Clin Obes June 2025 PMID 39800653

Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials.

Deborah B Horn, Scott Kahan, Rachel L Batterham, Dachuang Cao, Clare J Lee, Madhumita Murphy, Sylvia Gonsahn-Bollie, Farai Chigutsa, Adam Stefanski, Julia P Dunn

Mentions

75
Peak: 10 in Nov 2025
across 7 sources since Jan 2025

Extended reach

63,673
potential audience

Total likes

1,217

Video views

28,538

Mentions per month

Jan 2025 – Jan 2026

Where it's discussed

  • Reddit27 posts
  • TikTok22 posts
  • X / Twitter9 posts
  • News9 articles
  • Facebook4 posts
  • YouTube3 videos
  • Instagram1 posts

AI synopsis

What people are saying

The overall tone is neutral to cautiously analytical, with posts referencing demographic factors like age, sex, and BMI affecting weight plateau timelines. Discussions include mention of specific data points—such as activity around the 24–36 week range—and questions about variables influencing outcomes. The tone and word choices suggest a moderate level of curiosity and engagement centered on understanding which factors influence long-term weight stabilization, highlighting both the relevance of the findings and the need for further exploration.

AgreementNeither agree nor disagree

The discussions are mixed; some recognize the study's findings, while others question factors like demographic disparities.

InterestModerate interest

Moderate interest is evident, with some posters engaging actively and others showing minimal curiosity.

EngagementNeutral engagement

Most social discussions are brief, focusing on summarizing findings rather than deep analysis.

ImpactModerate impact

The conversations hint at significance for weight management treatments but lack widespread emphasis on clinical implications.

Abstract in brief

  • The study analyzed how long it takes for people treated with tirzepatide to reach a weight plateau, which is when weight loss stabilizes, during the SURMOUNT1 and SURMOUNT4 trials, finding that most participants hit this plateau by week 72, with higher doses, younger age, and female sex linked to a longer time to reach it.
  • Participants with higher BMI categories generally took longer to reach the weight plateau, and the findings were consistent across both trials, indicating similar patterns in different populations.
  • Understanding factors like dose, age, and sex that influence how quickly weight stabilization occurs can help tailor chronic weight management treatments using tirzepatide for better long-term outcomes.]

Top posts

Most liked on X and Bluesky
David Arterburn, MD, MPH
@davearterburn · X

Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9jm

Jan 13, 2025 · 5 likes · 3 shares · 2,232 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【備忘】 Clin Obes誌に、RCTデータを用いたセマグルチドによる減量作用持続期間解析。 開始後72週後までは減量が持続。「若年」「女性」では減量持続期間が延長。 https://t.co/sHUmvZ3EFS Jan 12 ( 「この体重でOK」まで下がったらどうすれば? )

May 22, 2025 · 1 like · 4,942 followers View post →
‏الشامخه
@fabulous__1990 · X

متى يوصل الجسم لثبات الوزن مع مونجارو؟ يصل ثبات الوزن خلال 24–36 أسبوع، حسب فئة الوزن: •زيادة وزن: 24 أسبوع •سمنة أولى: 26 أسبوع •سمنة ثانية وثالثة: 36 أسبوع ثبات الوزن يتأخر عند: ✅ الأصغر سنًا ✅ النساء ✅ من يستخدمون جرعات عالية (10-15mg) https://t.co/UgHU4WIMs7 https://t.co/31795BheBq

Jul 26, 2025 · 1 like · 1,732 followers View post →
Joe Zucchi, PA-C, CPT
@JPZfitness · X

Time to weight plateau with tirzepatide treatment in the SURMOUNT‐1 and SURMOUNT‐4 clinical trials - Wiley Online Library https://t.co/mZ2TpAyeIC

Jan 15, 2025 · 1 like · 246 followers View post →
Jen Can NuSH
@JCanNuSH · X

@bioinvestor24 Source: https://t.co/zVH9WSqdL5

Jan 6, 2026 · 1 like · 217 followers View post →
Jose C Souto, MD
@jcsouto · X

RT @davearterburn: Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9…

Jan 14, 2025 · 3 shares · 14,487 followers View post →

All mentions

Jen Can NuSH
@JCanNuSH · X

@bioinvestor24 Source: https://t.co/zVH9WSqdL5

Jan 6, 2026 · 1 like · 217 followers View post →
Jen Can NuSH
@JCanNuSH · X

@EliLillyandCo For example, this analysis of SURMOUNT-1 and -4 found certain demographics had longer periods of weight loss than others. Or might the disparity have been due to a shift in male/female ratios? https://t.co/zVH9WSqdL5 https://t.co/M5LuRjjROZ

Aug 7, 2025 · 217 followers View post →
‏الشامخه
@fabulous__1990 · X

متى يوصل الجسم لثبات الوزن مع مونجارو؟ يصل ثبات الوزن خلال 24–36 أسبوع، حسب فئة الوزن: •زيادة وزن: 24 أسبوع •سمنة أولى: 26 أسبوع •سمنة ثانية وثالثة: 36 أسبوع ثبات الوزن يتأخر عند: ✅ الأصغر سنًا ✅ النساء ✅ من يستخدمون جرعات عالية (10-15mg) https://t.co/UgHU4WIMs7 https://t.co/31795BheBq

Jul 26, 2025 · 1 like · 1,732 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【備忘】 Clin Obes誌に、RCTデータを用いたセマグルチドによる減量作用持続期間解析。 開始後72週後までは減量が持続。「若年」「女性」では減量持続期間が延長。 https://t.co/sHUmvZ3EFS Jan 12 ( 「この体重でOK」まで下がったらどうすれば? )

May 22, 2025 · 1 like · 4,942 followers View post →
Joe Zucchi, PA-C, CPT
@JPZfitness · X

Time to weight plateau with tirzepatide treatment in the SURMOUNT‐1 and SURMOUNT‐4 clinical trials - Wiley Online Library https://t.co/mZ2TpAyeIC

Jan 15, 2025 · 1 like · 246 followers View post →
Jose C Souto, MD
@jcsouto · X

RT @davearterburn: Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9…

Jan 14, 2025 · 3 shares · 14,487 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

RT @davearterburn: Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9…

Jan 14, 2025 · 3 shares · 10,363 followers View post →
Yu Ning Lin
@YuNingLin1 · X

RT @davearterburn: Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9…

Jan 13, 2025 · 3 shares · 46 followers View post →
David Arterburn, MD, MPH
@davearterburn · X

Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials https://t.co/ve62W3z9jm

Jan 13, 2025 · 5 likes · 3 shares · 2,232 followers View post →
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ZEPBOUND PLATEAU? : r/Zepbound
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https://onlinelibrary.wiley.com/doi/10.1111/cob.12734. Based on the Surmount trials with a focus on Surmount 4. Which also discussed this 18 ...

Jan 5, 2026 View →
50% of body weight? : r/Zepbound
Reddit

... not a dose bound. https://onlinelibrary.wiley.com/doi/10.1111/cob.12734. In short 20% loss is the average - some lose more and some less.

Jan 3, 2026 View →
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... a read about why low slow plateau is a terrible idea. https://onlinelibrary.wiley.com/doi/10.1111/cob.12734 · Smooth-Owl-5354. • 6d ago • ...

Jan 2, 2026 View →
Did you guys lose lost of your weight on 15mg : r/Zepbound
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Respuesta a @Zuly | TikTok
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Dec 10, 2025 View →
Timing for Max Dose : r/Zepbound
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... majority of participants. This is the full article: https://onlinelibrary.wiley.com/doi/10.1111/cob.12734 · OceanBlue011729. OP • 1mo ago.

Dec 2, 2025 View →
Stalled @15mg : r/Zepbound
Reddit

https://onlinelibrary.wiley.com/doi/10.1111/cob.12734. The link is information about the plateau happening as you mentioned. CuteProfile8576. • ...

Nov 28, 2025 View →
Welcome! : r/ZepboundMTD
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... 10.1111/cob.12734. Unfortunately for me, my provider wasn't that engaged is dose escalation. I was their first patient on Zepbound as they ...

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coming up on 2 years, and I think I may have reached stasis : r ...
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... 10.1111/cob.12734. Finally, there seems to be a tension between relying on the authority of science while also referencing anonymous ...

Nov 13, 2025 View →
Respuesta a @Iván | TikTok
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... 10.1111/cob.12734. #tirzepatide #glp1 #obesidad. pérdida de peso estudio, sobrepeso y obesidad diferencia, obesidad vs sobrepeso datos ...

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... según el estudio DOI: 10.1111/cob.12734. #tirzepatide #glp1 #obesidad”.

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... 10.1111/cob.12734 . I started at a BMI of 48 so Class III Obesity and I am older so when the scale didn't move down, I thought maybe I am ...

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? Zeppers di lunga data : r/Zepbound
Reddit

... 10.1111/cob.12734 parlano del tempo per raggiungere il plateau. Nel secondo articolo linkato: "Dosi più alte di tirzepatide (10/15 mg), età ...

Aug 28, 2025 View →
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Reddit

SURMOUNT-1 by starting BMI. (All doses are mixed together in this - 5/10/15mg.) https://onlinelibrary.wiley.com/doi/full/10.1111/cob.12734 · Ok- ...

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For people who started at a BMI 50+, did the medication actually ...
Reddit

... /doi/full/10.1111/cob.12734. Edit: This is where I pulled the average starting BMI # from for those with BMIs 40 or greater. ShiftyMcHax. • ...

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Reddit

... -1 by starting BMI category. (They also look at SURMOUNT-4.) https://onlinelibrary.wiley.com/doi/full/10.1111/cob.12734 · BoundToZepIt. • 5mo ...

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Reddit

It matters how much time has past. https://onlinelibrary.wiley.com/doi/10.1111/cob.12734 · https://onlinelibrary.wiley.com/doi/epdf/10.1002 ...

Jul 18, 2025 View →
Are you happy with titrating up every 4 weeks? : r/Zepbound
Reddit

https://onlinelibrary.wiley.com/doi/10.1111/cob.12734. Look at the graphs. All doses plateaued at 18 months. Its not hard to visually see ...

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... 10.1111/cob.12734. Depending on different factors you will reach a plateau between 24 and 72 weeks. GLP-1 and GIP are just two of eight ...

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... 10.1111/cob.12734 · https://www.nejm.org/doi/full/10.1056/NEJMoa2410819. I'll keep looking for the others. A few were articles about studies.

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Mounjaro Study : r/Zepbound
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... 10.1111/cob.12734 --which used the same definition of "plateau." This analysis of SURMOUNT-1 and 5 data found that (1) people with more ...

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... 10.1111/cob.12734. What does this study add? In this exploratory analysis, the majority of participants treated with tirzepatide reached a ...

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... 10.1111/cob.12734. What does this study add? In this exploratory analysis, the majority of participants treated with tirzepatide reached a ...

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... numbers. Here's the study this came from: https://onlinelibrary.wiley.com/doi/full/10.1111/cob.12734 · Content_Display844. OP • 10mo ago.

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Is there a time when you just stop losing weight even though you ...
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... 10.1111/cob.12734#. I say this a lot, buy this is why (and the study above supports) monthly titration to max tolerated dose (as per ELs ...

Mar 24, 2025 View →
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This study came out in January 2025. https://onlinelibrary.wiley.com/doi/full/10.1111/cob.12734. 1.Time To Weight-loss Plateau (TTWP) by BMI ...

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... 10.1111/cob.12734 I had read an earlier article as well. It's not just my analysis but others analysis as well plus there is a comment from ...

Mar 20, 2025 View →
Window of Opportunity? : r/tirzepatidecompound
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... 10.1111/cob.12734. Community Info Section. r/tirzepatidecompound. Join. tirzepatidecompound. Welcome to Reddit's largest Tirzepatide Community ...

Mar 16, 2025 View →
Exciting News! We are thrilled to share **Dr. Horn's latest publication ...
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Check it out here: https://onlinelibrary.wiley.com/doi/10.1111/cob. 12734 A huge thank you to the **COMMP Research Team** for your hard ...

Jan 16, 2025 View →
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