Cell Rep February 2025 PMID 39827461

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice.

Leonardo Matta, Peter Weber, Suheda Erener, Alina Walth-Hummel, Daniela Hass, Lea K Bühler, Katarina Klepac, Julia Szendroedi, Joel Guerra, Maria Rohm, Michael Sterr, Heiko Lickert, Alexander Bartelt, Stephan Herzig

Mentions

155
Peak: 44 in Apr 2024
across 7 sources since Apr 2024

Extended reach

408,647
potential audience

Total likes

374

Video views

3,555

Mentions per month

Apr 2024 – Sep 2025

Where it's discussed

  • News71 articles
  • X / Twitter65 posts
  • Blogs5 articles
  • Bluesky4 posts
  • Reddit4 posts
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

The discussions reflect strong agreement and interest, citing examples such as terms like 'impairs β cell maturation' and 'unsafe for teenagers,' which highlight concern for adolescent health. The tone is serious and analytical, discussing potential risks and biological mechanisms, indicating thoughtful engagement with the research's relevance and implications.

AgreementModerate agreement

Most discussions concur that chronic intermittent fasting has negative effects on β cell development in young mice, aligning with the published findings.

InterestHigh interest

Posts exhibit high interest, referencing the implications for teenagers and human health, showing curiosity about age-specific effects.

EngagementHigh engagement

Discussions include detailed mentions of mechanisms, methods like scRNA-seq, and implications for diseases like diabetes, demonstrating deep engagement.

ImpactHigh impact

Content suggests the study could influence dietary recommendations and health policies related to youth fasting practices, indicating high impact.

Abstract in brief

  • Short-term intermittent fasting (IF) improves glucose regulation across all ages without affecting pancreatic islet structure, but chronic IF can impair cell development and function, especially in young mice.
  • In young mice, chronic IF leads to reduced cell maturation and function scores, indicating possible negative effects on cell health, while adult mice benefit from the same fasting regimen.
  • Similar patterns are seen in human islets with type 1 diabetes, suggesting that prolonged IF during adolescence might contribute to cell dysfunction and influence diabetes development, highlighting the importance of age-specific considerations for IF.

Top posts

Most liked on X and Bluesky
Alexander Bartelt
@BarteltLab · X

Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-seq of islets we define a β-cell maturation score, which was linked to T1D in humans.

Apr 22, 2024 · 196 likes · 41 shares · 9,021 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7OBlVAXbDi

Jan 20, 2025 · 60 likes · 10 shares · 6,433 followers View post →
Maede
@Maede2024 · X

در موش‌ها، روزه‌داری متناوب کوتاه مدت قند خون را بهبود می‌بخشد، بدون اینکه تاثیری بر عملکرد یا ساختار جزایر پانکراس بگذارد. حال آنکه، روزه‌داری مزمن در موش‌های بالغ مفید، اما در موش‌های جوان موجب اختلال در عملکرد سلول‌های بتا و تشدید دیابت می‌شود. https://t.co/XViZFfV1aZ

Jan 21, 2025 · 6 likes · 394 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers This study reveals that age plays a significant role in the outcomes of intermittent fasting.

Feb 15, 2025 · 4 likes · 2 shares · 691 followers View post →
Samuele Laudani
@Sam_Laudani · X

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports https://t.co/WlGEB1oY8B

Feb 13, 2025 · 4 likes · 2 shares · 120 followers View post →
Deutsches Zentrum für Diabetesforschung (DZD)
@diabresearch-dzd.bsky.social · Bluesky

Jan 21, 2025 · 4 likes · 2 shares View post →

All mentions

おくさん/OKUSUN
@Astella6174 · X

【間欠的断食の年齢依存的影響】マウス実験。短期間の間欠的断食は全年齢で有効だが、長期間の断食は若いマウスのβ細胞の機能を大きく損なうことが判明。特に若い子たちは避けたほうがいいかも? Cell Reports, 2025 → https://t.co/A74SHchOtK https://t.co/yr0nt9iayG

Mar 11, 2025 · 1,186 followers View post →
AAK
@LifeOfASurgeon · X

Chronic intermittent fasting impairs β cell maturation and function in younger mice - interesting implications for young humans. The wisdom of feeding children healthy unprocessed foods at regular intervals seems to stand. https://t.co/XSEypRjmhp

Feb 19, 2025 · 2 likes · 1,000 followers View post →
William Lagakos
@caloriesproper2 · X

Study: Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice https://t.co/mxAEXPiD1z

Feb 17, 2025 · 2,709 followers View post →
サイエンスあれこれ
@sarekore · X

代謝が乱れます。また、この原因がベータ細胞の成熟不全にあることもわかりました。この障害は、自己免疫反応によってベータ細胞が破壊されるヒトの 1 型糖尿病でも起こるため、今回のマウスでの研究結果がヒトにも当てはまる可能性があります。Cell Reports誌https://t.co/JIJB0dIDkV

Feb 16, 2025 · 922 followers View post →
Nobuhiro Ariyoshi MD
@AriyoshiMd · X

短期インターミッテント・ファスティング(断続的断食:IF)はどの年代でも有効だけど、若いマウスでは長期IFがインスリンを作る膵β細胞の発達を妨げ、1型糖尿病リスクに近い変化が示唆された。若い人が長期IFやるのは注意が必要かも #インターミッテント・ファスティング https://t.co/2sfAFgsFCp

Feb 15, 2025 · 3,878 followers View post →
Bakhta
@bakhta_f · X

RT @TimePieChina: Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers This study reveals that a…

Feb 15, 2025 · 2 shares · 297 followers View post →
Alexander Bartelt
@BarteltLab · X

RT @TimePieChina: Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers This study reveals that a…

Feb 15, 2025 · 2 shares · 9,021 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers This study reveals that age plays a significant role in the outcomes of intermittent fasting.

Feb 15, 2025 · 4 likes · 2 shares · 691 followers View post →
Desiree Seib
@DesireeSeib · X

RT @Sam_Laudani: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports https://t.co/WlGEB1oY…

Feb 15, 2025 · 2 shares · 386 followers View post →
Anthony Knox
@KnoxAnthon52670 · X

In adolescent mice, long-term intermittent fasting inhibits the development of cells that produce insulin. #intermittentfasting #diabetes ⁦@drjasonfung⁩ https://t.co/LiKxNhWXds

Feb 14, 2025 · 39 followers View post →
Katie Guzzetta
@ktguzz · X

RT @Sam_Laudani: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports https://t.co/WlGEB1oY…

Feb 14, 2025 · 2 shares · 4,773 followers View post →
Samuele Laudani
@samuelelaud.bsky.social · Bluesky

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports www.cell.com/cell-reports...

Feb 13, 2025 View post →
Samuele Laudani
@Sam_Laudani · X

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports https://t.co/WlGEB1oY8B

Feb 13, 2025 · 4 likes · 2 shares · 120 followers View post →
Maede
@Maede2024 · X

در موش‌ها، روزه‌داری متناوب کوتاه مدت قند خون را بهبود می‌بخشد، بدون اینکه تاثیری بر عملکرد یا ساختار جزایر پانکراس بگذارد. حال آنکه، روزه‌داری مزمن در موش‌های بالغ مفید، اما در موش‌های جوان موجب اختلال در عملکرد سلول‌های بتا و تشدید دیابت می‌شود. https://t.co/XViZFfV1aZ

Jan 21, 2025 · 6 likes · 394 followers View post →
Petra Kienesberger, PhD
@PKienesberger · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 501 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 182 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 379 followers View post →
Deutsches Zentrum für Diabetesforschung (DZD)
@diabresearch-dzd.bsky.social · Bluesky

Jan 21, 2025 · 4 likes · 2 shares View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 3,345 followers View post →
ong beng hooi
@ongbenghooi1 · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 534 followers View post →
Tide2022
@Tide20221 · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 21, 2025 · 10 shares · 133 followers View post →
Dr Shraboni Ghosal, PhD
@ShraboniGhosal · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 20, 2025 · 10 shares · 1,931 followers View post →
Rafa Vázquez #SinCienciaNoHayFuturo
@monkeyplatillos · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 20, 2025 · 10 shares · 1,554 followers View post →
Alexander Bartelt
@BarteltLab · X

RT @Brunorm84: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7…

Jan 20, 2025 · 10 shares · 9,021 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice #diabetes @CellReports https://t.co/7OBlVAXbDi

Jan 20, 2025 · 60 likes · 10 shares · 6,433 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 28, 2024 · 41 shares · 573 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 28, 2024 · 41 shares · 253,991 followers View post →
Ozanne lab
@ozannelab · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 24, 2024 · 41 shares · 2,071 followers View post →
@docbio.bsky.social
@DocBio1509 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 453 followers View post →
Han Kim
@HanKimLab · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 533 followers View post →
Michelle Fitzmaurice
@DrMFitzmaurice · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 760 followers View post →
Georgy Leonov
@leonov_ge · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 1,125 followers View post →
Gökçe BİLGEHAN
@gokcespeaking · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 227 followers View post →
nike
@wot_mikey · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 462 followers View post →
Pablo B Martínez de Morentin
@pablomorentin · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 266 followers View post →
preLights
@preLights · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 7,455 followers View post →
Hamdi Frikha
@frikha_hamdi · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 52 followers View post →
Ronan Lordan
@el_ronan · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 1,275 followers View post →
Joe Gordon
@josephwgordon · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 2,109 followers View post →
Prateek Chawla, PhD
@ChawlaPrateek03 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 191 followers View post →
Leonardo Matta
@LeonardoMatta · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 963 followers View post →
Dr Meral Kayikcioglu
@MeralKayikcoglu · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 4,582 followers View post →
DZHK Germany
@dzhk_germany · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 2,457 followers View post →
Doris Kaltenecker
@Dorie00 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 368 followers View post →
Shinsuke Tokumoto MD., PhD.
@TokumotoMdPhd · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 413 followers View post →
Almudena Ortega-Gomez
@aortegagomez · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 141 followers View post →
Heiko Lickert
@LickertHeiko · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 3,048 followers View post →
RTG2719 PRO
@RTG2719_PRO · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 84 followers View post →
Paul Langerhans Institute Dresden - PLID
@PLID_Info · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 816 followers View post →
Filip K. Knop
@Filip_Knop · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 2,509 followers View post →
FrezzaLab
@FrezzaLab · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 26,996 followers View post →
Maria Rohm
@RohmMaria · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 673 followers View post →
Dr. Katharina Scherschel
@th3k4ty · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 638 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 23, 2024 · 41 shares · 405 followers View post →
Seyoon Lee
@Seyoon_L · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 213 followers View post →
garigalAnj
@garigalAnj · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 2,378 followers View post →
European Atherosclerosis Society
@society_eas · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 6,191 followers View post →
Arpita Kulkarni
@ArpitaBKulkarni · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 1,233 followers View post →
Bakhta
@bakhta_f · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 297 followers View post →
Gwen Kennedy
@Pen_gwen · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 137 followers View post →
CJara
@cjarao1 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 19 followers View post →
bioRxiv Physiology
@biorxiv-physio.bsky.social · Bluesky

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice https://www.biorxiv.org/content/10.1101/2024.04.18.590140v1

Apr 22, 2024 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice https://www.biorxiv.org/content/10.1101/2024.04.18.590140v1

Apr 22, 2024 View post →
biorxiv_physio
@biorxiv_physio · X

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice https://t.co/VuvKcaLVNK #biorxiv_physio

Apr 22, 2024 · 2 likes · 397 followers View post →
Hao Yin
@HaoYin20 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 12,202 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 3,649 followers View post →
Diego Morales
@diegomoralesvit · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 522 followers View post →
CLEESS
@CLEESS1 · X

RT @BarteltLab: Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-s…

Apr 22, 2024 · 41 shares · 179 followers View post →
Alexander Bartelt
@BarteltLab · X

Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-seq of islets we define a β-cell maturation score, which was linked to T1D in humans.

Apr 22, 2024 · 196 likes · 41 shares · 9,021 followers View post →