iScience February 2025 PMID 39877906

Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling.

Kelly G Jameson, Sabeen A Kazmi, Takahiro E Ohara, Celine Son, Kristie B Yu, Donya Mazdeyasnan, Emma Leshan, Helen E Vuong, Jorge Paramo, Arlene Lopez-Romero, Long Yang, Felix E Schweizer, Elaine Y Hsiao

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Mentions

76
Peak: 28 in Jan 2025
across 7 sources since Jan 2025

Extended reach

640,837
potential audience

Total likes

262

Video views

284

Mentions per month

Jan 2025 – Aug 2025

Where it's discussed

  • X / Twitter54 posts
  • News10 articles
  • Bluesky3 posts
  • Reddit3 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Discussions show clear enthusiasm for the study's findings, with many emphasizing the potential for new treatments and understanding of neurogastroenterology. Words like 'excited,' 'possibilities,' and 'advance' reflect high interest and perceived impact, while mentions of microbial metabolites and vagal activity showcase active engagement with the research's details.

AgreementStrong agreement

Most discussions express strong support or acknowledgment of the study's significance, emphasizing its potential for advancing understanding and treatments.

InterestHigh interest

Posts demonstrate high interest, with mentions of new therapies, scientific implications, and excitement about microbial mechanisms.

EngagementModerate engagement

While many comments praise the findings, some share personal insights or suggest new research avenues, indicating active engagement.

ImpactHigh impact

The discussions highlight the study's potential to influence future research, clinical approaches, and understanding of the gut-brain axis.

Abstract in brief

  • The study found that the gut microbiome influences vagal nerve activity through specific microbial metabolites like short-chain fatty acids, bile acids, and indoxyl sulfate, which stimulate the nerve via receptor-dependent signaling.
  • In germ-free mice, vagal tone is decreased, but it can be restored by introducing normal microbiota or intestinal filtrates from conventional mice, indicating that microbiota are essential for normal vagal function.
  • The research demonstrates that these microbial metabolites activate specific neurons in the brainstem through the vagus nerve, highlighting a pathway by which the gut microbiome communicates with and influences the brain.]

Top posts

Most liked on X and Bluesky
Elaine Hsiao
@pipethero · X

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity https://t.co/ngwSjk5lGi

Jan 29, 2025 · 108 likes · 35 shares · 3,491 followers View post →
Vipin M. Vashishtha
@vipintukur · X

The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10/10 https://t.co/t264bqIQVq https://t.co/7pvK6ECt6A

Feb 12, 2025 · 68 likes · 11 shares · 19,319 followers View post →
Elaine Hsiao
@pipethero.bsky.social · Bluesky

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity www.cell.com/iscience/ful...

Jan 29, 2025 · 38 likes · 16 shares View post →
Neuroscience News
@NeuroscienceNew · X

“Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling” by Kelly G. Jameson et al. iScience https://t.co/THFwHQ6Xhz

Feb 11, 2025 · 10 likes · 507,053 followers View post →
Micah G. Allen
@micahgallen.com · Bluesky

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling www.cell.com/iscience/ful...

Feb 11, 2025 · 10 likes · 2 shares View post →
Daniel Corchado
@med__gym · X

Los resultados de este estudio demuestran que la microbiota intestinal puede modular la actividad del nervio vago ❗️ Existe evidencia que apoya que la microbiota está en relación con el desarrollo de enfermedades neurodegenerativas

Feb 13, 2025 · 7 likes · 2 shares · 1,878 followers View post →

All mentions

Researching the Brain
@Brain_Database · X

The gut microbiome controls specific metabolites in the intestinal lumen, which uniquely stimulate vagal afferent neurons. This process allows microbes to influence chemosensory signaling, facilitating gut-brain communication. https://t.co/1QnAR4Q2Se

Mar 2, 2025 · 1 like · 1,037 followers View post →
MortenGroupOxford
@OxMEDiscovery · X

Very interesting paper in relation to Cryotherapy. https://t.co/NSoAQMmucW

Feb 16, 2025 · 2 likes · 2,851 followers View post →
R A Popalzai
@Radion_Popalzai · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 14, 2025 · 11 shares · 4,526 followers View post →
Richelle Flanagan
@RichelleFlan · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 14, 2025 · 35 shares · 5,708 followers View post →
Richelle Flanagan
@RichelleFlan · X

A lot to be excited about in this paper? @jfcryan @MaluTansey @ScienceofPD @ProfWhelan https://t.co/39t6Gux0Qn https://t.co/ChUWOENXor

Feb 14, 2025 · 6 likes · 5,708 followers View post →
fereshteh jahanbani
@fereshtehjahan1 · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 13, 2025 · 11 shares · 1,389 followers View post →
G O
@germanome · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 13, 2025 · 11 shares · 598 followers View post →
DOMMINUS BASSUKUS NAZARIUS Rigor Mortis
@alejo5597125221 · X

RT @med__gym: Los resultados de este estudio demuestran que la microbiota intestinal puede modular la actividad del nervio vago ❗️ Existe…

Feb 13, 2025 · 2 shares · 135 followers View post →
Daniel Corchado
@med__gym · X

Los resultados de este estudio demuestran que la microbiota intestinal puede modular la actividad del nervio vago ❗️ Existe evidencia que apoya que la microbiota está en relación con el desarrollo de enfermedades neurodegenerativas

Feb 13, 2025 · 7 likes · 2 shares · 1,878 followers View post →
佐原伸
@SlA74R852a28piP · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 13, 2025 · 11 shares · 578 followers View post →
José Xesspe
@josecaxeca · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 13, 2025 · 11 shares · 235 followers View post →
特別期間
@periodoespecial · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 12, 2025 · 11 shares · 195 followers View post →
Simone
@SimonePands1111 · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 12, 2025 · 11 shares · 2,734 followers View post →
Spam Again
@AgainIsitvalid · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 12, 2025 · 11 shares · 831 followers View post →
B Aleksander
@BAleksander_ · X

"The findings advance understanding of the gut-brain axis and may lead to new treatments for neurological and gastrointestinal disorders" @DoctorChrisVT @joeroganhq @joerogan @RFKJr_Official @nevrologeir @TheDigestionDoc @JNeurochem @fedonlindberg https://t.co/Ei21NyZe86

Feb 12, 2025 · 1,021 followers View post →
@msmaryjodetroit@union.place
@msmaryjodetroit · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 12, 2025 · 11 shares · 915 followers View post →
Pedicord Lab
@pedicordlab.bsky.social · Bluesky

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling: iScience www.cell.com/iscience/ful...

Feb 12, 2025 · 6 likes · 1 share View post →
db
@db11770382 · X

RT @vipintukur: The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10…

Feb 12, 2025 · 11 shares · 995 followers View post →
Catherine Mackay
@cmkhealthatwork · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 12, 2025 · 35 shares · 5,430 followers View post →
Vipin M. Vashishtha
@vipintukur · X

The study’s findings open up new possibilities for exploring treatments for neurological and gastrointestinal disorders. 10/10 https://t.co/t264bqIQVq https://t.co/7pvK6ECt6A

Feb 12, 2025 · 68 likes · 11 shares · 19,319 followers View post →
J Scotch McClure
@joshuamcclure · X

https://t.co/gStAi42yfQ

Feb 12, 2025 · 18,714 followers View post →
Nirmata
@En_formare · X

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling • iScience https://t.co/ldjqKYDlK5 https://t.co/QLNFHzmKgl

Feb 12, 2025 · 3 likes · 450 followers View post →
Micah G. Allen
@micahgallen.com · Bluesky

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling www.cell.com/iscience/ful...

Feb 11, 2025 · 10 likes · 2 shares View post →
Neuroscience News
@NeuroscienceNew · X

“Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling” by Kelly G. Jameson et al. iScience https://t.co/THFwHQ6Xhz

Feb 11, 2025 · 10 likes · 507,053 followers View post →
Gut-Brain Science
@GutBrainScience · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 4, 2025 · 35 shares · 619 followers View post →
बेष्ट Best
@Prabhat_Dhakal_ · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 4, 2025 · 35 shares · 1,792 followers View post →
Hypothesis Fund
@Hypothesisfund · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 3, 2025 · 35 shares · 1,282 followers View post →
Joram Mooiweer
@JoramMooiweer · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 2, 2025 · 35 shares · 876 followers View post →
Maxime Mahe
@MaximeMMahe · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Feb 2, 2025 · 35 shares · 653 followers View post →
Katie Guzzetta
@ktguzz · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 4,773 followers View post →
Ace Bryan Sotelo Cabal
@ace_cabal · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 1,132 followers View post →
Claudia Chien
@ClaudiaAcadem · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 946 followers View post →
Rajan Singh
@Rajan___Singh · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 1,475 followers View post →
Lin Chang
@LinChangMD · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 2,282 followers View post →
LJ Amaral MS, RD, CSO
@ljamaral1 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 186 followers View post →
Thomas Fung
@thomascf4116 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 295 followers View post →
Michelle Fitzmaurice
@DrMFitzmaurice · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 752 followers View post →
Marcus Böhme
@BoehmeMarcus · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 31, 2025 · 35 shares · 4,309 followers View post →
Abha Karki Rajbhandari, PhD
@BrainBody_Lab · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 1,409 followers View post →
Hiroshi Yano, PhD
@HiroTheHero_PhD · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 997 followers View post →
Wen Zhang
@wenzhang1120 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 431 followers View post →
给你中
@wzx_7926 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 79 followers View post →
Rochellys Heijtz
@HeijtzRochellys · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 1,575 followers View post →
Cheng Qian
@ChengQian_PKU · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 81 followers View post →
Ezgi Özcan
@eozcan_MinDgut · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 30, 2025 · 35 shares · 258 followers View post →
Marc Chevrette
@wildtypeMC · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 3,354 followers View post →
UCLA Gastroenterology and Hepatology
@UCLAGIHep · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 1,549 followers View post →
Aya Osman, PhD
@AyaOsman · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 3,451 followers View post →
Esther J. Han
@estherjwhan · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 97 followers View post →
Ping Fang
@PingFan78765311 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 50 followers View post →
Dr Kristy Townsend
@neuroadipo · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 1,395 followers View post →
Guillaume de Lartigue
@GdeLartigue · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 883 followers View post →
Andrea Salvador
@amsalvador1 · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 744 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 10,849 followers View post →
Elaine Hsiao
@pipethero.bsky.social · Bluesky

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity www.cell.com/iscience/ful...

Jan 29, 2025 · 38 likes · 16 shares View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @pipethero: Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intes…

Jan 29, 2025 · 35 shares · 3,521 followers View post →
Elaine Hsiao
@pipethero · X

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity https://t.co/ngwSjk5lGi

Jan 29, 2025 · 108 likes · 35 shares · 3,491 followers View post →