Metabolism August 2025 PMID 40228656

Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1.

Yo Han Lee, Jinyoung Lee, Joonho Jeong, Kieun Park, Bukyung Baik, Yuseong Kwon, Kimyeong Kim, Keon Woo Khim, Haneul Ji, Ji Young Lee, Kwangho Kim, Ji Won Kim, Tam Dao, Misung Kim, Tae Young Lee

Mentions

20
Peak: 8 in Sep 2025
across 4 sources since May 2025

Extended reach

138,756
potential audience

Total likes

3,678

Video views

97,575

Mentions per month

May 2025 – Oct 2025

Where it's discussed

  • X / Twitter7 posts
  • News6 articles
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

Discussions highlight the potential for niacin to modulate miR-93 levels, with users describing the findings as promising for future therapies, using words like 'important', 'game changer', and 'potential breakthrough', which reflect both high interest and perceived impact. The tone suggests a recognition of the research's significance in advancing understanding and treatment options for liver disease.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with many expressing support or agreement with the findings about miR-93's role in liver disease.

InterestHigh interest

Posts show high interest, with users emphasizing potential treatments like niacin and discussing implications for future therapies.

EngagementModerate engagement

Many users engage deeply by sharing thoughts on the mechanisms involved and potential impact, indicating moderate to high engagement levels.

ImpactModerate impact

The discussions hint at notable impact, with some posts suggesting this research could influence treatment approaches for MASLD.

Abstract in brief

  • The study shows that miR93 is significantly increased in the liver tissues of patients with MASLD and obese mice, and that knocking out miR93 reduces liver fat accumulation by increasing SIRT1 levels and promoting fatty acid breakdown.
  • miR93 directly targets SIRT1, a gene involved in regulating metabolism, and reducing miR93 boosts SIRT1 activity, which helps protect the liver from fat buildup through the LKB1-AMPK pathway.
  • The research suggests that treatments like niacin can lower miR93 levels, thereby enhancing SIRT1 function and potentially offering a new therapy for MASLD, a disease with limited current treatment options.]

Top posts

Most liked on X and Bluesky
Nutrition Detective
@NutriDetect · X

25mg Flush Niacin (start here!!!): https://t.co/KlQKHbLj0B 500mg Flush Niacin (advanced users): https://t.co/rnW84C0kTk REFERENCE: Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 https://t.co/2zkfslQX9F

Sep 15, 2025 · 5 likes · 36,821 followers View post →
sEGAo4DO5HLzTrO
@sEGAo4DO5HLzTrO · X

https://t.co/zIX3n5uEcU

Sep 20, 2025 · 2,286 followers View post →
trainerrueben
@trainerrueben · X

Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 https://t.co/irHgIhRDxF

Sep 15, 2025 · 955 followers View post →
Virginia Toma
@virginia_toma · X

"مفاجأة من العيار الثقيل: أخيرًا اكتشاف فيتامين يقضي على الكبد الدهني وي... https://t.co/oAWmKtUlrk via @YouTube

Oct 13, 2025 · 578 followers View post →
ahmed
@ahmedmohammedj3 · X

"مفاجأة من العيار الثقيل: أخيرًا اكتشاف فيتامين يقضي على الكبد الدهني وي... https://t.co/8n9cuMJS5v عبر @YouTube

Sep 21, 2025 · 309 followers View post →
Waseem Mostafa
@WaseemMost8873 · X

https://t.co/mtCVZYhPX5

Sep 25, 2025 · 150 followers View post →

All mentions

Virginia Toma
@virginia_toma · X

"مفاجأة من العيار الثقيل: أخيرًا اكتشاف فيتامين يقضي على الكبد الدهني وي... https://t.co/oAWmKtUlrk via @YouTube

Oct 13, 2025 · 578 followers View post →
Waseem Mostafa
@WaseemMost8873 · X

https://t.co/mtCVZYhPX5

Sep 25, 2025 · 150 followers View post →
ahmed
@ahmedmohammedj3 · X

"مفاجأة من العيار الثقيل: أخيرًا اكتشاف فيتامين يقضي على الكبد الدهني وي... https://t.co/8n9cuMJS5v عبر @YouTube

Sep 21, 2025 · 309 followers View post →
sEGAo4DO5HLzTrO
@sEGAo4DO5HLzTrO · X

https://t.co/zIX3n5uEcU

Sep 20, 2025 · 2,286 followers View post →
EL-KamelAhmed1
@ELKamelAhmed1 · X

https://t.co/feZFU3KjCi

Sep 19, 2025 · 83 followers View post →
Nutrition Detective
@NutriDetect · X

25mg Flush Niacin (start here!!!): https://t.co/KlQKHbLj0B 500mg Flush Niacin (advanced users): https://t.co/rnW84C0kTk REFERENCE: Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 https://t.co/2zkfslQX9F

Sep 15, 2025 · 5 likes · 36,821 followers View post →
trainerrueben
@trainerrueben · X

Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 https://t.co/irHgIhRDxF

Sep 15, 2025 · 955 followers View post →