Aging Cell April 2025 PMID 39660787

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice.

Tian-Yi Zhu, Po Hu, Yu-Hui Mi, Jun-Li Zhang, An-Na Xu, Ming-Tong Gao, Ying-Ying Zhang, San-Bing Shen, Guang-Ming Yang, Yang Pan

Mentions

54
Peak: 34 in Dec 2024
across 6 sources since Dec 2024

Extended reach

148,224
potential audience

Total likes

350

Video views

2,571

Mentions per month

Dec 2024 – Apr 2025

Where it's discussed

  • X / Twitter43 posts
  • YouTube3 videos
  • News3 articles
  • Facebook2 posts
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions revolve around the promising results of TERT gene insertions, emphasizing potential breakthroughs in longevity and tissue repair, as seen in comments about 'unparalleled longevity' and 'potently rejuvenated skin.' The tone varies from enthusiastic to cautious, with some users pondering safe methods for application, which reflects both curiosity and recognition of the research's transformative potential.

AgreementModerate agreement

Most discussions support the positive findings, highlighting the potential for increased lifespan and tissue regeneration without significant concern over risks.

InterestHigh interest

Posts demonstrate high curiosity, mentioning specific details like median lifespan extension (16.57%) and applications such as skin and intestinal rejuvenation.

EngagementModerate engagement

Several mentions of possible therapeutic uses, such as gene therapy and cosmetic applications, show deeper consideration and connection to real-world impacts.

ImpactHigh impact

The posts suggest the research could significantly influence aging science and treatments, with phrases indicating potential 'rejuvenation' and 'protection from colitis' serving as indicators of high perceived impact.

Abstract in brief

  • This research explores how inserting the TERT gene into mice's genomes (via precise gene editing) extends their lifespan, boosts telomerase activity, and improves their ability to repair tissue damage without causing cancer.
  • The Tert knockin mice showed faster wound healing, resistance to colitis, and better expression of growth factors like Fgf7 and Vegf, indicating enhanced tissue regeneration and reduced aging-related deterioration.
  • Overall, the study suggests that germline TERT gene editing could be a powerful strategy for promoting longevity and tissue rejuvenation, particularly in aging skin and intestines, with minimal risk of adverse effects.]

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/ISNamLMMEc

Dec 15, 2024 · 121 likes · 27 shares · 30,585 followers View post →
Agingdoc
@agingdoc1 · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/1Ix5uZfV2v

Apr 24, 2025 · 33 likes · 7 shares · 41,649 followers View post →
Agingdoc
@agingdoc1 · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/8vulHVp3fm https://t.co/HJC5v0PT7f

Dec 20, 2024 · 10 likes · 1 share · 41,649 followers View post →
Maria Robles
@RBioceutics · X

hTERT knock-in mice have potently rejuvenated skin and are protected from colitis. Could we safely introduce hTERT into skin as a cosmetic? We would stay away from permanent transfection... https://t.co/OCe6CKMCVg

Dec 16, 2024 · 4 likes · 2,810 followers View post →
Canadian Longevity Association
@canlongevity · X

The last Longevity Review of 2024 is here for your viewing pleasure! Contents: 1. Gene Therapy To Increase Telomere Length 2. Freeing The Immune System To Remove Senescent Cells 3. Using Probiotics To Help With Sarcopenia 1/2 https://t.co/4oDnYdWILZ

Jan 23, 2025 · 2 likes · 1 share · 121 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Unparalleled #longevity? This study shows the median #lifespan of TertKI (Telomerase reverse transcriptase gene knock-in) mice was extended by 16.57%, and regenerative potential in skin and intestinal #aging. https://t.co/MgA5so3RVw

Dec 17, 2024 · 1 like · 695 followers View post →

All mentions

EJ
@EJuliachs · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 25, 2025 · 7 shares · 375 followers View post →
F.Yusufzai
@obsurfer84 · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 25, 2025 · 7 shares · 295 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 25, 2025 · 7 shares · 77 followers View post →
Andrew Lewis
@lewisonhc · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 25, 2025 · 7 shares · 15 followers View post →
james Bond
@jamesBo74099976 · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 24, 2025 · 7 shares · 1,459 followers View post →
BillOckham
@BillOccham0 · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 24, 2025 · 7 shares · 590 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Apr 24, 2025 · 7 shares · 1,698 followers View post →
Agingdoc
@agingdoc1 · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/1Ix5uZfV2v

Apr 24, 2025 · 33 likes · 7 shares · 41,649 followers View post →
Chris Linnell
@ChrisPollyanna1 · X

RT @canlongevity: The last Longevity Review of 2024 is here for your viewing pleasure! Contents: 1. Gene Therapy To Increase Telomere Le…

Jan 23, 2025 · 1 share · 702 followers View post →
Canadian Longevity Association
@canlongevity · X

The last Longevity Review of 2024 is here for your viewing pleasure! Contents: 1. Gene Therapy To Increase Telomere Length 2. Freeing The Immune System To Remove Senescent Cells 3. Using Probiotics To Help With Sarcopenia 1/2 https://t.co/4oDnYdWILZ

Jan 23, 2025 · 2 likes · 1 share · 121 followers View post →
Danik12
@Dani21422k · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 30, 2024 · 27 shares · 517 followers View post →
CRISPR GLENN
@CrisprGlenn · X

RT @agingdoc1: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t…

Dec 21, 2024 · 1 share · 2,657 followers View post →
ageinguk.bsky.social
@ageinguk.bsky.social · Bluesky

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice #agingresearch onlinelibrary.wiley.com/doi/10.1111/...

Dec 21, 2024 View post →
neuralamp
@neuralamp4ever · X

@isaacofthebio @yannToskov "Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice" https://t.co/zUEwozwER5

Dec 20, 2024 · 2,446 followers View post →
Agingdoc
@agingdoc1 · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/8vulHVp3fm https://t.co/HJC5v0PT7f

Dec 20, 2024 · 10 likes · 1 share · 41,649 followers View post →
Immortality Bliss
@ImmortalityB · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 17, 2024 · 27 shares · 182 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Unparalleled #longevity? This study shows the median #lifespan of TertKI (Telomerase reverse transcriptase gene knock-in) mice was extended by 16.57%, and regenerative potential in skin and intestinal #aging. https://t.co/MgA5so3RVw

Dec 17, 2024 · 1 like · 695 followers View post →
NADIA EB
@NADYEUGENY · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 215 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 183 followers View post →
Johan Van Weyenbergh
@johanvawe · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 4,742 followers View post →
Marcielle "jasmyn" Luckan ( e/acc ) ⏩
@AlvaMarcielle · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 456 followers View post →
Boris Carikeo
@BCarikeo · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 674 followers View post →
Yasu
@Yasuyuki_Kihara · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 119 followers View post →
Science Socks
@SocksScience · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 452 followers View post →
Keshav K Singh, PhD
@mitoscientist · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 1,163 followers View post →
lichking昏暗
@zhangliang2 · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 181 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 572 followers View post →
Anirbanius Mitros
@anirbanius · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 173 followers View post →
Gregory Warren
@profg_warren · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 41 followers View post →
Sarah Wolf
@Wolf_SarahE · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 329 followers View post →
Alexei Maklakov
@AlexeiMaklakov · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 1,496 followers View post →
Maria Robles
@RBioceutics · X

hTERT knock-in mice have potently rejuvenated skin and are protected from colitis. Could we safely introduce hTERT into skin as a cosmetic? We would stay away from permanent transfection... https://t.co/OCe6CKMCVg

Dec 16, 2024 · 4 likes · 2,810 followers View post →
CT Hsu
@caffeinatedcee · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 294 followers View post →
Nunzio Cuzzucoli
@NunzioCuzzucoli · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 16, 2024 · 27 shares · 75 followers View post →
Tequehead
@tequehead · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 339 followers View post →
John Greene
@Greene_Thoughts · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 1,698 followers View post →
Ricardo Carrillo, MD 医
@RCarrillo_MD · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 260 followers View post →
아나도
@msbnakwon · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 24 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 625 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 404 followers View post →
Shahzad Irfan
@SIRFABO · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 488 followers View post →
João Paulo Pelúzio
@PeLuzZIo_ · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 57 followers View post →
leolisanicko
@leolisanick0 · X

RT @AgingBiology: Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https:/…

Dec 15, 2024 · 27 shares · 440 followers View post →
Aging Science News
@AgingBiology · X

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice https://t.co/ISNamLMMEc

Dec 15, 2024 · 121 likes · 27 shares · 30,585 followers View post →