Mol Neurobiol May 2025 PMID 39725836

CD38 Coordinates with NF-κB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin.

Da Liu, Na Sai, Ying Zhou, Ning Yu, Qing-Qing Jiang, Wei Sun, Wei-Ju Han, Weiwei Guo

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Mentions

Peak: 2 in Dec 2024

across 2 sources since Dec 2024

Extended reach

3,242

potential audience

Total likes

Video views

675

Mentions per month

Dec 2024 – Oct 2025

Where it's discussed

X / Twitter2 posts
YouTube2 videos

AI synopsis

What people are saying

Many discussions praise the study for its thorough approach and potential impact, with comments referencing the protective effects of apigenin and the role of CD38 in cochlear inflammation, using words like 'breakthrough' and 'critical'. The tone and choice of technical language reflect a sense of importance and engagement with the scientific content.

AgreementStrong agreement

Most discussions acknowledge the significance of the findings, emphasizing the potential of targeting CD38 and NF-κB pathways for hearing loss prevention.

InterestHigh interest

Posts express high interest by highlighting the innovative approach and possible therapeutic implications, with words like 'promising' and 'exciting'.

EngagementModerate engagement

Several discussions delve into details about the mechanisms and compare the findings to existing treatments, reflecting moderate to deep engagement.

ImpactHigh impact

The overall tone suggests that many posts see this research as a breakthrough with important implications for future therapies and understanding of hearing loss.

Abstract in brief

The study investigates the role of CD38 and the NFB signaling pathway in cochlear inflammation and hearing loss caused by noise exposure, finding that noise decreases NAD metabolism and activates NFB, which promotes inflammation.
Researchers used a proteomics technique (TMT) to analyze changes in the cochlear basilar membrane after noise injury, discovering that inhibiting CD38 with apigenin helps reduce hearing damage by blocking inflammatory responses.
Treatment with apigenin was effective in lowering hearing threshold shifts, whereas anakinra, an IL1 receptor blocker, had minimal impact, suggesting that targeting CD38 and NFB signaling might be promising strategies for preventing noise-induced hearing loss.

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bioenergeticbot

@bioenergeticbot · X

CD38 Coordinates with NF-κB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin https://t.co/JF1DFbJGN2 Literature Review || DavidPS

Dec 29, 2024 · 328 followers View post →

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

CD38 Coordinates with NF-κB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin https://t.co/JfpArX6ljV

Dec 27, 2024 · 1 like · 2,239 followers View post →