J Extracell Vesicles November 2024 PMID 39499013

Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer's disease.

Leelavathi N Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J Cai, Ashok K Shetty

Mentions

70
Peak: 10 in Nov 2024
across 4 sources since Jul 2023

Extended reach

575,952
potential audience

Total likes

55

Video views

416

Mentions per month

Jul 2023 – Dec 2024

Where it's discussed

  • News52 articles
  • X / Twitter13 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several comments emphasize the breakthrough nature of using extracellular vesicles from neural stem cells, with specific mentions of reduced neuroinflammation and cognitive improvements in mice. The tone varies from optimistic reports on potential clinical applications to detailed technical discussions, highlighting high engagement and perceived impact of this research.

AgreementModerate agreement

Most posts agree on the therapeutic potential of extracellular vesicles in Alzheimer's treatment, highlighting their anti-inflammatory properties.

InterestHigh interest

Discussions reflect high curiosity and enthusiasm, especially about the innovative method of intranasal delivery and its implications.

EngagementHigh engagement

Posts demonstrate detailed engagement, referencing specific mechanisms like microglia modulation and mentioning notable studies or institutions.

ImpactHigh impact

The discussions suggest a strong belief that this research could significantly influence future Alzheimer's therapies, with terms like 'game changer' and 'promising' used frequently.

Abstract in brief

  • Current Alzheimer's treatments are insufficient, highlighting the need for novel therapies that can slow disease progression and enhance brain function.
  • Anti-inflammatory extracellular vesicles (EVs) derived from human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) show potential as a disease-modifying option.
  • In a study involving 5xFAD mice, intranasal administration of hiPSC-NSC-EVs led to beneficial changes in brain immune cells, reduced inflammation, and improved cognitive and mood function, demonstrating the EVs' lasting positive effects on Alzheimer's disease.

Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer’s disease” by Ashok K. Shetty et al. Journal of Extracellular Vesicles https://t.co/0ah54Bm2yh

Nov 7, 2024 · 9 likes · 5 shares · 505,522 followers View post →
ISEV-Journals
@ISEV_Journals · X

Nov 8, 2024 · 4 likes · 1 share · 2,980 followers View post →
tune
@keisuke4713 · X

Dec 2, 2024 · 3 likes · 3,736 followers View post →
Agingdoc
@agingdoc1 · X

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice https://t.co/kgjFPKrtmX @FrontAging @FrontNeurosci https://t.co/dm5ORGcF81

Jul 10, 2023 · 2 likes · 1 share · 41,376 followers View post →
Ex_Citizen_BuckTweet
@GuyGadboisGuyG1 · X

RT @agingdoc1: Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly…

Jul 10, 2023 · 1 share · 4,444 followers View post →
ISEV
@IsevOrg · X

RT @ISEV_Journals:

Nov 8, 2024 · 1 share · 4,282 followers View post →

All mentions

tune
@keisuke4713 · X

Dec 2, 2024 · 3 likes · 3,736 followers View post →
Orlando_uy
@Orlando_uy · X

Extracellular vesicles from human‐induced pluripotent stem cell‐derived neural stem cells alleviate proinflammatory cascades within disease‐associated microglia in Alzheimer's disease. https://t.co/EHaog84tL1

Nov 15, 2024 · 692 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/XpXjDFaU6O

Nov 9, 2024 · 3,130 followers View post →
luis hernan graffe
@hernangraffe · X

RT @NeuroscienceNew: “Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory c…

Nov 9, 2024 · 5 shares · 3,130 followers View post →
NFLCSFacts
@NFLObjectors · X

Extracellular vesicles from human‐induced pluripotent stem cell‐derived neural stem cells alleviate proinflammatory cascades within disease‐associated microglia in Alzheimer's disease - Madhu - 2024 - Journal of Extracellular Vesicles - https://t.co/dnvC2G8Ndq

Nov 8, 2024 · 1,931 followers View post →
ISEV
@IsevOrg · X

RT @ISEV_Journals:

Nov 8, 2024 · 1 share · 4,282 followers View post →
ISEV-Journals
@ISEV_Journals · X

Nov 8, 2024 · 4 likes · 1 share · 2,980 followers View post →
Maciel
@Macieelll__ · X

RT @NeuroscienceNew: “Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory c…

Nov 7, 2024 · 5 shares · 135 followers View post →
Osvaldo Bramussi
@osvaldobramussi · X

RT @NeuroscienceNew: “Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory c…

Nov 7, 2024 · 5 shares · 62 followers View post →
Ufodaily
@Ufodaily16757 · X

RT @NeuroscienceNew: “Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory c…

Nov 7, 2024 · 5 shares · 4,059 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer’s disease” by Ashok K. Shetty et al. Journal of Extracellular Vesicles https://t.co/0ah54Bm2yh

Nov 7, 2024 · 9 likes · 5 shares · 505,522 followers View post →
Ex_Citizen_BuckTweet
@GuyGadboisGuyG1 · X

RT @agingdoc1: Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly…

Jul 10, 2023 · 1 share · 4,444 followers View post →
Agingdoc
@agingdoc1 · X

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice https://t.co/kgjFPKrtmX @FrontAging @FrontNeurosci https://t.co/dm5ORGcF81

Jul 10, 2023 · 2 likes · 1 share · 41,376 followers View post →