J Physiol May 2025 PMID 40345145

Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis.

Julien Bensalem, Xiao Tong Teong, Kathryn J Hattersley, Leanne K Hein, Célia Fourrier, Linh V P Dang, Sanjna Singh, Kai Liu, Gary A Wittert, Amy T Hutchison, Leonie K Heilbronn, Timothy J Sargeant

Mentions

28
Peak: 17 in May 2025
across 4 sources since May 2025

Extended reach

149,632
potential audience

Total likes

2,420

Video views

54,726

Mentions per month

May 2025 – Dec 2025

Where it's discussed

  • X / Twitter23 posts
  • YouTube2 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect enthusiasm for the study's implications, with many emphasizing the role of fasting in cellular health, using words like 'boosts' and 'potentially' to convey optimism, while others question the methodology and modest effects, indicating a nuanced but engaged debate.

AgreementModerate agreement

Most discussions support the idea that intermittent fasting can increase autophagy based on the study's findings.

InterestHigh interest

Posts show high curiosity and engagement with topics like cellular cleanup, fasting methods, and implications for aging.

EngagementModerate engagement

Some comments delve into technical details like measurement techniques and data interpretation, indicating active engagement.

ImpactModerate impact

The mention of potential health benefits and scientific advances suggests a moderate perceived impact on health and aging research.

Abstract in brief

  • Autophagy, a process that helps slow aging, is stimulated by nutrient restriction, but its effects on humans were previously untested.
  • In a study with 121 participants with obesity, those following intermittent fasting plus time-restricted eating (iTRE) showed a significant increase in autophagy after 6 months compared to a control group.
  • The findings suggest that nutrient restriction, particularly through iTRE, could enhance autophagy in humans and may help delay age-related diseases.

Top posts

Most liked on X and Bluesky
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging @sahmriAU https://t.co/i8UyIjVhzg

May 9, 2025 · 36 likes · 8 shares · 1,115 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@davidasinclair Link to the study: https://t.co/i8UyIjVhzg

May 11, 2025 · 10 likes · 1,115 followers View post →
Circadian: Your Natural Rhythm
@Circadian_App · X

Fasting Windows Rev Up Cellular Cleanup A six-month 16:8 TRE regimen in obese adults boosted autophagy (cellular recycling) markers by 35 %. Try eating early and finishing early, start fasting 3-4 hrs before bed give your cells a daily cleanup boost. https://t.co/c0POjfjb33 https://t.co/5CRzoVWoBk

Jun 14, 2025 · 8 likes · 3 shares · 978 followers View post →
Agingdoc
@agingdoc1 · X

Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis Highlights:

Jun 13, 2025 · 6 likes · 2 shares · 42,377 followers View post →
Upasana DasAdhikari
@UpasanaDA · X

6 months of Time restricted eating or Caloric restriction did not increase autophagy!

May 12, 2025 · 6 likes · 383 followers View post →
The Journal of Physiology
@jphysiol.bsky.social · Bluesky

Julien Bensalem et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans

May 22, 2025 · 2 likes · 2 shares View post →

All mentions

しゅうま
@shuma_fit · X

運動はオートファジーを活性化し、脂肪肝や代謝異常を改善する可能性。マウス実験では運動介入なしでは効果が消失。→週3回以上の有酸素+筋トレ習慣が推奨されます。 https://t.co/YW9bVcDwYx

Jul 30, 2025 · 4 followers View post →
Horatio
@B56451578 · X

RT @Circadian_App: Fasting Windows Rev Up Cellular Cleanup A six-month 16:8 TRE regimen in obese adults boosted autophagy (cellular recycli…

Jun 23, 2025 · 3 shares · 323 followers View post →
Jonathan
@Hair_Artiste · X

RT @Circadian_App: Fasting Windows Rev Up Cellular Cleanup A six-month 16:8 TRE regimen in obese adults boosted autophagy (cellular recycli…

Jun 14, 2025 · 3 shares · 792 followers View post →
Circadian: Your Natural Rhythm
@Circadian_App · X

Fasting Windows Rev Up Cellular Cleanup A six-month 16:8 TRE regimen in obese adults boosted autophagy (cellular recycling) markers by 35 %. Try eating early and finishing early, start fasting 3-4 hrs before bed give your cells a daily cleanup boost. https://t.co/c0POjfjb33 https://t.co/5CRzoVWoBk

Jun 14, 2025 · 8 likes · 3 shares · 978 followers View post →
R.A
@raan62 · X

RT @agingdoc1: Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis Highlights:

Jun 13, 2025 · 2 shares · 186 followers View post →
Tevfik KOÇAK
@dyttevfik · X

RT @agingdoc1: Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis Highlights:

Jun 13, 2025 · 2 shares · 157 followers View post →
Agingdoc
@agingdoc1 · X

Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis Highlights:

Jun 13, 2025 · 6 likes · 2 shares · 42,377 followers View post →
The Journal of Physiology
@jphysiol.bsky.social · Bluesky

Julien Bensalem et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans

May 22, 2025 · 2 likes · 2 shares View post →
Journal of Physiology
@JPhysiol · X

Julien Bensalem (@sahmriAU @UniofAdelaide) et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans

May 22, 2025 · 32,635 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@BachAggaloop @davidasinclair They study wasn't done on LC3 puncta, we used an ELISA and include data on it's performance. It was also a flux assay with lysosomal inhibition. You can read the paper here, it's open access: https://t.co/OhQ20gVuNe

May 12, 2025 · 1 like · 1,115 followers View post →
Upasana DasAdhikari
@UpasanaDA · X

6 months of Time restricted eating or Caloric restriction did not increase autophagy!

May 12, 2025 · 6 likes · 383 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@8Eevert @davidasinclair I know right! Here you go: https://t.co/i8UyIjVhzg

May 11, 2025 · 1 like · 1,115 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@wooddell_jim @davidasinclair Here you go: https://t.co/i8UyIjVhzg

May 11, 2025 · 1 like · 1,115 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@honglilai @davidasinclair Here you go: https://t.co/i8UyIjVhzg

May 11, 2025 · 1,115 followers View post →
Chulhwan Sean Kwak
@ChulhwanKwak · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 11, 2025 · 8 shares · 22 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 11, 2025 · 8 shares · 2,822 followers View post →
Edu Antuña
@EANT__ · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 11, 2025 · 8 shares · 179 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

@davidasinclair Link to the study: https://t.co/i8UyIjVhzg

May 11, 2025 · 10 likes · 1,115 followers View post →
Rapamycin News
@RapaNews · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 10, 2025 · 8 shares · 5,336 followers View post →
Iñaqui Jiménez-Loygorri
@InaquiConQ · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 10, 2025 · 8 shares · 431 followers View post →
Sanjna Singh
@SanjyySingh · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 10, 2025 · 8 shares · 92 followers View post →
Shima Taherkhani
@ShimaTaherkhani · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 10, 2025 · 8 shares · 353 followers View post →
Nell Rebowe
@NellRebowe · X

RT @TimSargeant1: New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the lar…

May 9, 2025 · 8 shares · 968 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging @sahmriAU https://t.co/i8UyIjVhzg

May 9, 2025 · 36 likes · 8 shares · 1,115 followers View post →