Biol Psychiatry October 2025 PMID 40131256

Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence.

Naghmeh Nikkheslat, Zuzanna Zajkowska, Cristina Legido-Quigley, Jin Xu, Pedro H Manfro, Laila Souza, Rivka Pereira, Fernanda Rohrsetzer, Jader Piccin, Anna Viduani, Brandon A Kohrt, Helen L Fisher, Christian Kieling, Valeria Mondelli

Mentions

25
Peak: 4 in Mar 2025
across 3 sources since Mar 2025

Extended reach

6,566
potential audience

Total likes

3

Video views

23

Mentions per month

Mar 2025 – Sep 2025

Where it's discussed

  • News18 articles
  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions demonstrate high interest with enthusiastic phrases like 'our NEW paper is out,' alongside mentions of how the study explains gender differences in depression. The tone varies from casual to slightly more analytical, reflecting curiosity about biological mechanisms and their implications, which justifies the moderate scores across all dimensions.

AgreementModerate agreement

Most discussions acknowledge the study's findings, especially the link between the kynurenine pathway and adolescent depression, showing general support.

InterestHigh interest

Posts express high curiosity and enthusiasm, particularly with phrases like 'our NEW paper is out' and mentioning the significance of the biological mechanisms involved.

EngagementModerate engagement

Some discussions delve into potential implications, such as understanding why depression rates are higher among girls, indicating moderate engagement with the content's depth.

ImpactModerate impact

The conversation hints at the potential for this research to influence future studies or treatments, but practical applications are not heavily emphasized.

Abstract in brief

  • The study investigates how sex-specific changes in the kynurenine pathway, which involves neuroactive metabolites, are linked to risk and remission of depression during adolescence, revealing that females with depression show lower levels of neuroprotective metabolites compared to males.
  • Findings from a longitudinal study showed that adolescents at high risk or with depression had altered kynurenine metabolites, especially in females, indicating a potential biological marker for depression risk and persistence related to immune system activity.
  • Reduced neuroprotective and increased neurotoxic metabolites in the kynurenine pathway were associated with higher risk and persistence of depression in female adolescents, suggesting that these metabolic changes may influence the course of adolescent depression in a sex-specific manner.

Top posts

Most liked on X and Bluesky
Patología Dual
@SEPD_es · X

Un nuevo estudio encuentra que la vía de la quinurenina influye en el desarrollo de la depresión durante la adolescencia, lo que podría ayudar a comprender por qué hay una mayor incidencia de este trastorno mental entre las chicas. https://t.co/eQtGF17oA0

Mar 27, 2025 · 2 likes · 5,087 followers View post →
Dr Naghmeh Nikkheslat
@nik_naghmeh · X

Our NEW paper is out

Mar 26, 2025 · 1 like · 230 followers View post →
Orchid Advocacy
@OrchidAdvocacy · X

Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adol… https://t.co/V4OPgoyekC

Apr 15, 2025 · 764 followers View post →
Genç İVEK
@gencivek · X

"Bilimde Bu Hafta" köşemiz 30/03/2025 - 06/04/2025 1.Depresyonun Cinsiyet Farkı Beyindeki Bu Mekanizmada Saklı Link:https://t.co/k0BOXwWfu1 2.Kilo Kaybında Daha Etkili Bir Sonuç ;4:3 Aralıklı Oruç Link: https://t.co/tz8CVr82Gc https://t.co/DxlUY8w925

Apr 6, 2025 · 356 followers View post →

All mentions

Ingentium
@Ingentium_Inc · X

Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence. https://t.co/OizJqgVvCW https://t.co/3AxzYep8u2

Sep 6, 2025 · 107 followers View post →
Orchid Advocacy
@OrchidAdvocacy · X

Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adol… https://t.co/V4OPgoyekC

Apr 15, 2025 · 764 followers View post →
Genç İVEK
@gencivek · X

"Bilimde Bu Hafta" köşemiz 30/03/2025 - 06/04/2025 1.Depresyonun Cinsiyet Farkı Beyindeki Bu Mekanizmada Saklı Link:https://t.co/k0BOXwWfu1 2.Kilo Kaybında Daha Etkili Bir Sonuç ;4:3 Aralıklı Oruç Link: https://t.co/tz8CVr82Gc https://t.co/DxlUY8w925

Apr 6, 2025 · 356 followers View post →
Patología Dual
@SEPD_es · X

Un nuevo estudio encuentra que la vía de la quinurenina influye en el desarrollo de la depresión durante la adolescencia, lo que podría ayudar a comprender por qué hay una mayor incidencia de este trastorno mental entre las chicas. https://t.co/eQtGF17oA0

Mar 27, 2025 · 2 likes · 5,087 followers View post →
Dr Naghmeh Nikkheslat
@nik_naghmeh · X

Our NEW paper is out

Mar 26, 2025 · 1 like · 230 followers View post →