This study is important because although effects were small, they were independent of depression and there was a dose effect. It showed increased risk of cognitive decline, death and fractures was associated with antidepressant use in people with dementia https://t.co/7fwpU6P9mC https://t.co/XfvNqRzb9d
Antidepressant use and cognitive decline in patients with dementia: a national cohort study.
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Feb 2025 – Nov 2025Where it's discussed
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News156 articles
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X / Twitter140 posts
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What people are saying
The group of social discussions demonstrates strong support and interest in the study's findings, as evidenced by phrases like 'raises questions about current practices' and 'faster cognitive decline linked to antidepressant use.' The tone is serious and investigative, with many posts referencing specific drugs (e.g., SSRIs, sertraline) and emphasizing the importance of personalized treatment, reflecting their deep engagement and recognition of the potential high impact on healthcare approaches.
Most discussions express support or acknowledgment of the study's findings that antidepressants may accelerate cognitive decline in dementia patients.
There is high interest, with many posts emphasizing the potential risks and prompting re-evaluations of current treatment practices.
Posts show deep engagement through references to specific research details, implications for medical care, and calls for cautious use of antidepressants.
The discussions highlight a significant impact on medical understanding and clinical practice, with implications for treatment guidelines and patient safety.
Abstract in brief
- The study investigates how antidepressant use affects cognitive decline, fractures, and mortality in patients with dementia, finding that certain antidepressants can worsen cognitive function.
- Involving 18,740 dementia patients, the research highlights that 22.8% used antidepressants, primarily SSRIs, with findings showing a significant and accelerated cognitive decline linked to these medications.
- The results indicate a stronger negative impact on cognitive function for specific drugs like sertraline and escitalopram, especially in patients with severe dementia, prompting concerns about the use of these antidepressants.
Top posts
Most liked on X and BlueskyL'étude : https://t.co/Tkwi0sHhnf
current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality #drugs #psychiatry #depression #dementia #brain #cognitive https://t.co/UycDWFbNiz
Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher doses associated with increased dementia, fractures, & death. Dose response curves are usually meaningful in such studies. https://t.co/kl0SG35JdM
_φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https://t.co/uijG1PVUBO https://t.co/y4RmEZgemi
All mentions
Does Antidepressant Use Accelerate Dementia Progression?
A recent study following nearly 19,000 dementia patients over four years found that antidepressants, especially SSRIs, may lead to faster cognitive decline, higher mortality, and increased fracture risk, raising…
Understanding SSRIs: Efficacy, Controversies, and Facts
In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman welcome neuroscientist Dr. Ben Rein to explore the complex world of selective serotonin reuptake inhibitors (SSRIs). The discussion examines their…
Impact of Antidepressants on Weight Change: A Comparative Study
This study compares weight changes among patients prescribed different first-line antidepressants over a 24-month period. Key findings reveal that certain medications led to significant weight gain, while others, like…
Insights on SSRIs: Effectiveness and Misconceptions Explored
In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman welcome neuroscientist Dr. Ben Rein to explore the complex world of selective serotonin reuptake inhibitors (SSRIs). They examine their effectiveness in…
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
@markeatsmeat It's worth studying if your'e interested in neurodegenerative diseases & the impact of SSRIs on brain problems. "However, older adults with depression receiving SSRIs/SNRIs were associated with an increased risk of dementia compared to psychotherapy" https://t.co/LTSUnWIgMQ
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/k0vKvKjFmw https://t.co/Dvjfien22e
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
RT @DrEvgenyLegedin: I hope that the UCL professor who uses depression
New Swedish research shows that the use of antidepressants in dementia is linked to faster cognitive decline. The results raise questions about current treatment practices. https://t.co/9M0I9RUXb4 @Demensforbundet
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
RT @KaaliPotti2: _φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https:/…
_φ(・_・ 一部の抗うつ薬「SSRI」は認知症患者の知能低下を加速させる可能性がある https://t.co/U0DDkUKqkb 抗うつ薬の使用と認知症患者の認知機能低下 https://t.co/Qvq9E7ks3U https://t.co/uijG1PVUBO https://t.co/y4RmEZgemi
@ray5ar @incredule_Ath @hopla_staub Aucune étude (qui ne soit pas réfutée) ne démontre une perte de QI à cause du Cannabis. Les SSRIs ne sont pas anodins non plus. https://t.co/C83THsV75B https://t.co/I2mfiiqTO9 https://t.co/N4gLoyc0mj https://t.co/o0o97MaB5c https://t.co/gKgy9sUZ2n
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
RT @silvano_trotta: L'étude : https://t.co/Tkwi0sHhnf
L'étude : https://t.co/Tkwi0sHhnf
Antidepressant use is associated with faster cognitive decline: “Antidepressant use and cognitive decline in patients with dementia: a national cohort study” — BMC Medicine (Full Text) https://t.co/yEu5zppxl0
RT @psiquicritic: El uso de antidepresivos en personas con demencia se asocia con un deterioro cognitivo más rápido, fracturas y mortalidad…
"a beneficial impact of SSRIs [anti-depressants] on neurogenesis and pathologic biomarkers, including amyloid burden and tau deposits, has been reported" https://t.co/0lLKLpvryD Medication for treating depression MAY possibly delay progress of dementia? Less Tau alleviates both?
@NeuroscienceNew Interesting…. https://t.co/JDSGfFeRuU
@drfreshwater @NeuroscienceNew https://t.co/g56ZhpiTtE https://t.co/nNlEO4gsKB
@NeuroscienceNew Don’t think that study is very reliable research considering the acknowledgements from the authors includes all the top pharmaceutical companies (see attached screenshot). A recent cohort study shows SSRI use was associated to faster cognitive decline
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associat…
current antidepressant use was associated with faster cognitive decline higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality #drugs #psychiatry #depression #dementia #brain #cognitive https://t.co/UycDWFbNiz
認知症患者さんでは、抗うつ薬使用者は、非使用者と比較して、追跡期間中の認知機能の低下速度が速く、SSRIの用量が多いほど認知機能低下が加速し、重度認知症、全死亡率、骨折のリスクを高めるそうです。 https://t.co/xK5pCyhRWb
RT @ChrisPalmerMD: @Christineschle7 This recent study found that they are "associated with" faster cognitive decline and all-cause mortalit…
Radās aizdomas, ka antidepresantu lietošana pazemina kognitīvās spējas (IQ) - un te nu ir nopietns longitudināls pētījums, kas to secina. Tas īpaši attiecas uz cilvēkiem, kuriem jau tā ir paaugstināts demences risks. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03851-3
Something that I have been suspecting - antidepressant use can decrease cognitive abilities and speed up cognitive decline, especially in persons with higher baseline risks. https://t.co/TfcBR3IVBB
RT @SaeedDoroudiani: current antidepressant use was associated with faster cognitive decline; furthermore, higher dispensed doses of SSRIs…
current antidepressant use was associated with faster cognitive decline; furthermore, higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality #psychiatry #drugs #dementia #SSRI #depression https://t.co/UycDWFbNiz
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
Title: Antidepressant use and cognitive decline in patients with dementia: a national cohort study DOI: https://t.co/NJmppqodLn --- Summary: This large national cohort study from Sweden investigated whether antidepressant use is associated with faster cognitive decline in https://t.co/qMJKVNQFjs https://t.co/tFyXTUeaz5
RT @StevePhillipsMD: Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher…
Recent study: SSRI's (antidepressants) associated with dementia. Even worse: A dose response curve was seen. Higher doses associated with increased dementia, fractures, & death. Dose response curves are usually meaningful in such studies. https://t.co/kl0SG35JdM
@Christineschle7 This recent study found that they are "associated with" faster cognitive decline and all-cause mortality. https://t.co/kncOOxr1sx
RT @joannamoncrieff: Study finds antidepressants associated with faster cognitive decline and increased risk of severe dementia, fractures…
Current antidepressant use associated with faster cognitive decline; furthermore, higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality. https://t.co/eW7F0KkIYJ
A study published in @BMCMedicine finds that use of antidepressants, particularly selective serotonin reuptake inhibitors (citalopram, sertraline and escitalopram) and mirtazapine, is associated with faster cognitive decline in patients with dementia. https://t.co/I5lbqz2C0V
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
Find the study about the link between the increase in cognitive decline and antidepressants https://t.co/iA19IGDjQB
RT @agingdoc1: Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/ZDARkPZiWs https:/…
RT @agingdoc1: Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/ZDARkPZiWs https:/…
Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/ZDARkPZiWs https://t.co/Is0eVt7bAR
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: Study finds antidepressants associated with faster cognitive decline and increased risk of severe dementia, fractures…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
RT @joannamoncrieff: This study is important because although effects were small, they were independent of depression and there was a dose…
This study is important because although effects were small, they were independent of depression and there was a dose effect. It showed increased risk of cognitive decline, death and fractures was associated with antidepressant use in people with dementia https://t.co/7fwpU6P9mC https://t.co/XfvNqRzb9d
https://t.co/gfuV0QwPf2
Antidepressant use and cognitive decline in patients with dementia: a national cohort study bmcmedicine.biomedcentral.com/articles/10....
RT @psiquicritic: El uso de antidepresivos en personas con demencia se asocia con un deterioro cognitivo más rápido, fracturas y mortalidad…
RT @kinoshitayakuhi: 抗鬱剤SSRIの服用で認知症に https://t.co/xpHE07rUNI 論文:認知症患者における抗うつ薬の使用と認知機能低下、全国コホート研究 執筆者:スウェーデンのカロリンスカ研究所 掲載誌:BMC medicine 公開日…
cohort study: Antidepressant use was associated with faster cognitive decline (β= −0.30; −0.39 to −0.21 points/year), in particular sertraline (−0.25), citalopram (−0.41), escitalopram (−0.76), and mirtazapine (−0.19) vs. non-use https://t.co/606g1GKu78 https://t.co/gZ00KP5hDl
RT @kinoshitayakuhi: 抗鬱剤SSRIの服用で認知症に https://t.co/xpHE07rUNI 論文:認知症患者における抗うつ薬の使用と認知機能低下、全国コホート研究 執筆者:スウェーデンのカロリンスカ研究所 掲載誌:BMC medicine 公開日…
RT @tsuyomiyakawa: アルツハイマー病患者1万8千人以上について調べ、抗うつ薬の使用が認知機能の低下に相関していること、処方量が多いほど認知症のリスクが高いことを示した大規模研究。歯状回の脱成熟が患者でも見られ、抗うつ薬投与で見られることを考えると合理的な結果。…
SSRIs & dementia acceleration (2 of 3) #dementia The study also revealed that higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality. (BMC Med 23, 82 (2025). https://t.co/KbP7p92com)
RT @JuanGrvas: ¿Demencia? ¡No tome guarrerías! (antidepresivos) Current antidepressant use associated with faster cognitive decline; furthe…
Antidepressant use and cognitive decline in patients with dementia: a national cohort study. Antidepressants accelerated cognitive decline, while others had a milder effect. These findings highlight the need for more personalized treatment strategies. https://t.co/QMM300C1MT
@SterlingCooley @X Meanwhile standard of care “antidepressants” may well contribute to cognitive decline: “Antidepressant use and cognitive decline in patients with dementia: a national cohort study” https://t.co/nNlEO4gsKB
One of our top rated articles according to @altmetric this past week was published OA in @BMCMedicine. You can read 'Antidepressant use and cognitive decline in patients with dementia: a national cohort study' here: https://t.co/SIkKPQwVkm
One of our top rated articles according to @altmetric.com this past week was published OA in @biomedcentral.bsky.social. You can read 'Antidepressant use and cognitive decline in patients with dementia: a national cohort study' here
RT @PharmacyOnline8:
RT @PharmacyOnline8:
RT @PharmacyOnline8:
RT @PharmacyOnline8:
RT @PharmacyOnline8:
Algunos antidepresivos de la familia del Prozac (ISRS) podrían acelerar el deterioro cognitivo n personas con demencia. Instituto Karolinska-Suecia Minjia Mo et al. “Antidepressant use and cognitive decline in patients with dementia: a national cohort study”. BMC Medicine (2025)
"In this cohort study, current antidepressant use was associated with faster cognitive decline ..." BUT, providers (GP, #Neurology doc et al.) usually say #antidepressant are safe & harmless #Healthcare #toxicity #dementia #MentalHealth #cognitive https://t.co/UycDWFbNiz
Mo, M., Abzhandadze, T., Hoang, M.T. et al. Antidepressant use and cognitive decline in patients with dementia: a national cohort study. BMC Med 23, 82 (2025). https://t.co/JmZS5EUmsv
Antidepressant use and cognitive decline in patients with dementia: a national cohort study bmcmedicine.biomedcentral.com/articles/10....
Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/H7e9T1OSZc
RT @GlobalPHObserv: Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/bGBf0rpLIk
RT @GlobalPHObserv: Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/bGBf0rpLIk
RT @GlobalPHObserv: Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/bGBf0rpLIk
‼️Antidepressant use and cognitive decline in patients with dementia: a national cohort study bmcmedicine.biomedcentral.com/articles/10....
Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/YNRwOZXsk8
Antidepressant use and cognitive decline in patients with dementia: a national cohort study https://t.co/bGBf0rpLIk
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