Cell Rep Med November 2024 PMID 39536751

PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers.

Yiqian Gu, Ann Ly, Sara Rodriguez, Hanwei Zhang, Jiyoon Kim, Zhiyuan Mao, Ankush Sachdeva, Nazy Zomorodian, Matteo Pellegrini, Gang Li, Sandy Liu, Alexandra Drakaki, Matthew B Rettig, Arnold I Chin

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Mentions

21
Peak: 3 in Dec 2024
across 4 sources since Nov 2024

Extended reach

39,056
potential audience

Total likes

1

Video views

9

Mentions per month

Nov 2024 – Dec 2024

Where it's discussed

  • News14 articles
  • X / Twitter3 posts
  • Blogs3 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions reflect a balanced view, with some comments noting the promising two-year survival rates and tolerability, using phrases like 'potential breakthrough' or 'hopeful developments,' while others simply acknowledge the publication without deep elaboration. The tone varies from cautious optimism to mild interest, which aligns with the moderate scores assigned.

AgreementModerate agreement

Most discussions recognize the promising response rates and manageable toxicity, indicating general agreement with the positive implications of the study.

InterestModerate interest

Comments show a moderate level of curiosity, with some users highlighting the relevance of the treatment for rare cancers but not expressing deep passion.

EngagementNeutral engagement

Posts tend to briefly acknowledge the study's findings without detailed analysis, reflecting a neutral level of engagement.

ImpactModerate impact

Participants suggest the research could influence future treatment options, but the overall tone remains cautious, indicating perceived moderate impact.

Abstract in brief

  • Small cell neuroendocrine cancers show similar characteristics across different tissues, often responding briefly to chemotherapy before rapidly worsening.
  • A phase 1b study tested pembrolizumab combined with platinum-based chemotherapy in 15 patients, showing an overall response rate of 43% and a promising two-year overall survival rate of 86% for small cell bladder cancer and 57% for small cell prostate cancer.
  • The treatment was generally well-tolerated, with 40% of patients experiencing severe side effects but no fatalities or treatment stoppages due to toxicity, alongside evidence of enhanced T cell activity linked to better outcomes.

Top posts

Most liked on X and Bluesky
Cell Reports Medicine
@CellRepMed · X

Online now: PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers https://t.co/fwDCOcf5uS

Dec 6, 2024 · 1 like · 18,931 followers View post →
Cell Reports Medicine
@CellRepMed · X

Online now: PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers https://t.co/O5Tw51WVgz

Dec 3, 2024 · 18,931 followers View post →

All mentions

Duprey Philippe. Velissariou:Bélisaire par ma mère
@PhilVelissariou · X

RT @CellRepMed: Online now: PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate…

Dec 6, 2024 · 1,185 followers View post →
Cell Reports Medicine
@CellRepMed · X

Online now: PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers https://t.co/fwDCOcf5uS

Dec 6, 2024 · 1 like · 18,931 followers View post →
Cell Reports Medicine
@CellRepMed · X

Online now: PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers https://t.co/O5Tw51WVgz

Dec 3, 2024 · 18,931 followers View post →