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Cell Stem Cell April 2025 PMID 40010350

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations.

Indranil Singh, Daniel Fernandez-Perez, Pedro Sanchez Sanchez, Alejo E Rodriguez-Fraticelli

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Mentions

126
Peak: 83 in Feb 2025
across 6 sources since May 2024

Extended reach

157,866
potential audience

Total likes

204

Video views

671

Mentions per month

May 2024 – Aug 2025

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AI synopsis

What people are saying

Discussions emphasize the importance of understanding stem cell heterogeneity in leukemia, with posts quoting the publication and sharing related methods and conference moments, indicating a high level of interest and perceived impact. Words like 'exciting,' 'new method,' and references to 'significant findings' highlight a positive tone and active engagement with the research's potential implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially recognizing its relevance to understanding leukemia development.

InterestHigh interest

The posts demonstrate high interest, with many sharing enthusiasm, recent citations, and highlighting the methods used.

EngagementModerate engagement

Posts include personal comments, mentions of conferences, and technical details, reflecting active engagement with the content.

ImpactModerate impact

The discussions suggest that the publication is seen as impactful, influencing future research methods and cancer understanding.

Abstract in brief

  • The study shows that the variability in stem cells before they turn into leukemia influences how they respond to cancer-driving mutations, with different stem cell types reacting uniquely.
  • The researchers developed a new method called STRACK to track and study how individual clones of stem cells change over time, especially when they acquire mutations like Dnmt3aR878H and Npm1c.
  • They found that certain stem cells that are already primed for differentiation tend to expand with these mutations, and Npm1c mutations can even shift these cells to more primitive, stem-like states, highlighting the importance of understanding cell history in cancer development.
Read the full abstract

Top posts

Most liked on X and Bluesky
Alejo Rodriguez-Fraticelli
@alejofraticelli.bsky.social · Bluesky

Feb 25, 2025 · 109 likes · 36 shares View post →
Cell Stem Cell
@CellStemCell · X

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.co/r1s6iSK0DM https://t.co/hAdsfsvxCD

Apr 3, 2025 · 55 likes · 9 shares · 58,414 followers View post →
Fraticelli lab
@FraticelliLab · X

Today at the EHA Research Conference in Malaga, Indra gave his last talk as a PhD student #EHAReCon25 #EHA @EHA_Hematology We hope you enjoyed it!!

Mar 18, 2025 · 23 likes · 1,670 followers View post →
IRB Barcelona
@irbbarcelona.org · Bluesky

Mar 4, 2025 · 5 likes · 3 shares View post →
RRID Robot
@rridrobot.bsky.social · Bluesky

RRID:Addgene_233208, was just reported to be used in "Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations". Thank you for making your methods matter! #methodsmatter #accelerateopenscience

Mar 27, 2025 · 1 like View post →
Cell Stem Cell
@cp-cellstemcell.bsky.social · Bluesky

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Apr 4, 2025 · 1 like View post →

All mentions

Anastasia
@discoverngenius · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 74 followers View post →
Stem Cells Research Unit
@ESCR_KFMRC · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 500 followers View post →
Karol Kaiser
@KarolKaiser1 · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 150 followers View post →
AnastasiaGrace
@Alihouston92 · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 111 followers View post →
nike
@wot_mikey · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 462 followers View post →
Jen
@jpadilla_DH · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 80 followers View post →
Shinnosuke Suzuki
@s_suzuki0224 · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 107 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 5, 2025 · 9 shares · 1,425 followers View post →
Peter
@BiotechPedro · X

RT @CellStemCell: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.…

Apr 4, 2025 · 9 shares · 754 followers View post →
Ciro Improta
@Ciro_Improta97 · X

RT @AlejoFraticelli:

Apr 4, 2025 · 73 shares · 61 followers View post →
Cell Stem Cell
@cp-cellstemcell.bsky.social · Bluesky

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Apr 4, 2025 · 1 like View post →
Cell Stem Cell
@CellStemCell · X

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.co/r1s6iSK0DM https://t.co/hAdsfsvxCD

Apr 3, 2025 · 55 likes · 9 shares · 58,414 followers View post →
Yao Yao
@Yao88951591 · X

RT @AlejoFraticelli:

Apr 1, 2025 · 73 shares · 18 followers View post →
RRID Robot
@rridrobot.bsky.social · Bluesky

RRID:Addgene_233208, was just reported to be used in "Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations". Thank you for making your methods matter! #methodsmatter #accelerateopenscience

Mar 27, 2025 · 1 like View post →
Miguel Ángel Sogorb
@MASogorb · X

Descubren cómo las mismas mutaciones dan lugar a leucemias muy diferentes https://t.co/De1Gnmo3L9 Más información: Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations https://t.co/CAnQkvhXpZ

Mar 22, 2025 · 158 followers View post →
Fraticelli lab
@FraticelliLab · X

Today at the EHA Research Conference in Malaga, Indra gave his last talk as a PhD student #EHAReCon25 #EHA @EHA_Hematology We hope you enjoyed it!!

Mar 18, 2025 · 23 likes · 1,670 followers View post →
Sonia Fernández Torices
@sonia_fdzt · X

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Mar 7, 2025 · 73 shares · 31 followers View post →
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@NikNikGiak · X

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Mahendra Singh, PhD
@mksin149 · X

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations - ScienceDirect https://t.co/cJpxZX0KeE

Feb 26, 2025 · 250 followers View post →
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@niseto · X

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@takashtoy · X

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@J_RodriguezVita · X

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Fraticelli lab
@FraticelliLab · X

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@DrWilliamHill · X

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Daichi Sadato
@DaichiSadato · X

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@PhD_Cream · X

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@VictoriaParreno · X

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David Lara-Astiaso
@Davidlarastiaso · X

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@Florian_SCaging · X

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@mayogisense · X

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@tito_tasks · X

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@fafian_juan · X

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@jpadilla_DH · X

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@MarkTransposon · X

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@mguarini1 · X

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@alejofraticelli.bsky.social · Bluesky

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bioRxiv Cancer Bio
@biorxiv-cancer.bsky.social · Bluesky

Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations https://www.biorxiv.org/content/10.1101/2024.05.14.594084v1

May 17, 2024 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations https://www.biorxiv.org/content/10.1101/2024.05.14.594084v1

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