Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning the efficacy of microdosing psychedelics for ADHD. https://t.co/DS3p9XnpOc https://t.co/7UbsLrrET2
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults: A Randomized Clinical Trial.
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Mar 2025 – Aug 2025Where it's discussed
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X / Twitter121 posts
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News16 articles
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Bluesky5 posts
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Blogs5 articles
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YouTube2 videos
AI synopsis
What people are saying
Numerous digital discussions emphasize the findings of the study, with posts like 'microdosing LSD is bullshit' and 'this RCT suggests NO' reflecting skepticism about LSD's effectiveness for ADHD treatment. The choice of strong language and a dismissive tone underscores the participants' doubts while maintaining a high level of engagement through references to the study. Additionally, users discuss the importance of evidence-based care, employing phrases like 'your brain gremlin deserves real, evidence-based care,' showcasing both concern for proper treatment and interest in the topic.
The majority of discussions express skepticism toward the efficacy of low-dose LSD for ADHD, indicating a collective agreement on the study's results.
Participants show high interest, referencing the study's results and discussing the implications of microdosing LSD in mental health treatment.
Many posts summarize detailed aspects of the study, though some merely echo the findings without additional analysis.
The study is viewed as having high impact, as it challenges popular anecdotal claims about microdosing LSD and contributes to ongoing discussions in mental health.
Abstract in brief
- A clinical trial investigated the safety and effectiveness of low-dose LSD for treating ADHD in adults, comparing it to a placebo over a 6-week period.
- 53 adults with moderate to severe ADHD symptoms participated, receiving either 20 µg of LSD or a placebo twice weekly, with the main outcome measured by changes in ADHD symptoms assessed by the Adult Investigator Symptom Rating Scale (AISRS).
- Results showed no significant difference in symptom improvement between the LSD group and placebo group, although LSD was found to be physically safe and psychologically well tolerated.
Top posts
Most liked on X and BlueskyTwice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.co/qrjE5ImA5Q https://t.co/4ceiDht1lA
LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning the efficacy of microdosing psychedelics for ADHD. https://t.co/bHho5PNnMd https://t.co/xfNZ9v4RRH
Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed studies are published provide us with a comprehensive perspective of the potential of psychedelics in psychiatry https://t.co/VvhXJphX5t
Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR #psychiatry #ADHDAwareness #ADD #pmhnp #psychedelic https://t.co/fT04XAwXCJ
All mentions
Chemists Flip 2 Atoms in LSD to Make it a Better Medicine (Educational Science Video)
Microdosing LSD for Adult ADHD: Recent Findings on Efficacy
This brief video examines the results of a recent clinical trial on low-dose LSD for managing adult ADHD. The study involved 53 participants and showed no significant symptom improvement compared to a placebo, though…
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults https://t.co/fcFo0isgW6
低用量のLSDは、成人のADHD症状を改善させる有意な効果なし https://t.co/KnwB0aeIsY
RT @MedicWalf: PSA to my ADHD fuzzbutts: Science says microdosing LSD is safe, but doesn’t actually help your ADHD symptoms. Your brain gre…
RT @SouthernPsy: 低容量反復LSDはADHD症状の軽減をもたらさない。 Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults https://t.co/PTqAXh2…
低容量反復LSDはADHD症状の軽減をもたらさない。 Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults https://t.co/PTqAXh25VZ
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.c…
Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.co/qrjE5ImA5Q https://t.co/4ceiDht1lA
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults
Des chimistes inversent deux atomes du LSD pour en faire un meilleur méd... https://t.co/oZLkstuNOX via @YouTube
RT @JAMAPsych:
RT @JAMAPsych:
RT @JAMAPsych:
RT @JAMAPsych:
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RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @MentalHealthLaw: Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with pla…
RT @SEPD_es: El tratamiento con dosis bajas de psicodélicos parece ser tan eficaz como un placebo para mejorar los síntomas del TDAH, según…
El tratamiento con dosis bajas de psicodélicos parece ser tan eficaz como un placebo para mejorar los síntomas del TDAH, según un estudio reciente. https://t.co/QnoNmGwIno
RT @chrisaikenmd: Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR…
Recent study shows microdosing LSD is bullshit. “LSD was not efficacious in reducing ADHD symptoms compared with placebo; these results question the anecdotal practice…” https://t.co/rP36IywNDr
Microdosing LSD ineffective in #ADHD https://t.co/aEjlOi8TEd
@PaulAustin3w So far research has not proven this so I don't know where you're getting this from. https://t.co/mwLcsAP1kq https://t.co/XGLQheBX4A
Repeated low-dose LSD shows promise for ADHD treatment! 6-week trial: multicenter, double-blind, placebo-controlled. #ADHDResearch PMID:40105807, JAMA Psychiatry 2025, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2025.0044 #Medsky #Pharmsky #RNA #ASHG #ESHG
Repeated low-dose LSD shows promise for ADHD treatment! 6-week trial: multicenter, double-blind, placebo-controlled. #ADHDResearch PMID:40105807, JAMA Psychiatry 2025, @JAMAPsych https://t.co/ym84XLUXmv #AI #Pharma #BioMed #RNA #ASHG #ESHG
RT @psychopharmacol: small RCT: twice-weekly 20 μg LSD over 6 weeks was not more efficacious than placebo in reducing ADHD symptoms (MD-AIS…
PSA to my ADHD fuzzbutts: Science says microdosing LSD is safe, but doesn’t actually help your ADHD symptoms. Your brain gremlin deserves real, evidence-based care. Source: pubmed.ncbi.nlm.nih.gov/40105807/
PSA to my ADHD fuzzbutts: Science says microdosing LSD is safe, but doesn’t actually help your ADHD symptoms. Your brain gremlin deserves real, evidence-based care. Source: https://t.co/V25GfNarQL https://t.co/r5uhkF4Yu6
Kim Kuypers will be at EPA2025 in Madrid later this week!✨https://t.co/srzikGXPEH At the conference, she will be presenting insights from our latest microdosing study, conducted in collaboration with Basel University, published in JAMA Psychiatry: https://t.co/2ibOjG0vNG
RT @JAMAPsych: Most viewed in the last 7 days from @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD s…
Most viewed in the last 7 days from @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.co/sDzWSFQf8k https://t.co/GMg187cugr
RT @agingdoc1: Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in AdultsA Randomized Clinical Trial https://t.co/5cfM1g7Uw…
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in AdultsA Randomized Clinical Trial https://t.co/5cfM1g7Uwx https://t.co/c9DLVwJUMG
RT @JAMAPsych: Most viewed in the last 7 days from @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD s…
RT @JAMAPsych: Most viewed in the last 7 days from @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD s…
Most viewed in the last 7 days from @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo. https://t.co/tQWeaTuDZn https://t.co/FJ3rojBnFa
El #placebo psicodélico: lo que nos enseña un ensayo clínico sobre LSD y TDAH. Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults https://t.co/fGQ6QehO1L @JAMAPsych #Tecnoestrés
Repeated low-dose LSD treatment for ADHD in adults was safe but showed no significant benefits over placebo. by Mueller L, Santos de Jesus J (...) Liechti ME et 9 al. in JAMA Psychiatry https://t.co/8TKPQpa3Ic #MedX #MedResearch
RT @chrisaikenmd: Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR…
Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/40105807 #psychiatry #ADHDAwareness #ADD #pmhnp #psychedelic
RT @chrisaikenmd: Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR…
RT @chrisaikenmd: Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR…
RT @chrisaikenmd: Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR…
Despite its popularity, microdosing #LSD failed to treat #ADHD in new placebo-controlled trial: https://t.co/LjbkiqYPbR #psychiatry #ADHDAwareness #ADD #pmhnp #psychedelic https://t.co/fT04XAwXCJ
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults: A Randomized Clinical Trial - PMC https://t.co/ujKihmF0nJ
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
ref. https://t.co/lqWseF4goY
Out in @JAMAPsych: A placebo-controlled trial of twice-weekly low-dose LSD in adults with ADHD showed no benefit over placebo. Challenging anecdotal claims.
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning the efficacy of microdosing psychedelics for ADHD. https://t.co/bHho5PNnMd https://t.co/xfNZ9v4RRH
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
RT @ChrisPalmerMD: LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
LSD for ADHD? This RCT suggests NO. https://t.co/GIqhGshSWE
ADHDに対するLSDのマイクロドーズ(低用量治療)はプラセボより効果がないということが臨床試験で判明。 スイスのバーゼル大学病院とオランダのマーストリヒト大学の論文。 過去いくつかの研究で効果ありとされていたものでも追加の研究で普通にひっくり返り得る。 https://t.co/x60Z4dNZnv
small RCT: twice-weekly 20 μg LSD over 6 weeks was not more efficacious than placebo in reducing ADHD symptoms (MD-AISRS=1.8; -1.0 to ∞) https://t.co/rAMV3zfkny https://t.co/uhFkyaBFgK
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @drrickbarnett: 20mics is a healthy “microdose” and still no conclusive benefit over placebo. @JAMAPsych https://t.co/4CKMKGr9vp
RT @drrickbarnett: 20mics is a healthy “microdose” and still no conclusive benefit over placebo. @JAMAPsych https://t.co/4CKMKGr9vp
20mics is a healthy “microdose” and still no conclusive benefit over placebo. @JAMAPsych https://t.co/4CKMKGr9vp
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning the efficacy of microdosing psychedelics for ADHD. https://t.co/z0pSZIUPiK https://t.co/Q2b8DfyaCV
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults: A Randomized Clinical Trial | Attention Deficit/Hyperactivity Disorders | JAMA Psychiatry | JAMA Network @Athens4Cannabis https://t.co/N1WxG3NWeg
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @NatRevNeurol: "LSD was not efficacious in reducing ADHD symptoms compared with placebo; these results question the anecdotal practice a…
RT @FarmaMadridAP: (JAMA Psychiatry) Seguridad y eficacia del LSD a dosis bajas repetidas para el tratamiento del TDAH en adultos.
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @NatRevNeurol: "LSD was not efficacious in reducing ADHD symptoms compared with placebo; these results question the anecdotal practice a…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
RT @rogersmcintyre: Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed stud…
Microdosing LSD in the treatment of ADHD not more effective than placebo It’s important that these negative/failed studies are published provide us with a comprehensive perspective of the potential of psychedelics in psychiatry https://t.co/VvhXJphX5t
@Psyched_Alpha 20 μg is closer to a museum dose rather than a microdose. Title of paper: “Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults” https://t.co/g094Qi3z3X
"LSD was not efficacious in reducing ADHD symptoms compared with placebo; these results question the anecdotal practice and highlight the importance of placebo-controlled trials in low-dose psychedelic research" https://t.co/o5Z7SdbDDQ
RT @ElPaido: ¿Las personas con TDAH deberían considerar la microdosificación o es solo un placebo con riesgos innecesarios? https://t.co/s…
ADHD症状に対する低用量LSDの有効性は認められなかった。 Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults https://t.co/ZVrFlimBTM
Interesting.. 20 ug of LSD 2x per week does not reduce ADHD symptoms compared to placebo.... LSD group presented a mean AISRS improvement of −7.1 points. The placebo group presented a mean AISRS improvement of −8.9 points.. https://t.co/06EN5Ns5yK
Low dose LSD doesn't help ADHD symptoms pubmed.ncbi.nlm.nih.gov/40105807/ We seem to have reached the "why not try it for X?" stage of psychedelic therapy
(JAMA Psychiatry) Seguridad y eficacia del LSD a dosis bajas repetidas para el tratamiento del TDAH en adultos.
RT @Psyched_Alpha: The study was published in JAMA Psychiatry today. https://t.co/iq7f4GlLG0
The study was published in JAMA Psychiatry today. https://t.co/iq7f4GlLG0
JAMAってトップジャーナルの最新でADHDにLSDマイクロドーズの研究出ていたな。結果、イマイチぽいな
¿Las personas con TDAH deberían considerar la microdosificación o es solo un placebo con riesgos innecesarios? https://t.co/sK25bjriXN
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
دوز پایین LSD دو بار در هفته به مدت 6 هفته، علائم ADHD در بزرگسالان را نسبت به دارونما به طور قابل توجهی کاهش نمیدهد. این نتایج، اثربخشی میکرو دوزینگ روانگردانها در درمان ADHD را مورد سوال قرار میدهد. https://t.co/Sn6P6vC1pm
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
New Study: Microdosing LSD is no better than placebo in treating ADHD. https://t.co/PEyKG7SZZa
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
RT @JAMAPsych: Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning…
Twice-weekly low-dose LSD over 6 weeks did not significantly reduce ADHD symptoms in adults compared to placebo, questioning the efficacy of microdosing psychedelics for ADHD. https://t.co/DS3p9XnpOc https://t.co/7UbsLrrET2