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Cell Stem Cell March 2025 PMID 39879989

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals.

Zhi-Kun Li, Li-Bin Wang, Le-Yun Wang, Xue-Han Sun, Ze-Hui Ren, Si-Nan Ma, Yu-Long Zhao, Chao Liu, Gui-Hai Feng, Tao Liu, Tian-Shi Pan, Qing-Tong Shan, Kai Xu, Guan-Zheng Luo, Qi Zhou

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Mentions

305
Peak: 23 in Jan 2025
across 7 sources since Jan 2025

Extended reach

807,443
potential audience

Total likes

273

Video views

342

Mentions per month

Jan 2025 – Nov 2025

Where it's discussed

  • News243 articles
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  • Bluesky6 posts
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  • Reddit2 posts

AI synopsis

What people are saying

Discussions revolve around the groundbreaking nature of the research, with many emphasizing its significance by phrases like 'enormous significance' and 'hot off the press,' illustrating excitement and recognition of its potential. The tone varies from highly positive to informational, with some references to ethical considerations and recent advances in reproductive technologies, which reflect both curiosity and cautious optimism regarding the implications of the findings.

AgreementModerate agreement

Most posts recognize the significance of the research, with many affirming its potential for advancing mammalian reproduction, although some use neutral or supportive language.

InterestHigh interest

Several discussions express curiosity and intrigue, especially with phrases like 'enormous significance' and 'amazing study,' indicating high interest. Others show basic acknowledgment, reflecting moderate curiosity.

EngagementModerate engagement

Posts mainly share links, summaries, or brief comments, with few deep analyses or critical discussions, suggesting a moderate level of engagement.

ImpactModerate impact

While many posts highlight the groundbreaking nature of creating offspring with two fathers, the tone remains cautious, indicating that the perceived impact is high but not universally considered transformative yet.

Abstract in brief

  • Imprinting abnormalities in embryonic stem cells and cloning create significant challenges due to their complexity and variability, with no universal correction methods available.
  • This study focused on correcting these defects in bi-paternal mouse embryos by introducing genetic edits at 20 key imprinted loci, resulting in the development of adult animals with a low survival rate.
  • The results highlight that imprinting defects hinder unisexual reproduction in mammals and suggest potential improvements in embryonic stem cell development and cloning, paving the way for advancements in regenerative medicine.
Read the full abstract

Top posts

Most liked on X and Bluesky
vittorio
@IterIntellectus · X

@CellPressNews link: https://t.co/pseXcfBcxn

Feb 10, 2025 · 160 likes · 3 shares · 120,432 followers View post →
Johanna Joyce
@johannajoyce.bsky.social · Bluesky

Amazing study

Jan 29, 2025 · 32 likes · 5 shares View post →
Cell Stem Cell
@CellStemCell · X

Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/HUxyrfdtIo #stemcells

Jan 28, 2025 · 27 likes · 4 shares · 58,429 followers View post →
Cell Stem Cell
@CellStemCell · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 6, 2025 · 15 likes · 5 shares · 58,429 followers View post →
Felicia Basilicata
@Feli_Bas · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/bb6ldXVN22

Mar 11, 2025 · 5 likes · 2 shares · 332 followers View post →
Akihiro KUNO / 久野 朗広
@akicuno · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/GGPvt0gVnH

Jan 28, 2025 · 5 likes · 223 followers View post →

All mentions

davida sosa vizcaino
@davidasosavizca · X

Descendencia bipaternal adulta generada mediante modificación directa de genes impresos en mamíferos: Cell Stem Cell https://t.co/8fkkaeF1GG

Aug 20, 2025 · 107 followers View post →
davida sosa vizcaino
@davidasosavizca · X

Y eso me lo dices tú? que de bonita no tienes ni la ropa. Si, ya se ha creado vida en animales creando óvulos a partir de células masculinas, de hecho los chinos ya lo han logrado solo con espermatozoides. En humanos no se a hecho porque no es ético. https://t.co/8fkkaeF1GG https://t.co/MZNRthxWFR

Aug 20, 2025 · 107 followers View post →
Pranav Adithya
@PranavAdithya10 · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/UMGf7iVlbW

Jun 25, 2025 · 197 followers View post →
AI, Drugs & Robots
@AIDrugsYRobots · X

https://t.co/P1RntdJkp7

Jun 4, 2025 · 149 followers View post →
Nelke 'Demon Lord' Shilovich
@nelke_IGB · X

RT @Feli_Bas: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/…

Apr 15, 2025 · 2 shares · 1,107 followers View post →
Cell Stem Cell
@cp-cellstemcell.bsky.social · Bluesky

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals

Mar 19, 2025 View post →
GrazianoMartello
@grazianone · X

RT @Feli_Bas: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/…

Mar 12, 2025 · 2 shares · 937 followers View post →
igdhk
@5yymfH · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals インプリント遺伝子のmodificationにより父方遺伝子のみの胚を発生させる。(マウス) 1倍体ES細胞標的遺伝子編集→体細胞核移植→4倍体補完法...20KO！ ”tour de force” https://t.co/wkMuaaNq2G

Mar 12, 2025 · 1 like · 2 followers View post →
Felicia Basilicata
@Feli_Bas · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/bb6ldXVN22

Mar 11, 2025 · 5 likes · 2 shares · 332 followers View post →
Le Tran Phuc Khoa
@LeTranPhucKhoa1 · X

RT @CellStemCell: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 7, 2025 · 5 shares · 264 followers View post →
Gilberto Duran-Bishop
@duran_bishop · X

RT @CellStemCell: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 7, 2025 · 5 shares · 170 followers View post →
Keiichi Ito
@itok10918 · X

RT @CellStemCell: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 6, 2025 · 5 shares · 1,240 followers View post →
Azusa Inoue | 井上梓
@a_z_usa__ · X

RT @CellStemCell: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 6, 2025 · 5 shares · 2,049 followers View post →
Cell Stem Cell
@CellStemCell · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/O02gGS6C2O

Mar 6, 2025 · 15 likes · 5 shares · 58,429 followers View post →
RRID Robot
@rridrobot.bsky.social · Bluesky

A paper using RRID:IMSR_JAX:003291 (from IMSR) was just published in Cell Stem Cell see "Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals". We appreciate the author's support of reproducibility. #accelerateopenscience #RRID

Feb 13, 2025 · 1 like View post →
Daniel Bogda
@dabogda · X

RT @IterIntellectus: @CellPressNews link: https://t.co/pseXcfBcxn

Feb 11, 2025 · 3 shares · 1,665 followers View post →
hannahhyemin06
@hannahhyemin06 · X

RT @IterIntellectus: @CellPressNews link: https://t.co/pseXcfBcxn

Feb 10, 2025 · 3 shares · 873 followers View post →
vittorio
@IterIntellectus · X

@CellPressNews link: https://t.co/pseXcfBcxn

Feb 10, 2025 · 160 likes · 3 shares · 120,432 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals" Li Z, Wang LB, Wang LY [..] Luo GZ, Zhou Q, Li W. Cell Stem Cell. 2025-01-28. https://t.co/5ZD377w96T https://t.co/KVYwS5Yc9r

Feb 6, 2025 · 1,917 followers View post →
Life Science Journal Content
@lsn_jc · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals #science #publication #research #journal https://t.co/IhiZSgF3nE

Feb 4, 2025 · 263 followers View post →
Shinpei Yamaguchi
@shinpeilab.bsky.social · Bluesky

発生工学を利用した卵子核をもたない二父性マウスの誕生。半数体Ag-ESCを樹立し、遺伝子操作を20箇所（7箇所では新生仔致死）施して、卵子核を脱核した受精卵に注入している。二母性マウスカグヤと違ってESCを経ているのが重要なポイント。Cell Stem Cell誌。 Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell www.cell.com/cell-stem-ce...

Feb 4, 2025 · 1 share View post →
Miguel Ángel Sogorb
@MASogorb · X

Un ratón engendrado por solo dos machos llega a la edad adulta https://t.co/VMRrmD5cCL Más información: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/J5z6l1DzYR

Feb 1, 2025 · 158 followers View post →
Neurosciencium
@neurosciencium · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/dpGsvToYSv

Jan 31, 2025 · 1 like · 26 followers View post →
Katebushfan♀️
@SofieIrene · X

@Echoing_Winds "Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals" https://t.co/jo3UMlyEog

Jan 31, 2025 · 1 like · 26 followers View post →
Tamino
@Gem12Shiny · X

RT @NeuroscienceNew: “Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals” by Wei Li et al. Cel…

Jan 30, 2025 · 1 share · 145 followers View post →
Gabriel Pipkin
@gabrielpipkin_ · X

El estudio que comentó @YammiSegovia Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/uPQWdksOhc #YAQPA @radioconvos899 @ddeurieta @tapettinato @ertenembaum

Jan 30, 2025 · 2 likes · 654 followers View post →
Domenico Coviello
@DomenicoCoviel1 · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/rElSLYohsf https://t.co/Y5nGE5fXgW https://t.co/fP8sybkulm

Jan 30, 2025 · 336 followers View post →
Johanna Joyce
@johannajoyce.bsky.social · Bluesky

Amazing study

Jan 29, 2025 · 32 likes · 5 shares View post →
Mahmoud Sami
@AIMahmoudSami · X

RT @CellStemCell: Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/…

Jan 29, 2025 · 4 shares · 2 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @CellStemCell: Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/…

Jan 29, 2025 · 4 shares · 572 followers View post →
Michele Boiani
@BoianiMichele · X

3/3 The new results hot off the press are of enormous significance. While at first glance they amount to just a couple of mice with two fathers (DOI 10.1016/j.stem.2025.01.005), they actually add a new option (unisexual) to the standard repertoire of mammalian reproduction

Jan 29, 2025 · 1 like · 295 followers View post →
Norio Nakatsuji
@norionakatsuji · X

RT @norionakatsuji: “Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell” https…

Jan 29, 2025 · 1 share · 15,694 followers View post →
Norio Nakatsuji
@norionakatsuji.bsky.social · Bluesky

ARTICLEOnline nowJanuary 28, 2025 Open Access | Cell Stem Cell [Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals] www.cell.com/cell-stem-ce...

Jan 29, 2025 · 1 like · 2 shares View post →
Norio Nakatsuji
@norionakatsuji · X

“Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell” https://t.co/F2cqa9qZFE

Jan 29, 2025 · 1 like · 1 share · 15,694 followers View post →
Akihiro KUNO / 久野 朗広
@akicuno · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/GGPvt0gVnH

Jan 28, 2025 · 5 likes · 223 followers View post →
ぜのぱす（初代_凍結から快復）
@Xenopus007 · X

【memo】 Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/Pfx1lR9HYt

Jan 28, 2025 · 2 likes · 852 followers View post →
/ɹɑb/
@RobertBorland7 · X

RT @CellStemCell: Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/…

Jan 28, 2025 · 4 shares · 956 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals” by Wei Li et al. Cell Stem Cell https://t.co/kmJ6RarXD9

Jan 28, 2025 · 4 likes · 1 share · 505,524 followers View post →
didaclopez
@didaclopez · X

RT @Fradbius: Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/…

Jan 28, 2025 · 1 share · 3,431 followers View post →
fradbius.bsky.social
@fradbius.bsky.social · Bluesky

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell www.cell.com/cell-stem-ce...

Jan 28, 2025 View post →
Pere Joan Sala
@Fradbius · X

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/WkzT2Q5XOs

Jan 28, 2025 · 1 like · 1 share · 248 followers View post →
Mark Borris Aldonza (@precursorcell.bsky.social
@PrecursorCell · X

RT @CellStemCell: Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/…

Jan 28, 2025 · 4 shares · 1,385 followers View post →
Cell Stem Cell
@CellStemCell · X

Online Now! Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/HUxyrfdtIo #stemcells

Jan 28, 2025 · 27 likes · 4 shares · 58,429 followers View post →
❤️Harold Coxeter is my math hero, prove me wrong.
@deepgreendesign · X

@DrNice2022 shhhhhh Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals https://t.co/BoEyUZ3spz

Jan 28, 2025 · 1 like · 10,926 followers View post →
José Antonio Ruiz #ElUltimoSapiens
@ElUltimoSapiens · X

@ElUltimoSapiens. Científicos chinos han logrado gestar embriones a partir de las células de progenitores del mismo sexo. Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals: Cell Stem Cell https://t.co/CnsiPM2Ijx

Jan 28, 2025 · 2 likes · 1,138 followers View post →