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Cell April 2025 PMID 40199321

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety.

Byeongjun Lee, Jeong-Tae Kwon, Yire Jeong, Hannah Caris, Dongsun Oh, Mengyang Feng, Irene Davila Mejia, Xiaoying Zhang, Tomoe Ishikawa, Brianna R Watson, Jeffrey R Moffitt, Kwanghun Chung, Jun R Huh, Gloria B Choi

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Mentions

163
Peak: 96 in Apr 2025
across 7 sources since Apr 2025

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Total likes

398

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Mentions per month

Apr 2025 – Jul 2025

Where it's discussed

  • X / Twitter95 posts
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  • Bluesky9 posts
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AI synopsis

What people are saying

There are numerous discussions highlighting the role of IL-17A and IL-10 in modulating anxiety, with posts referencing their influence on neuron excitability. The tone is largely informative, with comments like 'growing evidence that immune molecules can influence behavior' showcasing a blend of excitement and seriousness. This conveys the perceived importance of the research findings, as participants show a keen interest in understanding how cytokines can affect mental health.

AgreementModerate agreement

Most discussions reflect a general support for the findings of the publication.

InterestHigh interest

Participants express strong curiosity about the implications of cytokine interactions.

EngagementModerate engagement

Some posts delve into specifics about the cytokines and their effects on anxiety.

ImpactHigh impact

Many contributors believe that the research will have significant implications for understanding anxiety disorders.

Abstract in brief

  • Patients with autoimmune or infectious diseases may experience long-lasting mood changes following inflammatory events, potentially influenced by immune molecules like cytokines.
  • Researchers found that certain cytokines, particularly IL-17A and IL-17C, can increase anxiety by making specific neurons in the basolateral amygdala (BLA) more active.
  • In contrast, the anti-inflammatory cytokine IL-10 reduces anxiety by decreasing the excitability of the same BLA neurons, illustrating how both inflammatory and anti-inflammatory signals can affect mood through different mechanisms in the brain.
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John Lukens
@LukensJohnR · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @CellCellPress https://t.co/HOI963g5PD https://t.co/9jS4HoYRIn

Apr 7, 2025 · 166 likes · 40 shares · 14,066 followers View post →
Cell
@CellCellPress · X

Now online! Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/SgcW3xA0OZ

Apr 12, 2025 · 79 likes · 16 shares · 263,098 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1Yk7zIsOy

Apr 20, 2025 · 47 likes · 14 shares · 4,745 followers View post →
John Lukens
@lukensjohnr.bsky.social · Bluesky

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

Apr 7, 2025 · 23 likes · 8 shares View post →
Agingdoc
@agingdoc1 · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/hTz3HrwmO5

May 4, 2025 · 16 likes · 2 shares · 41,394 followers View post →
Bertoglio lab (FMC/UFSC)
@bertogliolab · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/c7IPscC75n

Apr 7, 2025 · 15 likes · 5 shares · 1,714 followers View post →

All mentions

theo·brom·ananda ♃
@theobromananda · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/6uXUROKuef

Jun 26, 2025 · 1 like · 271 followers View post →
Rene Sugar
@renesugar.bsky.social · Bluesky

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety #MECFS #LongCovid www.cell.com/cell/abstrac... "- IL-17A/IL-17C raises BLAa neuron excitability via IL-17RA, inducing anxiety phenotypes"

Jun 23, 2025 · 1 like · 1 share View post →
Lisa
@lilLeeLee168 · X

RT @renesugar: @MVGutierrezMD New research on a cytokine called IL-17 adds to growing evidence that immune molecules can influence behavior…

Jun 4, 2025 · 1 share · 651 followers View post →
Rene Sugar
@renesugar · X

@MVGutierrezMD New research on a cytokine called IL-17 adds to growing evidence that immune molecules can influence behavior ... https://t.co/D4dSrcztkf Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/EmUteA7pus

Jun 2, 2025 · 1 like · 1 share · 3,959 followers View post →
Allison Martinez
@allison19xxx · X

RT @agingdoc1: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/hTz…

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Mind Your Science!
@MindYourSci · X

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Agingdoc
@agingdoc1 · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/hTz3HrwmO5

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igdhk
@5yymfH · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/d6RbRDitSZ Hello anxiety, you are not so bad for me. I'm always with you. You were IL17’s doing! Be nice to IL10 too...

May 2, 2025 · 1 like · 2 followers View post →
Javi Ibarrondo
@jibarrondo.bsky.social · Bluesky

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell www.cell.com/cell/fulltex...

May 1, 2025 · 13 likes · 5 shares View post →
Pon｜食と健康
@PonNutr · X

原著 Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety. Cell, 188(8), 2190–2202.e15. https://t.co/o748AmRTze

Apr 23, 2025 · 4 likes · 2,625 followers View post →
Gisela
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RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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John Walakira
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RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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xxy
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priya joseph
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AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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iArmandoVBaneado
@iArmandoVBanned · X

RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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Leonardo Viana
@leonardopviana · X

RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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Daniel S.
@asecretcrow · X

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Luis
@lulopson · X

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@ericsophia12 · X

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@ShamsPath · X

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Inmunología Animal vs Virología Animal
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RT @Pluchinolab: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1…

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Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/i1Yk7zIsOy

Apr 20, 2025 · 47 likes · 14 shares · 4,745 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/KLW3QCDbby

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drPatricioReyPsiquiatra
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Leonhard Schilbach
@leoschilbach · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/DC0MAucnXm

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octavio
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Luis
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xxy
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R.A
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RRID Robot
@rridrobot.bsky.social · Bluesky

A paper using RRID:Addgene_105553 was just published in Cell see "Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety". We appreciate the author's support of reproducibility. #accelerateopenscience #methodsmatter

Apr 13, 2025 · 1 like View post →
Frank Paul Mora
@InTime_49 · X

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Takei Lab
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/2vxMqmAyQp

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Cell
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Now online! Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/SgcW3xA0OZ

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BryanRoth
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/dB6YfTrsCz

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な bot
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[Cell] Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/YzSsQxneDy

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HeatWave
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Yuji Marutani Planning Director
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/bjys0fqFFx

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AngryPhDstudent❗️❗️❗️
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/uYCswSOyAS

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Jen Herman
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/ZrKH5DqAa0

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Jen Herman
@jukebarosh.bsky.social · Bluesky

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell www.cell.com/cell/fulltex...

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RT @LukensJohnR: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @CellCellPress…

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RT @LukensJohnR: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @CellCellPress…

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Áǫᴜɪʟᴀ
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RT @zenbrainest: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t…

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t.ishikawa
@T_y_Ishikawa · X

In the accompanying paper, we also showed that the IL-17 family modulates anxiety behavior by affecting neuronal functions in the amygdala. Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/wj27f9Bdp2

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K SEIRIKI
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/2Og0PN8OoN

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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell www.cell.com/cell/fulltex...

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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: Cell https://t.co/dB6YfTrsCz

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Cell - a Cell Press journal
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Bertoglio lab (FMC/UFSC)
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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety www.cell.com/cell/fulltex...

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Bertoglio lab (FMC/UFSC)
@bertogliolab · X

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety https://t.co/c7IPscC75n

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Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

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Iñiguez Lab
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John Lukens
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