Sci Transl Med November 2024 PMID 39504351

Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice.

Victor Fattori, Tiago H Zaninelli, Fernanda S Rasquel-Oliveira, Olivia K Heintz, Ashish Jain, Liang Sun, Maya L Seshan, Daniëlle Peterse, Anne E Lindholm, Raymond M Anchan, Waldiceu A Verri, Michael S Rogers

Mentions

97
Peak: 53 in Nov 2024
across 6 sources since Aug 2023

Extended reach

344,186
potential audience

Total likes

284

Video views

39

Mentions per month

Aug 2023 – Mar 2025

Where it's discussed

  • X / Twitter65 posts
  • News22 articles
  • Bluesky3 posts
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Several discussions highlight that drugs commonly used for migraines, such as CGRP antagonists, may also benefit individuals suffering from endometriosis. Phrases like 'potential treatment' and 'nonhormonal option' indicate a hopeful tone, suggesting excitement around the possibility of new therapies. The language used reflects a strong belief in the study's findings, with many contributors eager to explore the practical applications of this research.

AgreementStrong agreement

The majority of posts express strong support for the findings and potential applications of the research.

InterestHigh interest

There is significant enthusiasm and curiosity, with many comments reflecting a keen interest in the implications for treatment.

EngagementModerate engagement

Some posts show a moderate level of engagement, mentioning the study's details but less focus on deeper discussions.

ImpactHigh impact

The discussions perceive the research as having a substantial impact on understanding and treating endometriosis.

Abstract in brief

  • Endometriosis is a painful inflammatory disease affecting around 15% of women and transgender men, with current treatments often proving ineffective.
  • Researchers explored the involvement of calcitonin gene-related peptide (CGRP) and its receptor RAMP1 in the disease, finding that both human and mouse endometriosis lesions contain these components.
  • Blocking CGRP/RAMP1 signaling in a mouse model not only reduced pain and lesion size but also uncovered cellular mechanisms that could lead to effective non-hormonal treatments for endometriosis in clinical settings.

Top posts

Most liked on X and Bluesky
Antoine Copra
@Cobra_FX_ · X

Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signalisation CGRP-RAMP1 a conduit à une réduction de la douleur et de la taille des lésions. https://t.co/dRofqvs3Ka https://t.co/GcALtheevR

Nov 8, 2024 · 65 likes · 15 shares · 39,977 followers View post →
Victor Fattori
@victor_fattori · X

I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZUsVw https://t.co/e1hxKByJA2

Nov 6, 2024 · 53 likes · 5 shares · 306 followers View post →
Victor Fattori
@victor_fattori · X

#Preprint Alert

Aug 29, 2023 · 40 likes · 4 shares · 306 followers View post →
ImmuNoah'sArk
@immunonoah · X

Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice | Science Translational Medicine https://t.co/HoUYTUOhVh

Nov 8, 2024 · 31 likes · 8 shares · 1,401 followers View post →
Waggoner Lab
@LabWaggoner · X

Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model of the disease @ScienceTM @victor_fattori https://t.co/V3VAyOhrrW https://t.co/ctrNS8igSI

Nov 6, 2024 · 17 likes · 6 shares · 11,353 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth https://t.co/R1IztAB0gX #biorxiv_neursci

Aug 29, 2023 · 13 likes · 4 shares · 59,862 followers View post →

All mentions

Association of Migraine Disorders®
@MigraineDisordr · X

Researchers in Boston found that CGRP-blocking drugs commonly used for #migraine may help with endometriosis pain and lesion size. Molly O’Brien has the details in this #MigraineMinute news update recognizing #Endometriosis Awareness Month. Read More: https://t.co/UFanJvGxqL https://t.co/W7vpr4PhMe

Mar 28, 2025 · 8 likes · 6,901 followers View post →
Agingdoc
@agingdoc1 · X

Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice "...targeting this axis may lead to clinical benefit for patients with endometriosis." https://t.co/cF5v6Iqgsn

Feb 7, 2025 · 3 likes · 41,376 followers View post →
Dr. Alexis Gonzales, ND, MS, IFMCP
@functionalendo · X

Research suggests CGRP antagonists (migraine meds like Nurtec) may reduce pain and lesion growth by targeting the neuroimmune connection. Human studies are lacking, but if CGRP fuels pain and inflammation, modulating it could be a nonhormonal way to help. https://t.co/qGasguxnz0

Feb 2, 2025 · 1 like · 26 followers View post →
Paulo Morais
@PauloMo60053925 · X

RT @NYUPainResearch: CGRP/RAMP1-mediated communication between TRPV1+ nociceptors and macrophages contributes to the growth of endometriosi…

Nov 28, 2024 · 3 shares · 141 followers View post →
Rajan Singh
@Rajan___Singh · X

RT @NYUPainResearch: CGRP/RAMP1-mediated communication between TRPV1+ nociceptors and macrophages contributes to the growth of endometriosi…

Nov 28, 2024 · 3 shares · 1,470 followers View post →
kara gross margolis
@karagm2009 · X

RT @NYUPainResearch: CGRP/RAMP1-mediated communication between TRPV1+ nociceptors and macrophages contributes to the growth of endometriosi…

Nov 28, 2024 · 3 shares · 685 followers View post →
NYU Pain Research Center
@NYUPainResearch · X

CGRP/RAMP1-mediated communication between TRPV1+ nociceptors and macrophages contributes to the growth of endometriosis lesions and associated pain, highlighting a potential treatment by inhibiting this pathway #Painresearch https://t.co/uRty2OvoXT

Nov 28, 2024 · 13 likes · 3 shares · 129 followers View post →
flora peyvandi
@flora_peyvandi · X

The authors demonstrated the effectiveness and underlying cellular mechanisms of nonhormonal and nonopioid CGRP/RAMP1 blockade in a mouse model of endometriosis, suggesting that targeting this axis may lead to clinical benefit for patients with endometrios https://t.co/Yp2004JaFR

Nov 12, 2024 · 3 likes · 2,376 followers View post →
Victor Fattori
@victor_fattori · X

RT @ScienceTM: Studying patient samples and mice, a team finds that crosstalk between nociceptors and #macrophages through the peptide CGRP…

Nov 11, 2024 · 1 share · 306 followers View post →
Science Translational Medicine
@ScienceTM · X

Studying patient samples and mice, a team finds that crosstalk between nociceptors and #macrophages through the peptide CGRP worsens pain and lesion size in #endometriosis, which can be disrupted with approved drugs. @victor_fattori @BostonChildrens https://t.co/vOSlh9EX6v https://t.co/1uGt4ydEwo

Nov 11, 2024 · 4 likes · 1 share · 33,719 followers View post →
Sarah Whiteside
@SarahKWhiteside · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 10, 2024 · 8 shares · 544 followers View post →
D'Ombre et de Lumière
@louvetou · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 10, 2024 · 8 shares · 132 followers View post →
XtrmHULK
@Xtrmhulk · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 10, 2024 · 15 shares · 21 followers View post →
ahm
@anthelmosk · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 796 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 9, 2024 · 8 shares · 181 followers View post →
AlainCo #JeSuisPrometheen e/acc
@alain_co · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 3,317 followers View post →
Martine
@TheSwissGirl17 · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 177 followers View post →
Rêveur voyageur
@reveur_voyageur · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 342 followers View post →
Le Mister
@CervinGB · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 3,297 followers View post →
Guillaume Gaulier
@ggaulier · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 3,791 followers View post →
stephane globe
@g_l_o_b · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 619 followers View post →
ouakam
@ouakam5150 · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 49 followers View post →
Vinciane dP
@de_periers · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 9, 2024 · 15 shares · 1,731 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 9, 2024 · 8 shares · 14,322 followers View post →
Lakmé
@tondouxregard · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 8, 2024 · 15 shares · 449 followers View post →
Augusta Crochet
@AugustaCrochet · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 8, 2024 · 15 shares · 4,162 followers View post →
Blanchard Ronan
@RonnyChou · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 8, 2024 · 15 shares · 1,137 followers View post →
MacChecker
@Karther_33 · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 8, 2024 · 15 shares · 282 followers View post →
Madeleine
@Madeleine1522 · X

RT @Cobra_FX_: Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signal…

Nov 8, 2024 · 15 shares · 173 followers View post →
Antoine Copra
@Cobra_FX_ · X

Un espoir pour le traitement de l’endométriose ? Le traitement des souris avec des médicaments approuvés bloquant la signalisation CGRP-RAMP1 a conduit à une réduction de la douleur et de la taille des lésions. https://t.co/dRofqvs3Ka https://t.co/GcALtheevR

Nov 8, 2024 · 65 likes · 15 shares · 39,977 followers View post →
David A Posner
@DavidPosner13 · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 8, 2024 · 8 shares · 1,019 followers View post →
Alex Chudnovskiy
@ChudnovskiyLab · X

RT @immunonoah: Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pai…

Nov 8, 2024 · 8 shares · 832 followers View post →
ImmuNoah'sArk
@immunonoah · X

Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice | Science Translational Medicine https://t.co/HoUYTUOhVh

Nov 8, 2024 · 31 likes · 8 shares · 1,401 followers View post →
Mikołaj Stańczak
@mstanczako · X

RT @AM_Malf: Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in…

Nov 7, 2024 · 1 share · 68 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Estudio que sugiere que las terapias para la migraña, también podrían ser útiles para la endometriosis. Science Translational Medicine https://t.co/JksnEjqIEr

Nov 7, 2024 · 9 likes · 1 share · 45,845 followers View post →
Luigi F. Iannone
@Luigi_Ian_ · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 7, 2024 · 6 shares · 81 followers View post →
Susan Chubb#FBPA⚫️#RejoinEU
@SusanChubb1 · X

RT @AndrewW66619812: The paper in "Science Translational Medicine" the above "Nature" article is based upon, & links to: “Nociceptor-to-ma…

Nov 7, 2024 · 1 share · 10,232 followers View post →
Andy_Weeble_Weaver
@AndrewW66619812 · X

The paper in "Science Translational Medicine" the above "Nature" article is based upon, & links to: “Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice” 2/2 https://t.co/ctdXIdyPgF

Nov 7, 2024 · 1 like · 1 share · 4,321 followers View post →
abcd
@DrFuGao · X

RT @victor_fattori: I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZU…

Nov 7, 2024 · 5 shares · 32 followers View post →
Virginia Camacho
@tcell_camacho · X

RT @victor_fattori: I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZU…

Nov 7, 2024 · 5 shares · 222 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @victor_fattori: I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZU…

Nov 7, 2024 · 5 shares · 10,772 followers View post →
Ewa Zarnowska
@ewadorotaz · X

RT @victor_fattori: I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZU…

Nov 6, 2024 · 5 shares · 1,990 followers View post →
Richard S
@Richard01173388 · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 6, 2024 · 6 shares · 147 followers View post →
bxFLgfubBCvHa5B
@bxFLgfubBCvHa5B · X

RT @takatoh_life: 【原著論文】 V. Fattori, et al. "Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-assoc…

Nov 6, 2024 · 1 share · 1,105 followers View post →
Dan Levy
@DanLevy919 · X

RT @victor_fattori: I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZU…

Nov 6, 2024 · 5 shares · 698 followers View post →
高遠 頼@生命科学VTuber
@takatohlife.bsky.social · Bluesky

【原著論文】 V. Fattori, et al. "Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice" Science Translational Medicine, 6 Nov 2024. Vol 16, Issue 772 www.science.org/doi/10.1126/...

Nov 6, 2024 · 1 like View post →
高遠 頼@生命科学VTuber(たかとー らい) 定期科学ニュース配信(日)
@takatoh_life · X

【原著論文】 V. Fattori, et al. "Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice" Science Translational Medicine, 6 Nov 2024. Vol 16, Issue 772 https://t.co/OybSsVvHJc

Nov 6, 2024 · 1 like · 1 share · 13,672 followers View post →
AM Malfait
@AM_Malf · X

Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice | Science Translational Medicine https://t.co/23nJoMMihd

Nov 6, 2024 · 11 likes · 1 share · 1,102 followers View post →
thetranscendedman
@atranscendedman · X

Blocking CGRP-RAMP1 reduced pain and lesion size in a mouse model of endometriosis. This pathway, linked to nerve-immune signaling, could offer a new nonhormonal treatment option for endometriosis pain. https://t.co/VIubFVZcls

Nov 6, 2024 · 4 likes · 6,900 followers View post →
Peng Zeng
@pengzeng4001 · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 6, 2024 · 6 shares · 200 followers View post →
Yeekien,Chong
@ykchong90 · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 6, 2024 · 6 shares · 245 followers View post →
Victor Fattori
@victor_fattori · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 6, 2024 · 6 shares · 306 followers View post →
Victor Fattori
@victor_fattori · X

I am happy to share that our work on endometriosis and pain has been now published on @ScienceTM https://t.co/aYL0wZUsVw https://t.co/e1hxKByJA2

Nov 6, 2024 · 53 likes · 5 shares · 306 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

RT @LabWaggoner: Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model o…

Nov 6, 2024 · 6 shares · 2,054 followers View post →
Waggoner Lab
@LabWaggoner · X

Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model of the disease @ScienceTM @victor_fattori https://t.co/V3VAyOhrrW https://t.co/ctrNS8igSI

Nov 6, 2024 · 17 likes · 6 shares · 11,353 followers View post →
Tiago Zaninelli
@TiagoZaninelli · X

RT @biorxiv_neursci: Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion gr…

Aug 30, 2023 · 4 shares · 33 followers View post →
Camila Ferraz
@PhDNeuroimmune · X

RT @victor_fattori: #Preprint Alert

Aug 30, 2023 · 4 shares · 143 followers View post →
Fernanda S. Rasquel de Oliveira
@RasquelOliveira · X

RT @biorxiv_neursci: Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion gr…

Aug 30, 2023 · 4 shares · 35 followers View post →
Fernanda S. Rasquel de Oliveira
@RasquelOliveira · X

RT @victor_fattori: #Preprint Alert

Aug 30, 2023 · 4 shares · 35 followers View post →
Juliet Mwirigi
@JulietMwirigi · X

RT @victor_fattori: #Preprint Alert

Aug 30, 2023 · 4 shares · 1,340 followers View post →
Juliet Mwirigi
@JulietMwirigi · X

RT @biorxiv_neursci: Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion gr…

Aug 30, 2023 · 4 shares · 1,340 followers View post →
Victor Fattori
@victor_fattori · X

RT @biorxiv_neursci: Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion gr…

Aug 29, 2023 · 4 shares · 306 followers View post →
Phage Papers
@Phage_Papers · X

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth https://t.co/DhrxbwhK5C

Aug 29, 2023 · 647 followers View post →
bioRxiv Neuroscience
@biorxiv-neursci.bsky.social · Bluesky

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth https://www.biorxiv.org/content/10.1101/2023.08.28.555101v1

Aug 29, 2023 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth https://www.biorxiv.org/content/10.1101/2023.08.28.555101v1

Aug 29, 2023 View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth https://t.co/R1IztAB0gX #biorxiv_neursci

Aug 29, 2023 · 13 likes · 4 shares · 59,862 followers View post →
Alles Lab
@AllesLab · X

RT @victor_fattori: #Preprint Alert

Aug 29, 2023 · 4 shares · 1,711 followers View post →
Victor Fattori
@victor_fattori · X

#Preprint Alert

Aug 29, 2023 · 40 likes · 4 shares · 306 followers View post →