Aging (Albany NY) April 2025 PMID 40188830

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.

Mauricio Moel, Girish Harinath, Virginia Lee, Andy Nyquist, Stefanie L Morgan, Anar Isman, Sajad Zalzala

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Mentions

Peak: 23 in May 2025

across 7 sources since Apr 2025

Extended reach

1,052,257

potential audience

Total likes

131

Video views

342

Mentions per month

Apr 2025 – Dec 2025

Where it's discussed

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AI synopsis

What people are saying

This collection of discussions highlights a generally positive and interested outlook on the PEARL trial results, with mentions of the safety profile, benefits for women such as increased lean mass, and the broader implications for aging research. Words like 'gained,' 'benefits,' and 'relatively safe' reflect optimistic tone and focus on health implications, whereas references to specific data and notable authors demonstrate a moderate level of deep engagement.

AgreementModerate agreement

Most discussions appear to support the findings, emphasizing the safety and potential benefits of rapamycin.

InterestHigh interest

The discussions show high curiosity and focus on healthspan improvement, particularly in relation to the trial results.

EngagementModerate engagement

Participants reference specific outcomes like lean mass gain and safety, indicating moderate engagement.

ImpactModerate impact

The emphasis on novel research and potential health benefits suggests moderate influence on ongoing science and health practices.

Abstract in brief

A 48-week trial tested the safety and health effects of low-dose rapamycin in healthy adults, finding it generally safe with no increase in adverse events and stable visceral fat levels.
Women taking 10 mg rapamycin experienced significant improvements in lean tissue mass and reduced pain, while both dosage groups reported better emotional wellbeing and overall health.
The results suggest that intermittent low-dose rapamycin is relatively safe and may provide benefits for healthspan, but further research is needed to explore different doses and long-term effects.

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Rapamycin's Safety and Benefits for Aging and Longevity

This 48-week trial evaluated the safety of low-dose rapamycin in healthy adults, showing it's generally safe with potential healthspan benefits, including improved lean tissue and emotional wellbeing in some cases.

Aging-US · Sep 26, 2025 180 views

Rapamycin's Impact on Safety and Healthspan in a 48-Week Trial

A 48-week trial evaluated the safety and health effects of low-dose rapamycin in healthy adults. Results indicate it is generally safe, with improvements in emotional wellbeing and lean tissue mass in women, suggesting…

Aging-US · May 7, 2025 162 views

Aging-US

@AgingJrnl · X

Dec 5, 2025 · 1 like · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

Dec 5, 2025 View post →

Carlos Ruiz

@crGenomics · X

RT @AgingJrnl:

Nov 27, 2025 · 1 share · 22 followers View post →

Aging-US

@AgingJrnl · X

Nov 26, 2025 · 2 likes · 1 share · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

Nov 26, 2025 View post →

Javier Gómez

@javiHistBuff · X

RT @AgingJrnl:

Nov 7, 2025 · 2 shares · 22 followers View post →

Aging-US

@AgingJrnl · X

#AgingShort:

Nov 7, 2025 · 1 like · 4,404 followers View post →

Reena Singh

@EndoReena · X

RT @AgingJrnl:

Nov 7, 2025 · 2 shares · 37 followers View post →

Aging-US

@AgingJrnl · X

Nov 7, 2025 · 2 shares · 4,404 followers View post →

Aging-US

@AgingJrnl · X

Nov 4, 2025 · 2 likes · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

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Aging-US

@AgingJrnl · X

Nov 1, 2025 · 3 likes · 4,404 followers View post →

Aging-US

@AgingJrnl · X

Oct 6, 2025 · 2 likes · 4,404 followers View post →

Phil

@EmenoguPhillip1 · X

RT @AgingJrnl:

Oct 2, 2025 · 1 share · 395 followers View post →

Phil

@EmenoguPhillip1 · X

https://t.co/um4lrb7Vrw @Potus

Oct 2, 2025 · 395 followers View post →

Aging-US

@AgingJrnl · X

Sep 26, 2025 · 4 likes · 1 share · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

Sep 26, 2025 View post →

Aging-US

@AgingJrnl · X

Sep 17, 2025 · 4 likes · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

Sep 17, 2025 View post →

Aging-US

@AgingJrnl · X

#AgingShort:

Sep 12, 2025 · 1 like · 4,404 followers View post →

Aging-US

@AgingJrnl · X

Sep 12, 2025 · 2 likes · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

#BehindtheStudy: Dr. Stefanie Morgan joins Dr. Robert Dudley from AgelessRx to discuss a #research paper she co-authored in Volume 17, Issue 4, titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.”

Sep 4, 2025 View post →

Aging-US

@AgingJrnl · X

#BehindtheStudy: Dr. Stefanie Morgan joins Dr. Robert Dudley @agelessrx_ to discuss a #research paper she co-authored in Volume 17, Issue 4, titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.”

Aug 6, 2025 · 3 likes · 4,404 followers View post →

Madam Mitochondria

@Madam_Mito · X

@ParrishLiz https://t.co/VqHkZ08biL

Jul 18, 2025 · 2 likes · 10,799 followers View post →

Aging-US

@AgingJrnl · X

Jul 7, 2025 · 3 likes · 4,404 followers View post →

Farah Darwish

@farah_lovescats · X

RT @AgingJrnl:

Jul 7, 2025 · 2 shares · 11 followers View post →

Aging-US

@AgingJrnl · X

#AgingShort:

Jul 7, 2025 · 2 likes · 4,404 followers View post →

QuantumAI+Crispr3D=QuInCy=QAI&C3D=LA

@1LEOOEL1 · X

RT @AgingJrnl:

Jul 7, 2025 · 2 shares · 2,935 followers View post →

Aging-US

@AgingJrnl · X

Jul 7, 2025 · 6 likes · 2 shares · 4,404 followers View post →

Aging-US

@AgingJrnl · X

Jun 6, 2025 · 3 likes · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

Dr. Stefanie Morgan joins Dr. Robert Dudley from AgelessRx to discuss a #research paper she co-authored in Volume 17, Issue 4 of Aging (Aging-US) titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.” www.youtube.com/watch?v=2qlI... #aging #rapamycin

Jun 6, 2025 View post →

The Longevist

@Dr_coachbear · X

RT @AgingBiology: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/Oahoo1LRr1

May 18, 2025 · 3 shares · 481,358 followers View post →

Lisa Vlad

@LisaVlad2 · X

RT @AgingBiology: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/Oahoo1LRr1

May 18, 2025 · 3 shares · 103 followers View post →

Agingdoc

@agingdoc1 · X

RT @agingdoc1: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results Mauricio Moel @AbolishAging, @S…

May 18, 2025 · 2 shares · 43,745 followers View post →

Aging Science News

@AgingBiology · X

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/Oahoo1LRr1

May 17, 2025 · 25 likes · 3 shares · 31,453 followers View post →

Aging Science News

@agingbiology.bsky.social · Bluesky

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results www.aging-us.com/article/2062...

May 17, 2025 View post →

Aging-US

@AgingJrnl · X

May 7, 2025 · 3 likes · 4,404 followers View post →

Aging-US

@AgingJrnl · X

#AgingShort:

May 7, 2025 · 3 likes · 4,404 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

May 7, 2025 View post →

Aging-US

@AgingJrnl · X

May 7, 2025 · 3 likes · 4,404 followers View post →

Hannah Scott

@covidhannah · X

RT @AgingJrnl:

May 7, 2025 · 1 share · 33 followers View post →

Aging-US

@AgingJrnl · X

May 7, 2025 · 2 likes · 1 share · 4,404 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/nRM1oQ2aeq

May 7, 2025 · 1 share · 130 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

May 7, 2025 View post →

Aging-US

@aging-us.bsky.social · Bluesky

May 7, 2025 View post →

Agingdoc

@agingdoc1 · X

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/nRM1oQ2aeq

May 7, 2025 · 8 likes · 1 share · 43,745 followers View post →

Aging Papers

@PapersAging · X

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results https://t.co/oBxyjV3xlQ

May 6, 2025 · 16 followers View post →

Aging-US

@aging-us.bsky.social · Bluesky

#AgingResearch: "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results" DOI ⬇️ doi.org/10.18632/agi... #aging #research #openaccess #openscience #peerreview #journal #publishing

May 5, 2025 View post →

Joshua Parker

@HealthTechJP · X

RT @AgingJrnl: #PaperoftheDay: "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results" DOI ⬇️ http…

May 5, 2025 · 2 shares · 20 followers View post →

Fadi Khalil

@fadi_grace · X

RT @AgingJrnl: #PaperoftheDay: "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results" DOI ⬇️ http…

May 5, 2025 · 2 shares · 1 followers View post →

Aging-US

@AgingJrnl · X

#PaperoftheDay: "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results" DOI ⬇️ https://t.co/dllFymyh0q #aging #research #openaccess #openscience #peerreview #journal #publishing

May 5, 2025 · 2 likes · 2 shares · 4,404 followers View post →

P.D. Mangan Health & Freedom Maximalist

@Mangan150 · X

Women who took 10 mg rapamycin weekly for a year *gained* lean mass. https://t.co/EjCuNSuSfo

Apr 16, 2025 · 21 likes · 1 share · 298,590 followers View post →

TimePie (focus on anti-aging science)

@TimePieChina · X

@SajadZMD and the team published the results of PEARL, a one-year human #rapamycin trial crowdfunded by @LifespanIO, finding the benefits were much stronger for women than men. https://t.co/tIXsHNZ9sS https://t.co/T6qVBuisQg

Apr 15, 2025 · 773 followers View post →

Orlando_uy

@Orlando_uy · X

Low-dose, intermittent rapamycin administration over 48 weeks is relatively safe in healthy, normative-aging adults, and was associated with significant improvements in lean tissue mass and pain in women. https://t.co/8hjeDrr6sC

Apr 15, 2025 · 1 like · 698 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results Mauricio Moel @AbolishAging, @S…

Apr 11, 2025 · 2 shares · 130 followers View post →

Agingdoc

@agingdoc1 · X

Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results Mauricio Moel @AbolishAging, @SZalzalaMD and co-authors | @AgingJrnl https://t.co/nRM1oQ2I3Y

Apr 9, 2025 · 14 likes · 2 shares · 43,745 followers View post →

Naomasa Kawashima

@NaomasaKawashim · X

https://t.co/ZASXiuNIxH

Apr 7, 2025 · 21 followers View post →

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Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Rapamycin's Safety and Benefits for Aging and Longevity

Rapamycin's Impact on Safety and Healthspan in a 48-Week Trial