Physiol Rev July 2025 PMID 40173020

A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise.

Erik A Richter, Philip J Bilan, Amira Klip

Mentions

186
Peak: 111 in Nov 2025
across 6 sources since Apr 2025

Extended reach

442,473
potential audience

Total likes

566

Video views

278

Mentions per month

Apr 2025 – Nov 2025

Where it's discussed

  • X / Twitter172 posts
  • Facebook6 posts
  • Instagram3 posts
  • YouTube2 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions demonstrate high enthusiasm and support for the review, with comments praising its comprehensiveness and relevance, such as calling it 'our most comprehensive review ever' and emphasizing the importance of GLUT4 transporters in health, disease, and sports, which reflect both high interest and perceived impact. The tone is positive, with some references to ongoing research collaborations, showing engagement and recognition of its significance.

AgreementStrong agreement

Most discussions express strong support and appreciation for the article's comprehensive review and significance to understanding muscle glucose regulation.

InterestHigh interest

Participants show high curiosity, often referencing related concepts like GLUT4 and metabolic health, indicating engaged interest.

EngagementModerate engagement

Posts reference detailed mechanisms, such as insulin’s role and muscle contractile activity, suggesting moderate-to-deep engagement.

ImpactHigh impact

Several comments highlight the article’s potential to influence research, clinical practices, and athletic performance, emphasizing its high impact.

Abstract in brief

  • Skeletal muscle is crucial for glucose uptake during meals and exercise, with glucose transport across muscle cell membranes being the limiting factor.
  • The translocation of the glucose transporter GLUT4, influenced by insulin and muscle contractions, is essential for glucose utilization in muscle cells.
  • Advances in bioinformatics and -omics technologies are enhancing our understanding of the complex molecular signaling processes regulating glucose metabolism, but validating these findings in human physiology is crucial for future research.

Top posts

Most liked on X and Bluesky
Antonio García-Hermoso
@a_garciahermoso · X

Revisión

Nov 4, 2025 · 299 likes · 93 shares · 9,461 followers View post →
Erik A. Richter
@proferikrichter · X

Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society https://t.co/JglfXP3Q3T

Apr 12, 2025 · 117 likes · 37 shares · 2,282 followers View post →
Jeremy Loenneke
@jploenneke · X

A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise https://t.co/K1sJyxauS0

Jun 5, 2025 · 38 likes · 11 shares · 8,592 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB4m6tUXma

Apr 3, 2025 · 38 likes · 18 shares · 3,945 followers View post →
Brian A. Irving, PhD, FACSM
@MitoPhys · X

Beautiful review. A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise | Physiological Reviews | American Physiological Society https://t.co/nlpv8HcBDB

Nov 3, 2025 · 35 likes · 7 shares · 1,381 followers View post →
Walter Suárez Carmona
@a_fisiolog57853 · X

https://t.co/laAdWkffm5

Nov 4, 2025 · 14 likes · 4 shares · 4,169 followers View post →

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RT @MVAitor: Understanding GLUT4 transporter and its role is critical to understand metabolism in health, disease and sports performance.…

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Beautiful review. A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise | Physiological Reviews | American Physiological Society https://t.co/nlpv8HcBDB

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A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise https://t.co/K1sJyxauS0

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A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society https://t.co/zJqAELSvFD

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Simone Porcelli
@PorcelliSimone · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 13, 2025 · 37 shares · 1,694 followers View post →
Matteo Fiorenza
@Matteo_Fiorenza · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 13, 2025 · 37 shares · 509 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 13, 2025 · 37 shares · 158,274 followers View post →
Argón
@metilargon · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 13, 2025 · 37 shares · 351 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 403 followers View post →
Alan Hayes
@alan_hayes_vu · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 206 followers View post →
Luis PENAILILLO
@LPENAILILLO · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 817 followers View post →
Eli
@Eli26669331 · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 37 followers View post →
Thomas E. Jensen
@tejensen23 · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 1,189 followers View post →
CB
@cebentrena · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 395 followers View post →
Koushik
@koushikphysio · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 520 followers View post →
Israel Podesta, PhD
@IsraelPodesta · X

A Comprehensive View of #Muscle #Glucose Uptake: Regulation by #Insulin , Contractile Activity and #Exercise ⁦@proferikrichter⁩ https://t.co/D081YBo35g

Apr 12, 2025 · 383 followers View post →
Joe Gordon
@josephwgordon · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 2,113 followers View post →
Arthur Cheng
@chenglabyorku · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 535 followers View post →
Gonzalo Marquez
@gmarquez_11 · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 966 followers View post →
José Antonio Benítez Muñoz
@jabenitezm4 · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 434 followers View post →
Alfonso Moreno-Cabañas
@AlfonsoMC_ · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 468 followers View post →
Samantha Gallero
@sgallero_ · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 77 followers View post →
Michael Riddell, PhD
@MCRiddell1 · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 3,309 followers View post →
Mitchell Sammut
@SammutMitchell · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 196 followers View post →
daniel varela PhD
@dr_dvarela_P4T · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 920 followers View post →
Eve Beavers-Fain BSN MPH
@espacetimeNOT · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 1,206 followers View post →
Wouter Franssen
@FranssenWouter_ · X

RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle…

Apr 12, 2025 · 37 shares · 78 followers View post →
Erik A. Richter
@proferikrichter · X

Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society https://t.co/JglfXP3Q3T

Apr 12, 2025 · 117 likes · 37 shares · 2,282 followers View post →
Qinlong Liu
@QinlongLiu · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 7, 2025 · 18 shares · 23 followers View post →
Adrián González
@adriangbonilla · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 5, 2025 · 18 shares · 35 followers View post →
AnastasiaGrace
@Alihouston92 · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 5, 2025 · 18 shares · 83 followers View post →
Thomas E. Jensen
@tejensen23 · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 5, 2025 · 18 shares · 1,189 followers View post →
Carlos Henríquez-Olguin
@MuscleBiology · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 3,151 followers View post →
Kristopher Mendes de Souza
@KristopherDoc · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 67 followers View post →
David Estébanez
@trinotas · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 228 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 1,073 followers View post →
Hec
@Muscles_n_Mitos · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 63 followers View post →
CB
@cebentrena · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 395 followers View post →
Fourth Grace
@EuphrosMD · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 37 followers View post →
daniel varela PhD
@dr_dvarela_P4T · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 4, 2025 · 18 shares · 920 followers View post →
Matthew Stratton PhD
@MTSstrength89 · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 3, 2025 · 18 shares · 165 followers View post →
Viviana
@VivianAya93 · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 3, 2025 · 18 shares · 133 followers View post →
Dave Hughes
@HughesDC_Muscle · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 3, 2025 · 18 shares · 11,010 followers View post →
Rafael Casuso
@rafaelcasuso · X

RT @CraigAGoodman1: A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB…

Apr 3, 2025 · 18 shares · 431 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise https://t.co/MB4m6tUXma

Apr 3, 2025 · 38 likes · 18 shares · 3,945 followers View post →
Craig A. Goodman
@craigagoodman1.bsky.social · Bluesky

A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise journals.physiology.org/doi/abs/10.1...

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