Cancer Prev Res (Phila) June 2025 PMID 40041932

Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer.

Jian-Min Yuan, Thomas W Kensler, Sanja Dacic, Douglas J Hartman, Renwei Wang, Paula A Balogh, Pamela Sufka, Melissa A Turner, Kimberly Fuhrer, Lindsey Seigh, Yen Thi-Hai Pham, Jennifer Adams-Haduch, Giuseppe Valacchi, Shivendra V Singh, James G Herman

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Mentions

Peak: 2 in Jun 2025

across 5 sources since Mar 2025

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741,271

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Mar 2025 – Oct 2025

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AI synopsis

What people are saying

Discussion emphasizes the importance of therapeutic prevention strategies and the promise shown by sulforaphane, with phrases like 'very exciting work' and questions about endpoints reflecting both interest and engagement. The tone balances cautious optimism with recognition of the trial's potential impact, illustrating the community's curiosity and belief in the research's future influence.

AgreementModerate agreement

Most discussions express support or recognition of the study's importance, though some show cautious optimism or curiosity.

InterestHigh interest

High interest is evident through enthusiasm and questions about endpoints and implications.

EngagementModerate engagement

Posts often mention specific aspects of the trial, like endpoints and preventive strategies, indicating moderate engagement.

ImpactModerate impact

Users recognize potential significance in advancing prevention strategies, even if it's early-stage research.

Abstract in brief

Dietary isothiocyanates, particularly sulforaphane, have shown promise in reducing potential cancer markers in animal studies, but human data was limited.
A clinical trial with 43 former smokers tested the effects of sulforaphane for 12 months, where those taking it experienced a 20% reduction in the Ki-67 index, suggesting lower cellular proliferation, compared to a 65% increase in the placebo group.
Although sulforaphane did not significantly affect other apoptotic markers, its ability to lower Ki-67 supports further research into its role as a potential preventative treatment for lung cancer.

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@MindOfIntra · X

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Cancer Prevention Research

@CAPR_AACR · X

ICYMI: Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer https://t.co/cAQ0FoMQ8C https://t.co/pJEXxNb7Ry

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Cancer Prevention Research

@CAPR_AACR · X

Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer: https://t.co/KsVBKJFqoZ https://t.co/xxL97InlY5

Jun 6, 2025 · 1,443 followers View post →

Northfield Acupuncture Clinic

@northfieldclin1 · X

Randomized phase II clinical trial of sulforaphane in former smokers at high risk for lung cancer https://t.co/GTBON0Yfu9

Apr 9, 2025 · 277 followers View post →

Adam Pennycuick

@adampennycuick · X

Mar 6, 2025 · 299 followers View post →