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Aging Cell January 2025 PMID 39421964

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes.

Steven K Malin, Daniel J Battillo, Michal S Beeri, Maja Mustapic, Francheska Delgado-Peraza, Dimitrios Kapogiannis

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Mentions

62
Peak: 9 in Jan 2025
across 5 sources since Nov 2024

Extended reach

215,111
potential audience

Total likes

47

Video views

39

Mentions per month

Nov 2024 – May 2025

Where it's discussed

  • News36 articles
  • X / Twitter18 posts
  • Blogs4 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The overall tone reflects strong support and enthusiasm, with posts citing specifics like changes in insulin signaling proteins and the potential to prevent dementia, using words like 'key,' 'improve,' and 'potential.' Such language underscores both the significance of the findings and the participants' genuine interest in their real-world applications, indicating deep engagement and a belief in the impact of the research.

AgreementModerate agreement

Most discussions agree that the study provides valuable evidence for exercise benefits in prediabetics, emphasizing improved brain insulin responses.

InterestHigh interest

The posts show high interest, highlighting the significance of how short-term exercise impacts brain health and dementia risk.

EngagementHigh engagement

People actively analyze the research, referencing the mechanisms involved and considering implications for cognitive health.

ImpactModerate impact

The discussions suggest the findings could influence health recommendations and motivate lifestyle changes, but still focus on potential rather than confirmed clinical outcomes.

Abstract in brief

  • Two weeks of exercise improved insulin sensitivity, aerobic fitness, and reduced weight in older adults with prediabetes, and caused changes in neuronal extracellular vesicle proteins related to insulin signaling and proBDNF.
  • The exercise increased the levels of insulin signaling proteins like pAkt during glucose challenges and decreased proBDNF levels, suggesting improved neuronal insulin responses and potentially lowered dementia risk.
  • These findings indicate that short-term aerobic exercise can modify neuronal signaling proteins in blood-derived extracellular vesicles, which may help explain how exercise reduces the risk of Alzheimer's and related dementias in prediabetics.
Read the full abstract

Top posts

Most liked on X and Bluesky
Dr Alexey Kulikov
@KulikovUNIATF · X

Specialized cells involved in how the body responds to insulin are activated in the

Jan 25, 2025 · 17 likes · 4 shares · 62,990 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

2 weeks of moderate intensity exercise enhances how our brain responds to insulin @drjasonfung @KenDBerryMD @ChrisPalmerMD https://t.co/eiDNhaOqEj

May 15, 2025 · 9 likes · 56,099 followers View post →
Agingdoc
@agingdoc1 · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes https://t.co/w7MTBEy3Mt https://t.co/4mWGZMrjro

Nov 4, 2024 · 9 likes · 1 share · 41,736 followers View post →
Agingdoc
@agingdoc1 · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes

Feb 10, 2025 · 6 likes · 2 shares · 41,736 followers View post →
#JournoRequest By JournoFinder
@journorequest_ · X

#journorequest Dementia Expert Needed to Comment on New Study ​ "Looking for an expert in dementia (MD ONLY: Geriatricians, Neurologists, PROFESSORS preferred) who can comment on the findings of this study ( https://t.co/4DTH8ZNpub ) and offer some recommendations for people

Feb 13, 2025 · 1 like · 1,437 followers View post →
おくさん/OKUSUN
@Astella6174 · X

【たった2週間の運動で脳が変わる】糖尿病予備群の高齢者に2週間の運動トレーニングを行ったところ、脳内インスリンシグナル伝達が改善し、認知症リスクに関わるタンパク質の量が減少したそうです。Aging Cell誌より→ https://t.co/eHJheFKDL1

Mar 24, 2025 · 1 like · 1,184 followers View post →

All mentions

Cynthia Thurlow, NP
@_CynthiaThurlow · X

2 weeks of moderate intensity exercise enhances how our brain responds to insulin @drjasonfung @KenDBerryMD @ChrisPalmerMD https://t.co/eiDNhaOqEj

May 15, 2025 · 9 likes · 56,099 followers View post →
Dr. LoBisco
@DrLoBisco · X

Recent research shows that just two weeks of moderate #exercise improves #insulin response in #brain cells, vital for memory and cognitive function. The study involved older adults with prediabetes, assessing insulin-related markers in their brain cells. https://t.co/hZcO614DZm https://t.co/i0FNq4x5Ch

May 5, 2025 · 965 followers View post →
おくさん/OKUSUN
@Astella6174 · X

【たった2週間の運動で脳が変わる】糖尿病予備群の高齢者に2週間の運動トレーニングを行ったところ、脳内インスリンシグナル伝達が改善し、認知症リスクに関わるタンパク質の量が減少したそうです。Aging Cell誌より→ https://t.co/eHJheFKDL1

Mar 24, 2025 · 1 like · 1,184 followers View post →
#JournoRequest By JournoFinder
@journorequest_ · X

#journorequest Dementia Expert Needed to Comment on New Study ​ "Looking for an expert in dementia (MD ONLY: Geriatricians, Neurologists, PROFESSORS preferred) who can comment on the findings of this study ( https://t.co/4DTH8ZNpub ) and offer some recommendations for people

Feb 13, 2025 · 1 like · 1,437 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with pre…

Feb 13, 2025 · 2 shares · 133 followers View post →
Alper Aydın (Dietitian )
@aydinnalper · X

RT @agingdoc1: Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with pre…

Feb 10, 2025 · 2 shares · 1,428 followers View post →
Agingdoc
@agingdoc1 · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes

Feb 10, 2025 · 6 likes · 2 shares · 41,736 followers View post →
Bina Pattel
@BinaPattel · X

#EXERCISE IMPROVES BRAIN FUNCTION – NEW STUDY https://t.co/L0mbbLBf4S FINDINGS SHOW HOW SPECIALISED CELLS INVOLVED IN HOW BODY RESPONDS TO INSULIN ARE ACTIVATED IN BRAIN AFTER EXERCISE RECENT STUDY – EXERCISE LINKED OFFSET OR PREVENT DEMENTIA PROGRESSION https://t.co/OaKQdOO84K

Feb 6, 2025 · 36 followers View post →
Evermore Wellness
@shelly_evermore · X

Exercise may be the key to reducing your risk for dementia. Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro‐BDNF in older adults with prediabetes - Malin - 2025 - Aging Cell - Wiley Online Library https://t.co/qfLNTQOo9Z

Jan 31, 2025 · 359 followers View post →
Mohamed Mohideen
@rifdeen · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro‐BDNF in older adults with prediabetes - Malin - 2025 - Aging Cell - Wiley Online Library https://t.co/23YkpoIMvo

Jan 27, 2025 · 1 like · 326 followers View post →
Sophie Hart
@COHEALPR · X

RT @KulikovUNIATF: Specialized cells involved in how the body responds to insulin are activated in the

Jan 26, 2025 · 4 shares · 97 followers View post →
María Moral
@twittmariamoral · X

RT @KulikovUNIATF: Specialized cells involved in how the body responds to insulin are activated in the

Jan 25, 2025 · 4 shares · 854 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @KulikovUNIATF: Specialized cells involved in how the body responds to insulin are activated in the

Jan 25, 2025 · 4 shares · 573 followers View post →
Melisa Burke
@MelisaB39884862 · X

RT @KulikovUNIATF: Specialized cells involved in how the body responds to insulin are activated in the

Jan 25, 2025 · 4 shares · 4,837 followers View post →
Dr Alexey Kulikov
@KulikovUNIATF · X

Specialized cells involved in how the body responds to insulin are activated in the

Jan 25, 2025 · 17 likes · 4 shares · 62,990 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes https://t.co/s356VHsNFn https://t.co/ODwmuVNgFv

Jan 23, 2025 · 1 like · 93 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with pre…

Nov 4, 2024 · 1 share · 133 followers View post →
Agingdoc
@agingdoc1 · X

Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes https://t.co/w7MTBEy3Mt https://t.co/4mWGZMrjro

Nov 4, 2024 · 9 likes · 1 share · 41,736 followers View post →