Mov Disord Clin Pract February 2025 PMID 39499184

Predicting Post-Mortem α-Synuclein Pathology by the Combined Presence of Probable REM sleep behavior disorder and Hyposmia.

Cécilia Tremblay, Charles H Adler, Holly A Shill, Erika Driver-Dunckley, Shyamal Mehta, Parichita Choudhury, Christine Belden, David R Shprecher, Joyce K Lee-Iannotti, Alireza Atri, Geidy E Serrano, Thomas G Beach

Mentions

8
Peak: 5 in Mar 2025
across 2 sources since Nov 2024

Extended reach

9,450
potential audience

Total likes

14

Video views

269

Mentions per month

Nov 2024 – Sep 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group exhibits high interest by encouraging readers to review the full paper and emphasizing its potential for cost-effective prediction of neurodegenerative pathology. Words like 'predict,' 'cost-effective,' and phrases such as 'interested to learn more' reflect enthusiasm and value placed on the research, while references to 'combination of probable RBD and hyposmia' highlight their focus on practical diagnostic strategies that may impact future studies.

AgreementModerate agreement

Most discussions acknowledge the potential usefulness and validity of the study findings, showing general agreement with its conclusions.

InterestHigh interest

Participants are highly interested, as evidenced by their enthusiasm for sharing the publication and encouraging further reading.

EngagementModerate engagement

Posts demonstrate moderate engagement by sharing links, summarizing the research, and prompting others to explore the methods and implications.

ImpactModerate impact

The debates suggest the findings could influence future screening practices or research directions, though they stop short of claiming immediate clinical implementation.

Abstract in brief

  • The study investigated whether the combination of probable REM sleep behavior disorder (PRBD) and hyposmia (reduced sense of smell) can predict the presence of Lewy type synucleinopathies (LTS) in elderly individuals after death.
  • Results showed that individuals with both PRBD and low olfactory function had a higher likelihood of postmortem LTS, with the predictive combination increasing specificity to 97.2%, making it a reliable indicator.
  • Using PRBD diagnosis alongside olfactory testing could offer an effective, cost-efficient way to identify those at risk for synucleinopathies in the general community without needing extensive sleep studies.]

Top posts

Most liked on X and Bluesky
Movement Disorders Clinical Practice
@MDCP_Journal · X

Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-type α-synucleinopathy @cece_tremblay https://t.co/hwQLxT6WG5 https://t.co/vyQVUenq5i

Mar 23, 2025 · 10 likes · 3 shares · 7,185 followers View post →
My Neuropath News
@NeuropathClinic · X

Predicting Post-Mortem α-Synuclein Pathology by the Combined Presence of Probable REM sleep behavior disorder and Hyposmia #neuropath https://t.co/rAyR9qT6QK

Nov 6, 2024 · 1 share · 1,587 followers View post →
Cecilia Tremblay
@cece_tremblay · X

Here is the full paper if you are interested to learn more about the prediction of postmortem synuclein pathology using olfactory testing and sleep questionnaire! @MDCP_Journal https://t.co/loGYuVWZmP

Mar 12, 2025 · 140 followers View post →
Keita Hiraga
@NEUR0TRAVELER · X

RT @MDCP_Journal: Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-ty…

Mar 23, 2025 · 3 shares · 97 followers View post →
Daniel Rebolledo, PhD, MD
@DanielReb1989 · X

RT @MDCP_Journal: Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-ty…

Mar 23, 2025 · 3 shares · 94 followers View post →
Centroblast
@CD10positive · X

RT @NeuropathClinic: Predicting Post-Mortem α-Synuclein Pathology by the Combined Presence of Probable REM sleep behavior disorder and Hypo…

Nov 6, 2024 · 1 share · 57 followers View post →

All mentions

Keita Hiraga
@NEUR0TRAVELER · X

RT @MDCP_Journal: Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-ty…

Mar 23, 2025 · 3 shares · 97 followers View post →
Daniel Rebolledo, PhD, MD
@DanielReb1989 · X

RT @MDCP_Journal: Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-ty…

Mar 23, 2025 · 3 shares · 94 followers View post →
Movement Disorders Clinical Practice
@MDCP_Journal · X

Probable RBD combined with reduced olfactory function may provide a cost-effective means of predicting postmortem Lewy-type α-synucleinopathy @cece_tremblay https://t.co/hwQLxT6WG5 https://t.co/vyQVUenq5i

Mar 23, 2025 · 10 likes · 3 shares · 7,185 followers View post →
Cecilia Tremblay
@cece_tremblay · X

Here is the full paper if you are interested to learn more about the prediction of postmortem synuclein pathology using olfactory testing and sleep questionnaire! @MDCP_Journal https://t.co/loGYuVWZmP

Mar 12, 2025 · 140 followers View post →
Centroblast
@CD10positive · X

RT @NeuropathClinic: Predicting Post-Mortem α-Synuclein Pathology by the Combined Presence of Probable REM sleep behavior disorder and Hypo…

Nov 6, 2024 · 1 share · 57 followers View post →
My Neuropath News
@NeuropathClinic · X

Predicting Post-Mortem α-Synuclein Pathology by the Combined Presence of Probable REM sleep behavior disorder and Hyposmia #neuropath https://t.co/rAyR9qT6QK

Nov 6, 2024 · 1 share · 1,587 followers View post →