Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab.
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Dec 2024 – Nov 2025Where it's discussed
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X / Twitter122 posts
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News3 articles
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Bluesky2 posts
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YouTube2 videos
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Facebook2 posts
AI synopsis
What people are saying
Many discussions highlight the study's conclusion that very low levels of LDL cholesterol do not lead to cognitive decline. For instance, phrases like 'no evidence of cognitive impairment' and references to the study's design and participant demographics (e.g., median age) demonstrate engagement with the research. The tone is generally optimistic, using terms such as 'game changer' and 'well done' to emphasize the importance of these findings in understanding heart health and cognition.
Most discussions reflect a positive reception and endorsement of the study's findings.
There is a high level of curiosity about the implications of the research.
Posts show moderate interaction, with some referencing specific details of the study and its context.
Participants perceive that the study has significant implications for public health and treatment options.
Abstract in brief
- Long-term effects of very low LDL cholesterol levels on cognitive function are still uncertain, despite short-term studies showing no issues.
- A study involving 473 participants, previously part of the EBBINGHAUS trial, assessed cognitive outcomes after long-term treatment with evolocumab, a PCSK9 inhibitor.
- Results indicated that there was no significant change in executive function for those treated with evolocumab, whether they originally received the drug or placebo.
Top posts
Most liked on X and BlueskyIn this study of 473 patients, very low levels of LDL achieved via PCSK9 inhibitors was not associated with cognitive decline over a median of 5 years. Further studies are needed to assess the generalizability to adults at higher risk of dementia. https://t.co/tEwPvCCMCb https://t.co/NX0EHH5otf
Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/NJQANLysqo
Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et al. https://t.co/tEwPvCCMCb @rgiugliano @TIMIStudyGroup #Cardiology #ClinicalTrials https://t.co/4y9VlUHsPJ
New Study: No Cognitive Decline with Very Low LDL-C!
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Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/PhCJdUpNLT
RT @NEJMEvidence: Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et…
RT @NEJMEvidence: Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et…
Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et al. https://t.co/3tIp1s2m57 @rgiugliano @TIMIStudyGroup #Cardiology #ClinicalTrials https://t.co/OriBPjwGE5
RT @NEJMEvidence: Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et…
RT @NEJMEvidence: Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et…
RT @NEJMEvidence: Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et…
Original Article: “Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab” by @AndreZimerman et al. https://t.co/tEwPvCCMCb @rgiugliano @TIMIStudyGroup #Cardiology #ClinicalTrials https://t.co/4y9VlUHsPJ
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @BrighamResearch: In a new study, researchers from @TIMIStudyGroup and colleagues found long-term low LDL was not associated with cognit…
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @SABOURETCardio: Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
Long-Term #Cognitive Safety of Achieving Very #LowLDL #lipids https://t.co/DsOhhKTlml
RT @CiccaroneCenter: New Study: No Cognitive Decline with Very Low LDL-C!
RT @BrighamResearch: In a new study, researchers from @TIMIStudyGroup and colleagues found long-term low LDL was not associated with cognit…
RT @CiccaroneCenter: New Study: No Cognitive Decline with Very Low LDL-C!
RT @CiccaroneCenter: New Study: No Cognitive Decline with Very Low LDL-C!
New Study: No Cognitive Decline with Very Low LDL-C!
RT @rblument1: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/NJQANLysqo
RT @rblument1: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/NJQANLysqo
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/NJQANLysqo
RT @BrighamResearch: In a new study, researchers from @TIMIStudyGroup and colleagues found long-term low LDL was not associated with cognit…
(NEJM) Seguridad cognitiva a largo plazo de lograr un cLDL muy bajo con evolocumab https://t.co/oHagP9Payv Análisis 2º de ECA https://t.co/SbGFpHhDxS
In a new study, researchers from @TIMIStudyGroup and colleagues found long-term low LDL was not associated with cognitive impairment. The study was published in @NEJMEvidence. Read more: https://t.co/hmo5BSS2q1 @rgiugliano https://t.co/phsxT4aDTu
RT @NEJMEvidence: In this study of 473 patients, very low levels of LDL achieved via PCSK9 inhibitors was not associated with cognitive dec…
RT @NEJMEvidence: In this study of 473 patients, very low levels of LDL achieved via PCSK9 inhibitors was not associated with cognitive dec…
In this study of 473 patients, very low levels of LDL achieved via PCSK9 inhibitors was not associated with cognitive decline over a median of 5 years. Further studies are needed to assess the generalizability to adults at higher risk of dementia. https://t.co/tEwPvCCMCb https://t.co/NX0EHH5otf
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Seguridad cognitiva a largo plazo de lograr un colesterol LDL muy bajo con evolocumab. Los pacientes que alcanzaron un nivel de LDL de 35 mg/dL, las pruebas neuropsicológicas no encontraron cambios en la función cognitiva después de 5 años de seguimiento.https://t.co/H1OYxi8NuI
Myth busting
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/FOgrPx2OjP
https://t.co/t6jaYwSlZP
@AndreZimerman The Disclosure Form for Companies of Interest is very interesting to say the least.. I’m sure it’s nothing. https://t.co/wtfzfmPcYp https://t.co/dxNik7jOa9
Exposure to very low levels of LDL cholesterol, achieved via PCSK9 inhibition and statin therapy, was not associated with cognitive impairment over 5 years https://t.co/oRS40CWDF4
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Cholesterol, lipid-lowering medications, and cognitive function with @NutritionMadeS3 https://t.co/rN2rXg6KUd
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
youtu.be/Wqaq7GT76vU
https://t.co/iwfEKSMsQP
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab https://t.co/zE2eZFQMRN
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab derived from our Ebbinghaus trial of a PCSK9 inhibiting mononclonal antibody in patients with CAD/PAD/CVD very low LDL works Well done @rgiugliano and team https://t.co/gLpYLuHCwr https://t.co/ZwNqmVNTzs
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/Bkh0lG4gGe
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/Bkh0lG4gGe
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/Bkh0lG4gGe
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/Bkh0lG4gGe
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/Bkh0lG4gGe
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: In summary, for patients requiring lipid-lowering meds: i) There is *no* evidence of cognitive impairment over the long…
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: In summary, for patients requiring lipid-lowering meds: i) There is *no* evidence of cognitive impairment over the long…
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @MohammedAlo: Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Długoterminowe obserwacje wykazały, że niskie stężenia cholesterolu LDL nie wpływają negatywnie na funkcje poznawcze. Badanie przeprowadzono na grupie osób, w której mediana wieku wynosiła 62 lata. https://t.co/RcliETlvyc
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
RT @AndreZimerman: In summary, for patients requiring lipid-lowering meds: i) There is *no* evidence of cognitive impairment over the long…
RT @AndreZimerman: "Does lowering LDL-C to very low levels result in long-term cognitive impairment?"
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/JM7PrGSW4Q
Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab | NEJM Evidence https://t.co/899D8kSVS8
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