JAMA Surg April 2025 PMID 39969871

Early vs Delayed Bypass Surgery in Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial.

Derek Y F So, George A Wells, Marie Lordkipanidzé, Aun Yeong Chong, Marc Ruel, Louis P Perrault, Michel R Le May, Louise Sun, Diem Tran, Marino Labinaz, Christopher Glover, Juan Russo, Mélanie Welman, Vincent Chan, Lily Chen

Mentions

20
Peak: 6 in Apr 2025
across 4 sources since Feb 2025

Extended reach

211,128
potential audience

Total likes

38

Video views

110

Mentions per month

Feb 2025 – May 2025

Where it's discussed

  • X / Twitter14 posts
  • Facebook3 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The collective discussions demonstrate high engagement through references to the study's key findings, such as the noninferiority of early surgery, and utilize confident language like 'noninferior' and 'shorter hospital stays,' which showcases the relevance and potential impact on patient care. Questions about timing indicate ongoing curiosity and assessment of clinical practices surrounding the findings.

AgreementModerate agreement

Most discussions support the findings, emphasizing that early surgery is as safe as delayed procedures, reflecting general agreement with the study’s conclusions.

InterestHigh interest

Participants display high curiosity, as evidenced by questions like 'How soon is too soon for surgery?' and references to the study in prominent outlets, indicating strong interest in clinical implications.

EngagementModerate engagement

Posts reference specific details such as noninferiority and perioperative bleeding rates, showing a meaningful level of analysis and engagement with the research data.

ImpactModerate impact

The discussions highlight the potential influence on surgical timing decisions, with phrases like 'early surgery is noninferior' and mentions of shortened hospital stays, indicating a moderate but meaningful impact on clinical practice.

Abstract in brief

  • Perioperative bleeding is a significant risk for patients undergoing CABG surgery after receiving ticagrelor for acute coronary syndromes, prompting the need for this study.
  • The RAPID CABG trial aimed to determine if performing surgery 2 to 3 days after ticagrelor cessation is as safe as delaying the procedure for 5 to 7 days in terms of bleeding outcomes.
  • Results indicated that early surgery had comparable bleeding rates, with severe perioperative bleeding occurring in 4.6% of early patients vs. 5.2% in the delayed group, demonstrating noninferiority and resulting in shorter hospital stays for those who underwent early surgery.

Top posts

Most liked on X and Bluesky
JAMA Surgery
@JAMASurgery · X

Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS treated with ticagrelor. @DerekSoMD @HeartInstitute @ICMtl https://t.co/Hjp64uZKM1

Apr 15, 2025 · 11 likes · 1 share · 57,030 followers View post →
JAMA Surgery
@JAMASurgery · X

Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS treated with ticagrelor. https://t.co/ISVyrHfao0 @DerekSoMD @HeartInstitute @ICMtl https://t.co/pESzsQYnmG

Feb 20, 2025 · 8 likes · 4 shares · 57,030 followers View post →
Coronary 4Front
@Coronary4front · X

Early vs Delayed CABG Surgery for Acute Coronary Syndrome After Ticagrelor https://t.co/G8AtOi4wXa

Apr 10, 2025 · 8 likes · 3 shares · 1,774 followers View post →
Anesthesiology
@_Anesthesiology · X

Read a summary of "Early vs delayed bypass surgery in patients with acute coronary syndrome receiving ticagrelor: The RAPID CABG randomized open-label noninferiority trial," in the June 2025 Science, Medicine, and the Anesthesiologist: https://t.co/WMh7WcJg1z https://t.co/vJR51b4O5B

May 16, 2025 · 5 likes · 1 share · 38,146 followers View post →
Coronary 4Front
@Coronary4front · X

Early vs Delayed CABGin Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial JAMA Surgery | ⁦@JAMA_current⁩ https://t.co/yM6p4kXeC5

Feb 19, 2025 · 5 likes · 2 shares · 1,774 followers View post →
Chadi Alraies, MD FACC FSCAI
@chadialraies · X

How soon is too soon for surgery after starting ticagrelor?

May 31, 2025 · 34,256 followers View post →

All mentions

Chadi Alraies, MD FACC FSCAI
@chadialraies · X

How soon is too soon for surgery after starting ticagrelor?

May 31, 2025 · 34,256 followers View post →
Marcelo Ramalho
@marceloramalho · X

RT @_Anesthesiology: Read a summary of "Early vs delayed bypass surgery in patients with acute coronary syndrome receiving ticagrelor: The…

May 17, 2025 · 1 share · 352 followers View post →
Anesthesiology
@_Anesthesiology · X

Read a summary of "Early vs delayed bypass surgery in patients with acute coronary syndrome receiving ticagrelor: The RAPID CABG randomized open-label noninferiority trial," in the June 2025 Science, Medicine, and the Anesthesiologist: https://t.co/WMh7WcJg1z https://t.co/vJR51b4O5B

May 16, 2025 · 5 likes · 1 share · 38,146 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @JAMASurgery: Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS tre…

Apr 15, 2025 · 1 share · 11,289 followers View post →
JAMA Surgery
@JAMASurgery · X

Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS treated with ticagrelor. @DerekSoMD @HeartInstitute @ICMtl https://t.co/Hjp64uZKM1

Apr 15, 2025 · 11 likes · 1 share · 57,030 followers View post →
Fernando Biguria
@FernandoBiguria · X

RT @Coronary4front: Early vs Delayed CABG Surgery for Acute Coronary Syndrome After Ticagrelor https://t.co/G8AtOi4wXa

Apr 11, 2025 · 3 shares · 791 followers View post →
JorgeEdoChava75
@QicenoJorge · X

RT @Coronary4front: Early vs Delayed CABG Surgery for Acute Coronary Syndrome After Ticagrelor https://t.co/G8AtOi4wXa

Apr 10, 2025 · 3 shares · 997 followers View post →
Association of VA Surgeons (AVAS)
@VAsurgeons · X

RT @Coronary4front: Early vs Delayed CABG Surgery for Acute Coronary Syndrome After Ticagrelor https://t.co/G8AtOi4wXa

Apr 10, 2025 · 3 shares · 836 followers View post →
Coronary 4Front
@Coronary4front · X

Early vs Delayed CABG Surgery for Acute Coronary Syndrome After Ticagrelor https://t.co/G8AtOi4wXa

Apr 10, 2025 · 8 likes · 3 shares · 1,774 followers View post →
Stefano Urso
@StefanoUrsoMD · X

RT @Coronary4front: Early vs Delayed CABGin Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Labe…

Feb 20, 2025 · 2 shares · 263 followers View post →
José Miguel Torres Viera
@torresviera · X

RT @Coronary4front: Early vs Delayed CABGin Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Labe…

Feb 20, 2025 · 2 shares · 6,093 followers View post →
Medical Research Library of Brooklyn
@DMCLibraryBKLYN · X

RT @JAMASurgery: Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS tre…

Feb 20, 2025 · 4 shares · 328 followers View post →
JAMA Surgery
@JAMASurgery · X

Early bypass surgery at 2-3 days is noninferior to surgery at 5-7 days for perioperative bleeding in patients with ACS treated with ticagrelor. https://t.co/ISVyrHfao0 @DerekSoMD @HeartInstitute @ICMtl https://t.co/pESzsQYnmG

Feb 20, 2025 · 8 likes · 4 shares · 57,030 followers View post →
Coronary 4Front
@Coronary4front · X

Early vs Delayed CABGin Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial JAMA Surgery | ⁦@JAMA_current⁩ https://t.co/yM6p4kXeC5

Feb 19, 2025 · 5 likes · 2 shares · 1,774 followers View post →