Nat Metab March 2025 PMID 40140714

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.

Sandhya P Chakravartti, Kay Jann, Ralf Veit, Hanyang Liu, Alexandra G Yunker, Brendan Angelo, John R Monterosso, Anny H Xiang, Stephanie Kullmann, Kathleen A Page

Mentions

366
Peak: 21 in Apr 2025
across 7 sources since Mar 2025

Extended reach

483,973
potential audience

Total likes

2,085

Video views

53,384

Mentions per month

Mar 2025 – Aug 2025

Where it's discussed

  • News298 articles
  • X / Twitter47 posts
  • Blogs10 articles
  • YouTube5 videos
  • Reddit3 posts
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The comments reflect a strong curiosity and concern about how non-caloric sweeteners like sucralose may stimulate appetite through brain connectivity changes, evidenced by phrases such as 'increase in hypothalamic blood flow' and warnings like 'beware diet drinks.' The tone varies from scientific and analytical to cautious and skeptical, showing an engaged audience that recognizes the potential influence of these findings but also questions their broader implications.

AgreementNeither agree nor disagree

The discussions generally acknowledge the findings but show mixed views on their implications, with some posts supporting the idea that artificial sweeteners influence appetite regulation, while others remain cautious or skeptical.

InterestHigh interest

Most discussions express high interest, with users engaging actively in sharing the research's details, potential health impacts, and related debates.

EngagementModerate engagement

Posts include detailed summaries of the study, references to specific brain mechanisms, and mention of broader health contexts, indicating a moderate level of analytical engagement.

ImpactModerate impact

While some posts suggest the research could influence dietary choices and public health policies, other discussions remain exploratory, so the perceived overall impact is moderate.

Abstract in brief

  • Noncaloric sweeteners like sucralose can stimulate appetite by activating brain regions involved in hunger, even without providing calories.
  • Consuming sucralose increases blood flow in the hypothalamus and alters brain connectivity related to motivation and sensory processing, but does not directly increase hunger ratings as sucrose does.
  • While sucrose raises blood sugar and decreases hypothalamic blood flow, sucralose does not significantly affect glucose levels, indicating different mechanisms behind their influence on appetite and brain activity.

Top posts

Most liked on X and Bluesky
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolism https://t.co/IMB3plqePq

Mar 26, 2025 · 19 likes · 4 shares · 6,432 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights “Sucralose, compared to sucrose and water, results in increased functional connections between the hypothalamus and brain regions involved in motivation and somatosensory

Apr 2, 2025 · 13 likes · 3 shares · 41,232 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaWZT

May 2, 2025 · 12 likes · 5 shares · 41,232 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaWZT https://t.co/Gw0gmFOjsX

Apr 3, 2025 · 7 likes · 1 share · 41,232 followers View post →
Cardio
@PesarCardio · X

سوکرالوز یک شیرین‌کننده‌ی بدون کالری پرکاربرد، میتونه با تأثیر روی هیپوتالاموس حتی بدون افزایش قند خون باعث افزایش احساس گرسنگی بشه و تنظیم اشتها رو مختل کنه. مصرف شیرین‌کننده‌های بدون کالری ممکنه برخلاف تصور، به افزایش اشتها و احتمالاً پرخوری منجر بشه. https://t.co/2kLMpRCVYq

Mar 26, 2025 · 7 likes · 1,140 followers View post →
Neil Floch MD
@NeilFlochMD · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/MkIuWhFi2c

Mar 27, 2025 · 6 likes · 1 share · 130,111 followers View post →

All mentions

Dr Facts
@AndrewDewey · X

@esaagar : https://t.co/u4AYNoDmlm

Aug 17, 2025 · 342 followers View post →
お茶柱/心理学のべレスク
@otea_stalk · X

【Co】人工甘味料で脳がバグる? 体型の異なる成人75人の脳をスキャン スクラロース摂取で、視床下部の血流が増加 主観的空腹感も増加 他の脳領域と機能的結合が変化 スクロールでは、血糖値が上昇し視床下部の血流が減少、満腹感が増加 特に肥満女性で悪影響が大きい https://t.co/YYnZsQ74el

Jul 10, 2025 · 18 followers View post →
お茶柱/心理学のべレスク
@otea_stalk · X

【RCT】人工甘味料はダイエットに逆効果!? 75人にスクラロース飲料を飲んだ脳を調査 視床下部の血流が少し増えただけ 空腹感は、ただの水を飲んだ場合とほぼ同じ https://t.co/YYnZsQ6woN

Jun 11, 2025 · 18 followers View post →
Maciel Tomio
@MacielTomio · X

Ref.: https://t.co/VtMNj9fEQs

Jun 8, 2025 View post →
Isao Uno(宇野勲)/リハ栄養指導士/栄養嚥下理学療法
@isao_reha_nutri · X

若年成人では、スクラロース(ノンカロリー甘味料)はスクロースと比較して、血糖値は上昇させずに視床下部の血流を増加させ、視床下部と脳の「動機づけ」「感覚処理」の領域との結びつきを強化させたそうです。 https://t.co/xMoPUkpVPV

Jun 2, 2025 · 1 like · 1,834 followers View post →
Peeref
@Peeref1 · X

May 30, 2025 · 161 followers View post →
Canadian Sugar Institute Nutrition Info Centre
@CdnSugarNutr · X

DYK? Sucralose may stimulate appetite by disrupting normal brain signals that regulate hunger. In a crossover trial, it increased hypothalamic blood flow & altered brain connectivity vs. sucrose or water.

May 20, 2025 · 610 followers View post →
Soheil Saeedi
@SoheilSaeedi5 · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

May 2, 2025 · 5 shares · 395 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

May 2, 2025 · 5 shares · 188 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

May 2, 2025 · 5 shares · 1,061 followers View post →
Dr Richard Palmquist
@DrRPalmquist · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

May 2, 2025 · 5 shares · 4,729 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

May 2, 2025 · 5 shares · 133 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaWZT

May 2, 2025 · 12 likes · 5 shares · 41,232 followers View post →
OnlyHalfKorean
@OnlyHalfKorean · X

RT @AeroUprising19: Here is your interesting read for the day: Non-caloric sweeteners in “diet” drinks actually lead to increased appetite…

Apr 17, 2025 · 1 share · 215 followers View post →
Aero Uprising
@AeroUprising19 · X

Here is your interesting read for the day: Non-caloric sweeteners in “diet” drinks actually lead to increased appetite https://t.co/IbpgHYjgvy

Apr 17, 2025 · 1 like · 1 share · 810 followers View post →
RRID Robot
@rridrobot.bsky.social · Bluesky

A paper using RRID:SCR_009550 was just published in Nature Metabolism see "Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights". Thank you for making your methods matter! #reproducibility #ReproducibleResearch

Apr 10, 2025 · 1 like View post →
&NAME™︎
@andidentifier · X

RT @keita_masui: 人工甘味料水は、砂糖水よりも、より空腹感をもたらすとの研究結果。本末転倒だ。。。 Chakravartti, S.P., Jann, K., Veit, R. et al. Non-caloric sweetener effects on br…

Apr 7, 2025 · 2 shares · 87 followers View post →
Tatsuhiko Fujimoto
@Tatsu_Fujimoto · X

RT @keita_masui: 人工甘味料水は、砂糖水よりも、より空腹感をもたらすとの研究結果。本末転倒だ。。。 Chakravartti, S.P., Jann, K., Veit, R. et al. Non-caloric sweetener effects on br…

Apr 7, 2025 · 2 shares · 4,811 followers View post →
Keita Masui
@keita_masui · X

人工甘味料水は、砂糖水よりも、より空腹感をもたらすとの研究結果。本末転倒だ。。。 Chakravartti, S.P., Jann, K., Veit, R. et al. Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights. Nat Metab 7, 574–585 (2025).

Apr 7, 2025 · 6 likes · 2 shares · 4,261 followers View post →
sumico@多趣味なアラサー♀
@sumico55895357 · X

RT @NatureJapan: Kathleen A. Pageらのノンカロリー甘味料が脳の食欲調節に及ぼす影響に関する@NatMetabolism #論文 Non-caloric sweetener effects on brain appetite regulation…

Apr 7, 2025 · 3 shares · 467 followers View post →
備忘録
@bibourokuabc · X

RT @NatureJapan: Kathleen A. Pageらのノンカロリー甘味料が脳の食欲調節に及ぼす影響に関する@NatMetabolism #論文 Non-caloric sweetener effects on brain appetite regulation…

Apr 6, 2025 · 3 shares · 230 followers View post →
Trigonal
@tuttavia07 · X

RT @NatureJapan: Kathleen A. Pageらのノンカロリー甘味料が脳の食欲調節に及ぼす影響に関する@NatMetabolism #論文 Non-caloric sweetener effects on brain appetite regulation…

Apr 6, 2025 · 3 shares · 74 followers View post →
Nature Japan
@NatureJapan · X

Kathleen A. Pageらのノンカロリー甘味料が脳の食欲調節に及ぼす影響に関する@NatMetabolism #論文 Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/dwFX7pDqSX 閲覧用リンク:https://t.co/TJsVRfEGRp @USC @uni_tue https://t.co/ZP4VdMVIji

Apr 6, 2025 · 4 likes · 3 shares · 90,045 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism, 4 Jul 24 https://t.co/IhvOfNONWH

Apr 4, 2025 · 360 followers View post →
matiere*
@matiere · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/Vt6oOct6J5 Published 26 March 2025

Apr 4, 2025 · 2,831 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaW…

Apr 3, 2025 · 1 share · 133 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights “Sucralose, compared…

Apr 3, 2025 · 3 shares · 133 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/CArzfdaWZT https://t.co/Gw0gmFOjsX

Apr 3, 2025 · 7 likes · 1 share · 41,232 followers View post →
সামর্থ । ⊿³ ⟭⟬
@SimpCore6899 · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights “Sucralose, compared…

Apr 3, 2025 · 3 shares · 187 followers View post →
r b
@rb2928694234933 · X

RT @agingdoc1: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights “Sucralose, compared…

Apr 2, 2025 · 3 shares · 462 followers View post →
Agingdoc
@agingdoc1 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights “Sucralose, compared to sucrose and water, results in increased functional connections between the hypothalamus and brain regions involved in motivation and somatosensory

Apr 2, 2025 · 13 likes · 3 shares · 41,232 followers View post →
Mady Hornig, MA, MD
@mhornig · X

Beware diet drinks if you care about your hypothalamus and how it regulates appetite (

Apr 1, 2025 · 3 likes · 1 share · 2,974 followers View post →
Chilalausunai™
@chilalausunai · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/TQstTeRBGN

Apr 1, 2025 · 225 followers View post →
IFFN
@iffnmanchester · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights https://t.co/GiYRVVJyIQ @NatMetabolism

Mar 31, 2025 · 4,230 followers View post →
サイエンスあれこれ
@sarekore · X

レベル、空腹感にどのような変化をもたらすかを調べるため、75人の男女に対し無作為化試験を行った結果、スクラロースが空腹に関連する脳の活動を変化させ、特に肥満の人々の食欲を増進させることがわかりました。Nature Metabolism誌https://t.co/c1iBLfj86h

Mar 28, 2025 · 1 like · 922 followers View post →
Alberto Dias Filho
@albertodiasf · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism ⁦@DrNadolsky⁩ https://t.co/sL3J0ya2pu

Mar 27, 2025 · 231 followers View post →
Rahman LAB
@rahmanLAB2023 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/ITLUI7TQTj

Mar 27, 2025 · 210 followers View post →
Beverly G. Tchang, MD
@BevTchangMD · X

RT @NeilFlochMD: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism…

Mar 27, 2025 · 1 share · 6,103 followers View post →
Neil Floch MD
@NeilFlochMD · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/MkIuWhFi2c

Mar 27, 2025 · 6 likes · 1 share · 130,111 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Brunorm84: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolis…

Mar 27, 2025 · 4 shares · 188 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @Brunorm84: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolis…

Mar 27, 2025 · 4 shares · 32,533 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @Brunorm84: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolis…

Mar 26, 2025 · 4 shares · 1,423 followers View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @Brunorm84: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolis…

Mar 26, 2025 · 4 shares · 3,345 followers View post →
Mahendra Singh, PhD
@mksin149 · X

Sugar substitutes make you feel more hungry? Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | Nature Metabolism https://t.co/yE0VOZYxMe

Mar 26, 2025 · 248 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights #obesity @NatMetabolism https://t.co/IMB3plqePq

Mar 26, 2025 · 19 likes · 4 shares · 6,432 followers View post →
Alper Aydın (Dietitian )
@aydinnalper · X

RT @IsraelPodesta: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | ⁦@NatMetabolism⁩…

Mar 26, 2025 · 1 share · 1,426 followers View post →
Israel Podesta, PhD
@IsraelPodesta · X

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights | ⁦@NatMetabolism⁩ https://t.co/sQHfXXWvyN

Mar 26, 2025 · 1 like · 1 share · 381 followers View post →
Cardio
@PesarCardio · X

سوکرالوز یک شیرین‌کننده‌ی بدون کالری پرکاربرد، میتونه با تأثیر روی هیپوتالاموس حتی بدون افزایش قند خون باعث افزایش احساس گرسنگی بشه و تنظیم اشتها رو مختل کنه. مصرف شیرین‌کننده‌های بدون کالری ممکنه برخلاف تصور، به افزایش اشتها و احتمالاً پرخوری منجر بشه. https://t.co/2kLMpRCVYq

Mar 26, 2025 · 7 likes · 1,140 followers View post →