Geroscience June 2025 PMID 39951177

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

Amanda E Coleman, Kate E Creevy, Rozalyn Anderson, May J Reed, Virginia R Fajt, Kathleen M Aicher, Genna Atiee, Brian G Barnett, Ryan D Baumwart, Beth Boudreau, Suzanne M Cunningham, Matthew D Dunbar, Bobbie Ditzler, Anna M Ferguson, Kiersten K Forsyth

Mentions

44
Peak: 15 in Mar 2025
across 3 sources since Nov 2024

Extended reach

726,043
potential audience

Total likes

151

Video views

1,517

Mentions per month

Nov 2024 – Nov 2025

Where it's discussed

  • X / Twitter32 posts
  • Bluesky10 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reveal high enthusiasm with phrases like 'excited to celebrate milestones,' and detailed references to scientific posters and events, highlighting deep interest and engagement. Words like 'groundbreaking' and mentions of 'rigorous evidence' contribute to the perception that the study could have a substantial impact on aging science, especially by leveraging dogs as a model for human aging.

AgreementModerate agreement

Most discussions highlight excitement and support for the TRIAD study, emphasizing its importance and progress, indicating a generally positive consensus.

InterestHigh interest

The posts consistently show strong curiosity and enthusiasm for the study, with multiple mentions of milestones, scientific posters, and events, reflecting high interest.

EngagementHigh engagement

Many discussions reference specific aspects of the study, such as its design, milestones, and upcoming events, showing deep engagement with the research details.

ImpactHigh impact

The repeated focus on progress, scientific findings, and outreach efforts demonstrates that the community sees this study as having significant potential to influence aging research and pet health.

Abstract in brief

  • The TRIAD study is a large, carefully designed clinical trial testing whether rapamycin can extend the lifespan and improve health markers in healthy middle-aged pet dogs, which serve as an effective model for human aging due to their genetic variability and shared environment.
  • Using a double-masked, randomized, placebo-controlled setup across multiple centers, the study aims to provide rigorous evidence on the effects of rapamycin on aging in a real-world setting outside the lab, making it significant for understanding potential anti-aging interventions.
  • The research leverages the naturally shorter lifespan of dogs to quickly evaluate the impacts of rapamycin on lifespan and healthspan, offering insights that could inform human aging research and treatments.]

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project https://t.co/ZAjXS8NL1Y

Mar 22, 2025 · 33 likes · 4 shares · 30,998 followers View post →
Agingdoc
@agingdoc1 · X

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project https://t.co/ihX9q2TRQL @DogAgingProject

Mar 13, 2025 · 26 likes · 10 shares · 42,377 followers View post →
Dog Aging Project
@DogAgingProject · X

We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical trial.

Feb 19, 2025 · 9 likes · 4 shares · 4,377 followers View post →
Cerebro Digital
@cerebrodigital.net · Bluesky

Sep 6, 2025 · 9 likes · 8 shares View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

"Exciting milestones are being celebrated by the Dog Aging Project as the first canine participants graduate from the groundbreaking Test of Rapamycin in Aging Dogs (TRIAD) clinical trial." Read the full article to learn more: citydogmagazine.com/dog-aging-pr... #dogs #DogAgingProject

May 29, 2025 · 6 likes · 1 share View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

We’re proud of our team!

May 12, 2025 · 6 likes View post →

All mentions

Advances in Anti-Aging Treatments for Dogs

This video discusses clinical trials exploring health improvements and lifespan extension in dogs, including reducing hormonal levels and testing rapamycin. The research aims to understand aging mechanisms and potential…

Un Veterinario · Oct 6, 2025 1,208 views
Cerebro Digital
@cerebrodigital.net · Bluesky

Nov 4, 2025 · 4 likes View post →
Victor Algra
@Victor_Algra · X

Oct 6, 2025 · 1,552 followers View post →
Cerebro Digital
@cerebrodigital.net · Bluesky

Sep 6, 2025 · 9 likes · 8 shares View post →
Hee-Hoon Kim
@Hee_Hoon_Kim · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 29, 2025 · 10 shares · 50 followers View post →
Einstein Aging Center
@EinsteinAging · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 28, 2025 · 10 shares · 482 followers View post →
American Aging Association
@americanaging · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 6,812 followers View post →
Native Girl
@AzizaEil · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 662 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 42,377 followers View post →
CraftmeatI
@CraftmeatI · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 987 followers View post →
Dog Aging Project
@DogAgingProject · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 4,377 followers View post →
備忘録
@bibourokuabc · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 27, 2025 · 10 shares · 227 followers View post →
GeroScience
@GeroScienceAGE · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Jun 26, 2025 · 10 shares · 3,679 followers View post →
Dog Aging Project
@DogAgingProject · X

We're excited to celebrate our amazing team!

Jun 24, 2025 · 5 likes · 4,376 followers View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

We're excited to celebrate our amazing team!

Jun 24, 2025 · 3 likes View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

"Exciting milestones are being celebrated by the Dog Aging Project as the first canine participants graduate from the groundbreaking Test of Rapamycin in Aging Dogs (TRIAD) clinical trial." Read the full article to learn more: citydogmagazine.com/dog-aging-pr... #dogs #DogAgingProject

May 29, 2025 · 6 likes · 1 share View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

"The Dog Aging Project is pleased to announce that the first enrolled dogs have completed their participation in the three-year clinical trial for the Test of Rapamycin in Aging Dogs (TRIAD)" - TAMU Vet Med

May 14, 2025 · 4 likes · 1 share View post →
DeScAI agent
@longevity_agent · X

RT @agingdoc1: The scientific poster on Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD) @DogAgingProject

May 12, 2025 · 1 share · 735 followers View post →
Agingdoc
@agingdoc1 · X

The scientific poster on Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD) @DogAgingProject

May 12, 2025 · 1 like · 1 share · 42,086 followers View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

We’re proud of our team!

May 12, 2025 · 6 likes View post →
Dog Aging Project
@DogAgingProject · X

We’re proud of our team!

May 12, 2025 · 3 likes · 4,376 followers View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

If you haven't already, check out our March 2025 Pack Event, where you can learn more about Sydney's scientific poster, "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." ➡️Watch it on our YouTube channel: youtu.be/X472ui1CarQ?... #dogscience #TRIAD

Apr 2, 2025 · 2 likes View post →
Dog Aging Project
@DogAgingProject · X

If you haven't already, check out our March 2025 Pack Event, where you can learn more about Sydney's scientific poster, "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." ➡️Watch it on our YouTube channel: https://t.co/8Rdiwn0k2z #dogscience #TRIAD https://t.co/fKRTlxEAii

Apr 2, 2025 · 3 likes · 4,376 followers View post →
Jocelin B Villarreal
@justjossn · X

RT @DogAgingProject: Join us today for our March 2025 Pack Event at 3 PM CDT, where you can learn more about Sydney's scientific poster tit…

Mar 26, 2025 · 1 share · 197 followers View post →
Jocelin B Villarreal
@justjossn · X

Join me today at 3 PM CDT for the DAP Pack Event to learn about Sydney's poster on "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." Watch it on the Dog Aging Project’s YouTube channel: https://t.co/HY89RkUVWd https://t.co/BLt856yVNX

Mar 26, 2025 · 197 followers View post →
Dog Aging Project
@DogAgingProject · X

Join us today for our March 2025 Pack Event at 3 PM CDT, where you can learn more about Sydney's scientific poster titled "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." Watch it on our YouTube channel: https://t.co/8Rdiwn0k2z

Mar 26, 2025 · 3 likes · 1 share · 4,376 followers View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

Join us today for our March 2025 Pack Event at 3 PM CDT, where you can learn more about Sydney's scientific poster titled "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." Watch it on our YouTube channel: youtu.be/X472ui1CarQ?...

Mar 26, 2025 · 2 likes View post →
Dog Aging Project
@dogagingproject.bsky.social · Bluesky

Join us for our upcoming Pack Event on March 26, 2025, where you can learn more about Sydney's scientific poster titled "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." Save the date and watch it on our YouTube channel: youtu.be/X472ui1CarQ?...

Mar 24, 2025 · 2 likes View post →
Dog Aging Project
@DogAgingProject · X

Join us for our upcoming Pack Event on March 26, 2025, where you can learn more about Sydney's scientific poster titled "Canine Cognition Assessments in the Test of Rapamycin in Aging Dogs (TRIAD)." Save the date and watch it on our YouTube channel: https://t.co/8Rdiwn0RS7

Mar 24, 2025 · 3 likes · 4,376 followers View post →
Motion Planet
@WDS1U · X

RT @AgingBiology: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, r…

Mar 24, 2025 · 4 shares · 362 followers View post →
octavio
@dontavo66 · X

RT @AgingBiology: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, r…

Mar 24, 2025 · 4 shares · 332 followers View post →
The Longevist
@Dr_coachbear · X

RT @AgingBiology: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, r…

Mar 23, 2025 · 4 shares · 508,665 followers View post →
Andrew Lewis
@lewisonhc · X

RT @AgingBiology: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, r…

Mar 22, 2025 · 4 shares · 22 followers View post →
Aging Science News
@AgingBiology · X

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project https://t.co/ZAjXS8NL1Y

Mar 22, 2025 · 33 likes · 4 shares · 30,998 followers View post →
NADIA EB
@NADYEUGENY · X

RT @agingdoc1: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, random…

Mar 13, 2025 · 10 shares · 217 followers View post →
Agingdoc
@agingdoc1 · X

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project https://t.co/ihX9q2TRQL @DogAgingProject

Mar 13, 2025 · 26 likes · 10 shares · 42,377 followers View post →
INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1 · X

RCT description: "Test of Rapamycin in Aging Dogs (TRIAD):....from the Dog Aging Project." https://t.co/OeR2GbyEkM @brunovellas @isaperarnau @InfinityTLS @I2mcT

Mar 11, 2025 · 674 followers View post →
Dog Aging Institute
@dogaginginst · X

RT @DogAgingProject: We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical t…

Feb 24, 2025 · 4 shares · 191 followers View post →
UofL's Christina Lee Brown Envirome Institute
@UofLEnvirome · X

RT @DogAgingProject: We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical t…

Feb 20, 2025 · 4 shares · 658 followers View post →
GeroScience
@GeroScienceAGE · X

RT @DogAgingProject: We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical t…

Feb 20, 2025 · 4 shares · 3,679 followers View post →
Clayton Bob
@PygmyClay · X

RT @DogAgingProject: We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical t…

Feb 19, 2025 · 4 shares · 5,345 followers View post →
Dog Aging Project
@DogAgingProject · X

We’re excited to share a new publication detailing the rationale, design, and goals of the TRIAD randomized clinical trial.

Feb 19, 2025 · 9 likes · 4 shares · 4,377 followers View post →
Jay Roshe
@jayroshe.bsky.social · Bluesky

Dive into the Test of Rapamycin In Aging Dogs (TRIAD) clinical trial from Dog Aging Project: dogagingproject.org/inside-triad...

Nov 13, 2024 · 3 likes · 1 share View post →