June 2025 PMID 39569437

Creatine with guanidinoacetic acid improves prefrontal brain oxygenation before, during, and after a cognitive task: A randomized controlled pilot trial.

Dragana Zanini, Nikola Todorovic, Sergej M Ostojic

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Mentions

Peak: 18 in Jul 2025

across 2 sources since Jul 2025

Extended reach

61,948

potential audience

Total likes

786

Video views

20,187

Mentions per month

Jul 2025 – Oct 2025

Where it's discussed

X / Twitter26 posts
YouTube3 videos

AI synopsis

What people are saying

The overall tone reflects interest and cautious optimism, with comments like Menno Henselmans' noting the observed increase in prefrontal cortex oxygenation and suggesting it could be relevant for conditions like brain fog and Long Covid. The discussions include references to specific studies and potential benefits, demonstrating an active engagement with scientific content and curiosity about future applications.

AgreementModerate agreement

Most discussions acknowledge the positive findings of the study, with several posts referencing the potential benefits of creatine combined with GAA and their implications for brain health.

InterestHigh interest

The detailed mentions of specific studies, brain oxygenation improvements, and potential applications like for brain fog or Long Covid indicate a high level of curiosity and focus on the research’s significance.

EngagementModerate engagement

Participants discuss the study methodology, cite related research, and mention future implications, showing active engagement beyond superficial comments.

ImpactModerate impact

While the discussions highlight promising results, they mainly emphasize potential and need for further research, indicating moderate perceived impact at this stage.

Abstract in brief

The study investigates whether a supplement combining creatine and guanidinoacetic acid (GAA) can improve brain oxygenation in the prefrontal cortex during rest, meditation, and cognitive tasks in healthy young adults, showing that this mixture increases oxygen saturation more effectively than a placebo.
Over a 7-day period, 19 participants took the supplement or placebo in a crossover design, with measurements taken before and after, revealing significant improvements in oxygen saturation in the brain when using the combined creatine and GAA treatment, especially during rest, meditation, and recovery phases.
The results suggest that creatine and GAA may act as vasodilators, enhancing brain oxygenation during cognitive activities, but further extensive studies are needed to confirm these findings and explore their implications for nutritional neuroscience.

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All mentions

Creatine and GAA Enhance Prefrontal Brain Oxygenation During Cognitive Tasks

The study investigates whether a supplement combining creatine and guanidinoacetic acid can improve brain oxygenation in the prefrontal cortex during rest, meditation, and cognitive tasks in healthy young adults…

TAIGA SAMURAI · Oct 28, 2025 14,576 views

Enhancing Brain Oxygenation with Creatine and GAA Supplementation

This study investigates whether a supplement combining creatine and guanidinoacetic acid (GAA) can improve brain oxygenation in the prefrontal cortex during rest, meditation, and cognitive tasks in healthy young adults…

Thomas DeLauer · Oct 21, 2025 5,612 views

Enhancing Brain Oxygenation with Creatine and GAA Supplements

Elevate Your Mind · Oct 31, 2025 0 views

lifetime_high

@lifetime_high · X

@workouteating https://t.co/Lks5vFQCCM

Oct 30, 2025 · 3 likes · 25 followers View post →

Alethuros Kosmarche

@alethuros · X

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Oct 24, 2025 · 92 followers View post →

TechCritic (Daredevil)

@TechDialectic · X

@janvoss81 Hast Du Erfahrungen mit GAA? https://t.co/iYadVFmo4d

Oct 22, 2025 · 1 like · 1,034 followers View post →

Rowena's

@the_meat_market · X

Subscribe and watch the full video here: https://t.co/yglYztXsPp

Oct 22, 2025 · 1 like · 313 followers View post →

Tony Re

@AnthonyR7299 · X

@iheartmindy https://t.co/Sm8IaU9FhD

Oct 21, 2025 · 1 like · 40 followers View post →

Tony Re

@AnthonyR7299 · X

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Oct 21, 2025 · 1 like · 40 followers View post →

Tony Re

@AnthonyR7299 · X

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Oct 21, 2025 · 1 like · 40 followers View post →

Tony Re

@AnthonyR7299 · X

https://t.co/Sm8IaU9FhD

Oct 21, 2025 · 1 like · 40 followers View post →