J Am Geriatr Soc May 2025 PMID 40040336

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk.

Ilse Vom Hofe, Bruno H Stricker, M Kamran Ikram, Frank J Wolters, M Arfan Ikram

Mentions

147
Peak: 36 in Mar 2025
across 5 sources since Mar 2025

Extended reach

484,174
potential audience

Total likes

82

Video views

92

Mentions per month

Mar 2025 – Aug 2025

Where it's discussed

  • News95 articles
  • X / Twitter40 posts
  • Blogs8 articles
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The overall tone reflects both curiosity and cautious optimism, with posts mentioning the study’s findings that long-term NSAID use might reduce dementia risk. Phrases like 'potential for prevention' and references to historical studies such as the Cache County study reveal an interest in the broader implications. The tone varies from factual reporting—'long-term use may be associated with a 12% reduction'—to speculative enthusiasm, highlighting the significance attributed to the research, but also acknowledging the need for further exploration.

AgreementModerate agreement

Most discussions acknowledge the potential link between long-term NSAID use and reduced dementia risk, with many referencing the study’s findings and supporting the idea that prolonged use might be beneficial.

InterestHigh interest

The posts demonstrate high curiosity around the research, highlighting historical studies, potential mechanisms, and implications for dementia prevention, indicating strong relevance and engagement.

EngagementModerate engagement

Several posts delve into specific details such as the distinction between duration and dosage of NSAID use, and implications for future research, showing a moderate but thoughtful level of involvement.

ImpactModerate impact

The discussions suggest that the publication could influence future studies and clinical considerations, though the tone remains cautious, indicating perceived but not definitive high impact.

Abstract in brief

  • Long-term use of NSAIDs (more than 24 months) is linked to a reduced risk of developing dementia, while short-term or intermediate use may slightly increase the risk.
  • The study didn't find a clear relationship between the total dose of NSAIDs taken and dementia risk, suggesting duration may be more important than amount.
  • NSAIDs that do not lower amyloid levels showed a somewhat stronger association with reduced dementia risk compared to those that do lower amyloid, indicating different effects depending on the medication type.

Top posts

Most liked on X and Bluesky
Ian Kremer
@LEAD_Coalition · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu #Alzheimers #inflammation #health https://t.co/lBtdVRjGGd

Mar 11, 2025 · 20 likes · 10 shares · 65,790 followers View post →
İlaç Uzm.Ecz.Leyla Aygün
@leylaaygn91 · X

Mar 15, 2025 · 19 likes · 7,409 followers View post →
Hans Collin
@HansCollin2 · X

Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarrollar demencia en un 20%. En éste estudio (n=14.926) con seguimiento por 14.5 años, curiosamente encontraron que los AINEs que *NO*

Mar 19, 2025 · 15 likes · 5 shares · 2,058 followers View post →
Erik Musiek
@ErikMusiek · X

This harkens back to the Cache County study and the interest in the early 2000s around NSAIDs. Would love to see this stimulate new research on COX-2 and PGs in AD, particularly with modern insights into microglia function. https://t.co/3fm4VjPO4b

Mar 11, 2025 · 7 likes · 2 shares · 2,525 followers View post →
JAGS
@AGSJournal · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. #geriatrics https://t.co/moWNmxGX1T https://t.co/mpnxe9wADe

Mar 17, 2025 · 5 likes · 3 shares · 11,214 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk - vom Hofe - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/iO78SbALVK

Mar 6, 2025 · 4 likes · 2 shares · 78,983 followers View post →

All mentions

NSAIDs May Reduce Dementia Risk with Long-Term Use

Long-term use of NSAIDs (more than 24 months) is linked to a reduced risk of developing dementia, according to recent research. The study suggests duration may be more important than dosage, highlighting potential…

Heliox · Mar 27, 2025 18 views
Elea Rom
@Lbnromro · X

Más información Stricker, B. H., Ikram, M. K., Wolters, F. J., & Ikram, M. A. (2025) Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. Journal of the American Geriatrics Society. https://t.co/QpG4w6VKQQ

Aug 13, 2025 · 4 followers View post →
Elea Rom
@Lbnromro · X

¿Pueden los AINEs prevenir la demencia? Descubre la ciencia detrás

Aug 13, 2025 · 4 followers View post →
Isao Uno(宇野勲)/リハ栄養指導士/栄養嚥下理学療法
@isao_reha_nutri · X

認知症がない地域在住高齢者では、NSAIDsを長期(>24ヵ月)使用していると認知症リスクが低下し、短期(<1ヵ月)または中期(1~24ヵ月)では認知症リスクがわずかに増加したそうです。 https://t.co/3veBNhOkhQ

Jun 2, 2025 · 1,843 followers View post →
Art Walaszek, MD
@walaszek.medsky.social · Bluesky

1- In observational studies, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with ⬇️risk of #dementia. But randomized controlled trials of NSAIDs have not found them to reduce dementia risk or progression. Findings from a new observational study add some nuance ...

May 24, 2025 · 4 likes · 1 share View post →
キムリン@FL_PPMM(BA.1)P(XBB.1.5)
@lapin214_gn · X

非ステロイド性抗炎症薬の長期投与と認知症リスクの関連 https://t.co/G9MIydJfzh

May 8, 2025 · 738 followers View post →
青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中!
@syuichiao89 · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk https://t.co/xWnNPf0w9Z

May 3, 2025 · 8,608 followers View post →
白土大成┃第12回日本サルコペニア・フレイル学会大会 副実行委員長
@shiratsuchi_ger · X

JAGS NSAIDsと認知症 Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk https://t.co/zBbx8SZTn1

May 2, 2025 · 2 likes · 822 followers View post →
にいやん
@niiyan51 · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk https://t.co/NTzY0DH1oX

Mar 26, 2025 · 1,075 followers View post →
Johns Hopkins Memory & Aging
@JH_Memory_Aging · X

RT @AGSJournal: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. #geriatrics https://t.co/moW…

Mar 20, 2025 · 3 shares · 2,902 followers View post →
Patricio Rojas Silva
@patorojassilva · X

RT @HansCollin2: Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarro…

Mar 19, 2025 · 5 shares · 1,460 followers View post →
Verónica Athié BSc, MSc, PhD.
@VeronicaAthie · X

RT @HansCollin2: Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarro…

Mar 19, 2025 · 5 shares · 4,765 followers View post →
guadalupe
@guadalu31632151 · X

RT @HansCollin2: Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarro…

Mar 19, 2025 · 5 shares · 801 followers View post →
Eder Andrés
@ederandres152 · X

RT @HansCollin2: Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarro…

Mar 19, 2025 · 5 shares · 909 followers View post →
San
@scalde50 · X

RT @HansCollin2: Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarro…

Mar 19, 2025 · 5 shares · 334 followers View post →
StonyBrookGeriatrics
@stonybrookgeri · X

RT @AGSJournal: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. #geriatrics https://t.co/moW…

Mar 19, 2025 · 3 shares · 87 followers View post →
Hans Collin
@HansCollin2 · X

Tomar ciertos antiinflamatorios no esteroideos (AINEs) por mucho tiempo (más de 2 años) puede reducir el riesgo de desarrollar demencia en un 20%. En éste estudio (n=14.926) con seguimiento por 14.5 años, curiosamente encontraron que los AINEs que *NO*

Mar 19, 2025 · 15 likes · 5 shares · 2,058 followers View post →
Orlando_uy
@Orlando_uy · X

Long-term NSAID use, but not cumulative dose, was associated with decreased dementia risk. This suggests that prolonged rather than intensive exposure to anti-inflammatory medication may hold potential for dementia prevention. https://t.co/On43zR9SLg

Mar 19, 2025 · 693 followers View post →
Ian Smith
@IjsSmith · X

RT @AGSJournal: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. #geriatrics https://t.co/moW…

Mar 17, 2025 · 3 shares · 726 followers View post →
JAGS
@AGSJournal · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk. #geriatrics https://t.co/moWNmxGX1T https://t.co/mpnxe9wADe

Mar 17, 2025 · 5 likes · 3 shares · 11,214 followers View post →
İlaç Uzm.Ecz.Leyla Aygün
@leylaaygn91 · X

Mar 15, 2025 · 19 likes · 7,409 followers View post →
Annie Curtis - Clock Lab RCSI
@curtisclocklab · X

RT @ErikMusiek: This harkens back to the Cache County study and the interest in the early 2000s around NSAIDs. Would love to see this stimu…

Mar 13, 2025 · 2 shares · 1,772 followers View post →
Divinity Seven♻️
@SevenDivinity · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 12, 2025 · 10 shares · 1,511 followers View post →
Debbie Hampton
@dlhampton · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 12, 2025 · 10 shares · 11,730 followers View post →
Johns Hopkins Memory & Aging
@JH_Memory_Aging · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 12, 2025 · 10 shares · 2,902 followers View post →
Jillian Peeling
@Jilliemary · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 12, 2025 · 10 shares · 203,732 followers View post →
Janis Cottee
@janis_cottee · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 12, 2025 · 10 shares · 3,560 followers View post →
Miles Berger
@RealMilesBerger · X

RT @ErikMusiek: This harkens back to the Cache County study and the interest in the early 2000s around NSAIDs. Would love to see this stimu…

Mar 11, 2025 · 2 shares · 2,525 followers View post →
Erik Musiek
@ErikMusiek · X

This harkens back to the Cache County study and the interest in the early 2000s around NSAIDs. Would love to see this stimulate new research on COX-2 and PGs in AD, particularly with modern insights into microglia function. https://t.co/3fm4VjPO4b

Mar 11, 2025 · 7 likes · 2 shares · 2,525 followers View post →
Anima Gitane
@oceanerazzurro · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 11, 2025 · 10 shares · 5,735 followers View post →
Jeff - Palmer Report Reader
@jmilam44 · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 11, 2025 · 10 shares · 12,473 followers View post →
Lre
@detous · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 11, 2025 · 10 shares · 2,210 followers View post →
ramona quazzola
@r_quazzy · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 11, 2025 · 10 shares · 2,257 followers View post →
angeleyez407
@angeleyez407 · X

RT @LEAD_Coalition: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu…

Mar 11, 2025 · 10 shares · 20,438 followers View post →
Ian Kremer
@LEAD_Coalition · X

Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to #Dementia Risk https://t.co/tnioy2aiAu #Alzheimers #inflammation #health https://t.co/lBtdVRjGGd

Mar 11, 2025 · 20 likes · 10 shares · 65,790 followers View post →
Dr. Tannahill Glen
@tannahillglen · X

RT @DrLenaDobson: This study found that long-term use of OTC pain medications (e.g., aspirin, ibuprofen) may be associated with a 12% reduc…

Mar 11, 2025 · 1 share · 1,527 followers View post →
Dr. Lena Dobson
@DrLenaDobson · X

This study found that long-term use of OTC pain medications (e.g., aspirin, ibuprofen) may be associated with a 12% reduction in #dementia risk. It found that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) was linked to a decreased risk. https://t.co/2OO5K7xBqS

Mar 11, 2025 · 4 likes · 1 share · 5,746 followers View post →
Kenneth A. Vatz
@KenV54 · X

Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk - ⁦@ProfRobHoward⁩ https://t.co/XqmLFFLTBO

Mar 6, 2025 · 857 followers View post →
CMIN
@IcahnCMIN · X

A new large prospective study by @IlsevomH, Arfan Ikram, et al. @ErasmusMC provides additional evidence that long-term NSAID use is linked to decreased risk of developing #Dementia. @AmerGeriatrics

Mar 6, 2025 · 852 followers View post →
16kthir0GRXgNqn
@16kthir0GRXgNqn · X

RT @ichiipsy: Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk - vom Hofe - Journal of the Ame…

Mar 6, 2025 · 2 shares · 1,063 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk - vom Hofe - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/iO78SbALVK

Mar 6, 2025 · 4 likes · 2 shares · 78,983 followers View post →
Professor Erwin Loh
@erwinloh · X

People who use anti-inflammatory drugs over a long period of time may be at a lower risk of dementia regardless of the dosage, according to international research. https://t.co/5xskJRZphz https://t.co/1wx3KFF0Q6

Mar 5, 2025 · 9,113 followers View post →