April 2025 PMID 40063041

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial.

Eric Thouvenot, David Laplaud, Christine Lebrun-Frenay, Nathalie Derache, Emmanuelle Le Page, Elisabeth Maillart, Caroline Froment-Tilikete, Giovanni Castelnovo, Olivier Casez, Marc Coustans, Anne-Marie Guennoc, Olivier Heinzlef, Laurent Magy, Chantal Nifle, Xavier Ayrignac

Mentions

221
Peak: 92 in Mar 2025
across 7 sources since Mar 2025

Extended reach

2,508,671
potential audience

Total likes

391

Video views

2,688

Mentions per month

Mar 2025 – Sep 2025

Where it's discussed

  • X / Twitter145 posts
  • News56 articles
  • Bluesky6 posts
  • Facebook4 posts
  • Reddit4 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions emphasize the effectiveness of high-dose cholecalciferol, with phrases like 'significantly reduced disease activity' and 'these results warrant further investigation' creating a tone of optimism and urgency. Additionally, users reference the study's methodology and advocate for further research, showcasing both good understanding and concern over broader implications of vitamin D in MS treatment.

AgreementStrong agreement

The majority of posts express strong support for the findings of the trial, highlighting the reduced disease activity associated with high-dose vitamin D.

InterestHigh interest

Discussions indicate a high level of curiosity and relevance, with many contributors eager to learn more about the implications of the study.

EngagementHigh engagement

Participants refer to specific findings and clinical implications, showing deep engagement with the topic and the research methodologies used.

ImpactHigh impact

Most users perceive the study as potentially transformative for treatment approaches to multiple sclerosis, suggesting significant future implications.

Abstract in brief

  • Vitamin D deficiency is linked to multiple sclerosis (MS), and while studies show mixed results on supplementation, this trial seeks to determine the effectiveness of high-dose cholecalciferol as solo treatment in patients with clinically isolated syndrome (CIS) typical for MS.
  • The D-Lay MS trial, conducted in France, randomized 316 participants aged 18-55 with low vitamin D levels to receive either high-dose cholecalciferol or a placebo over 24 months, tracking disease activity through relapses and MRI results.
  • Results indicated that disease activity occurred in 60.3% of the vitamin D group compared to 74.1% in the placebo group, suggesting that vitamin D supplementation significantly

Top posts

Most liked on X and Bluesky
Mauricio Ambriz
@AmbrizMau · X

El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el síndrome clínico aislado y en la esclerosis múltiple recurrente-remitente en sus etapas iniciales. JAMA 2025; DOI: 10.1001/jama.2025.1604 https://t.co/FVn3mrRfmY

Mar 11, 2025 · 54 likes · 10 shares · 71,497 followers View post →
JAMA
@JAMA_current · X

Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-remitting multiple sclerosis. https://t.co/pYeaDm5WBM

Apr 22, 2025 · 46 likes · 8 shares · 488,658 followers View post →
JAMA
@JAMA_current · X

Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleSclerosis and early relapsing-emitting #MS? #MSAwarenessWeek Learn more: https://t.co/FDxqIJ8WZp https://t.co/jr2M1QANLn

Mar 15, 2025 · 27 likes · 11 shares · 488,658 followers View post →
Agingdoc
@agingdoc1 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial

Mar 16, 2025 · 18 likes · 2 shares · 41,754 followers View post →
_MCRicardo_
@_MCRicardo_ · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an effective treatment for the neurodegenerative condition multiple sclerosis. https://t.co/eaDp6bgfRa @DHPSP @dronita_de @guani_vic @drfherediaz @DrGrimaldesJ

Apr 1, 2025 · 15 likes · 7 shares · 1,988 followers View post →
Science News
@scinews.bsky.social · Bluesky

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial jamanetwork.com/journals/jam...

Mar 11, 2025 · 14 likes · 2 shares View post →

All mentions

Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Sep 18, 2025 · 10 shares · 13,637 followers View post →
Nutrition Science
@NutrioSci · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 63,971 followers View post →
Advances in Reproduction
@AdvReproduction · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 14,056 followers View post →
Top Science
@isciverse · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 40,419 followers View post →
The Innovation Oncology
@InnovOncology · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 2,859 followers View post →
Science News
@SciencNews · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 31,153 followers View post →
Medical Advances
@MedicalAdv · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 29,803 followers View post →
Top Biomedical Science
@imedverse · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 90,399 followers View post →
Jo Gray
@j0_gray · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #…

Jul 12, 2025 · 8 shares · 62 followers View post →
Nutrition Science
@NutrioSci · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial #Meded #MedX #TIC2025 https://t.co/atMtsol9T5 https://t.co/Ob2T3pHX6w

Jul 12, 2025 · 9 likes · 8 shares · 63,971 followers View post →
Erin T. Pharm.D.,BSPS,BCACP
@eltpharmd · X

RT @IJMSCtweets: "Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-remitting…

Jun 19, 2025 · 2 shares · 1,475 followers View post →
şule terzili
@terzilis · X

RT @IJMSCtweets: "Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-remitting…

Jun 19, 2025 · 2 shares · 102 followers View post →
IJMSC
@IJMSCtweets · X

"Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-remitting #MultipleSclerosis. These results warrant further investigation, including potential role of pulse high-dose vitamin D..." https://t.co/k0KeOCZGpv https://t.co/ryuRTFSW0z

Jun 19, 2025 · 5 likes · 2 shares · 1,144 followers View post →
Maciel Tomio
@MacielTomio · X

Ref.: doi:10.1001/jama.2025.1604

May 31, 2025 View post →
Sandeep Palakodeti, MD MPH
@DrDeepMD · X

Not that big of a theoretical leap to believe this hormonally active vitamin has other anti-inflammatory and disease modulating effects Link: https://t.co/A13ioBVPf7

May 16, 2025 · 4,850 followers View post →
N und Auto
@naoto140 · X

https://t.co/rZIW6cnDFK

May 11, 2025 · 6 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial. https://t.co/Tec9kn9L1H

May 2, 2025 · 2,070 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis The D-Lay MS Randomized Clinical Trial. https://t.co/Tec9kn9L1H

Apr 30, 2025 · 2,070 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https://t.co/Tec9kn9L1H

Apr 29, 2025 · 2,070 followers View post →
Robert West, PhD ✝️
@westr · X

RT @beckerbarroso: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/MiP7dPuIG1

Apr 24, 2025 · 1 share · 19,314 followers View post →
Antonio Cruz-Culebras
@CulebrasCruz · X

Sube el precio de la vitamina D High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/d3D648GrW8

Apr 24, 2025 · 1 like · 1,127 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @3stars67664378: 多発性硬化症に対する

Apr 23, 2025 · 1 share · 1,784 followers View post →
Manu Morales Sánchez
@Manumoraless · X

RT @FarmaMadridAP: (JAMA) Vitamina D en dosis altas en el síndrome clínicamente aislado (SCA) típico de la esclerosis múltiple: en este ens…

Apr 23, 2025 · 2 shares · 465 followers View post →
CIMES
@cimesalvador · X

RT @FarmaMadridAP: (JAMA) Vitamina D en dosis altas en el síndrome clínicamente aislado (SCA) típico de la esclerosis múltiple: en este ens…

Apr 23, 2025 · 2 shares · 1,491 followers View post →
Karl C. Mayer
@Neuro24de · X

Hochdosis Vitamin D reduzierte in kleiner Studie die Anzahl der erneuten Schübe bei "klinisch isoliertem Syndrom". Die Ergebnisse sollten in einer größeren Studie repliziert werden, machen aber Hoffnung. #MultipleSklerose, #CIS, #KIS https://t.co/PE3jvyVO8q

Apr 23, 2025 · 1,319 followers View post →
Cardio
@PesarCardio · X

فعالیت بیماری رو توی تصویربرداری مغز کاهش بده، بدون اینکه عوارض جدی‌ای ایجاد کنه. https://t.co/O9svEM8nPq

Apr 23, 2025 · 3 likes · 1,159 followers View post →
Farmacia Madrid AP
@FarmaMadridAP · X

(JAMA) Vitamina D en dosis altas en el síndrome clínicamente aislado (SCA) típico de la esclerosis múltiple: en este ensayo clínico aleatorizado se redujo la actividad de la enfermedad en el SCA y en la esclerosis múltiple recurrente-remitente temprana https://t.co/NTKClUWKnr

Apr 23, 2025 · 4 likes · 2 shares · 8,368 followers View post →
SWA
@swalexander.bsky.social · Bluesky

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial jamanetwork.com/journals/jam...

Apr 23, 2025 View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https://t.co/Tec9kn9L1H

Apr 22, 2025 · 2 likes · 2,070 followers View post →
Kaporal Yoda
@Stephan67358673 · X

JAMA (March 2025): "Oral high-dose cholecalciferol (vitamin D) reduced disease activity in clinically isolated syndrome and in early relapsing-remitting multiple sclerosis" https://t.co/r3x0EYuITZ

Apr 22, 2025 · 72 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

多発性硬化症に対する

Apr 22, 2025 · 8 likes · 1 share · 1,784 followers View post →
Lovings Webmistress
@lovingsgirl · X

Interesting study. High doses of vitamin D appear to help with MS. https://t.co/BeUWq4Xppd

Apr 22, 2025 · 837 followers View post →
Bailey Nelsons
@Baileybillyb · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 284 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

"High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis The D-Lay MS Randomized Clinical Trial." Publié ce jour dans @jama.com #MedSky #NeuroSky jamanetwork.com/journals/jam...

Apr 22, 2025 · 1 like View post →
Oscarelo A.
@Oscarelo2x · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 3,194 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial | Demyelinating Disorders | JAMA | JAMA Network https://t.co/x7AFezPFbz

Apr 22, 2025 · 360 followers View post →
crisguijarro
@crisguijarro1 · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 1,877 followers View post →
Shan Wang, BS., PharmD., BCCCP, BCPS, FCCM
@shanwangsicurx · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 387 followers View post →
José Luis Bustos Sanchez
@NEUROLOGOBUSTOS · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 1,122 followers View post →
scott novick
@novicksj · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Apr 22, 2025 · 8 shares · 1,873 followers View post →
JAMA
@JAMA_current · X

Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-remitting multiple sclerosis. https://t.co/pYeaDm5WBM

Apr 22, 2025 · 46 likes · 8 shares · 488,658 followers View post →
Un1v3rs0 Z3r0
@Un1v3rs0Z3r0 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/6caNmRGHM5

Apr 22, 2025 · 508 followers View post →
@JaganNeuron
@Jagan1234 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/VJyS0hfU7g. This does not work in dark-skinned individuals.

Apr 19, 2025 · 263 followers View post →
William Rand
@rand_rand17 · X

There are now many trials demonstrating the effectiveness of high doses of Vitamin D against diseases. Here's one. 50,000 units per week Vitamin D in Clinically Trial of Multiple Sclerosis in a Randomized Clinical Trial. https://t.co/ls52pypyyz

Apr 16, 2025 · 1 like · 846 followers View post →
Mary Sombra
@Marisombrita · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 16, 2025 · 7 shares · 51 followers View post →
Abdullah MR
@Ramam791Mr · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/P3N79tixpF

Apr 11, 2025 · 1,156 followers View post →
Fahri Çizmecioğlu
@FCizmecioglu · X

RT @IsilDr22: Yeni çalışma: Yüksek doz D vitamini izole klinik sendromu olan ve erken relaps Multipl skleroz hastalarında hastalık aktivite…

Apr 9, 2025 · 1 share · 14,505 followers View post →
Doç. Dr. Işıl
@IsilDr22 · X

Yeni çalışma: Yüksek doz D vitamini izole klinik sendromu olan ve erken relaps Multipl skleroz hastalarında hastalık aktivitesini azalttı. https://t.co/skxCR5PyNt

Apr 9, 2025 · 12 likes · 1 share · 29,212 followers View post →
Epoch Health
@epochhealth · X

@avsangies https://t.co/N1YC19P6Mj

Apr 8, 2025 · 2 likes · 93,116 followers View post →
Ronita De, PhD
@dronita_de · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 5, 2025 · 7 shares · 1,504 followers View post →
Katsuhiko Fukuda MD PhD 福田 克彦
@eitchan · X

https://t.co/CHlYzdF532

Apr 4, 2025 · 2 likes · 23,655 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitting MS. These results warrant further investigation, including the potential role of pulse high-dose vitamin D as add-on therapy. https://t.co/Tec9kn9L1H

Apr 2, 2025 · 2,070 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial. https://t.co/Tec9kn9L1H

Apr 2, 2025 · 2,070 followers View post →
Slawomir
@Slawomi18369321 · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 2, 2025 · 7 shares · 84 followers View post →
Daniel Grimaldes MD
@DrGrimaldesJ · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 1, 2025 · 7 shares · 1,016 followers View post →
maye ❤️
@maye28350 · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 1, 2025 · 7 shares · 1,007 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 1, 2025 · 7 shares · 1,056 followers View post →
fausto heredia z.
@drfherediaz · X

RT @_MCRicardo_: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an ef…

Apr 1, 2025 · 7 shares · 4,356 followers View post →
_MCRicardo_
@_MCRicardo_ · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Supplements of vitamin D could be an effective treatment for the neurodegenerative condition multiple sclerosis. https://t.co/eaDp6bgfRa @DHPSP @dronita_de @guani_vic @drfherediaz @DrGrimaldesJ

Apr 1, 2025 · 15 likes · 7 shares · 1,988 followers View post →
Orchid Advocacy
@OrchidAdvocacy · X

https://t.co/wGiIsrSMzN

Mar 31, 2025 · 763 followers View post →
Dr. Victor Rannyo - Naturópata / Ortomolecular ⚡
@naturopatia_br · X

RT @cjbakermd: Vitamin D for the win again! Mainstream medicine is begrudgingly starting to acknowledge the value in Vit D, including agai…

Mar 29, 2025 · 4 shares · 741 followers View post →
Chris Turner
@leadfreeH2OinDC · X

RT @cjbakermd: Vitamin D for the win again! Mainstream medicine is begrudgingly starting to acknowledge the value in Vit D, including agai…

Mar 29, 2025 · 4 shares · 2,864 followers View post →
Deidra Lowe
@DeidraLowe2 · X

RT @cjbakermd: Vitamin D for the win again! Mainstream medicine is begrudgingly starting to acknowledge the value in Vit D, including agai…

Mar 29, 2025 · 4 shares · 740 followers View post →
December Snow
@DecemberSnow152 · X

RT @cjbakermd: Vitamin D for the win again! Mainstream medicine is begrudgingly starting to acknowledge the value in Vit D, including agai…

Mar 29, 2025 · 4 shares · 454 followers View post →
Clayton J Baker MD
@cjbakermd · X

Vitamin D for the win again! Mainstream medicine is begrudgingly starting to acknowledge the value in Vit D, including against MS! High-Dose Vitamin D in Syndrome Typical of Multiple Sclerosis @Honest_Medicine @NicHulscher @RobertKennedyJr @drdrew https://t.co/e7ZA3ah1if

Mar 29, 2025 · 5 likes · 4 shares · 8,969 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis The D-Lay MS Randomized Clinical Trial "…

Mar 28, 2025 · 1 share · 133 followers View post →
Agingdoc
@agingdoc1 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis The D-Lay MS Randomized Clinical Trial "Oral high-dose cholecalciferol reduced disease activity in clinically isolated syndrome and in early relapsing-remitting multiple sclerosis." https://t.co/p21FFy9qOt

Mar 27, 2025 · 2 likes · 1 share · 41,754 followers View post →
Reiner 
@erlesen · X

RT @erlesen: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https:…

Mar 26, 2025 · 2 shares · 7,862 followers View post →
Productive While Doomed / Pharmagal
@sleepyinIl · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/FpZ00pdawy

Mar 25, 2025 · 1,619 followers View post →
Christof Meinhold
@nutri_cologne · X

RT @erlesen: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https:…

Mar 25, 2025 · 2 shares · 2,509 followers View post →
NutriTips
@HappyNutricolor · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial h…

Mar 25, 2025 · 4 shares · 32 followers View post →
Reiner
@erlangen.bsky.social · Bluesky

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial jamanetwork.com/journals/jam... Clinical trial: High‑dose vitamin D significantly reduces disease activity in early multiple sclerosis onset medicalxpress.com/news/2025-03...

Mar 24, 2025 · 7 likes · 2 shares View post →
Reiner 
@erlesen · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https://t.co/QyRfEBsWjp Clinical trial: High‑dose vitamin D significantly reduces disease activity in early multiple sclerosis onset https://t.co/KzePLd1Zba

Mar 24, 2025 · 5 likes · 2 shares · 7,862 followers View post →
Fifoubraz
@Fifoubraz · X

Vitamine D et SEP. Bon article pour la LCA des externes! High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/NbHRsglyeZ

Mar 20, 2025 · 1 like · 541 followers View post →
Daniel Coyne
@DrDanMO · X

And the JAMA Article... High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial | Demyelinating Disorders | JAMA | JAMA Network https://t.co/GeF2oQJlmi

Mar 18, 2025 · 3,472 followers View post →
Gabriella ⭕️
@femigabi · X

RT @Med58ll: Vitamine D 100 000 IE elke 2 weken verminderde de ziekteactiviteit significant bij CIS en vroege recidiverende-remitterende MS…

Mar 18, 2025 · 1 share · 171 followers View post →
MAH
@Med58ll · X

Vitamine D 100 000 IE elke 2 weken verminderde de ziekteactiviteit significant bij CIS en vroege recidiverende-remitterende MS. Deze resultaten rechtvaardigen verder onderzoek, waaronder de rol van pulshooggedoseerde vitamine D als add-on therapie. https://t.co/eJ8YCP0Asr

Mar 18, 2025 · 7 likes · 1 share · 885 followers View post →
Jessa Raye
@JsssaRaye0820 · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial h…

Mar 17, 2025 · 4 shares · 466 followers View post →
mpdehesaisidoro
@mpdehesaisidoro · X

RT @agingdoc1: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial

Mar 17, 2025 · 2 shares · 33 followers View post →
gino fino
@FinoGinofino · X

RT @agingdoc1: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial

Mar 16, 2025 · 2 shares · 631 followers View post →
Agingdoc
@agingdoc1 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial

Mar 16, 2025 · 18 likes · 2 shares · 41,754 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

“High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis The D-Lay MS Randomized Clinical Trial.” Publié en mars dans @jama.com. #MedSky #NeuroSky jamanetwork.com/journals/jam...

Mar 16, 2025 View post →
şule terzili
@terzilis · X

RT @ULLR64_1: CIS 316人を対象に、高用量ビタミンD (10万 IU、2週間毎24ヶ月投与) の有効性を評価したフランスのRCT (D-Lay MS試験)。 再発またはMRIの疾患活動のリスクはビタミンD群で34%低下した。MRIでの新規病巣や造影病巣は少なか…

Mar 15, 2025 · 1 share · 102 followers View post →
@strhon2018
@strhon2018 · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 4,117 followers View post →
Elena Becker-Barroso
@beckerbarroso · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/MiP7dPuIG1

Mar 15, 2025 · 2 likes · 1 share · 982 followers View post →
It'sthatgirlSteph
@stephyandjj · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 187 followers View post →
flavio quarantiello
@flavioquara · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 302 followers View post →
大橋 高志
@ULLR64_1 · X

CIS 316人を対象に、高用量ビタミンD (10万 IU、2週間毎24ヶ月投与) の有効性を評価したフランスのRCT (D-Lay MS試験)。 再発またはMRIの疾患活動のリスクはビタミンD群で34%低下した。MRIでの新規病巣や造影病巣は少なかったが、再発率や身体機能の悪化に有意差はなかった。https://t.co/g8MR7Q1HZf

Mar 15, 2025 · 12 likes · 1 share · 382 followers View post →
Tarun Solanki
@tarun_solanki · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 130 followers View post →
AllShadesOfGray
@AllShadesOfGray · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 198 followers View post →
A N E W
@ANEWANEW · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 81,143 followers View post →
Ferran Roca
@roca_ferran · X

Mar 15, 2025 · 1 like · 2,191 followers View post →
Pokrath Hansasuta
@pokrath · X

RT @JAMA_current: Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleScle…

Mar 15, 2025 · 11 shares · 94,530 followers View post →
JAMA
@JAMA_current · X

Can vitamin D reduce disease activity in patients with clinically isolated syndrome that typically precedes #MultipleSclerosis and early relapsing-emitting #MS? #MSAwarenessWeek Learn more: https://t.co/FDxqIJ8WZp https://t.co/jr2M1QANLn

Mar 15, 2025 · 27 likes · 11 shares · 488,658 followers View post →
旅人 tabito
@tabibito250 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial | Demyelinating Disorders | JAMA | JAMA Network https://t.co/VTz3sTblLs

Mar 14, 2025 · 1 like · 1,072 followers View post →
Kevin C. Klatt, PhD, RD
@KCKlatt · X

RT @NatRevNeurol: "Oral high-dose cholecalciferol reduced disease activity in clinically isolated syndrome and in early relapsing-remitting…

Mar 14, 2025 · 4 shares · 21,100 followers View post →
efinara
@FjvJjo · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial h…

Mar 14, 2025 · 4 shares · 1,366 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @JCrippsSciGuy: “Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitti…

Mar 14, 2025 · 4 shares · 190 followers View post →
PubMed Trending
@PubTrend · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial. https://t.co/wJUeIXd0KS

Mar 13, 2025 · 5,164 followers View post →
EARLの医学&AIノート
@EARL_med_tw · X

Mar 13, 2025 · 7 likes · 148,090 followers View post →
Sofia
@Aiphos2 · X

RT @JCrippsSciGuy: “Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitti…

Mar 13, 2025 · 4 shares · 2,269 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @JCrippsSciGuy: “Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitti…

Mar 13, 2025 · 4 shares · 158,568 followers View post →
Moka(づ ̄ ³ ̄)づ
@KathieMohka · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Mar 13, 2025 · 10 shares · 47 followers View post →
Shashi Iyengar | Accredited Metabolic Health Coach
@shashiiyengar · X

RT @JCrippsSciGuy: “Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitti…

Mar 13, 2025 · 4 shares · 28,952 followers View post →
John Cripps
@JCrippsSciGuy · X

“Oral cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in CIS and early relapsing-remitting MS”13.8%ARR @SMHP @FatEmperor @BrianLenzkes @NutritionNetwrk @DoctorTro @LDLSkeptic @DavidPerlmutter @lowcarbusa @drmclphillips https://t.co/DQ8K4QK2Bi

Mar 13, 2025 · 13 likes · 4 shares · 428 followers View post →
Doug Earle
@EarleDoug · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/XESAP4ye7d

Mar 12, 2025 · 1,113 followers View post →
StillerNP
@LogosFNP · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial | Demyelinating Disorders | JAMA | JAMA Network https://t.co/LMeMvfPe24

Mar 12, 2025 · 1 like · 31 followers View post →
WalterMC
@scrutario · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Mar 12, 2025 · 10 shares · 435 followers View post →
Abi B
@abudd.bsky.social · Bluesky

pubmed.ncbi.nlm.nih.gov/40063041/ #MultipleSclerosis

Mar 12, 2025 · 1 like · 1 share View post →
Mithu Storoni
@MithuStoroni · X

☀️ Oral vitamin D☀️supplements (cholecalciferol) at a dose of 100 000 IU every 2 weeks significantly reduced disease activity in patients with early (CIS/RRM) Multiple Sclerosis. https://t.co/AwHotIBJ5K

Mar 12, 2025 · 4,182 followers View post →
rincondesisifo
@rincondesisifo · X

(JAMA) Seguridad y eficacia de la administración de altas dosis de vit D en el síndrome clínicamente aislado típico de la esclerosis múltiple https://t.co/q610VUtMPb ECA https://t.co/ZUE3luylp5

Mar 12, 2025 · 8,454 followers View post →
えぬゆ
@enu_you · X

RT @NatRevNeurol: "Oral high-dose cholecalciferol reduced disease activity in clinically isolated syndrome and in early relapsing-remitting…

Mar 11, 2025 · 4 shares · 40 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Mar 11, 2025 · 10 shares · 548 followers View post →
Pablo Naval-Baudin
@pnavalbaudin · X

RT @IJMSCtweets: JAMA: "Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-rem…

Mar 11, 2025 · 2 shares · 1,135 followers View post →
şule terzili
@terzilis · X

RT @IJMSCtweets: JAMA: "Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-rem…

Mar 11, 2025 · 2 shares · 102 followers View post →
IJMSC
@IJMSCtweets · X

JAMA: "Oral #cholecalciferol 100 000 IU every 2 weeks significantly reduced disease activity in #CIS & early relapsing-remitting #MS. These results warrant further investigation, including potential role of pulse high-dose #VitaminD as add-on therapy." https://t.co/01qZmSqkHy https://t.co/PXC2kDAmSV

Mar 11, 2025 · 2 likes · 2 shares · 1,144 followers View post →
旅人 tabito
@tabibito250 · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial | Demyelinating Disorders | JAMA | JAMA Network https://t.co/VTz3sTblLs

Mar 11, 2025 · 3 likes · 1,072 followers View post →
@Hombre lobo
@juanito72880151 · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Mar 11, 2025 · 10 shares · 22 followers View post →
Miguel A.
@AsimovIsaac1919 · X

2/ Incluso en caso de niveles insuficientes, la vitamina D tiene un efecto beneficioso. https://t.co/Ne4Faysm8h

Mar 11, 2025 · 1 like · 7,825 followers View post →
Gilberto
@DrDgzg · X

RT @AmbrizMau: El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el sí…

Mar 11, 2025 · 10 shares · 1,113 followers View post →
Mauricio Ambriz
@AmbrizMau · X

El colecalciferol oral a dosis de 100,000 UI cada 2 semanas redujo significativamente la actividad de la enfermedad en el síndrome clínico aislado y en la esclerosis múltiple recurrente-remitente en sus etapas iniciales. JAMA 2025; DOI: 10.1001/jama.2025.1604 https://t.co/FVn3mrRfmY

Mar 11, 2025 · 54 likes · 10 shares · 71,497 followers View post →
Соломія Гнат
@GnatSolomia · X

RT @NutrioSci: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial h…

Mar 11, 2025 · 4 shares · 5 followers View post →
Nutrition Science
@NutrioSci · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial https://t.co/atMtsokC3x https://t.co/5zIMSxmM5e

Mar 11, 2025 · 8 likes · 4 shares · 63,971 followers View post →
Science News
@scinews.bsky.social · Bluesky

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial jamanetwork.com/journals/jam...

Mar 11, 2025 · 14 likes · 2 shares View post →
şule terzili
@terzilis · X

RT @NatRevNeurol: "Oral high-dose cholecalciferol reduced disease activity in clinically isolated syndrome and in early relapsing-remitting…

Mar 11, 2025 · 4 shares · 102 followers View post →
Hernandez Edgar
@Internistacl · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/gYvlPMcBHB

Mar 11, 2025 · 519 followers View post →
Javier Villacieros Álvarez
@Villacieros_J · X

So promising! https://t.co/kGbSj0iPxT

Mar 11, 2025 · 1 like · 565 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

"Oral high-dose cholecalciferol reduced disease activity in clinically isolated syndrome and in early relapsing-remitting multiple sclerosis" https://t.co/T6HBzoQKd7

Mar 11, 2025 · 13 likes · 4 shares · 46,494 followers View post →
Karl C. Mayer
@Neuro24de · X

Hochdosiertes Vitamin D in der Frühphase der MS wirksam https://t.co/PE3jvyVgiS

Mar 11, 2025 · 2 likes · 1,319 followers View post →
Giuseppe Biondi-Zoccai
@gbiondizoccai · X

RT @AbbateAntonio: High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/NzCM9fdm0o fascinating

Mar 11, 2025 · 1 share · 12,164 followers View post →
drtpalanichamy palanichamy
@drtpalanichamy · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/MeTIAY9WKD

Mar 11, 2025 · 5 followers View post →
hoeman
@_hoeman · X

RT @Carcos2: This RCT showed the efficacy and low risk of adverse events of oral cholecalciferol 100 000IU monotherapy every 2 weeks to red…

Mar 11, 2025 · 1 share · 1,218 followers View post →
Carlos Coscollar
@Carcos2 · X

This RCT showed the efficacy and low risk of adverse events of oral cholecalciferol 100 000IU monotherapy every 2 weeks to reduce disease activity in patients with clinically isolated syndrome for multiple sclerosis and early RRMS ¿Qué hacemos @rafabravo? https://t.co/wg8WYT1ate

Mar 11, 2025 · 3 likes · 1 share · 1,149 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple SclerosisThe D-Lay MS Randomized Clinical Trial https://t.co/Tec9kn9L1H

Mar 10, 2025 · 2,070 followers View post →
just another Nikos
@another_nikos · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 418 followers View post →
Muhammad Abdelshafi
@Muhamma65897791 · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 53 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 11,308 followers View post →
Victor H Jimenez-Zepeda
@vhugo8762 · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 622 followers View post →
Dr EJ
@EamonJL · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 1,602 followers View post →
Khalid Alshehri
@khalidneuro · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 395 followers View post →
AntonioAbbate
@AbbateAntonio · X

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis https://t.co/NzCM9fdm0o fascinating

Mar 10, 2025 · 4 likes · 1 share · 1,658 followers View post →
El6Pollo
@El6Pollo · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 47 followers View post →
خليفة الشايجي
@5alifa_alshaiji · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 1,463 followers View post →
Disobey
@DisobeyGB2 · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 597 followers View post →
j..
@josue_ · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 97 followers View post →
Liz Tucker
@lizctucker · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 2,321 followers View post →
Erin T. Pharm.D.,BSPS,BCACP
@eltpharmd · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 1,475 followers View post →
Philippe Froguel
@philippefroguel · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 5,025 followers View post →
The Nutritional Handguide
@NutritionalBook · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 422 followers View post →
Mc
@marcioclebio · X

Vitamina D em altas doses na esclerose múltipla. https://t.co/7GqG55GA4V

Mar 10, 2025 · 3 likes · 1,373 followers View post →
Catherine GOI
@CatherineGOI · X

RT @JAMA_current: Oral high-dose vitamin D reduced disease activity in patients with clinically isolated syndrome and in early relapsing-re…

Mar 10, 2025 · 64 shares · 1,407 followers View post →