Aging Dis February 2025 PMID 39965245

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent.

Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W Y Lok, Fadi E Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W Pun

Mentions

30
Peak: 13 in Feb 2025
across 2 sources since Feb 2025

Extended reach

301,576
potential audience

Total likes

55

Video views

323

Mentions per month

Feb 2025 – Aug 2025

Where it's discussed

  • X / Twitter29 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussions reflect high enthusiasm and interest, with phrases like 'breakthrough' and 'game changer' illustrating excitement about the potential of TNIK inhibition for aging therapy. Posts mention the integration of AI and robotics as innovative, and some highlight the significance for future pharmaceutical advancements, demonstrating recognition of substantial scientific and societal impact.

AgreementModerate agreement

Most discussions express support or optimism about the significance of the research, with many highlighting its potential for age-related disease treatment and longevity.

InterestHigh interest

Posts show high curiosity, referencing specific aspects like the AI-driven approach, the compound ISM001-055, and the implications for aging and pharmacology.

EngagementModerate engagement

Several discussions delve into the tools and methods used, such as AI and robotic laboratories, although some comments remain more general or enthusiastic without deep technical analysis.

ImpactHigh impact

Many posts emphasize the transformative potential of the findings, suggesting they could revolutionize aging treatment, which indicates the perceived high impact of this research.

Abstract in brief

  • The study explores the role of the kinase TNIK in aging and cellular senescence, showing that inhibiting TNIK with the compound INS018055 can decrease senescent cell accumulation and reduce proinflammatory secretions called SASP.
  • Using automated robotic testing, researchers found that TNIK inhibition not only lessens cellular aging markers but also impacts gene expression related to aging and fibrosis, especially through TGF signaling pathways.
  • These findings suggest that targeting TNIK is a promising new approach to develop drugs that could treat age-related diseases by modulating cellular aging processes, potentially improving health span and lifespan.]

Top posts

Most liked on X and Bluesky
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent". I’m excited to share a breakthrough that underscores the future of pharma innovation. By leveraging cutting-edge AI, advanced aging clocks, and our https://t.co/CN5VJec795

Feb 20, 2025 · 18 likes · 6 shares · 32,060 followers View post →
Insilico Medicine
@InSilicoMeds · X

From https://t.co/4S8Lj1Qecd: How a Drug Candidate for Rare Diseases Could Be the Key to Living Longer Check out our latest paper: "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent." https://t.co/MZXUCEtR2Z

Mar 31, 2025 · 10 likes · 2 shares · 8,338 followers View post →
Agingdoc
@agingdoc1 · X

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

Mar 3, 2025 · 4 likes · 1 share · 41,753 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Researchers from @InSilicoMeds and two partner institutions published a study concluding that its lead candidate ISM001-055 could function as a senomorphic agent. #aging https://t.co/LLvhIUTkcV https://t.co/nFmz1RgNUO

Feb 23, 2025 · 4 likes · 2 shares · 700 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0MZS2X

Feb 23, 2025 · 3 likes · 1 share · 32,060 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

Link to the paper exploring rentosertib as a senomorphic agent: https://t.co/GgKp0N0pSv

Jun 3, 2025 · 3 likes · 1 share · 32,060 followers View post →

All mentions

Sukumar
@SophiaVirtanen_ · X

RT @TimePieChina: Researchers from @InSilicoMeds and two partner institutions published a study concluding that its lead candidate ISM001-0…

Aug 5, 2025 · 2 shares · 28 followers View post →
Patricia Marqués González
@Pmarques_G · X

RT @biogerontology: Link to the paper exploring rentosertib as a senomorphic agent: https://t.co/GgKp0N0pSv

Jun 24, 2025 · 1 share · 20 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

Link to the paper exploring rentosertib as a senomorphic agent: https://t.co/GgKp0N0pSv

Jun 3, 2025 · 3 likes · 1 share · 32,060 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0MZS2X

Apr 5, 2025 · 1 like · 32,060 followers View post →
Bioecomatics
@bioecomatic · X

RT @biogerontology: https://t.co/GgKp0MZS2X

Apr 4, 2025 · 3 shares · 106 followers View post →
Nacho
@nachirulo21 · X

RT @biogerontology: https://t.co/GgKp0MZS2X

Apr 3, 2025 · 3 shares · 408 followers View post →
John Greene
@Greene_Thoughts · X

RT @biogerontology: https://t.co/GgKp0MZS2X

Apr 3, 2025 · 3 shares · 1,700 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0MZS2X

Apr 3, 2025 · 1 like · 3 shares · 32,060 followers View post →
Fёdor Galkin
@Theo_Lotrus · X

RT @InSilicoMeds: From https://t.co/4S8Lj1Qecd: How a Drug Candidate for Rare Diseases Could Be the Key to Living Longer Check out our lat…

Apr 1, 2025 · 2 shares · 103 followers View post →
John Silver
@JohnGolf_CA · X

RT @InSilicoMeds: For more information, please visit: https://t.co/4Lsn4D3d2M

Mar 31, 2025 · 1 share · 34 followers View post →
John Silver
@JohnGolf_CA · X

RT @InSilicoMeds: From https://t.co/4S8Lj1Qecd: How a Drug Candidate for Rare Diseases Could Be the Key to Living Longer Check out our lat…

Mar 31, 2025 · 2 shares · 34 followers View post →
Insilico Medicine
@InSilicoMeds · X

For more information, please visit: https://t.co/4Lsn4D3d2M

Mar 31, 2025 · 1 like · 1 share · 8,338 followers View post →
Insilico Medicine
@InSilicoMeds · X

From https://t.co/4S8Lj1Qecd: How a Drug Candidate for Rare Diseases Could Be the Key to Living Longer Check out our latest paper: "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent." https://t.co/MZXUCEtR2Z

Mar 31, 2025 · 10 likes · 2 shares · 8,338 followers View post →
Somaya Althobaiti
@soma_al3tybe · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Mar 6, 2025 · 6 shares · 723 followers View post →
Sunrise
@carachili · X

RT @agingdoc1: AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

Mar 3, 2025 · 1 share · 248 followers View post →
Agingdoc
@agingdoc1 · X

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

Mar 3, 2025 · 4 likes · 1 share · 41,753 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @biogerontology: https://t.co/GgKp0MZS2X

Mar 1, 2025 · 1 share · 627 followers View post →
Insilico Medicine
@InSilicoMeds · X

RT @TimePieChina: Researchers from @InSilicoMeds and two partner institutions published a study concluding that its lead candidate ISM001-0…

Feb 24, 2025 · 2 shares · 8,338 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Researchers from @InSilicoMeds and two partner institutions published a study concluding that its lead candidate ISM001-055 could function as a senomorphic agent. #aging https://t.co/LLvhIUTkcV https://t.co/nFmz1RgNUO

Feb 23, 2025 · 4 likes · 2 shares · 700 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0MZS2X

Feb 23, 2025 · 3 likes · 1 share · 32,060 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0N0pSv

Feb 21, 2025 · 1 like · 1 share · 32,060 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Feb 21, 2025 · 6 shares · 244 followers View post →
Richard
@riz73176 · X

RT @biogerontology: https://t.co/GgKp0MZS2X

Feb 20, 2025 · 1 share · 55 followers View post →
Richard
@riz73176 · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Feb 20, 2025 · 6 shares · 55 followers View post →
Anthony M. Hopper
@elander777 · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Feb 20, 2025 · 6 shares · 4,356 followers View post →
Horváth Gergő
@TreepMax · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Feb 20, 2025 · 6 shares · 64 followers View post →
Nacho
@nachirulo21 · X

RT @biogerontology: Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic…

Feb 20, 2025 · 6 shares · 408 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/GgKp0MZS2X

Feb 20, 2025 · 3 likes · 1 share · 32,060 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

Big new paper alert – "AI-driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent". I’m excited to share a breakthrough that underscores the future of pharma innovation. By leveraging cutting-edge AI, advanced aging clocks, and our https://t.co/CN5VJec795

Feb 20, 2025 · 18 likes · 6 shares · 32,060 followers View post →