J Clin Oncol August 2025 PMID 39965171

Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma.

Martin F Kaiser, Pieter Sonneveld, David A Cairns, Marc S Raab, Jesús San-Miguel Izquierdo, Rick Zhang, Jorge Acosta, Alessandra Larocca, Rakesh Popat, Cong Li, Marc-A Baertsch, Sarah R Brown, JuanJose Lahuerta Palacios, Anita K Gandhi, Sandrine Macé

Mentions

50
Peak: 16 in Feb 2025
across 4 sources since Feb 2025

Extended reach

242,786
potential audience

Total likes

80

Video views

117

Mentions per month

Feb 2025 – Sep 2025

Where it's discussed

  • X / Twitter41 posts
  • News5 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions reflect a consensus on the critical importance of the study, with users highlighting its relevance to treatment outcomes and future research. The tone, emphasizing phrases like 'significantly worse survival' and 'urgent need for tailored therapies,' exemplifies a strong recognition of the study’s significance and practical implications in the field of multiple myeloma research.

AgreementStrong agreement

Most discussions strongly support the findings of the publication, emphasizing that having two or more high-risk chromosomal abnormalities in multiple myeloma leads to worse survival outcomes.

InterestHigh interest

Posts demonstrate high curiosity, referencing the clinical significance and the need for tailored therapies, indicating that the research resonates with ongoing medical debates.

EngagementHigh engagement

Many responses entail detailed comments, quotes, and references to related discussions or podcasts, showing deep engagement with the study's implications.

ImpactHigh impact

The discourse underscores the publication’s high perceived impact, highlighting its importance for treatment strategies and the urgent need for targeted interventions.

Abstract in brief

  • The study investigates how co-occurrence of high-risk cytogenetic abnormalities (HRCAs) affects survival outcomes in patients with newly diagnosed and relapsed/refractory multiple myeloma (MM).
  • A systematic review of randomized controlled trials was conducted, including data from 24 trials and 13,926 patients, analyzing the impact of one or more HRCAs on progression-free and overall survival using a federated approach.
  • Results showed that patients with two or more HRCAs had significantly worse survival rates, highlighting the need for targeted treatment strategies for high-risk patients in MM.

Top posts

Most liked on X and Bluesky
Martin Kaiser
@MyMKaiser · X

Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associated with highest unmet need in NDMM and RRMM, across time and treatment modalities. https://t.co/SLXKqCTfdo

Mar 7, 2025 · 34 likes · 14 shares · 1,716 followers View post →
Muzaffar Qazilbash
@Transplant_Doc · X

Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bmtsm @MyMKaiser @JCO_ASCO https://t.co/qIqZhwgzhV

Feb 21, 2025 · 17 likes · 10 shares · 7,400 followers View post →
Muzaffar Qazilbash
@Transplant_Doc · X

Presence of ≥2 high-risk chromosomal abnormalities is associated with the poorest outcome in NDMM and RRMM, and across treatment modalities #mmsm #bmtsm @JCO_ASCO @MyMKaiser https://t.co/dFcdjw3Dd2

Jul 24, 2025 · 10 likes · 4 shares · 7,400 followers View post →
Fundación ECO
@FundacionECO · X

#Paper | Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory #MultipleMyeloma @ASCO @JCO_ASCO Access the entire article here

Feb 27, 2025 · 5 likes · 1 share · 3,103 followers View post →
Michael Hughes
@MSHughes_MD · X

To hear @SLentzsch and myself on a related topic (high-risk #MYELOMA) in our recent @JCO_ASCO Editorial Fellow podcast: https://t.co/a4VBqrRETb @columbiacancer

Jun 3, 2025 · 5 likes · 3 shares · 64 followers View post →
Journal of Clinical Oncology
@JCO_ASCO · X

Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma: https://t.co/x248hNXsQk. #mmsm

Feb 26, 2025 · 4 likes · 54,569 followers View post →

All mentions

Nathan Punwani
@npunwani · X

Having 2 or more high-risk cytogenetic abnormalities - t(4;14), t(14;16), del(17p), and gain(1q) - in multiple myeloma is worse than having 1 or no high-risk cytogenetic abnormality https://t.co/lhtMQRBC4C https://t.co/P1KJACCxaS

Sep 7, 2025 · 2 likes · 7,264 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

High-risk cytogenetic abnormalities in multiple myeloma drastically worsen progression-free and overall survival, signaling urgent need for tailored therapies. by Kaiser MF, Sonneveld P (...) Weinhold N et 26 al. in J Clin Oncol https://t.co/YPJ7phKFrJ #MedX #MedResearch

Aug 29, 2025 · 83 followers View post →
Alfredo I. Sagredo
@ASagredo3 · X

RT @Transplant_Doc: Presence of ≥2 high-risk chromosomal abnormalities is associated with the poorest outcome in NDMM and RRMM, and across…

Jul 24, 2025 · 4 shares · 328 followers View post →
Journal of Clinical Oncology
@JCO_ASCO · X

RT @Transplant_Doc: Presence of ≥2 high-risk chromosomal abnormalities is associated with the poorest outcome in NDMM and RRMM, and across…

Jul 24, 2025 · 4 shares · 54,569 followers View post →
Muhammad Husnain
@drhusnain04 · X

RT @Transplant_Doc: Presence of ≥2 high-risk chromosomal abnormalities is associated with the poorest outcome in NDMM and RRMM, and across…

Jul 24, 2025 · 4 shares · 10 followers View post →
Muzaffar Qazilbash
@Transplant_Doc · X

Presence of ≥2 high-risk chromosomal abnormalities is associated with the poorest outcome in NDMM and RRMM, and across treatment modalities #mmsm #bmtsm @JCO_ASCO @MyMKaiser https://t.co/dFcdjw3Dd2

Jul 24, 2025 · 10 likes · 4 shares · 7,400 followers View post →
Herbert Irving Comprehensive Cancer Center
@columbiacancer · X

RT @MSHughes_MD: To hear @SLentzsch and myself on a related topic (high-risk #MYELOMA) in our recent @JCO_ASCO Editorial Fellow podcast: ht…

Jun 3, 2025 · 3 shares · 4,666 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @MSHughes_MD: To hear @SLentzsch and myself on a related topic (high-risk #MYELOMA) in our recent @JCO_ASCO Editorial Fellow podcast: ht…

Jun 3, 2025 · 3 shares · 94 followers View post →
Suzanne Lentzsch, MD, PhD
@SLentzsch · X

RT @MSHughes_MD: To hear @SLentzsch and myself on a related topic (high-risk #MYELOMA) in our recent @JCO_ASCO Editorial Fellow podcast: ht…

Jun 3, 2025 · 3 shares · 4,140 followers View post →
Michael Hughes
@MSHughes_MD · X

To hear @SLentzsch and myself on a related topic (high-risk #MYELOMA) in our recent @JCO_ASCO Editorial Fellow podcast: https://t.co/a4VBqrRETb @columbiacancer

Jun 3, 2025 · 5 likes · 3 shares · 64 followers View post →
Monique Minnema
@MinnemaMonique · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 8, 2025 · 14 shares · 389 followers View post →
Annamaria Brioli
@abrioli · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 8, 2025 · 14 shares · 159 followers View post →
M. El Mehdi م. المهدي
@melmehdi · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 1,153 followers View post →
Gurbakhash Kaur
@GKaurMD · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 1,285 followers View post →
Bhuvan Kishore
@bloodmed · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 540 followers View post →
Suzanne Lentzsch, MD, PhD
@SLentzsch · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 4,154 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 97 followers View post →
Marc S. Raab
@RaabMarc · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 410 followers View post →
Journal of Clinical Oncology
@JCO_ASCO · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 54,569 followers View post →
Pat Adams
@PathologyPat · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 1,510 followers View post →
Uriel Suárez
@UsuarezMD · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 3,342 followers View post →
awechalekar
@awechalekar · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 1,218 followers View post →
Eddie Cliff
@Eddie_Cliff · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 4,648 followers View post →
Simon Stern
@DrSStern · X

RT @MyMKaiser: Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associa…

Mar 7, 2025 · 14 shares · 356 followers View post →
Martin Kaiser
@MyMKaiser · X

Very happy to see our global collaborative effort published in @JCO_ASCO : co-occurrence of ≥2 HRCAs is consistently associated with highest unmet need in NDMM and RRMM, across time and treatment modalities. https://t.co/SLXKqCTfdo

Mar 7, 2025 · 34 likes · 14 shares · 1,716 followers View post →
Pat Adams
@PathologyPat · X

RT @FundacionECO: #Paper | Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory #Mul…

Feb 27, 2025 · 1 share · 1,510 followers View post →
Fundación ECO
@FundacionECO · X

#Paper | Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory #MultipleMyeloma @ASCO @JCO_ASCO Access the entire article here

Feb 27, 2025 · 5 likes · 1 share · 3,103 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Patients with two or more high-risk cytogenetic abnormalities have significantly worse survival outcomes in multiple myeloma, highlighting urgent treatment needs. by Kaiser MF, Sonneveld P (...) Weinhold N et 26 al. in J Clin Oncol https://t.co/YPJ7phKFrJ #MedX #MedResearch

Feb 27, 2025 · 1 like · 83 followers View post →
Journal of Clinical Oncology
@JCO_ASCO · X

Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma: https://t.co/x248hNXsQk. #mmsm

Feb 26, 2025 · 4 likes · 54,569 followers View post →
Paul Shaughnessy
@PaulS1594 · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 22, 2025 · 10 shares · 246 followers View post →
Cyrus Khandanpour
@c_khandanpour · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 22, 2025 · 10 shares · 408 followers View post →
Elias K. Mai MD
@EliasKarlMai · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 22, 2025 · 10 shares · 492 followers View post →
Rahul Banerjee, MD, FACP
@RahulBanerjeeMD · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 22, 2025 · 10 shares · 11,183 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 22, 2025 · 10 shares · 97 followers View post →
Mujtaba Naqvi, MD
@MujtabaNaqvi20 · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 21, 2025 · 10 shares · 141 followers View post →
Bruno A. Costa, MD
@mdbrunocosta · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 21, 2025 · 10 shares · 1,252 followers View post →
Eddie Cliff
@Eddie_Cliff · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 21, 2025 · 10 shares · 4,648 followers View post →
Dr.マローウ(プリンじゃない方)
@DrBMLNMMML · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 21, 2025 · 10 shares · 1,692 followers View post →
Daisuke Minakata
@D_M_kappa_MM · X

RT @Transplant_Doc: Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bm…

Feb 21, 2025 · 10 shares · 97 followers View post →
Muzaffar Qazilbash
@Transplant_Doc · X

Occurrence of ≥two HRCAs is associated with the poorest outcome in NDMM and RRMM, across treatment modalities #mmsm #bmtsm @MyMKaiser @JCO_ASCO https://t.co/qIqZhwgzhV

Feb 21, 2025 · 17 likes · 10 shares · 7,400 followers View post →
Dr Akhil Santhosh
@tuttsakhil · X

Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma | Journal of Clinical Oncology @JCO_ASCO https://t.co/XTUPMBtQQ6

Feb 18, 2025 · 2 likes · 884 followers View post →