Lancet April 2025 PMID 40174598

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial.

William F Fearon, Frederik M Zimmermann, Victoria Y Ding, Kuniaki Takahashi, Zsolt Piroth, Albert H M van Straten, Laszlo Szekely, Giedrius Davidavičius, Gintaras Kalinauskas, Samer Mansour, Rajesh Kharbanda, Nikolaos Östlund-Papadogeorgos, Adel Aminian, Keith G Oldroyd, Nawwar Al-Attar

Mentions

30
Peak: 11 in Apr 2025
across 5 sources since Mar 2025

Extended reach

752,261
potential audience

Total likes

40

Video views

660

Mentions per month

Mar 2025 – May 2025

Where it's discussed

  • X / Twitter14 posts
  • News8 articles
  • Blogs4 articles
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions demonstrate high interest through mentions of the 5-year follow-up and overall significance of outcomes, with some comments referencing the detailed methodology and potential influence on clinical practice, showing a moderate level of engagement and recognition of impact.

AgreementModerate agreement

Most discussions acknowledge the study results, highlighting that both PCI and CABG have similar long-term outcomes, indicating general agreement with the findings.

InterestHigh interest

Participants show high interest, often referencing key aspects like 5-year follow-up and significance for treatment decisions, which suggests engagement with the clinical implications.

EngagementModerate engagement

There are mentions of details like the trial's multicenter design and calls for further research, indicating moderate to deep engagement beyond surface-level commentary.

ImpactModerate impact

Some discussions emphasize the importance of the study for future clinical guidelines and practice, reflecting a moderate impact perception.

Abstract in brief

  • The FAME 3 trial analyzed the long-term effectiveness of FFR-guided PCI versus CABG in patients with three-vessel coronary artery disease over a 5-year period, involving multiple hospitals across Europe, the USA, Canada, Australia, and Asia.
  • Results showed no significant differences in major adverse outcomes (death, stroke, or myocardial infarction) between the PCI and CABG groups, with 16% of PCI patients and 14% of CABG patients experiencing these events by the end of the study.
  • The trial's findings indicate that both treatment options have similar long-term outcomes, as the rates of death and other complications were comparable for both techniques, suggesting that advancements in care did not

Top posts

Most liked on X and Bluesky
The Lancet
@TheLancet · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial https://t.co/a3xAnYGTOB https://t.co/ryWfDTjdsX

Apr 29, 2025 · 10 likes · 2 shares · 735,244 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Best ACC 2025 Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting 5-year follow-up no significant difference in a composite outcome of death, stroke, or myocardial infarction https://t.co/UEvyCg5QIn

Apr 2, 2025 · 7 likes · 2,637 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up At the 5-year follow-up, there was no significant difference of death, stroke, or myocardial infarction https://t.co/UEvyCg5iSP

Mar 30, 2025 · 2 likes · 2,637 followers View post →
Christian Caroli
@DrCCaroli · X

✨Great evidence summaries in a unique format! Subscribe to the YouTube channel Evidence-Based Cardiology Talks

Apr 28, 2025 · 2 likes · 2,403 followers View post →
Latidos Con Ciencia
@latidoscc · X

May 4, 2025 · 2 likes · 1 share · 4 followers View post →
Dr. Pedro A. Carrillo Moreno
@cardiodocpedro · X

RT @latidoscc:

May 4, 2025 · 1 share · 4,253 followers View post →

All mentions

Dr. Pedro A. Carrillo Moreno
@cardiodocpedro · X

RT @latidoscc:

May 4, 2025 · 1 share · 4,253 followers View post →
Latidos Con Ciencia
@latidoscc · X

May 4, 2025 · 2 likes · 1 share · 4 followers View post →
Danni Morinich-Content Ed Net US
@DanniReprints · X

New from @TheLancet Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3) #AbbottCardiovascular #OmniWire #Philips #pressurewire contact me for reprints https://t.co/3zssYZkMU3

May 1, 2025 · 16 followers View post →
Weise
@weisse_Ok · X

RT @TheLancet: Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAM…

May 1, 2025 · 2 shares · 22 followers View post →
Guy-Stone, MD, MPH
@MPH_Stone · X

RT @TheLancet: Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAM…

Apr 29, 2025 · 2 shares · 600 followers View post →
The Lancet
@TheLancet · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial https://t.co/a3xAnYGTOB https://t.co/ryWfDTjdsX

Apr 29, 2025 · 10 likes · 2 shares · 735,244 followers View post →
Christian Caroli
@DrCCaroli · X

✨Great evidence summaries in a unique format! Subscribe to the YouTube channel Evidence-Based Cardiology Talks

Apr 28, 2025 · 2 likes · 2,403 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

"Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial." Publié ce jour dans @thelancet.bsky.social #MedSky #CardioSky www.thelancet.com/journals/lan...

Apr 26, 2025 View post →
トンヌラ
@37phoenix · X

FFRガイドのPCIはCABGと比較して死亡、脳卒中、心筋梗塞の複合アウトカムに有意差はなかった。MIや血行再建はPCIで多かった。FAME3試験。Lancet. PMID: 40174598. https://t.co/yzRUMwobqM

Apr 25, 2025 · 2,045 followers View post →
Un1v3rs0 Z3r0
@Un1v3rs0Z3r0 · X

[Articles] Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial https://t.co/RJrM7LyYLq

Apr 24, 2025 · 511 followers View post →
Société Française de Cardiologie
@societe69849 · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial

Apr 10, 2025 · 5 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Best ACC 2025 Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting 5-year follow-up no significant difference in a composite outcome of death, stroke, or myocardial infarction https://t.co/UEvyCg5QIn

Apr 2, 2025 · 7 likes · 2,637 followers View post →
Abstream
@abstreamme · X

[Articles] Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial #science #publication #research #publications https://t.co/uojE3irfEK

Mar 31, 2025 · 788 followers View post →
Ahmad Awan
@ArmoghanMD · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial - The Lancet https://t.co/2OTRY0zFQs

Mar 31, 2025 · 421 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up At the 5-year follow-up, there was no significant difference of death, stroke, or myocardial infarction https://t.co/UEvyCg5iSP

Mar 30, 2025 · 2 likes · 2,637 followers View post →