December 2024 PMID 39467291

Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer.

Uri Ladabaum, Ajitha Mannalithara, Robert E Schoen, Jason A Dominitz, David Lieberman

Mentions

102
Peak: 7 in Nov 2024
across 5 sources since Oct 2024

Extended reach

391,116
potential audience

Total likes

24

Video views

233

Mentions per month

Oct 2024 – Apr 2025

Where it's discussed

  • News76 articles
  • X / Twitter17 posts
  • Blogs6 articles
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reveals a keen interest in less invasive screening methods like blood and stool tests, with posts citing data about their benefits and limitations. Many emphasize that while these new tests could significantly reduce colorectal cancer incidence and mortality, they are still less impactful than colonoscopy, as shown by phrases such as 'less profoundly effective' and 'still recommends colonoscopy.' The tone and choice of words suggest an acknowledgment of the potential impact of these innovations but also stress the importance of traditional methods for thorough detection.

AgreementModerate agreement

Most discussions acknowledge the potential benefits of novel molecular tests but emphasize that they are less effective than traditional colonoscopy.

InterestHigh interest

Participants show high interest in new screening options, often highlighting their less invasive nature and potential to increase screening rates.

EngagementModerate engagement

The posts reference specific findings from the study, citing comparisons between testing methods and discussing clinical implications.

ImpactModerate impact

The discussions recognize that the adoption of these tests could influence screening practices, though emphasizing that colonoscopy remains the gold standard.

Abstract in brief

  • The study evaluates the potential clinical and economic benefits of new molecular blood and stool tests, such as cfbDNA, for colorectal cancer screening, comparing them against traditional methods like colonoscopy and FIT.
  • Results suggest that these novel tests could significantly reduce CRC incidence and mortality, often being more cost-effective and sometimes even less costly than current screening options, especially if used every 3 years or more.
  • However, the effectiveness depends on factors like test intervals, uptake rates, and follow-up procedures, with shorter testing intervals sometimes increasing costs and adverse effects unless balanced by higher adoption rates.

Top posts

Most liked on X and Bluesky
Annals of Int Med
@AnnalsofIM · X

ICYMI: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/wpsmFuj9XC

Nov 4, 2024 · 7 likes · 2 shares · 72,417 followers View post →
Steven Artandi, MD, PhD
@SCIDirector · X

SCI member Uri Ladabaum & others found that 1st gen novel cf-bDNA tests may potentially < the incidence and mortality of #ColorectalCancer compared with no screening, but substantially less profoundly than screening #colonoscopy or stool tests.  https://t.co/1zlEGimrF7 https://t.co/Z5mqNxcL6B

Nov 1, 2024 · 7 likes · 3,712 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: First-gen novel cell free blood DNA tests could decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/R9aX4ZnC78 @StanfordMed https://t.co/wnlBYNKgiR

Jan 31, 2025 · 3 likes · 1 share · 72,417 followers View post →
Annals of Int Med
@AnnalsofIM · X

New: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/SItkPMeqVD

Oct 29, 2024 · 2 likes · 1 share · 72,417 followers View post →
Annals of Int Med
@AnnalsofIM · X

ICYMI: Don’t skip the colonoscopy. First-gen novel cell free blood DNA tests have the potential to decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/jdNElqgssr

Oct 31, 2024 · 1 like · 1 share · 72,417 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: First-gen novel cell free blood DNA tests could decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests: https://t.co/HaIg02lCLU @StanfordMed https://t.co/vTkR7LgSIy

Feb 17, 2025 · 1 like · 72,417 followers View post →

All mentions

Ramesh Shanker MD(Res)
@rameshshan777 · X

https://t.co/4O4JQnKwM7 This study reiterates cell-free blood-based DNA screening tests for CRC should only be offered who declined colonoscopy/ and stool testing. @ESGE_news @my_ueg @ASGEendoscopy @BritSocGastro #GITwitter

Apr 2, 2025 · 923 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: First-gen novel cell free blood DNA tests could decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests: https://t.co/HaIg02lCLU @StanfordMed https://t.co/vTkR7LgSIy

Feb 17, 2025 · 1 like · 72,417 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: First-gen novel cell free blood DNA tests could decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/R9aX4ZnC78 @StanfordMed https://t.co/wnlBYNKgiR

Jan 31, 2025 · 3 likes · 1 share · 72,417 followers View post →
Luigi Fontana, MD, PhD, FRACP
@LuigiFontanaMD · X

New less-invasive screening options, like stool-based and blood-based DNA tests, are gaining attention. However, a recent study confirms that colonoscopies remain the most effective tool for early detection. https://t.co/pEpvGiPd7z https://t.co/Ez3Mc7JNtx

Dec 11, 2024 · 1 like · 3,164 followers View post →
N und Auto
@naoto140 · X

https://t.co/vKvSNnOkRg

Nov 6, 2024 · 6 followers View post →
Revista MFAndalucia
@RevistaMFSamfyc · X

Impacto proyectado y rentabilidad de las nuevas pruebas de cribado moleculares de sangre o de heces para cáncer colorrectal https://t.co/qrc2IusMDY PMID 39467291

Nov 5, 2024 · 1 like · 722 followers View post →
Tatyana Shamliyan
@ShamliyanTA · X

RT @AnnalsofIM: ICYMI: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence…

Nov 4, 2024 · 2 shares · 252 followers View post →
Binay Panjiyar MD
@BinayMd · X

RT @AnnalsofIM: ICYMI: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence…

Nov 4, 2024 · 2 shares · 835 followers View post →
Annals of Int Med
@AnnalsofIM · X

ICYMI: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/wpsmFuj9XC

Nov 4, 2024 · 7 likes · 2 shares · 72,417 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer https://t.co/EzDuAywNj4

Nov 2, 2024 · 18,414 followers View post →
Steven Artandi, MD, PhD
@SCIDirector · X

SCI member Uri Ladabaum & others found that 1st gen novel cf-bDNA tests may potentially < the incidence and mortality of #ColorectalCancer compared with no screening, but substantially less profoundly than screening #colonoscopy or stool tests.  https://t.co/1zlEGimrF7 https://t.co/Z5mqNxcL6B

Nov 1, 2024 · 7 likes · 3,712 followers View post →
Tatyana Shamliyan
@ShamliyanTA · X

RT @AnnalsofIM: ICYMI: Don’t skip the colonoscopy. First-gen novel cell free blood DNA tests have the potential to decrease the incidence a…

Oct 31, 2024 · 1 share · 252 followers View post →
Annals of Int Med
@AnnalsofIM · X

ICYMI: Don’t skip the colonoscopy. First-gen novel cell free blood DNA tests have the potential to decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/jdNElqgssr

Oct 31, 2024 · 1 like · 1 share · 72,417 followers View post →
Tatyana Shamliyan
@ShamliyanTA · X

RT @AnnalsofIM: New: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence a…

Oct 31, 2024 · 1 share · 252 followers View post →
puls | あなたに合わせて届く、最新論文ダイジェスト
@puls_anesthlink · X

本日のおすすめ記事(消化器内科) https://t.co/1vLhILCylG

Oct 31, 2024 · 27 followers View post →
Yuri Gorelik
@GorelikYuri · X

Oct 29, 2024 · 218 followers View post →
Annals of Int Med
@AnnalsofIM · X

New: First-generation novel cell free blood DNA (cf-bDNA) tests have the potential to meaningfully decrease the incidence and mortality of CRC compared with no screening, but substantially less profoundly than colonoscopy or stool tests. https://t.co/V507lZuRA3 @StanfordMed https://t.co/SItkPMeqVD

Oct 29, 2024 · 2 likes · 1 share · 72,417 followers View post →