Geroscience June 2025 PMID 40011348

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle.

Zachary D Von Ruff, Matthew J Miller, Tatiana Moro, Paul T Reidy, Scott M Ebert, Elena Volpi, Christopher M Adams, Blake B Rasmussen

Mentions

21
Peak: 11 in Feb 2025
across 3 sources since Feb 2025

Extended reach

126,843
potential audience

Total likes

127

Video views

3,234

Mentions per month

Feb 2025 – Jul 2025

Where it's discussed

  • X / Twitter19 posts
  • Bluesky1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Overall, the discussions emphasize the positive effects of resistance exercise on aging muscles, with specific mentions of reduced stress markers and improved muscle health, using words like 'reduces' and 'nice things' to convey both scientific and practical significance. The tone reflects support and interest in applying these findings for health improvements.

AgreementModerate agreement

Most discussions express support and alignment with the article's findings on resistance training benefits for older adults.

InterestHigh interest

Participants show high curiosity, highlighting phrases like 'nice things' and emphasizing the importance of muscle health.

EngagementModerate engagement

Comments include references to molecular mechanisms, health outcomes, and research implications, indicating moderate to deep involvement.

ImpactModerate impact

The discussions acknowledge potential health benefits such as reduced frailty and improved muscle function, showing recognition of the study’s significance.

Abstract in brief

  • Resistance exercise training in older men reduces the levels of ATF4-activated and senescence-associated mRNAs in skeletal muscle, indicating a potential anti-aging effect at the molecular level.
  • The study found that the gene expression response to resistance training varies between young and older men, with older adults showing a larger number of differentially expressed genes.
  • Key findings include that resistance exercise increases mitochondrial-related mRNAs and muscle strength-related mRNAs, suggesting improvements in muscle function and health through targeted gene expression changes.]

Top posts

Most liked on X and Bluesky
Craig A. Goodman
@CraigAGoodman1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/1oPZuwHddq

Feb 27, 2025 · 33 likes · 7 shares · 3,903 followers View post →
Rasmussen Lab
@TheRasmussenLab · X

New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men including reducing markers of stress, inflammation and cellular senescence. https://t.co/LRlUOrjfjA

Feb 27, 2025 · 33 likes · 4 shares · 427 followers View post →
Agingdoc
@agingdoc1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/vHiGJa5xrh https://t.co/WDyZP1uo42

Jul 2, 2025 · 14 likes · 2 shares · 41,394 followers View post →
Agingdoc
@agingdoc1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/vHiGJa4ZBJ

Mar 5, 2025 · 14 likes · 41,394 followers View post →
GeroScience
@GeroScienceAGE · X

Mar 4, 2025 · 4 likes · 1 share · 3,634 followers View post →
Craig A. Goodman
@craigagoodman1.bsky.social · Bluesky

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle link.springer.com/article/10.1...

Feb 27, 2025 · 4 likes · 1 share View post →

All mentions

System
@liyongcsco12 · X

RT @agingdoc1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https:/…

Jul 3, 2025 · 2 shares · 63 followers View post →
DeScAI agent
@longevity_agent · X

RT @agingdoc1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https:/…

Jul 2, 2025 · 2 shares · 698 followers View post →
Agingdoc
@agingdoc1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/vHiGJa5xrh https://t.co/WDyZP1uo42

Jul 2, 2025 · 14 likes · 2 shares · 41,394 followers View post →
Allison Martinez
@allison19xxx · X

RT @TheRasmussenLab: New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men includi…

May 5, 2025 · 4 shares · 684 followers View post →
Agingdoc
@agingdoc1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/vHiGJa4ZBJ

Mar 5, 2025 · 14 likes · 41,394 followers View post →
Springer Medicine
@ClinMedJournals · X

RT @GeroScienceAGE:

Mar 5, 2025 · 1 share · 9,085 followers View post →
GeroScience
@GeroScienceAGE · X

Mar 4, 2025 · 4 likes · 1 share · 3,634 followers View post →
Ryotaro Kano 狩野遼太郎
@4H_622 · X

Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves muscle size and function; however, the… Source: SpringerLink Shared via the Google app https://t.co/2f5xEgeFls

Mar 4, 2025 · 1 like · 522 followers View post →
Annie Kalenta
@kalentos · X

RT @TheRasmussenLab: New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men includi…

Mar 2, 2025 · 4 shares · 234 followers View post →
javierbutra
@javierbutra · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 28, 2025 · 7 shares · 14,338 followers View post →
Shima Taherkhani
@ShimaTaherkhani · X

RT @TheRasmussenLab: New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men includi…

Feb 28, 2025 · 4 shares · 353 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 27, 2025 · 7 shares · 403 followers View post →
Joe Gordon
@josephwgordon · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 27, 2025 · 7 shares · 2,107 followers View post →
tsutaki.a
@ATsutaki2011 · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 27, 2025 · 7 shares · 8 followers View post →
Victoria C. Sanfrancesco
@VCSanfran · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 27, 2025 · 7 shares · 266 followers View post →
Sam & Ann Barshop Institute
@UTHealthBarshop · X

RT @TheRasmussenLab: New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men includi…

Feb 27, 2025 · 4 shares · 178 followers View post →
David Morales-Álamo
@D_Morales_Alamo · X

RT @CraigAGoodman1: Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle htt…

Feb 27, 2025 · 7 shares · 3,762 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle https://t.co/1oPZuwHddq

Feb 27, 2025 · 33 likes · 7 shares · 3,903 followers View post →
Craig A. Goodman
@craigagoodman1.bsky.social · Bluesky

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle link.springer.com/article/10.1...

Feb 27, 2025 · 4 likes · 1 share View post →
Rasmussen Lab
@TheRasmussenLab · X

New publication from the lab in GeroScience. Resistance exercise does some nice things to muscle in older men including reducing markers of stress, inflammation and cellular senescence. https://t.co/LRlUOrjfjA

Feb 27, 2025 · 33 likes · 4 shares · 427 followers View post →