August 2025 PMID 40341348

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses.

Trine Tollerup Nielsen, Paraskevi Bali, Jakob Grove, Christina Mohr-Jensen, Thomas Werge, Søren Dalsgaard, Anders D Børglum, Edmund Sonuga-Barke, Helen Minnis, Ditte Demontis, Elizabeth C Corfield, Ludger Tbartz van Elst, Manuel Mattheisen, Melanie M de Wit

Mentions

45
Peak: 23 in May 2025
across 6 sources since May 2025

Extended reach

840,597
potential audience

Total likes

361

Video views

5,853

Mentions per month

May 2025 – Aug 2025

Where it's discussed

  • X / Twitter35 posts
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Several discussions cite the genetic links to childhood maltreatment, like mentions of high polygenic scores for ADHD and educational attainment, illustrating strong support and interest in the study’s findings. The tone is analytical, with comments emphasizing the potential for genetics to enhance risk stratification, which indicates deep engagement and recognition of their impact on psychiatric research.

AgreementStrong agreement

Most discussions strongly support the study’s findings, emphasizing the link between genetic factors such as ADHD polygenic scores and childhood maltreatment, indicating broad consensus on the importance of these results.

InterestHigh interest

Posts demonstrate high curiosity, as evidenced by mentions of detailed genetic analysis, implications, and references to specific disorders and measures, showing engagement with the topic's scientific complexity.

EngagementHigh engagement

Many discussions delve into the methodology and broader implications, such as how genetics may help in stratifying risk beyond environmental factors, reflecting deep engagement.

ImpactModerate impact

Participants generally perceive this research as impactful, highlighting its potential to influence understanding of childhood maltreatment and psychiatric risks, though some discussions remain optimistic rather than definitively concluding high impact.

Abstract in brief

  • The study examined how genetic factors (measured by polygenic scores or PGS) influence the risk of childhood maltreatment (CM) across different psychiatric disorders like ADHD, autism, schizophrenia, bipolar disorder, and depression, using data from a large population cohort.
  • It found that certain genetic predispositions, especially for ADHD and educational attainment, are linked to a higher likelihood of experiencing childhood maltreatment, and individuals with higher genetic risk had a significantly increased absolute risk of CM.
  • The research highlights the complex interplay between genetics and environmental factors in childhood maltreatment and psychiatric disorders, suggesting that genetics can modulate the risk even in the presence of high-impact environmental factors like parental mental health issues.

Top posts

Most liked on X and Bluesky
JAMA Psychiatry
@JAMAPsych · X

Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatment. https://t.co/vIkHmRbSDa https://t.co/L76cylcGUB

Aug 23, 2025 · 77 likes · 19 shares · 56,646 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatment. https://t.co/ZSO5yArqib

May 9, 2025 · 27 likes · 11 shares · 56,646 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses” by Ditte Demontis et al. JAMA Psychiatry https://t.co/YqJfZv1jdA

Jul 21, 2025 · 6 likes · 505,527 followers View post →
Yann Le Strat
@YannLe_Strat · X

Les enfants à haut risque génétique de #TDAH et faible niveau éducatif sont plus vulnérables à la maltraitance. La génétique permet de stratifier ce risque au-delà des facteurs familiaux. https://t.co/K9Q1jbnOkV

May 13, 2025 · 6 likes · 2 shares · 2,300 followers View post →
PGC Consortium
@PGCgenetics · X

May 19, 2025 · 5 likes · 5,655 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Genetics and Childhood Maltreatment Across 5 Psychiatric Diagnoses https://t.co/Ovi6vgOzmz

May 10, 2025 · 3 likes · 71,753 followers View post →

All mentions

Prof Marios Adamou OBE
@DrMariosAdamou · X

Genetics and Childhood Maltreatment Across 5 Psychiatric Diagnoses https://t.co/wuVGzIkMnQ

Aug 23, 2025 · 1,016 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 10,770 followers View post →
CON TACTO NOAHIDA
@CONTACTONOAJIDA · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 164 followers View post →
J.
@AnoEnby · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 845 followers View post →
Manjarrez-Gutiérrez L.
@docmanjarrez · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 322 followers View post →
Orbit Health
@OrbitTelepsych · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 437 followers View post →
Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 13,621 followers View post →
ソーシャ
@pic_chie · X

RT @JAMAPsych: Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatme…

Aug 23, 2025 · 19 shares · 2,093 followers View post →
Dra. Teraiza Mesa R Cuenta Oficial ®
@Dra_TeraizaMesa · X

Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatment. https://t.co/TDbNukoz8h https://t.co/zTxbSW1M0O

Aug 23, 2025 · 2 likes · 1 share · 9,069 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Individuals with high polygenic scores for #ADHD and low educational attainment had an elevated risk of childhood maltreatment. https://t.co/vIkHmRbSDa https://t.co/L76cylcGUB

Aug 23, 2025 · 77 likes · 19 shares · 56,646 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

“Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses” by Ditte Demontis et al. JAMA Psychiatry https://t.co/TGZ3weooTk https://t.co/bn3bO1IRw6

Jul 23, 2025 · 1 like · 24,166 followers View post →
TheAuDHDysTConnection
@AUconnective · X

ADHD and child maltreatment links https://t.co/S8ZYMOSKhd

Jul 21, 2025 · 692 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses” by Ditte Demontis et al. JAMA Psychiatry https://t.co/YqJfZv1jdA

Jul 21, 2025 · 6 likes · 505,527 followers View post →
Lan Ember Zhou
@Lauren_LanZhou · X

RT @sha_zhiqiang: Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses | JAMA Psychiatry https://t.co/4z1…

Jun 11, 2025 · 1 share · 99 followers View post →
Shicheng Guo
@ShihchengGuo · X

Genetics in childhood maltreatment impact: 13 polygenic scores analyzed across 5 psychiatric disorders in iPSYCH study. Complex but insightful! #GeneticPsychiatry PMID:40341348, JAMA Psychiatry 2025, @JAMAPsych @broadinstitute https://t.co/TNdRFDdNbS #AI #Pharma #BioMed #RNA

May 25, 2025 · 1 like · 499 followers View post →
PGC Consortium
@PGCgenetics · X

May 19, 2025 · 5 likes · 5,655 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

High ADHD genetic risk significantly increases childhood maltreatment likelihood, particularly in girls with psychiatric parent histories. by Nielsen TT, Bali P (...) Polderman TJC et 17 al. in JAMA Psychiatry https://t.co/cvZo6EgTvz #MedX #MedResearch

May 18, 2025 · 83 followers View post →
sarah Moussouni
@sarahMoussouni1 · X

RT @YannLe_Strat: Les enfants à haut risque génétique de #TDAH et faible niveau éducatif sont plus vulnérables à la maltraitance. La généti…

May 13, 2025 · 2 shares · 198 followers View post →
Yann Le Strat
@YannLe_Strat · X

Les enfants à haut risque génétique de #TDAH et faible niveau éducatif sont plus vulnérables à la maltraitance. La génétique permet de stratifier ce risque au-delà des facteurs familiaux. https://t.co/K9Q1jbnOkV

May 13, 2025 · 6 likes · 2 shares · 2,300 followers View post →
Dr Alok Gupta MD, FIAP, Jaipur
@docalok · X

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network ⁦@DocAlokGupta⁩ https://t.co/tpofA9RWwb

May 10, 2025 · 2,581 followers View post →
@gen0m1cs
@gen0m1cs · X

RT @SciencesNetwork: #GWAS: https://t.co/6vsDYHWjMN https://t.co/cBJMW1idaZ https://t.co/PkJB6EIX94 https://t.co/6bwr7KvFv2 https://t.co/Ax…

May 10, 2025 · 1 share · 28,582 followers View post →
SouthernPsy
@SouthernPsy · X

Genetics and Childhood Maltreatment Across 5 Psychiatric Diagnoses https://t.co/E7ppTwHvcI

May 10, 2025 · 1 like · 611 followers View post →
SciencesNetwork
@SciencesNetwork · X

#GWAS: https://t.co/6vsDYHWjMN https://t.co/cBJMW1idaZ https://t.co/PkJB6EIX94 https://t.co/6bwr7KvFv2 https://t.co/AxpmegGAls https://t.co/DzI04e8Kb3

May 10, 2025 · 3 likes · 1 share · 345 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Genetics and Childhood Maltreatment Across 5 Psychiatric Diagnoses https://t.co/Ovi6vgOzmz

May 10, 2025 · 3 likes · 71,753 followers View post →
nddpsych
@nddpsych.bsky.social · Bluesky

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses | Psychiatry and Behavioral Health | JAMA Psychiatry | Nielsen et al 2025 jamanetwork.com/journals/jam...

May 9, 2025 View post →
nddpsych
@nddpsych · X

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses | Psychiatry and Behavioral Health | JAMA Psychiatry | Nielsen et al 2025 https://t.co/uyEfnDFzTK

May 9, 2025 · 52 followers View post →
Marcia S Newman
@marciasgreen · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 4,934 followers View post →
Zhiqiang Sha (@zhiqiangsha.bsky.social)
@sha_zhiqiang · X

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses | JAMA Psychiatry https://t.co/4z1iH1QBLF

May 9, 2025 · 3 likes · 1 share · 1,155 followers View post →
Jordan Vajda MD MPH MA MDiv
@jordan_vajda · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 485 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 10,770 followers View post →
Toru Ishihara
@toru_ishihara · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 89 followers View post →
Robert Howard also on BlueSky as @ProfRobHoward
@ProfRobHoward · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 18,034 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 378 followers View post →
Felipe Guillen, M.D
@pipeguillenMD · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 1,319 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

RT @JAMAPsych: Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatmen…

May 9, 2025 · 11 shares · 2,288 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Individuals with high polygenic scores for ADHD and low educational attainment had an elevated risk of childhood maltreatment. https://t.co/ZSO5yArqib

May 9, 2025 · 27 likes · 11 shares · 56,646 followers View post →