Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity.
The digital discussions about the article reveal a strong consensus that prolonged sedentary behavior is linked to neurodegeneration and cognitive decline in older adults, even among those who exercise regularly. This is exemplified by language emphasizing 'shrinking brain' and 'reducing risk,' as well as cues like 'even if you exercise daily,' which underline the perceived high impact and relevance of the findings. The tone is serious and health-conscious, reflecting a shared interest in aging well and adopting relevant lifestyle changes.
AgreementStrong agreement
Most discussions strongly support the findings, emphasizing that even high physical activity doesn't negate the risks associated with prolonged sitting, indicating widespread agreement on the study's conclusions.
InterestHigh interest
Posts demonstrate high curiosity, with users referencing detailed study data and potential health implications, showing they find the topic relevant to aging and health.
EngagementHigh engagement
Several discussions delve into specific aspects such as hippocampal shrinkage and Alzheimer's risks, indicating deep engagement with the research methodology and implications.
ImpactHigh impact
The discussions highlight significant health concerns and actionable advice, like reducing sitting time, implying users perceive this research as having a high potential for influencing health behaviors.
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Julio Rodríguez, PhD | Genética Clínica
@bitacorabeagle · X
Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodegeneración, se reduce el rendimiento cognitivo, la memoria se deteriora y el hipocampo pierde volumen
https://t.co/V8acWr7Jro https://t.co/revlcbdTDd
May 21, 2025 · 129 likes · 47 shares · 29,413 followersView post →
“Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity” by Marissa Gogniat et al. Alzheimer’s & Dementia
https://t.co/FWWVR5BU4h
May 18, 2025 · 20 likes · 8 shares · 507,268 followersView post →
CB
Christoph Burch
@ChristophBurch · X
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
https://t.co/jsrhWIeua9
Nov 8, 2025 · 17 likes · 4 shares · 15,489 followersView post →
Chronic sitting increases dementia risk and cannot be offset by regular exercise. Long periods of inactivity are linked to neurodegeneration and cognitive decline in older adults, despite high physical activity levels.
Chewing hard materials like wood increases brain antioxidant levels, specifically glutathione, which may enhance cognitive functions such as memory, suggesting a potential method to support brain health.
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
https://t.co/jsrhWIeua9
Nov 8, 2025 · 17 likes · 4 shares · 15,489 followersView post →
HG
Health Action Research Group
@HealthAction_UK · X
Keep moving! As we get older sedentary time is associated with smaller brain volume, greater neurodegeneration and worse cognitive performance. https://t.co/ymCfMSoixB https://t.co/dJbK68icTB
+4min Keep your feet, hands, on the ground
May 2025 "Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity" https://t.co/0M7N5Q2L0i https://t.co/V9TxKMbNcn
Greater sedentary behavior is related to neurodegeneration and worse cognition.
Associations differed by APOE-ε4 carrier status in cross-sectional models.
Sedentary behavior is an independent risk factor for Alzheimer's disease.
https://t.co/anBocRpYBI
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity.
https://t.co/anBocRpYBI
Increased sedentary behavior is associated with neurodegeneration, worse cognition in older adults over a 7‐year period despite high levels of physical activity -greater sedentary time related to a smaller AD-neuroimaging signature (β = -0.0001, p = 0.01), https://t.co/1D4VcjyINK
@DimiKarev @DrDominicNg The study's claims hold up based on the paper (doi:10.1002/alz.70157):
- n=404 older adults over 7 years.
- More sedentary time linked to faster hippocampal atrophy, worse episodic memory, and slower processing speed.
- Effects independent of exercise; 87% met ≥150 min/week
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Sitting less is even more important than exercising www.t-online.de/gesundheit/a...
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
https://t.co/3IMLLOO8o3
Sitting less is even more important than exercising https://t.co/ruLQehzlm5
Bewegungsmangel
What does that mean for you? Instead of just going for your daily evening walk, move your body regularly.
Get a standing desk, a walking pad, go for a walk on your lunch break….
Read more here: https://t.co/1t5qE81ZqE
Jun 26, 2025 · 1 share · 1,185 followersView post →
おO
おくさん/OKUSUN
@Astella6174 · X
座り過ぎが脳に悪影響、運動していても要注意
https://t.co/dJy7p1kaPn
Jun 25, 2025 · 3 likes · 1 share · 1,185 followersView post →
?
@guardian_xcu · X
➡️ Die US-Studie im Fachmagazin "Alzheimer 's & Dementia"
https://t.co/zhAm4yo5R8 3/3
Jun 14, 2025 · 1 like · 2,329 followersView post →
R
Reiner
@erlesen · X
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
https://t.co/3IMLLOO8o3
Greater sedentary time ⟿ worse episodic memory performance
https://t.co/m41m1M5Jvn
Jun 13, 2025 · 3 likes · 7,863 followersView post →
KD
Kristie Leong M.D.
@DrKristieLeong · X
@RuggerioSu36738 Here's a link to the study, Sue: https://t.co/dz6hDfD4Fj
I think any kind of movement that breaks up sitting, including frequent short walks, helps. :-)
Jun 6, 2025 · 1 like · 59,952 followersView post →
EB
Esmeralda Broncano
@EsmeraldaB97609 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 28, 2025 · 5 likes · 1 share · 214,052 followersView post →
마
마당엔Rosa
@MadangNRosa · X
RT @Zeebachu: - 참고 논문: https://t.co/o5GbjNEJQR
May 27, 2025 · 4 shares · 2,272 followersView post →
DN
Dr. Uma Naidoo
@DrUmaNaidoo · X
Your brain needs movement!
New research reveals that even if you exercise daily, long periods of sitting are linked to faster brain shrinkage and memory decline in older adults.
https://t.co/ZLJA2cCA3J https://t.co/F6hpTIsSsr
May 27, 2025 · 3 likes · 1 share · 12,909 followersView post →
K김
Kay Kim (김기웅)
@KayKiwoongKim · X
RT @Zeebachu: - 참고 논문: https://t.co/o5GbjNEJQR
May 27, 2025 · 4 shares · 2,575 followersView post →
"Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity" Wiley Online Library https://t.co/mYJCVD5VsE
May 25, 2025 · 1 like · 1,759 followersView post →
DB
Doç. Dr. ilhan Bahşi
@drilhanbahsi · X
Başlık: "Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity"
Dergi: Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
Yayın Tarihi: 13 Mayıs 2025
May 24, 2025 · 3 likes · 6,427 followersView post →
DB
Doç. Dr. ilhan Bahşi
@drilhanbahsi · X
Bu bulgular, 7 yıl boyunca günlük ortalama 13 saat oturan kişilerde saptanmış. Böyle bir araştırma Türkiye'de yapılmazdı zaten
May 24, 2025 · 3 likes · 6,427 followersView post →
AA
Andrés Afonzo
@andreyeski · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 23, 2025 · 47 shares · 897 followersView post →
May 23, 2025 · 3 shares · 311 followersView post →
IS
inmobi-info.bsky.social
@inmobi-info.bsky.social · Bluesky
長時間座り続ける生活で脳が萎縮するとの研究結果、運動もほぼ効果なしか – GIGAZINE
座りっぱなしの生活は一般的に良くないとされており、定期的に立ち上がったり、軽い運動をしたりするのが良いとされています。50歳以上の人を対象にした新たな研究で、座っている時間が長い人は脳が萎縮して認知機能が低下する可能性があり、さらに運動もほぼ効果がない可能性があることが明らかになりました。 Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over…
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 23, 2025 · 47 shares · 11 followersView post →
U認
uMRI(高次脳機能障害・発達障害・認知症情報bot)
@sug100foroba · X
【chat GPTによる簡単要約】
☆ざっくり要約
高齢者では、身体活動量が多くても、座りすぎは脳萎縮や認知機能低下と関連し、特にアルツハイマー病の遺伝的リスクを持つ人で顕著。
Gogniat et al. Increased sedentary behavior is associated with neurodegeneration and worse cognition in older
May 23, 2025 · 6 likes · 8,197 followersView post →
May 23, 2025 · 12 likes · 3 shares · 8,197 followersView post →
AO
Adrian Olmedo
@adrianolmedo · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 855 followersView post →
JC
Julio Rodríguez, PhD | Genética Clínica
@bitacorabeagle · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 29,413 followersView post →
RP
Ricardo Perilla
@perillaricardo · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 778 followersView post →
SP
Scott Lear, PhD
@DrScottLear · X
1/2 Can sitting shrink your brain?
Study in older adults found greater sitting time associated with ⬇️ in hippocampal volume and cognitive function over 7 years: https://t.co/mTBGOt2FbE
#BrainHealth https://t.co/yMZboekilP
May 22, 2025 · 3 likes · 3,036 followersView post →
A
AlejandroCC
@alemmjo · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 45 followersView post →
EG
Edmundo González
@Edmundo1455 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 951 followersView post →
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AldeaCiencia
@AldeaCiencia · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 7,676 followersView post →
DZ
David Zamorano
@LaEFdeDavid · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 2,151 followersView post →
BO
BATERIA OSCURA
@BATERIA_OSCURA · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 1,017 followersView post →
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Miyiva
@Miyiva · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 3,282 followersView post →
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Elsalvajeeste
@Elsalvajeeste · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 22, 2025 · 47 shares · 240 followersView post →
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The Comic Book Guy
@TheComicBookGu5 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 81 followersView post →
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wbeimar veloza
@siemprembajador · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,407 followersView post →
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Gustavo Peñuela
@gustavopenuela · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 306 followersView post →
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Jhonatan M. Garay
@Jhona_M_Garay · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 34 followersView post →
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Mcardenashe
@mcardenash71116 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 97 followersView post →
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Alb3rtOF.
@Modulepahablar · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,013 followersView post →
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Anibal Velasquez
@Anibal_v_v · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,216 followersView post →
OM
Oscar Mauricio
@osmapo83 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 81 followersView post →
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Carlos
@Capf__ · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 534 followersView post →
OV
OsMar Vela
@MartinSkar · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,509 followersView post →
EC
Emilio Pérez Córdova
@emilioperezc1 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 43 followersView post →
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Antonio Juárez
@tonojuarezjaj · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 73 followersView post →
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Juan Becerra Avila
@j_becerra_a · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 120 followersView post →
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Diego Jiménez
@Diegoajb1 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,133 followersView post →
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Perse Omnibus
@Fgaro13 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
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Reimer Agustín Romero
@romeroreimer · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
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Francisco Català
@Paco_Catala · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 1,217 followersView post →
CP
CARLOS PRATT
@carlospratt · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 5,665 followersView post →
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NegociosyB.IA
@NegociosyB · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 809 followersView post →
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ANTONIO
@ANTONIO15890213 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 464 followersView post →
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Gina Moreno
@Ginn_Moreno · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 141 followersView post →
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JC Moreno
@Carlosm_10 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 286 followersView post →
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Carlos
@MarvinHarris76 · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 4,519 followersView post →
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Oscarelo A.
@Oscarelo2x · X
RT @bitacorabeagle: Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodeg…
May 21, 2025 · 47 shares · 3,198 followersView post →
JC
Julio Rodríguez, PhD | Genética Clínica
@bitacorabeagle · X
Estar sentado varias horas al día reduce el tamaño del cerebro, aunque vayas al gimnasio
Aumenta el riesgo de neurodegeneración, se reduce el rendimiento cognitivo, la memoria se deteriora y el hipocampo pierde volumen
https://t.co/V8acWr7Jro https://t.co/revlcbdTDd
May 21, 2025 · 129 likes · 47 shares · 29,413 followersView post →
Prolonged sitting is linked to Alzheimer’s-related brain changes. Even daily workouts may not offset it.
“Minimizing the time spent sitting, even if you exercise daily, reduces the likelihood of developing Alzheimer’s.” — Dr. Gogniat
Study: pubmed.ncbi.nlm.nih.gov/40357887/
#BrainHealth
Prolonged sedentary behavior in adults over 50 is linked to cognitive decline and brain shrinkage in regions vulnerable to Alzheimer’s disease.
Even among those who exercise regularly, spending more time sitting was associated with worse cognition.
https://t.co/EcirjOORHl https://t.co/kXvIXJYOR9
RT @NeuroscienceNew: “Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year p…
May 18, 2025 · 8 shares · 188 followersView post →
K
KaTe21
@Te21Ka · X
RT @NeuroscienceNew: “Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year p…
May 18, 2025 · 8 shares · 436 followersView post →
PS
Pere Joan Sala
@Fradbius · X
L'augment del sedentarisme està relacionat amb neurodegeneració i una pitjor cognició en adults grans (durant un període de 7 anys) malgrat alts nivells d'activitat física. El sedentarisme és un factor de risc independent per a la malaltia d'Alzheimer.
https://t.co/71y3DEhAeS
RT @NeuroscienceNew: “Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year p…
May 18, 2025 · 8 shares · 1,574 followersView post →
H
HealthNut
@HealthNutDSc · X
RT @NeuroscienceNew: “Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year p…
May 18, 2025 · 8 shares · 1,580 followersView post →
NN
Neuroscience News
@NeuroscienceNew · X
“Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity” by Marissa Gogniat et al. Alzheimer’s & Dementia
https://t.co/FWWVR5BU4h
May 18, 2025 · 20 likes · 8 shares · 507,268 followersView post →
B
breizh2008
@breizh2008 · X
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity - Gogniat - 2025 - Alzheimer's & Dementia - Wiley Online Library https://t.co/3vRI0HUkpn
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
https://www.madshrimps.be/news/increased-sedentary-behavior-is-associated-with-neurodegeneration-and-worse-cognition-in-older-adults-ove
Sitting for a long time shrinks your brain even if you exercise https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70157 (https://news.ycombinator.com/item?id=44000724)
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity - Gogniat - 2025 - Alzheimer's & Dementia - Wiley Online Library https://t.co/n2ZdoEnvp3
Sitting for a long time shrinks your brain even if you exercise https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70157 (https://news.ycombinator.com/item?id=44000724)
Sitting for a long time shrinks your brain even if you exercise
L: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70157
C: https://news.ycombinator.com/item?id=44000724
posted on 2025.05.15 at 20:32:32 (c=1, p=4)
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity - Gogniat - 2025 - Alzheimer's & Dementia - Wiley Online Library. https://t.co/jXY2D3pn78
May 14, 2025 · 1 like · 1,065 followersView post →
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