoc · X

RT @Jozo_Grgic: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and…

Oct 14, 2024 · 5 shares · 67 followers View post →
Madhan Ramanathan
@sportsphysiouk · X

RT @Jozo_Grgic: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and…

Oct 14, 2024 · 5 shares · 1,151 followers View post →
PT_Thunem
@PT_Thunem · X

RT @Jozo_Grgic: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and…

Oct 14, 2024 · 5 shares · 81 followers View post →
Nick Krontiris
@nick_krontiris · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females (open access) https://t.co/ZTGVKuLTtn

Oct 14, 2024 · 2 likes · 2 shares · 19,470 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/0Cqd8O8rYN https://t.co/6NzDhRFS4h

Oct 14, 2024 · 23 likes · 5 shares · 5,479 followers View post →
Tadej Debevec
@DebevecTadej · X

New in @JPhysiol Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/FfiMm6MxcO

Oct 13, 2024 · 1 like · 3,809 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

RT @CraigAGoodman1: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mas…

Oct 13, 2024 · 4 shares · 1,076 followers View post →
Marcus Goncalves
@MarcusDGon · X

RT @CraigAGoodman1: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mas…

Oct 13, 2024 · 4 shares · 2,634 followers View post →
Benhaida Ismaël
@mesinabot · X

RT @BradSchoenfeld: A 100+ kg squat in untrained women at baseline? A 150+ squat after 12 wks???

Oct 13, 2024 · 1 share · 61 followers View post →
AKSHAY
@Danaveni_Akshay · X

RT @CraigAGoodman1: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mas…

Oct 13, 2024 · 4 shares · 115 followers View post →
CJ Cleary
@cleary_cj · X

@LagaceJc @BradSchoenfeld Estimated from a 5RM and here you go! https://t.co/5reo5hn7FH

Oct 12, 2024 · 3 likes · 96 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/U9y8daZYHt

Oct 12, 2024 · 31 likes · 4 shares · 3,941 followers View post →
Brad Schoenfeld, PhD
@BradSchoenfeld · X

A 100+ kg squat in untrained women at baseline? A 150+ squat after 12 wks???

Oct 12, 2024 · 113 likes · 1 share · 95,744 followers View post →
Baker Institute OAR
@BakerResOAR · X

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females https://t.co/n7pHhFRd49

Oct 11, 2024 · 207 followers View post →
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