Int J Dev Neurosci February 2025 PMID 39703043

Folinic acid as a treatment for autism in children: A within-subjects open-label study on safety and efficacy.

Chui Mae Wong, Charmain Samantha Tan, Hwan Cui Koh, Xinyi Gan, Szu Liang Hie, Seyed Ehsan Saffari, Joo Guan Yeo, Joyce Ching Mei Lam

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Mentions

38
Peak: 16 in Apr 2025
across 4 sources since Dec 2024

Extended reach

94,525
potential audience

Total likes

33

Video views

152

Mentions per month

Dec 2024 – Nov 2025

Where it's discussed

  • X / Twitter18 posts
  • Facebook12 posts
  • Instagram6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects genuine interest, with posts emphasizing that folinic acid appears safe and feasible for autism treatment, as highlighted by phrases like 'justifies the need for a larger placebo-controlled trial' and mentions of it being 'potentially safe.' The tone is cautiously optimistic, indicating a recognition of the study's importance but also understanding that further research is needed to confirm efficacy.

AgreementModerate agreement

Most discussions support the potential safety and promising indications of folinic acid as a treatment for autism, reflecting cautious optimism.

InterestHigh interest

Social discussions show high interest, with repeated mentions of the treatment's safety and the importance of further research.

EngagementModerate engagement

Participants reference specific aspects of the study, such as its safety profile and the need for larger trials, indicating moderate depth of engagement.

ImpactModerate impact

The conversations suggest some recognition of the study’s potential significance, though they acknowledge the preliminary nature of these findings.

Abstract in brief

  • The study explored whether folinic acid is safe and effective for improving communication and behavior in children with autism, finding that it was well-tolerated without adverse effects.
  • It involved 10 children, who received oral folinic acid over 12-24 weeks, with some indications of behavioral improvements, although not statistically significant due to the small sample size.
  • The results suggest that folinic acid could be a promising treatment for autism, justifying further research with a larger, controlled study to confirm its benefits.]

Top posts

Most liked on X and Bluesky
LE COLLECTIF
@tatiann69922625 · X

« L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote justifient la nécessité d'un essai contrôlé par placebo à plus grande échelle. » https://t.co/gsYA50TrCO L’acide folinique est une forme active de la vitamine

Apr 25, 2025 · 19 likes · 11 shares · 65,348 followers View post →
José Ignacio Leyda
@ignacioleyda · X

Jan 15, 2025 · 4 likes · 8,266 followers View post →
Marcus Fidelicus
@MarcusFidelicus · X

@dr_andrealove If only you were a real doctor Folinic acid is a safe and feasible potential treatment for autism, and results from this pilot justify the need for a larger placebo-controlled trial. https://t.co/h84zdX9glD

Sep 23, 2025 · 3 likes · 346 followers View post →
Il potere forte è sempre più nelle mani di pochi
@iniziamoda0 · X

Quindi, ecco qua, perché faccia il giro del web... https://t.co/61PDwiMGjJ https://t.co/bNZPIAHYP9

Apr 25, 2025 · 2 likes · 1 share · 4,280 followers View post →
FABIENNE CAZE
@Diem_fabienne · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 2,431 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Folinic acid as a treatment for autism in children: A within-subjects open-label study on safety and efficacy https://t.co/8Ng9GryzjP

Dec 28, 2024 · 2,236 followers View post →

All mentions

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Folate Folinic Acid B9's impact on MTHFR, autism, thyroid, and wellness. This video discusses the role of folic acid, especially in individuals with MTHFR mutations, and its potential effects on mental health and…

OotoTV · Sep 9, 2025 104 views
Marcus Fidelicus
@MarcusFidelicus · X

@dr_andrealove If only you were a real doctor Folinic acid is a safe and feasible potential treatment for autism, and results from this pilot justify the need for a larger placebo-controlled trial. https://t.co/h84zdX9glD

Sep 23, 2025 · 3 likes · 346 followers View post →
Ramucho67
@ramucho67 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 1,853 followers View post →
Antonio Meloni
@antomas92 · X

RT @iniziamoda0: Quindi, ecco qua, perché faccia il giro del web... https://t.co/61PDwiMGjJ https://t.co/bNZPIAHYP9

Apr 25, 2025 · 1 share · 640 followers View post →
Il potere forte è sempre più nelle mani di pochi
@iniziamoda0 · X

Quindi, ecco qua, perché faccia il giro del web... https://t.co/61PDwiMGjJ https://t.co/bNZPIAHYP9

Apr 25, 2025 · 2 likes · 1 share · 4,280 followers View post →
CLAUDINE GAUTIER
@vicmahec · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 1,561 followers View post →
Clément chantal
@CClem64 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 736 followers View post →
wolferine
@blackcarat95 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 1,900 followers View post →
Alexandra A
@Alexand39740511 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 2,027 followers View post →
Ed Dreamer
@EdDreamer8 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 997 followers View post →
Vito Bruno
@itoBruno7 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 207 followers View post →
L’amourdegaïa
@amour8paix8joie · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 177 followers View post →
Jean Michel
@JeanMic89137974 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 159 followers View post →
FABIENNE CAZE
@Diem_fabienne · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 2,431 followers View post →
Delphine Estivalet
@Delph2552 · X

RT @tatiann69922625: « L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote…

Apr 25, 2025 · 11 shares · 353 followers View post →
LE COLLECTIF
@tatiann69922625 · X

« L'acide folinique est un traitement potentiel sûr et réalisable pour l'autisme, et les résultats de cet essai pilote justifient la nécessité d'un essai contrôlé par placebo à plus grande échelle. » https://t.co/gsYA50TrCO L’acide folinique est une forme active de la vitamine

Apr 25, 2025 · 19 likes · 11 shares · 65,348 followers View post →
MARA BARDARE'
@MaraBardare · X

Folinic acid as a treatment for autism in children: A within-subjects open-label study on safety and efficacy https://t.co/wQrw7B5gYA Acido folinico come trattamento per l'autismo nei bambini: uno studio aperto intra-soggetto su sicurezza ed efficacia

Apr 24, 2025 · 409 followers View post →
José Ignacio Leyda
@ignacioleyda · X

Jan 15, 2025 · 4 likes · 8,266 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Folinic acid as a treatment for autism in children: A within-subjects open-label study on safety and efficacy https://t.co/8Ng9GryzjP

Dec 28, 2024 · 2,236 followers View post →
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