PubHawk
Nat Biomed Eng August 2025 PMID 40011582

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades.

Ameya R Kirtane, Jianling Bi, Netra U Rajesh, Chaoyang Tang, Miguel Jimenez, Emily Witt, Megan K McGovern, Arielle B Cafi, Samual J Hatfield, Lauren Rosenstock, Sarah L Becker, Nicole Machado, Veena Venkatachalam, Dylan Freitas, Xisha Huang

Full text PDF Download social card

Mentions

109
Peak: 22 in Mar 2025
across 5 sources since Feb 2025

Extended reach

230,306
potential audience

Total likes

223

Video views

81

Mentions per month

Feb 2025 – Mar 2025

Where it's discussed

  • News63 articles
  • X / Twitter32 posts
  • Blogs6 articles
  • YouTube5 videos
  • Bluesky3 posts

AI synopsis

What people are saying

The discussions reflect a mix of curiosity and cautious optimism, with posts emphasizing the innovative approach of protecting healthy tissues during radiation therapy, such as mentions of 'mRNA that produces the tardigrade protein Dsup' for radiation protection, and questions like 'Are tardigrades what turns humans into greys?', which reveal both fascination and skepticism that drive ongoing engagement.

AgreementModerate agreement

Most discussions show support or curiosity about the research; some question its implications or potential misuse.

InterestModerate interest

Posts generally express moderate curiosity, especially regarding the innovative use of tardigrade proteins and nanotechnology.

EngagementModerate engagement

Discussions include references to the methodology and potential applications, indicating active consideration.

ImpactModerate impact

Comments suggest recognition of the significance in medicine and technology, though some dismiss it as preliminary.

Abstract in brief

  • Patients undergoing radiation therapy often suffer severe side effects due to DNA damage in normal cells surrounding tumors.
  • Inspired by tardigrades, which can withstand extreme radiation thanks to a specific damage-suppressor protein, researchers found that temporarily expressing this protein can protect oral and rectal tissues during radiation treatment.
  • Using advanced delivery methods like lipid nanoparticles, they successfully delivered messenger RNA for the protein in mice, preserving healthy tissue function while maintaining the effectiveness of the radiation therapy.
Read the full abstract

Top posts

Most liked on X and Bluesky
vittorio
@IterIntellectus · X

https://t.co/zeQf8LkPp6

Mar 5, 2025 · 153 likes · 13 shares · 119,391 followers View post →
Saber Atualizado
@AtualizadoSaber · X

(1) Publicação do estudo: Kirtane et al. (2025). Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nature Biomedical Engineering. https://t.co/pHVvQP4mOl

Mar 1, 2025 · 18 likes · 30,089 followers View post →
_MCRicardo_
@_MCRicardo_ · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades mRNA that produces the tardigrade protein Dsup, when injected into cells, protects them from radiation during cancer treatments https://t.co/zewGPBPRrU https://t.co/dkuJ89xptn

Feb 26, 2025 · 14 likes · 9 shares · 1,964 followers View post →
ShorterLab
@ShorterLab · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades: https://t.co/zYVHJ6sGRp

Feb 27, 2025 · 10 likes · 12,021 followers View post →
Brian D. Wade
@astrobrian.bsky.social · Bluesky

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in #tardigrades www.nature.com/articles/s41...

Feb 27, 2025 · 8 likes · 2 shares View post →
Saber Atualizado
@saberatualizado.bsky.social · Bluesky

(1) Publicação do estudo: Kirtane et al. (2025). Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nature Biomedical Engineering. doi.org/10.1038/s415...

Mar 1, 2025 · 7 likes · 1 share View post →

All mentions

Seiichi Mori
@seiichi_mori · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades https://t.co/lVjAHQ2fMY

Mar 16, 2025 · 313 followers View post →
Eric Minwei Liu
@EricM_Liu · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Mar 8, 2025 · 9 shares · 933 followers View post →
Ralph Cerchione
@Dry_Observer · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 6, 2025 · 13 shares · 9,087 followers View post →
Mindful_Warrior
@MaryAnn_Warrior · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades #nanotechnology Are Tardigrades what turns humans into greys ?!

Mar 6, 2025 · 4,456 followers View post →
*insert name here*
@itsCO_LEAK · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 6, 2025 · 13 shares · 3,444 followers View post →
MasterThief, Diogenes of the Hellsite
@MasterThiefEsq · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 6, 2025 · 13 shares · 588 followers View post →
Anirudh
@anirudhmurali88 · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 197 followers View post →
Daniel Cobbett ₿TC
@DannyCobbett · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 139 followers View post →
Richard de los Santos
@ZeusRadls · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 4,977 followers View post →
CUI LUN
@omnicui · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 448 followers View post →
Liam Debono
@leeloumt · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 100 followers View post →
Simon Manning
@_Simon_K · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 1,767 followers View post →
Scorpiotiger77
@scorpiotiger77 · X

RT @IterIntellectus: https://t.co/zeQf8LkPp6

Mar 5, 2025 · 13 shares · 2,421 followers View post →
vittorio
@IterIntellectus · X

https://t.co/zeQf8LkPp6

Mar 5, 2025 · 153 likes · 13 shares · 119,391 followers View post →
ぜのぱす（初代_凍結から快復）
@Xenopus007 · X

【memo】 Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades | Nature Biomedical Engineering https://t.co/oRrwfe3vaN

Mar 2, 2025 · 853 followers View post →
Saber Atualizado
@saberatualizado.bsky.social · Bluesky

(1) Publicação do estudo: Kirtane et al. (2025). Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nature Biomedical Engineering. doi.org/10.1038/s415...

Mar 1, 2025 · 7 likes · 1 share View post →
Saber Atualizado
@AtualizadoSaber · X

(1) Publicação do estudo: Kirtane et al. (2025). Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nature Biomedical Engineering. https://t.co/pHVvQP4mOl

Mar 1, 2025 · 18 likes · 30,089 followers View post →
Layla Haddad
@LaylaGenes · X

RT @LabWaggoner: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 28, 2025 · 1 share · 6 followers View post →
Waggoner Lab
@LabWaggoner · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades @natBME @cgtraverso https://t.co/p1h9Qo5Qab

Feb 28, 2025 · 4 likes · 1 share · 11,266 followers View post →
Waggoner Lab
@labwaggoner.bsky.social · Bluesky

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades www.nature.com/articles/s41...

Feb 28, 2025 · 3 likes · 1 share View post →
Brian D. Wade
@astrobrian.bsky.social · Bluesky

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in #tardigrades www.nature.com/articles/s41...

Feb 27, 2025 · 8 likes · 2 shares View post →
ShorterLab
@ShorterLab · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades: https://t.co/zYVHJ6sGRp

Feb 27, 2025 · 10 likes · 12,021 followers View post →
Diana
@PharmphoodTM · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 27, 2025 · 9 shares · 557 followers View post →
マイナー次郎☄️
@mj_IRIAM · X

RT @ma31stm: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrade…

Feb 27, 2025 · 1 share · 1,713 followers View post →
まつこ
@ma31stm · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. https://t.co/KcPuG3HfDI https://t.co/6uytjFlThF

Feb 27, 2025 · 2 likes · 1 share · 2,236 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 27, 2025 · 9 shares · 11,292 followers View post →
サイエンスあれこれ
@sarekore · X

重要なことです。今後は、クマムシのタンパク質が引き起こす可能性のある免疫反応を引き起こさないように改変されたDsupタンパク質の開発に取り組む予定です。https://t.co/931R7FI0Tb

Feb 27, 2025 · 922 followers View post →
blut des schweigens
@BlutDes · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 330 followers View post →
Dr. Joy Odimegwu
@Nwauka · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 1,319 followers View post →
Lisa Vlad
@LisaVlad2 · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 101 followers View post →
Gentle Mutt
@GentleMutt · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 783 followers View post →
Sagittarius
@guani_vic · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 673 followers View post →
fausto heredia z.
@drfherediaz · X

RT @_MCRicardo_: Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardig…

Feb 26, 2025 · 9 shares · 4,349 followers View post →
Daniel Grimaldes MD
@DrGrimaldesJ · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades Thank you @_MCRicardo_ https://t.co/AC5OOdsyAb

Feb 26, 2025 · 1 like · 1,009 followers View post →
_MCRicardo_
@_MCRicardo_ · X

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades mRNA that produces the tardigrade protein Dsup, when injected into cells, protects them from radiation during cancer treatments https://t.co/zewGPBPRrU https://t.co/dkuJ89xptn

Feb 26, 2025 · 14 likes · 9 shares · 1,964 followers View post →