March 2025 PMID 39809356

Neoadjuvant intratumoral MBT(A) immunotherapy prevents distant metastases and recurrence in murine models.

Ondrej Uher, Katerina Hadrava Vanova, Rachael Labitt, Katerina Petrlakova, Juan Ye, Herui Wang, Michal Masarik, Milan Jakubek, Jan Zenka, Zhengping Zhuang, Karel Pacak

Mentions

7
Peak: 4 in Oct 2025
across 3 sources since May 2025

Extended reach

2,464
potential audience

Total likes

15

Video views

770

Mentions per month

May 2025 – Oct 2025

Where it's discussed

  • X / Twitter3 posts
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions emphasize the promising nature of the research, with statements like 'Neoadjuvant MBTA immunotherapy prevents cancer recurrence' and remarks about how the results could revolutionize cancer surgery, reflecting enthusiasm. The mention of a former student author, Ondřej Uher, adds a personal and credible touch, while phrases like 'the future of cancer surgery is here' convey excitement about the study's potential impact.

AgreementModerate agreement

Most discussions express strong support for the findings and implications, highlighting the significance of the research and its potential to change cancer treatment strategies.

InterestHigh interest

The posts demonstrate high interest, especially with references to the innovative approach and the involvement of a notable author who is a former student, generating curiosity about future applications.

EngagementHigh engagement

Many posts delve into specific details, such as the method's ability to prevent metastasis and the relevance of omitting certain therapy components, indicating deep engagement.

ImpactModerate impact

While the findings are viewed as promising, the overall perceived impact is moderate, mainly because these are preclinical results in mouse models, though they suggest significant potential.

Abstract in brief

  • This study explores how pre-surgery immunotherapy using MBTA (which includes mannanBAM, TLR ligands, and anti-CD40 antibody) can prevent the spread and return of cancer in mouse models, even with larger tumors.
  • Results showed that this neoadjuvant approach completely prevented metastases in a pheochromocytoma model and slowed tumor growth with longer survival in more aggressive cancers, indicating strong immune activation and memory.
  • Findings suggest that omitting the anti-CD40 antibody from the therapy still provides similar protection, encouraging further research into this immunotherapy method for tough tumors that are prone to metastasis or recurrence.

Top posts

Most liked on X and Bluesky
Nathan Goodyear, MD, MD(H)
@drgoodyear · X

Inject Before You Cut: The Future of Cancer Surgery Is Here Supporting Evidence: Uher O et al., Cancer Lett. 2025;612:217464. Neoadjuvant intratumoral MBT(A) immunotherapy prevented metastasis and recurrence in mouse models. doi:10.1016/j.canlet.2025.217464. https://t.co/jJmTYmtZsn

May 8, 2025 · 2 likes · 1,659 followers View post →
USB Faculty of Science
@Science_USB · X

Neoadjuvant MBTA immunotherapy prevents cancer recurrence and metastases. One of the authors of the article is our former student Ondřej Uher. Read more: https://t.co/pYLUkY9Zvo https://t.co/Lhoc6ck9Uh

Oct 2, 2025 · 1 like · 22 followers View post →
Přírodovědecká fakulta JU
@Prirodoveda_JU · X

Neoadjuvantní MBTA imunoterapie zabraňuje recidivě rakoviny a metastázám. Jedním z autorů článku je náš bývalý student Ondřej Uher. Více zde: https://t.co/f2j7bkQ7xw https://t.co/FijTAlVIC6

Oct 2, 2025 · 1 like · 14 followers View post →
Faculty of Science, University of South Bohemia
@fscusb.bsky.social · Bluesky

Neoadjuvant MBTA immunotherapy prevents cancer recurrence and metastases. One of the authors of the article is our former student Ondřej Uher. Read more: pubmed.ncbi.nlm.nih.gov/39809356/

Oct 2, 2025 · 1 like View post →

All mentions

Faculty of Science, University of South Bohemia
@fscusb.bsky.social · Bluesky

Neoadjuvant MBTA immunotherapy prevents cancer recurrence and metastases. One of the authors of the article is our former student Ondřej Uher. Read more: pubmed.ncbi.nlm.nih.gov/39809356/

Oct 2, 2025 · 1 like View post →
USB Faculty of Science
@Science_USB · X

Neoadjuvant MBTA immunotherapy prevents cancer recurrence and metastases. One of the authors of the article is our former student Ondřej Uher. Read more: https://t.co/pYLUkY9Zvo https://t.co/Lhoc6ck9Uh

Oct 2, 2025 · 1 like · 22 followers View post →
Přírodovědecká fakulta, Jihočeská univerzita v Č. Budějovicích
@prfju.bsky.social · Bluesky

Neoadjuvantní MBTA imunoterapie zabraňuje recidivě rakoviny a metastázám. Jedním z autorů článku je náš bývalý student Ondřej Uher. Více zde: pubmed.ncbi.nlm.nih.gov/39809356/

Oct 2, 2025 View post →
Přírodovědecká fakulta JU
@Prirodoveda_JU · X

Neoadjuvantní MBTA imunoterapie zabraňuje recidivě rakoviny a metastázám. Jedním z autorů článku je náš bývalý student Ondřej Uher. Více zde: https://t.co/f2j7bkQ7xw https://t.co/FijTAlVIC6

Oct 2, 2025 · 1 like · 14 followers View post →
Nathan Goodyear, MD, MD(H)
@drgoodyear · X

Inject Before You Cut: The Future of Cancer Surgery Is Here Supporting Evidence: Uher O et al., Cancer Lett. 2025;612:217464. Neoadjuvant intratumoral MBT(A) immunotherapy prevented metastasis and recurrence in mouse models. doi:10.1016/j.canlet.2025.217464. https://t.co/jJmTYmtZsn

May 8, 2025 · 2 likes · 1,659 followers View post →