Science December 2024 PMID 39418343

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants.

Marianna Boccia, Danny Kessler, Wibke Seibt, Veit Grabe, Carlos E Rodríguez López, Dagny Grzech, Sarah Heinicke, Sarah E O'Connor, Prashant D Sonawane

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Mentions

Peak: 27 in Oct 2024

across 5 sources since Oct 2024

Extended reach

148,133

potential audience

Total likes

122

Video views

305

Mentions per month

Oct 2024 – Jun 2025

Where it's discussed

X / Twitter36 posts
News11 articles
Bluesky2 posts
YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

The analysis highlights a collective recognition of the study's importance, exemplified by comments calling it a 'game changer' and noting 'a scaffold protein manages the biosynthesis of defense compounds.' The tone combines scientific interest with enthusiasm, showing both deep engagement and an understanding of the ecological and practical implications.

AgreementStrong agreement

Most discussions acknowledge the significance of the discovery, referring to it as a 'game changer' and emphasizing the protein’s key role in plant defense.

InterestHigh interest

Participants show high interest, discussing the biosynthesis pathways and ecological importance with enthusiasm and technical details.

EngagementHigh engagement

The mentions include references to scientific methods, implications, and specific proteins, indicating deep engagement.

ImpactHigh impact

The consensus reflects that this research could have a major impact on plant science and agricultural biotechnology, as seen through phrases like 'crucial', 'manages biosynthesis', and 'game changer'.

Abstract in brief

Plants generate two key types of sterol-derived compounds—steroidal glycoalkaloids and steroidal saponins—from cholesterol, but efforts to produce them outside their natural environment have not succeeded.
Researchers discovered a cellulose synthase-like protein that plays a crucial role in the biosynthesis of these compounds by interacting with early pathway enzymes.
Knocking out this gene in black nightshade not only eliminated the production of steroidal molecules but also highlighted their ecological importance by showing that steroidal saponins can protect plants from harmful insects.

Read the full abstract

All mentions

Role of GAME15 Protein in Plant Alkaloid Biosynthesis

A key discovery shows that the GLYCOALKALOID METABOLISM15 (GAME15) protein plays a crucial role in the biosynthesis of steroidal glycoalkaloids (SGAs) in Solanaceae plants, influencing plant defense mechanisms and…

三島彩子 a.k.a. 植物たん · Jun 15, 2025 221 views

Protein Discovery Enhances Plant Defense Against Pathogens

Researchers from Max Planck Institute identified GAME15, a key protein in biosynthesis of plant defense compounds, illustrating its ecological role in protecting plants from pests by managing steroidal metabolite…

Science Wonders Unveiled · Oct 22, 2024 84 views

彩恵りり

@Science_Release · X

RT @botany_tan: 日曜日20:00からは後編！結構難しい内容だとは思うんですが、私なりに「良い論文だ」と思ったものを持ってきたので、なるべくわかりやすく噛み砕いてお絵描きもしながら説明しますね！ https://t.co/LHmU25qhUb

Jun 12, 2025 · 4 shares · 44,336 followers View post →

津巳石編陣

@c5ksUsLtwq11999 · X

Jun 9, 2025 · 4 shares · 1,494 followers View post →

まつこ

@ma31stm · X

Jun 9, 2025 · 4 shares · 2,246 followers View post →

あかまる

@aka_maru_k · X

Jun 9, 2025 · 4 shares · 967 followers View post →

三島彩子

@botany_tan · X

Jun 9, 2025 · 10 likes · 4 shares · 4,619 followers View post →

Shunsuke Miyashima

@chinnen1982 · X

RT @peechan1970: ナス科植物は、共通の原料から多様なステロイドを作る。その合成に重要な新しい酵素を特定。この酵素を欠く植物では、害虫から身を守るための物質が作られず、害虫に食べられることが判明。植物の物質生産技術開発や、植物の防御機構の解明に期待。Scienc…

Dec 27, 2024 · 1 share · 428 followers View post →

ぴーちゃん

@peechan1970 · X

Dec 26, 2024 · 8 likes · 1 share · 870 followers View post →

Danve Castroverde

@DanveC · X

Study #1 on a cellulose synthase–like protein GAME15 that directs the biosynthesis of plant steroid-based defence metabolites! @ScienceMagazine https://t.co/vGTYUJp4gy

Dec 20, 2024 · 2 likes · 1,593 followers View post →

Dragan Perovic

@DraganPerovic13 · X

https://t.co/lKzJWkjHtH

Dec 20, 2024 · 135 followers View post →

Marc Somssich

@somssich.bsky.social · Bluesky

Dec 20, 2024 · 11 likes · 6 shares View post →

n/a

@OliverBerkowitz · X

GAME changer https://t.co/aXA4HU1se7

Dec 19, 2024 · 332 followers View post →

The Lipid Chronicles

@lipidchronicles · X

A scaffold protein manages the biosynthesis of steroidal defence compounds in plants https://t.co/nrzdGKEWNx (@ScienceMagazine)

Dec 4, 2024 · 2 likes · 5,852 followers View post →

YMED-X

@YmedX269 · X

RT @hLife_Journal: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/TY4mBSY67W…

Oct 22, 2024 · 1 share · 229 followers View post →

hLife

@hLife_Journal · X

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/TY4mBSY67W @The_InnovationJ #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #ResearchPapers

Oct 21, 2024 · 1 like · 1 share · 21 followers View post →

Jeffrey Dean

@jeffdean-uga.bsky.social · Bluesky

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science www.science.org/doi/10.1126/...

Oct 21, 2024 · 2 likes · 1 share View post →

Jeffrey Dean

@JeffDean_UGA · X

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/N8qTjYqsR6

Oct 21, 2024 · 1,906 followers View post →

Kumar Saurabh Singh

@Kumar_S_Singh · X

RT @DeyangXu_CN: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/b5VRz2wwrn

Oct 20, 2024 · 1 share · 547 followers View post →

Kenichi Tsuda

@Billion_of_Gods · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 6,114 followers View post →

津田賢一

@KenichiTsuda4 · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 10,692 followers View post →

mary williams

@PlantTeaching · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 23,826 followers View post →

Nick Talbot

@talbotlabTSL · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 11,258 followers View post →

Nelke 'Demon Lord' Shilovich

@nelke_IGB · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 1,107 followers View post →

Chenxin Li, PhD (@chenxinli2.bsky.social)

@ChenxinLi2 · X

RT @HeeKyungAhn1: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 6 shares · 10,300 followers View post →

Hee-Kyung Ahn | 안희경

@HeeKyungAhn1 · X

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/ZL2NLY0Htt

Oct 20, 2024 · 20 likes · 6 shares · 1,388 followers View post →

Coney von 1Land ☮️✨

@coneyvon1 · X

RT @PlantSciDBG_en: Crucial protein for the #biosynthesis of steroidal glycoalkaloids and saponins in Solanum identified by team around @OC…

Oct 20, 2024 · 2 shares · 549 followers View post →

Deyang Xu

@DeyangXu_CN · X

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science https://t.co/b5VRz2wwrn

Oct 20, 2024 · 21 likes · 1 share · 676 followers View post →

Rob Field, PVC Science, UEA

@Rob_Field_Lab · X