March 2025 PMID 40050437

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men.

Trine S Nicolaisen, Aslak E Lyster, Kim A Sjøberg, Daniel T Haas, Christian T Voldstedlund, Anne-Marie Lundsgaard, Jakob K Jensen, Ea M Madsen, Casper K Nielsen, Mads Bloch-Ibenfeldt, Nicolai J Wewer Albrechtsen, Adam J Rose, Natalie Krahmer, Christoffer Clemmensen, Erik A Richter

Mentions

31
Peak: 18 in Mar 2025
across 5 sources since Mar 2025

Extended reach

263,576
potential audience

Total likes

7,737

Video views

211,835

Mentions per month

Mar 2025 – Sep 2025

Where it's discussed

  • X / Twitter22 posts
  • YouTube4 videos
  • Reddit2 posts
  • News2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The overall tone exhibits high agreement and interest, with posts emphasizing the study's contribution to understanding FGF21's role in metabolism and weight management, using words like 'important', 'significant', and 'adds nuance', reflecting deep engagement and recognition of its potential impact.

AgreementStrong agreement

Most discussions express strong support or validation for the findings, emphasizing their significance.

InterestHigh interest

The discussions demonstrate high enthusiasm and curiosity, showing keen engagement with the study's implications.

EngagementModerate engagement

Participants actively reference specific mechanisms and broader scientific contexts, indicating thoughtful participation.

ImpactHigh impact

The discussions highlight the importance of the research in advancing understanding of metabolism and weight regulation.

Abstract in brief

  • Dietary protein restriction in lean men leads to an increase in energy requirements to maintain body weight, regardless of whether proteins are replaced with fats or carbs.
  • Fasting plasma FGF21 levels go up during protein restriction, and this hormone seems to influence mitochondrial changes in fat tissue, especially in male mice.
  • When men return to a higher protein diet, their energy requirements normalize, indicating that FGF21-driven mitochondrial changes help adapt to lower protein intake without causing weight loss.]

Top posts

Most liked on X and Bluesky
Nathan Owens
@NathanEqualsOne · X

Brand new honey diet adjacent study: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men “energy intake had to be gradually increased to maintain body weight, resulting in a 20% higher energy intake at the end of week 5”

Mar 9, 2025 · 31 likes · 1 share · 2,115 followers View post →
David Morales-Álamo
@D_Morales_Alamo · X

New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements needed to maintain body weight in lean men. Important implications for understanding metabolism & weight management! #Nutrition #Metabolism https://t.co/GXmSC7zi7S

Mar 15, 2025 · 19 likes · 4 shares · 3,768 followers View post →
Andreas Mæchel Fritzen
@AndreasMFritzen · X

Happy to be part of this in @NatMetabolism: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in men. It adds nuances to the discussion on dietary protein for body weight regulation and to FGF21 biology. https://t.co/PyUkHYHzDr

Mar 10, 2025 · 18 likes · 2 shares · 569 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.co/tEP0duXaYe

Mar 11, 2025 · 14 likes · 2 shares · 1,478 followers View post →
Israel Podesta, PhD
@IsraelPodesta · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. "unchanged fat and LBM and body water content with eucaloric protein restriction do not suggest repartitioning of muscle to FM" @NatMetabolism https://t.co/YBgDwPKpB1

Mar 7, 2025 · 5 likes · 1 share · 380 followers View post →
William Lagakos
@caloriesproper2 · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.co/02rj9cSwxg FGF21 vs Protein Leverage Hypothesis https://t.co/kg8nJNIkPm

Aug 5, 2025 · 1 like · 2,698 followers View post →

All mentions

山下安音
@SelfRetreat12 · X

もっと強力な長寿ホルモン FGF21 線維芽細胞活性因子 https://t.co/uBPNGjjyp8 PPARαを介した 線維芽細胞増殖因子21の誘導による絶食反応の内分泌調節

Sep 3, 2025 · 197 followers View post →
山下安音
@SelfRetreat12 · X

もっと強力な長寿ホルモン FGF21 線維芽細胞活性因子 https://t.co/uBPNGjk6eG PPARαを介した 線維芽細胞増殖因子21の誘導による絶食反応の内分泌調節

Aug 8, 2025 · 197 followers View post →
William Lagakos
@caloriesproper2 · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.co/02rj9cSwxg FGF21 vs Protein Leverage Hypothesis https://t.co/kg8nJNIkPm

Aug 5, 2025 · 1 like · 2,698 followers View post →
Anthony Knox
@KnoxAnthon52670 · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men - PubMed https://t.co/zvp9deT79D

Aug 4, 2025 · 35 followers View post →
Neil Rieck
@neilrieck · X

The Most Potent Longevity Hormone you’ve Never Heard - and How to Activate it, Naturally https://t.co/WP3ZF4UNdF

Jul 31, 2025 · 114 followers View post →
Eve rosemary Winter
@Everosemary11 · X

RT @AndreasMFritzen: Happy to be part of this in @NatMetabolism: Dietary protein restriction elevates FGF21 levels and energy requirements…

Mar 24, 2025 · 2 shares · 1,364 followers View post →
Human Obesity Metabolism (HOMe) Lab
@HOMeScienceLab · X

RT @D_Morales_Alamo: New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements ne…

Mar 16, 2025 · 4 shares · 97 followers View post →
erog
@rogedj1 · X

RT @D_Morales_Alamo: New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements ne…

Mar 16, 2025 · 4 shares · 7 followers View post →
Chris Gaffney
@cgaffneyphd · X

RT @D_Morales_Alamo: New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements ne…

Mar 15, 2025 · 4 shares · 631 followers View post →
Marcela Gonzalez- Gross
@GrossMarcela · X

RT @D_Morales_Alamo: New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements ne…

Mar 15, 2025 · 4 shares · 1,028 followers View post →
David Morales-Álamo
@D_Morales_Alamo · X

New study reveals that dietary protein restriction significantly increases FGF21 levels and the energy requirements needed to maintain body weight in lean men. Important implications for understanding metabolism & weight management! #Nutrition #Metabolism https://t.co/GXmSC7zi7S

Mar 15, 2025 · 19 likes · 4 shares · 3,768 followers View post →
Joe Gordon
@josephwgordon · X

RT @SchertzerLab: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.c…

Mar 14, 2025 · 2 shares · 2,107 followers View post →
Dr. Swapneil Parikh
@swapneilparikh · X

RT @SchertzerLab: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.c…

Mar 12, 2025 · 2 shares · 6,510 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men https://t.co/tEP0duXaYe

Mar 11, 2025 · 14 likes · 2 shares · 1,478 followers View post →
Nick Krontiris
@nick_krontiris · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men (open access) https://t.co/RsPcNZdYKV

Mar 11, 2025 · 18,977 followers View post →
andreasmfritzen.bsky.social
@andreasmfritzen.bsky.social · Bluesky

Happy to be a part of this out now in @NatMetabolism: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. Adding nuances to the discussion on dietary protein for body weight regulation and into FGF21 biology. www.nature.com/articles/s42...

Mar 10, 2025 View post →
Aaron Novikoff
@AaronNovikoff · X

RT @AndreasMFritzen: Happy to be part of this in @NatMetabolism: Dietary protein restriction elevates FGF21 levels and energy requirements…

Mar 10, 2025 · 2 shares · 437 followers View post →
Andreas Mæchel Fritzen
@AndreasMFritzen · X

Happy to be part of this in @NatMetabolism: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in men. It adds nuances to the discussion on dietary protein for body weight regulation and to FGF21 biology. https://t.co/PyUkHYHzDr

Mar 10, 2025 · 18 likes · 2 shares · 569 followers View post →
exfatloss
@exfatloss · X

RT @NathanEqualsOne: Brand new honey diet adjacent study: Dietary protein restriction elevates FGF21 levels and energy requirements to main…

Mar 9, 2025 · 1 share · 6,580 followers View post →
Nathan Owens
@NathanEqualsOne · X

Brand new honey diet adjacent study: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men “energy intake had to be gradually increased to maintain body weight, resulting in a 20% higher energy intake at the end of week 5”

Mar 9, 2025 · 31 likes · 1 share · 2,115 followers View post →
Wilson (Yuqin Wu)
@Wilson79078233 · X

RT @IsraelPodesta: Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. "unchange…

Mar 9, 2025 · 1 share · 725 followers View post →
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@Higa_Kazuo · X

タンパク質の摂取不足は肥満に繋がる可能性が示唆される。 https://t.co/bcLioUDRZS

Mar 7, 2025 · 1,656 followers View post →
Israel Podesta, PhD
@IsraelPodesta · X

Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. "unchanged fat and LBM and body water content with eucaloric protein restriction do not suggest repartitioning of muscle to FM" @NatMetabolism https://t.co/YBgDwPKpB1

Mar 7, 2025 · 5 likes · 1 share · 380 followers View post →