Neuron February 2025 PMID 39689709

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating.

Bo Lei, Bilin Kang, Yuejun Hao, Haoyu Yang, Zihan Zhong, Zihan Zhai, Yi Zhong

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Mentions

Peak: 4 in Dec 2024

across 3 sources since Dec 2024

Extended reach

329

potential audience

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Video views

320

Mentions per month

Dec 2024 – May 2025

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Bluesky6 posts
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AI synopsis

What people are saying

The group emphasizes the novel approach used to track memory engrams and its implications for understanding remote memory updating, with phrases like 'revolutionary' and mentions of the role of neurogenesis and neuroplasticity. The tone reflects genuine interest and recognition of the study’s potential to deepen knowledge of hippocampal function, yet some posts remain cautious about immediate applications.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly supporting the idea that it advances understanding of memory reconsolidation.

InterestHigh interest

The discussions show strong curiosity, especially with repeated mentions of the study’s focus on memory updating and hippocampal engrams.

EngagementModerate engagement

Participants reference the methodology and theoretical implications, indicating moderate engagement and interest in the mechanisms involved.

ImpactModerate impact

While some believe the findings could influence future studies, the overall perception of immediate practical impact remains moderate.

Abstract in brief

The study developed a special labeling method and used two-photon imaging to track how hippocampal memory groups (engrams) change from initial learning to later reconsolidation, finding that new engrams are formed during remote memory recall.
This new hippocampal engram incorporates new contextual information, which allows the memory to be updated, and its formation is supported by adult hippocampal neurogenesis that silences the original engram.
The updated engram is integrated with emotional and valence aspects of the memory through interactions between the hippocampus, prefrontal cortex, and amygdala, explaining how remote memories are modified with new information.]

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All mentions

Hippocampal Engram Updating for Remote Memory Reconsolidation

This study demonstrates that hippocampal activity during remote recall is crucial for systems reconsolidation with new engram recruitment. Findings show adult neurogenesis supports this process, enabling memory updating…

Aspirational Neuroscience · Apr 11, 2025 198 views

Hippocampal Role in Memory Reconsolidation and Update

This study shows hippocampal activity during remote recall is essential for memory reconsolidation, involving new engram formation supported by adult neurogenesis, and integration with emotional and contextual…

Carboncopies Foundation · Apr 17, 2025 80 views

Hippocampal Engram Reclassification for Remote Memory Updating

This study demonstrates that hippocampal activity during remote recall is essential for memory reconsolidation, involving new engram formation supported by adult neurogenesis and interactions with prefrontal cortex and…

Carboncopies Foundation · Apr 20, 2025 42 views

Bertoglio lab (FMC/UFSC)

@bertogliolab.bsky.social · Bluesky

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.sciencedirect.com/science/arti...

May 7, 2025 · 3 likes · 1 share View post →

Juan Linde-Domingo

@lindedomingo.bsky.social · Bluesky

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.sciencedirect.com/science/arti...

Feb 7, 2025 · 2 likes View post →

CLaE

@claeneuro.bsky.social · Bluesky

Neuron Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.cell.com/neuron/abstr...

Dec 16, 2024 · 14 likes · 4 shares View post →

NeuroPaperBot

@neuropaperbot.bsky.social · Bluesky

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.cell.com/neuron/abstr...

Dec 16, 2024 View post →

AleX

@alex-mjm.bsky.social · Bluesky

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.cell.com/neuron/fullt...

Dec 16, 2024 View post →

Bertoglio lab (FMC/UFSC)

@bertogliolab.bsky.social · Bluesky

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating www.cell.com/neuron/abstr...

Dec 16, 2024 View post →

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Hippocampal Engram Updating for Remote Memory Reconsolidation

Hippocampal Role in Memory Reconsolidation and Update

Hippocampal Engram Reclassification for Remote Memory Updating