Adv Healthc Mater March 2025 PMID 39523700

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons.

Angel Bu, Ferdows Afghah, Nicolas Castro, Maheera Bawa, Sonika Kohli, Karina Shah, Brandon Rios, Vincent Butty, Ritu Raman

Mentions

135
Peak: 54 in Nov 2024
across 6 sources since Nov 2024

Extended reach

5,115,735
potential audience

Total likes

222

Video views

3,783

Mentions per month

Nov 2024 – Nov 2025

Where it's discussed

  • X / Twitter67 posts
  • News48 articles
  • Blogs8 articles
  • Reddit5 posts
  • YouTube4 videos
  • Facebook3 posts

AI synopsis

What people are saying

Numerous discussions afford specific insights into the research, such as references to how myokines released during muscle contractions can significantly enhance neuron growth. Phrases like 'this goes much further' and 'could inform therapies' express enthusiasm and a belief in the practical implications of the study. The tone is largely positive, with an emphasis on the potential for transformation in nerve repair and cognitive enhancements driven by exercise.

AgreementStrong agreement

The majority of discussions express a strong alignment with the research findings, highlighting the positive effects of muscle contractions on neuron behavior.

InterestHigh interest

Participants show high interest, as evidenced by multiple detailed summaries and analyses of the research presented.

EngagementHigh engagement

Many comments delve into specific aspects of the study, discussing the role of myokines and their implications for treatment.

ImpactHigh impact

Numerous posts emphasize the significant potential impact of these findings on nerve repair and neurodegenerative disease therapies.

Abstract in brief

  • This study investigates how muscle contractions affect motor neurons, focusing on separating the mechanical and biochemical influences of muscle activity, using in vitro models rather than in vivo due to challenges in isolating these effects.
  • Researchers developed a method to culture highly contractile muscle tissues with controlled mechanical properties, enabling them to assess the impact of exercised muscle on motor neuron behavior and the molecules they release.
  • Findings indicate that muscle-derived signals enhance motor neuron growth and migration, with differing effects based on the intensity of muscle contraction, as well as distinct molecular pathways activated by mechanical versus biochemical signals.

Top posts

Most liked on X and Bluesky
Medical Xpress
@medical_xpress · X

MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This finding could inform therapies for nerve repair and neurodegenerative diseases. @MIT https://t.co/4SG0Y9CQ1f https://t.co/FxxjFMHCjR

Nov 12, 2024 · 54 likes · 34 shares · 173,095 followers View post →
Nicholas Fabiano, MD
@NTFabiano · X

These findings are from a study in @WileyGlobal which examined the impact of myokines, released during exercise, on neuron growth. https://t.co/4jscIBayQC 2/10 https://t.co/cBGdnWFLNv

Apr 29, 2025 · 38 likes · 2 shares · 110,860 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 38 likes · 7 shares · 75,553 followers View post →
Advanced Portfolio News
@AdvPortfolio · X

A research team led by @DrRituRaman @MIT find that bottom-up biochemical and mechanical signaling from muscles to motor neurons (green) during exercise helps nerves grow faster and farther. Learn more: https://t.co/nkptzAfZ5z https://t.co/lN9DaV2gHv

Nov 14, 2024 · 14 likes · 4 shares · 34,797 followers View post →
Consejo COLEF
@ConsejoCOLEF · X

"Cuando los músculos se contraen durante el ejercicio, liberan mioquinas. En presencia de estas señales generadas por los músculos, las neuronas crecían cuatro veces más rápido, en comparación con las que no estaban expuestas a las mioquinas"

Jan 29, 2025 · 10 likes · 3 shares · 15,285 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Evidencias in vivo emergentes sugieren que la contracción muscular repetida, o el ejercicio, tiene un efecto significativo en el crecimiento de los nervios periféricos https://t.co/KUuVsLpjjd https://t.co/22D25TYQfk https://t.co/cENpKEkJT0

Nov 13, 2024 · 9 likes · 1 share · 45,824 followers View post →

All mentions

Ranjit Bawa
@rsbawa · X

RT @jalam1001: Detailed Summaries: --- Title: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle…

Jul 7, 2025 · 1 share · 274 followers View post →
COLEF Andalucía, Ceuta y Melilla
@ColefAndalucia · X

RT @ConsejoCOLEF: "Las reacciones bioquímicas y físicas que se producen en el ejercicio son útiles para curar posibles lesiones nerviosas q…

Jun 24, 2025 · 1 share · 3,856 followers View post →
Consejo COLEF
@ConsejoCOLEF · X

"Las reacciones bioquímicas y físicas que se producen en el ejercicio son útiles para curar posibles lesiones nerviosas que conectan el cerebro con la médula espinal y otras partes del cuerpo, preservando la memoria". Vía @20m

Jun 23, 2025 · 1 share · 15,285 followers View post →
Taner
@HTanerTeker · X

https://t.co/7SlGaHaN3L

May 2, 2025 · 75 followers View post →
Patricio Castro (#new
@pacastrom · X

RT @NTFabiano: These findings are from a study in @WileyGlobal which examined the impact of myokines, released during exercise, on neuron g…

Apr 30, 2025 · 2 shares · 284 followers View post →
Sunflower
@Cailinspeir · X

RT @NTFabiano: These findings are from a study in @WileyGlobal which examined the impact of myokines, released during exercise, on neuron g…

Apr 29, 2025 · 2 shares · 1,110 followers View post →
Nicholas Fabiano, MD
@NTFabiano · X

These findings are from a study in @WileyGlobal which examined the impact of myokines, released during exercise, on neuron growth. https://t.co/4jscIBayQC 2/10 https://t.co/cBGdnWFLNv

Apr 29, 2025 · 38 likes · 2 shares · 110,860 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons https://t.co/VINLNZEWBg https://t.co/sviQwIghYB

Apr 15, 2025 · 94 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons. https://t.co/ocvTTPKHca

Apr 3, 2025 · 2,064 followers View post →
Roy Sweetin
@RoySweetin · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - 2025 - Advanced Healthcare Materials - Wiley Online Library https://t.co/B3tz6NOi1K

Apr 2, 2025 · 427 followers View post →
Jeremy Loenneke
@jploenneke · X

"This study leverages actuating extracellular matrices to robustly validate a previously hypothesized role for muscle contraction in regulating motor neuron growth and maturation from the bottom-up through both mechanical and biochemical signaling." https://t.co/WVQRtzAzsf

Mar 19, 2025 · 4 likes · 8,615 followers View post →
Ignacio Ribot Colomer
@ignacio_ribot · X

RT @ConsejoCOLEF: "Cuando los músculos se contraen durante el ejercicio, liberan mioquinas. En presencia de estas señales generadas por los…

Jan 29, 2025 · 3 shares · 121 followers View post →
Consejo COLEF
@ConsejoCOLEF · X

"Cuando los músculos se contraen durante el ejercicio, liberan mioquinas. En presencia de estas señales generadas por los músculos, las neuronas crecían cuatro veces más rápido, en comparación con las que no estaban expuestas a las mioquinas"

Jan 29, 2025 · 10 likes · 3 shares · 15,285 followers View post →
Kimberly Feist
@kfeist916 · X

RT @sadiestlawrence: Full study: https://t.co/DpDKMeaQAD

Jan 4, 2025 · 1 share · 497 followers View post →
Sadie St Lawrence
@sadiestlawrence · X

Full study: https://t.co/DpDKMeaQAD

Jan 4, 2025 · 1 like · 1 share · 1,970 followers View post →
HYBRATH
@clubAsociali · X

Humans have an obligation to keep their biological systems in shape. To the best of one's ability. It is necessary in order to develop, increase and maintain one's superior computational abilities. Mens sana in corpore sano. A duty. https://t.co/vRthIdcKvC

Nov 24, 2024 · 70 followers View post →
Mikołaj Stańczak
@mstanczako · X

RT @BernatBusca72: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons…

Nov 23, 2024 · 1 share · 70 followers View post →
Mikołaj Stańczak
@mstanczako · X

RT @DrImranSheikh: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons…

Nov 23, 2024 · 1 share · 70 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Descubren que el esfuerzo de los músculos ayuda a crecer a las neuronas https://t.co/NgYkCIOi1B Más información: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons https://t.co/aCmwTY42GC

Nov 23, 2024 · 158 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons https://t.co/N159TEWrFE https://t.co/8yRsfwBN0z

Nov 22, 2024 · 1 like · 1 share · 24,187 followers View post →
Bernat Buscà
@BernatBusca72 · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/Hi81u8bYkT

Nov 20, 2024 · 2 likes · 1 share · 871 followers View post →
Fernando M-R
@fernando7mr · X

RT @gorkanunez: Sabíamos que el ejercicio mejora el rendimiento congnitivo. Pero esto va mucho más allá. https://t.co/IQhQGlIBLs

Nov 20, 2024 · 1 share · 661 followers View post →
Gorka Nuñez
@gorkanunez · X

Sabíamos que el ejercicio mejora el rendimiento congnitivo. Pero esto va mucho más allá. https://t.co/IQhQGlIBLs

Nov 20, 2024 · 3 likes · 1 share · 2,774 followers View post →
Javed Alam
@jalam1001 · X

Detailed Summaries: --- Title: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons Author(s): Angel Bu, Ferdows Afghah, Nicolas Castro, Maheera Bawa, Sonika Kohli, Karina Shah, Brandon Rios, Vincent Butty, and

Nov 17, 2024 · 1 share · 995 followers View post →
Mega
@LilianaMega1 · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 15, 2024 · 7 shares · 2,435 followers View post →
Muscles - Fascia - Posture - Nutrition
@fitat45plus · X

Original article: https://t.co/j1NrIOCeiQ Also: https://t.co/c6GDwpsIjG

Nov 15, 2024 · 3,166 followers View post →
Mitzi
@NavalCelina · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 7 followers View post →
almaseelesoul
@almaseelesoul · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 1,023 followers View post →
Núcleo de Darkschewitsch
@PopcornTits · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/F2zpAy6fuR

Nov 14, 2024 · 349 followers View post →
Ramon Morata
@RamonMoSenar · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 639 followers View post →
Hugo Ramirez
@hugoram47 · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 701 followers View post →
Víctor
@Vic31416 · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 36 followers View post →
JAIME ALVAREZ
@JAIMECAGUA · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 186 followers View post →
ferminacevesd
@ferminacevesd · X

RT @chayito09: Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 7 shares · 2,687 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuente: https://t.co/ei7RcQfdQv Artículo original https://t.co/LL4taurvhL

Nov 14, 2024 · 38 likes · 7 shares · 75,553 followers View post →
Jane A.D
@doey_ann · X

RT @AdvPortfolio: A research team led by @DrRituRaman @MIT find that bottom-up biochemical and mechanical signaling from muscles to motor n…

Nov 14, 2024 · 4 shares · 1,255 followers View post →
sciencenews
@Scieducation1 · X

RT @AdvPortfolio: A research team led by @DrRituRaman @MIT find that bottom-up biochemical and mechanical signaling from muscles to motor n…

Nov 14, 2024 · 4 shares · 5,131 followers View post →
Ntwrk23
@SchamHarry · X

Sehr interessant! Wenn Muskeln trainieren, helfen sie Neuronen beim Wachsen, zeigt eine neue Studie. Die Ergebnisse deuten darauf hin, dass die biochemischen und physischen Effekte von Bewegung dazu beitragen könnten, Nerven zu heilen. https://t.co/GtMqoPAkuq

Nov 14, 2024 · 23 followers View post →
Advanced Portfolio News
@AdvPortfolio · X

A research team led by @DrRituRaman @MIT find that bottom-up biochemical and mechanical signaling from muscles to motor neurons (green) during exercise helps nerves grow faster and farther. Learn more: https://t.co/nkptzAfZ5z https://t.co/lN9DaV2gHv

Nov 14, 2024 · 14 likes · 4 shares · 34,797 followers View post →
Matt Hurewitz
@MattHurewitz · X

@misraetel Link between muscle contraction and muscle growth https://t.co/Z6oISw9kDk

Nov 13, 2024 · 72 followers View post →
Jesús
@LGs596 · X

RT @IlindelatorreMD: Evidencias in vivo emergentes sugieren que la contracción muscular repetida, o el ejercicio, tiene un efecto significa…

Nov 13, 2024 · 1 share · 67 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Evidencias in vivo emergentes sugieren que la contracción muscular repetida, o el ejercicio, tiene un efecto significativo en el crecimiento de los nervios periféricos https://t.co/KUuVsLpjjd https://t.co/22D25TYQfk https://t.co/cENpKEkJT0

Nov 13, 2024 · 9 likes · 1 share · 45,824 followers View post →
Hmmm...
@HmmmNiceee · X

Scientists have found that during exercise muscles release a soup of biochemical signals called myokines, which help the neurons to grow four times farther compared to neurons that were not exposed to myokines. This suggests that exercise can have a sign… https://t.co/iKYDdQBhGd

Nov 13, 2024 · 342 followers View post →
Furquan Pathan, MD
@MDCrit · X

Full paper here: https://t.co/w7hhRIM2VP

Nov 13, 2024 · 1,094 followers View post →
pislashpi
@pislashpi · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/T4OPialS6q

Nov 12, 2024 · 22 followers View post →
tabula rasa
@tabulla_rassa · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 157 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 384 followers View post →
Errant Thoughts
@ErrantThoughts · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 272 followers View post →
Alex Kupreev
@alex_kupreev · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 130 followers View post →
turón
@AleeTuron · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 440 followers View post →
Mika Ainasoja
@MikaAinasoja · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 2,127 followers View post →
Even Cloutier
@EvenCloutier · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 107 followers View post →
Ugo Rivera
@ugo_r_b · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 334 followers View post →
Walter Sawyer
@Walter5awyer · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 59 followers View post →
Roy Sweetin
@RoySweetin · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/QgHdIxnbv9

Nov 12, 2024 · 1 like · 427 followers View post →
Luis Alberto Luengo
@luengo1958 · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 17,819 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 3,531 followers View post →
NicorDesigns LLC
@NicoUSAXZA1 · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 470 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This f…

Nov 12, 2024 · 34 shares · 1,024,093 followers View post →
Medical Xpress
@medical_xpress · X

MIT engineers discovered that #exercise promotes neuron growth through biochemical signals and physical impacts. This finding could inform therapies for nerve repair and neurodegenerative diseases. @MIT https://t.co/4SG0Y9CQ1f https://t.co/FxxjFMHCjR

Nov 12, 2024 · 54 likes · 34 shares · 173,095 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/QuucQVaJYo

Nov 12, 2024 · 1 like · 1,293 followers View post →
Mery
@Mery20083825 · X

RT @themacrowizard: Link al estudio: https://t.co/BSsGZpup7z

Nov 12, 2024 · 1 share · 150 followers View post →
Alberto Alvarez
@themacrowizard · X

Link al estudio: https://t.co/BSsGZpup7z

Nov 12, 2024 · 2 likes · 1 share · 26,078 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons” by Ritu Raman et al. Advanced Healthcare Materials https://t.co/85IHYfybwl

Nov 12, 2024 · 6 likes · 1 share · 505,554 followers View post →
Chopdubeeus
@l_a_chop70 · X

RT @MCHammer: Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons Bu -…

Nov 12, 2024 · 1 share · 2,956 followers View post →
MC HAMMER e/acc
@MCHammer · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons Bu - Advanced Healthcare Materials Wiley Online Library #Hamm400✨✍

Nov 12, 2024 · 7 likes · 1 share · 2,984,990 followers View post →
John Maki
@John_W_Maki · X

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons - Bu - Advanced Healthcare Materials - Wiley Online Library https://t.co/QASvUd3M51

Nov 12, 2024 · 241 followers View post →