Langmuir May 2025 PMID 40309829

HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.

Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Nagashree Bhat, Angel Covarrubias, Valeria Martinez, Lucine Devejian, Bao Nhi Nguyen, Subhrangsu S Mandal

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Peak: 5 in Aug 2025

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Abstract in brief

Macrophages are key players in inflammation, and their dysfunction is linked to diseases like cardiovascular issues and atherosclerosis due to imbalanced cholesterol and lipid metabolism.
HDLR-SR-BI (SR-BI) is important for cholesterol transport and maintaining cholesterol balance, and its expression decreases with inflammation, regulated by NF-κB activation.
Indoleamine-2,3-dioxygenase 1 (IDO1) is essential for regulating SR-BI expression; inhibiting IDO1 reduces inflammation and restores SR-BI expression and cholesterol uptake in macrophages.

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HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Enzyme Blocking Inflammation-Related Cholesterol Dysregulation for Disease Treatment

Identifying an Off Switch to Prevent Heart Disease and Related Conditions