Alzheimers Dement (N Y) January 2025 PMID 39839078

Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review.

Benjamin R Underwood, Ilianna Lourida, Jessica Gong, Stefano Tamburin, Eugene Yee Hing Tang, Emad Sidhom, Xin You Tai, Matthew J Betts, Janice M Ranson, Margarita Zachariou, Olajide E Olaleye, Saswati Das, Neil P Oxtoby, Shanquan Chen, David J Llewellyn

Mentions

438
Peak: 41 in Jan 2025
across 6 sources since Jan 2025

Extended reach

817,588
potential audience

Total likes

229

Video views

3,975

Mentions per month

Jan 2025 – May 2025

Where it's discussed

  • News369 articles
  • X / Twitter46 posts
  • Blogs14 articles
  • YouTube4 videos
  • Bluesky3 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a high level of engagement, with posts citing specific drug classes like vaccines and antibiotics associated with reduced risk, and expressing curiosity about the implications for treatment. The tone combines scientific interest and optimism, emphasizing the importance of these findings for medical research and potential therapeutic strategies.

AgreementModerate agreement

Most discussions support the findings, emphasizing that some medications like vaccines and antimicrobials are linked to lower dementia risk, showing strong consensus.

InterestHigh interest

The posts demonstrate high interest, highlighting key findings and implications that captivate readers about potential ways to prevent dementia.

EngagementHigh engagement

Numerous posts reference specific study details, such as the large sample size of over 130 million people and the types of medications involved, indicating deep engagement.

ImpactHigh impact

The widespread discussion about how existing drugs could influence dementia risk suggests significant potential impact on future research and clinical approaches.

Abstract in brief

  • This systematic review examined 14 studies involving over 130 million people to identify how existing medications for other conditions might influence dementia risk, finding some consistent patterns despite mixed results.
  • The review suggests that certain drug classes, like antimicrobials, vaccinations, and anti-inflammatories, could be associated with a reduced risk of dementia, while diabetes medications, vitamins, supplements, and antipsychotics might increase risk; however, evidence for antihypertensives and antidepressants was conflicting.
  • These findings highlight potential drug candidates for repurposing to slow dementia progression and can help prioritize future research and clinical trials, especially focusing on biological mechanisms behind these associations.]

Top posts

Most liked on X and Bluesky
Hannah Davis
@ahandvanish · X

Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were associated with reduced risk of dementia 2) Diabetes drugs, vitamins/supplements & antipsychotics were associated with increased risk https://t.co/FQU2lS4tUP

Jan 21, 2025 · 146 likes · 27 shares · 55,991 followers View post →
Dan Jagger
@auditorynerves.bsky.social · Bluesky

Open access

Jan 21, 2025 · 9 likes · 3 shares View post →
Neuroscience News
@NeuroscienceNew · X

“Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review” by Ben Underwood et al. Alzheimer’s and Dementia: Translational Research & Clinical Interventions https://t.co/IdVl567ohY

Jan 21, 2025 · 4 likes · 1 share · 505,553 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review - Underwood - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library https://t.co/x2tPP39BwJ

Jan 22, 2025 · 3 likes · 78,984 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

@EricTopol @PJeffcock @EckerleIsabella According to the latest systematic review published this year based on medical records of more than 130 million individuals antimicrobial treatment was perhaps more surprisingly associated with decreased risk of developing dementia. https://t.co/xEK6PfqZP1

Mar 18, 2025 · 3 likes · 379 followers View post →
alfred fischer
@alfredfischer17 · X

Als besonders faszinierend erachteten die Autoren den Zusammenhang zwischen Antibiotika, antiviralen Subs­tanzen sowie Impfungen und einem reduzierten Demenzrisiko. #impfen #alzheimer #epidemiologie https://t.co/erbCXtgy4Y

Jan 27, 2025 · 2 likes · 362 followers View post →

All mentions

猫被り医(PhD, MD, 中の人は獰猛かなぁ)
@shh_toyama · X

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review - Underwood - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library https://t.co/z805wwEfKR

May 23, 2025 · 1 like · 280 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

@gerontologist34 Great

Apr 13, 2025 · 1 like · 379 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

@jonathanstea @CaulfieldTim Yes. Antimicrobials, vaccinations, and anti-inflammatories were associated with reduced risk. https://t.co/xEK6PfqZP1 While diabetes drugs, vitamins and supplements, and antipsychotics were associated with increased risk. Approximately 1 in 10 adults worldwide currently has

Apr 4, 2025 · 379 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

The good news is that we now have data from over 136 million people on the medicines that can prevent the disease. https://t.co/xEK6PfqZP1 https://t.co/O8Rq5RlbTQ https://t.co/NQgl3XAmeY

Mar 30, 2025 · 1 like · 379 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

@EricTopol @PJeffcock @EckerleIsabella According to the latest systematic review published this year based on medical records of more than 130 million individuals antimicrobial treatment was perhaps more surprisingly associated with decreased risk of developing dementia. https://t.co/xEK6PfqZP1

Mar 18, 2025 · 3 likes · 379 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

A systematic review of studies reporting on 139 million people showed that Vaccines, antibiotics, antiviral medications, and anti-inflammatory drugs are all associated with a reduced risk of dementia. Scientific Consensus is the way forward

Mar 1, 2025 · 379 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

Vaccines, antibiotics, antiviral medications and anti-inflammatory drugs are all associated with a reduced risk of dementia, researchers reported in a systematic review published this week in the journal Alzheimer's and dementia. https://t.co/xEK6PfqZP1

Feb 20, 2025 · 379 followers View post →
サイエンスあれこれ
@sarekore · X

れました。リスクを低減させた薬については、一般的なタイプの認知症がウイルスまたは細菌の感染によって引き起こされる可能性があるという理論を裏付けています。また、炎症が認知症において中心的な役割を果たしていることも示唆しています。https://t.co/q4gZCCDLxD

Feb 8, 2025 · 1 like · 921 followers View post →
Alzheimer's & Dementia Journals
@alzdemjournals · X

What is the association between medications and dementia risk? New #TRCI systematic review demonstrates some treatments like vaccines are associated with reduced risk while some diabetes & antipsychotic drugs have increased risk. Read the full article: https://t.co/2MMRX706Ko

Feb 5, 2025 · 1 like · 2,468 followers View post →
HealthyBuilds
@HealthyBuilds · X

Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review https://t.co/O30ZB82Qg4

Jan 30, 2025 · 203 followers View post →
HealthyBuilds
@JamesSw70043542 · X

Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review https://t.co/DdY3R4BX9r

Jan 30, 2025 · 20 followers View post →
Awakened Princess
@GastricpH · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 27, 2025 · 27 shares · 1,013 followers View post →
alfred fischer
@alfredfischer17 · X

Als besonders faszinierend erachteten die Autoren den Zusammenhang zwischen Antibiotika, antiviralen Subs­tanzen sowie Impfungen und einem reduzierten Demenzrisiko. #impfen #alzheimer #epidemiologie https://t.co/erbCXtgy4Y

Jan 27, 2025 · 2 likes · 362 followers View post →
darcy darnoc
@darcydarnoc · X

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review - Underwood - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library https://t.co/5YTpYnRraZ

Jan 24, 2025 · 3,143 followers View post →
K
@LongCovid_Me · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 23, 2025 · 27 shares · 1,527 followers View post →
lillian medville
@lillianmedville · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 23, 2025 · 27 shares · 342 followers View post →
Billy Hanlon
@bhanlon15 · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 23, 2025 · 27 shares · 13,605 followers View post →
Nick Wellings
@Nick_Wellings · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 23, 2025 · 27 shares · 3,136 followers View post →
SWA
@swalexander.bsky.social · Bluesky

Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Jan 23, 2025 · 1 share View post →
Colleen Griffith
@Griffith17431 · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 23, 2025 · 27 shares · 932 followers View post →
WinAlly
@WinAlly_com · X

Data-driven discovery of associations between prescribed drugs and #dementia risk: A systematic review #demans #ilaç #winally https://t.co/L0ecdhb36G

Jan 23, 2025 · 1,016 followers View post →
Kelly Fawcett
@kellymfawcett · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 370 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review - Underwood - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library https://t.co/x2tPP39BwJ

Jan 22, 2025 · 3 likes · 78,984 followers View post →
amanasleep
@ticketdust · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 562 followers View post →
Hannah Davis
@ahandvanish · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 55,991 followers View post →
Alina MSN, RN, CCRC
@Alina_MSN_RN · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 2,422 followers View post →
Researching the Brain
@Brain_Database · X

The use of antimicrobials, vaccinations, and anti-inflammatory medications was linked to a lower risk of dementia, whereas diabetes medications, vitamins and supplements, and antipsychotics were associated with a higher risk. https://t.co/hWxB83Jc4M

Jan 22, 2025 · 1,039 followers View post →
Kellie O’Callaghan
@kellieocallaghan.bsky.social · Bluesky

Jan 22, 2025 View post →
Professor Erwin Loh
@erwinloh · X

Antibiotics, antivirals and vaccines could help tackle dementia, study suggests. Using drugs approved for other conditions could dramatically speed up hunt for cure, experts say. https://t.co/j1A4PHIwdy https://t.co/0dMT0uuFlM

Jan 22, 2025 · 9,113 followers View post →
Mary Jane
@MTW1952 · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 317 followers View post →
Emily Johnson (is on Mastadon and Bsky)
@emily_rj · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 7,897 followers View post →
Dr Nicola Clague-Baker
@ClagueNjc36 · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 4,493 followers View post →
Francesca
@alasitfrancesca · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 22, 2025 · 27 shares · 34 followers View post →
Jay
@994rela · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 1,046 followers View post →
karenk_____
@karenk_____ · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 895 followers View post →
Judy Stone
@DrJudyStone · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 13,262 followers View post →
tragedy magnet
@mm_donohue · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 159 followers View post →
DM
@dustinmcd123 · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 774 followers View post →
Aimée Hall
@astronaimee · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 2,436 followers View post →
CURE ID
@id_cure · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 3,584 followers View post →
charlos
@loscharlos · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 26,350 followers View post →
Dwight Williams (
@DewlineO · X

RT @ahandvanish: Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were ass…

Jan 21, 2025 · 27 shares · 989 followers View post →
Hannah Davis
@ahandvanish · X

Super interesting study looking at drugs & dementia found: 1) Antimicrobials, vaccinations & anti-inflammatories were associated with reduced risk of dementia 2) Diabetes drugs, vitamins/supplements & antipsychotics were associated with increased risk https://t.co/FQU2lS4tUP

Jan 21, 2025 · 146 likes · 27 shares · 55,991 followers View post →
KillingEve
@Killing87152220 · X

Why is nobody talking about it? https://t.co/17xqaRXG3K Funded by Gnodde Goldman Sachs Gives, trying to tell you that Hepatitis A & B vaxx lowers dementia risk, while it is clear as water antipsychotics increase it, as do NSAIDS etc.

Jan 21, 2025 · 408 followers View post →
CMIN
@IcahnCMIN · X

.@DrBenUnderwood1 @DrDJLlewellyn, et al. @DemonNetworkUK analyzed data & found antibiotics, antivirals, vaccines & anti-inflammatory medications assoc w/ reduced risk of #Dementia. Learn More @alzdemjournals https://t.co/Jn6XvxdeXV Overview @SciTechDaily1 https://t.co/9m2JxYJWHL

Jan 21, 2025 · 852 followers View post →
For health-promoting environments
@SilkeLeFay · X

#Alzheimers #agedcare #gerontology #geriatrics A systematic review with data from 130 million individuals and 1 million dementia cases finds that diabetes drugs, vitamins and supplements, and antipsychotics are associated with increased dementia risk. https://t.co/ibn2L0kDPx https://t.co/ynemXeDsPw

Jan 21, 2025 · 4,582 followers View post →
Lillith O
@Orland1M · X

RT @NeuroscienceNew: “Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review” by Ben Underwo…

Jan 21, 2025 · 1 share · 2,961 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review” by Ben Underwood et al. Alzheimer’s and Dementia: Translational Research & Clinical Interventions https://t.co/IdVl567ohY

Jan 21, 2025 · 4 likes · 1 share · 505,553 followers View post →
Dan Jagger
@auditorynerves.bsky.social · Bluesky

Open access

Jan 21, 2025 · 9 likes · 3 shares View post →