Sci Transl Med May 2025 PMID 40367195

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study.

Becca A Flitter, Joshua Gillard, Susan N Greco, Maria D Apkarian, Nick P D'Amato, Lam Quynh Nguyen, Elena D Neuhaus, Darreann Carmela M Hailey, Marcela F Pasetti, Mallory Shriver, Christina Quigley, Robert W Frenck, Lisa C Lindesmith, Ralph S Baric, Lee-Jen Wei

Mentions

60
Peak: 35 in May 2025
across 6 sources since May 2025

Extended reach

127,764
potential audience

Total likes

873

Video views

684

Mentions per month

May 2025 – Jul 2025

Where it's discussed

  • X / Twitter35 posts
  • News16 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Discussions reflect a high level of interest and engagement through comments that praise the study’s findings, such as 'promising results' and 'one-of-a-kind' vaccine, and cite specific immune responses like mucosal immunity. The tone indicates support and curiosity, but some posts also note the need for further clinical trials to confirm impact.

AgreementModerate agreement

Most discussions acknowledge the positive findings of the vaccine study, emphasizing immune response and reduced viral shedding, which indicates general support.

InterestHigh interest

The discussions display high interest, with multiple posts highlighting the promising phase 2 results and potential applications, using words like 'promising' and 'innovative'.

EngagementHigh engagement

The posts exhibit deep engagement by referencing specific results, such as mucosal immunity and immune markers, and mentioning related research or companies, indicating active interest and analysis.

ImpactModerate impact

Though the conversations recognize the significance of the findings for vaccine development, many are still exploratory and anticipate future results; thus, the impact is seen as potentially high but not definitively transformative yet.

Abstract in brief

  • The study shows that the oral norovirus vaccine VXAG11NN is safe, well tolerated, and helps protect against norovirus infection while also reducing the amount of virus shed in stool and vomit.
  • Immunization with the vaccine increased specific antibodies in blood and mucosal tissues (like saliva, nasal fluid, and feces), with responses measured 7 days after vaccination correlating with immune cells that produce protective antibodies.
  • Machine learning analysis identified that the best indicators of vaccine protection are serum blocking antibodies and fecal IgA, which are key immune responses linked to the vaccine's effectiveness.]

Top posts

Most liked on X and Bluesky
Javi Ibarrondo
@jibarrondo.bsky.social · Bluesky

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study | Science Translational Medicine www.science.org/doi/10.1126/...

May 14, 2025 · 753 likes · 169 shares View post →
真理波
@MDPHD_mouchoi · X

より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2OzH3n

May 19, 2025 · 22 likes · 3 shares · 2,899 followers View post →
Agnieszka Szuster-Ciesielska
@AgnieszkaSzust3 · X

tabletki, a konieczne będą też badania kliniczne 3 fazy. End. Źródła: 1.https://t.co/rjx8CpdOOr 2.https://t.co/Mc04RTKBSN 3.https://t.co/w3M9ray8dF

Jul 27, 2025 · 16 likes · 2 shares · 8,436 followers View post →
Science Translational Medicine
@ScienceTM · X

An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and reduces shedding of the virus in vaccinated volunteers, according to results from a new phase 2 trial. https://t.co/05vLzo8pLY @Vaxart https://t.co/oFfcgJpGWh

May 24, 2025 · 15 likes · 4 shares · 33,690 followers View post →
Waggoner Lab
@LabWaggoner · X

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study https://t.co/EVE4Iegan3 @ScienceTM https://t.co/KYj9zIJrY6

May 14, 2025 · 13 likes · 4 shares · 11,302 followers View post →
Science Translational Medicine
@ScienceTM · X

An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and reduces shedding of the virus in vaccinated volunteers, according to results from a new phase 2 trial. https://t.co/05vLzo8pLY @Vaxart https://t.co/QHfb0d1e8q

May 16, 2025 · 10 likes · 3 shares · 33,690 followers View post →

All mentions

Ada#SnaW#Trzaskowski2025
@ada_popiel · X

RT @AgnieszkaSzust3: tabletki, a konieczne będą też badania kliniczne 3 fazy. End. Źródła: 1.https://t.co/rjx8CpdOOr 2.https://t.co/Mc04RT…

Jul 27, 2025 · 2 shares · 5,525 followers View post →
TrueBlue
@trueblue00000 · X

RT @AgnieszkaSzust3: tabletki, a konieczne będą też badania kliniczne 3 fazy. End. Źródła: 1.https://t.co/rjx8CpdOOr 2.https://t.co/Mc04RT…

Jul 27, 2025 · 2 shares · 704 followers View post →
Agnieszka Szuster-Ciesielska
@AgnieszkaSzust3 · X

tabletki, a konieczne będą też badania kliniczne 3 fazy. End. Źródła: 1.https://t.co/rjx8CpdOOr 2.https://t.co/Mc04RTKBSN 3.https://t.co/w3M9ray8dF

Jul 27, 2025 · 16 likes · 2 shares · 8,436 followers View post →
ティータイムの探求心/podcast
@teatime_tankyu · X

Phase2の論文はこちら(購読が必要です)https://t.co/x64xf5vtSQ

Jun 24, 2025 · 62 followers View post →
テストユーザー
@RIerXfx3toHSmIh · X

RT @carpe_diem0820: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challen…

Jun 1, 2025 · 3 shares · 57 followers View post →
Marie Ehrlichová
@EhrlichovaMarie · X

RT @SnihIniciativa: 1/2 Američtí vědci testovali experimentální ústní vakcínu VXA-G1.1-NN, podávanou ve formě tablety, která má ochránit pr…

May 30, 2025 · 1 share · 998 followers View post →
Iniciativa Sníh
@SnihIniciativa · X

1/2 Američtí vědci testovali experimentální ústní vakcínu VXA-G1.1-NN, podávanou ve formě tablety, která má ochránit právě proti nejběžnějšímu typu noroviru. https://t.co/lV8gsD2Gc1

May 30, 2025 · 7 likes · 1 share · 3,658 followers View post →
ふむふむ
@9KqCc0LDTkZhG8O · X

RT @carpe_diem0820: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challen…

May 30, 2025 · 3 shares · 161 followers View post →
ヰ蝶
@kohsonju · X

RT @carpe_diem0820: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challen…

May 29, 2025 · 3 shares · 54 followers View post →
Mugen UJIIE (氏家 無限)
@carpe_diem0820 · X

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study 経口ノロウイルスワクチン、第2b相試験で粘膜免疫を誘導しウイルス排出を抑制 https://t.co/j2g9IiuMWk

May 29, 2025 · 2 likes · 3 shares · 12,386 followers View post →
mychemical_no76
@mychemical_no76 · X

RT @ScienceTM: An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and redu…

May 24, 2025 · 4 shares · 3,317 followers View post →
Dr. Stephen Parker
@FutureHealthSP · X

RT @ScienceTM: An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and redu…

May 24, 2025 · 4 shares · 40 followers View post →
Science Translational Medicine
@ScienceTM · X

An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and reduces shedding of the virus in vaccinated volunteers, according to results from a new phase 2 trial. https://t.co/05vLzo8pLY @Vaxart https://t.co/oFfcgJpGWh

May 24, 2025 · 15 likes · 4 shares · 33,690 followers View post →
血祭謙之介(左党)【愚論極論多事暴論】@エコロジーなエロジジイ
@Eco_Ero_ZZ · X

RT @MDPHD_mouchoi: より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2O…

May 19, 2025 · 3 shares · 904 followers View post →
yiteucie
@musshumunieru · X

RT @MDPHD_mouchoi: より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2O…

May 19, 2025 · 3 shares · 603 followers View post →
澪
@Mizushige_Mio · X

RT @MDPHD_mouchoi: より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2O…

May 19, 2025 · 3 shares · 206 followers View post →
地球防衛
@support_fighter · X

RT @MDPHD_mouchoi: より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2O…

May 19, 2025 · 3 shares · 287 followers View post →
真理波
@MDPHD_mouchoi · X

より多様なウイルス型に対応する二価経口ワクチンも開発中。 今回の試験で血清や糞便中抗体が感染防御を予測する指標に使えそうという知見も得られ、今後は臨床試験もより発展してゆくかもしれない。 論文リンク https://t.co/mCAt2OzH3n

May 19, 2025 · 22 likes · 3 shares · 2,899 followers View post →
Alex Morgan
@GenuineAlex · X

RT @ScienceTM: An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and redu…

May 16, 2025 · 3 shares · 15 followers View post →
Henry Ruiz-Garcia
@HenryRuizMD · X

RT @ScienceTM: An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and redu…

May 16, 2025 · 3 shares · 699 followers View post →
Matthew Brown, PhD
@matt_brown04 · X

RT @ScienceTM: An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and redu…

May 16, 2025 · 3 shares · 184 followers View post →
Science Translational Medicine
@ScienceTM · X

An oral tablet vaccine for #norovirus generates strong immune responses in the mucosa against the viral VP1 protein and reduces shedding of the virus in vaccinated volunteers, according to results from a new phase 2 trial. https://t.co/05vLzo8pLY @Vaxart https://t.co/QHfb0d1e8q

May 16, 2025 · 10 likes · 3 shares · 33,690 followers View post →
BioPharmaInvestor
@BioPharmaMrkt · X

$VXRT The paper + supplementary docs can be found here https://t.co/7iX0Fke8sh Just going through them now...

May 15, 2025 · 178 followers View post →
Eric
@ericsophia12 · X

RT @LabWaggoner: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge…

May 15, 2025 · 4 shares · 96 followers View post →
BioPharmaInvestor
@BioPharmaMrkt · X

Vaxart ($VXRT) just published Phase 2 data for their oral norovirus tablet vaccine (VXA-G1.1-NN) in Science Translational Medicine. Quick take.

May 15, 2025 · 1 like · 178 followers View post →
Tanya
@tooltimetanya · X

RT @Benonewayin: @ScienceTM $VXRT @CruiseNorwegian @PrincessCruises #Vaxart #Norovirus #Data #Mucosal #Oral #Pill @FoxNews @CarnivalCruis…

May 14, 2025 · 1 share · 80 followers View post →
Ben
@Benonewayin · X

@ScienceTM $VXRT @CruiseNorwegian @PrincessCruises #Vaxart #Norovirus #Data #Mucosal #Oral #Pill @FoxNews @CarnivalCruise One of a kind… Vaxart Norovirus data shows promising results. https://t.co/cgsXEZ9Ayu

May 14, 2025 · 1 like · 1 share · 60 followers View post →
Ben
@Benonewayin · X

https://t.co/GarddefL22

May 14, 2025 · 60 followers View post →
Stephanie Gomez, PhD
@ScientistStephG · X

RT @LabWaggoner: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge…

May 14, 2025 · 4 shares · 483 followers View post →
InfoBull
@InfoBull777 · X

$vxrt https://t.co/v4deRd4ZWE

May 14, 2025 · 54 followers View post →
Gabe M. Barrón
@gabebarron · X

RT @LabWaggoner: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge…

May 14, 2025 · 4 shares · 762 followers View post →
Reena Singh
@EndoReena · X

RT @LabWaggoner: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge…

May 14, 2025 · 4 shares · 33 followers View post →
KyleIridian
@kyleiridian.bsky.social · Bluesky

Science Translational Medicine: An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study Becca A. Flitter et al www.science.org/doi/10.1126/...

May 14, 2025 View post →
Waggoner Lab
@LabWaggoner · X

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study https://t.co/EVE4Iegan3 @ScienceTM https://t.co/KYj9zIJrY6

May 14, 2025 · 13 likes · 4 shares · 11,302 followers View post →
Waggoner Lab
@labwaggoner.bsky.social · Bluesky

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study www.science.org/doi/10.1126/...

May 14, 2025 · 3 likes View post →
D'Ombre et de Lumière
@louvetou · X

RT @greg_folkers: Science Translational Medicine: An oral #norovirus vaccine generates mucosal immunity and reduces viral shedding in a pha…

May 14, 2025 · 1 share · 132 followers View post →
Greg Folkers
@greg_folkers · X

Science Translational Medicine: An oral #norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study Becca A. Flitter et al https://t.co/2Hb21IJY4O

May 14, 2025 · 1 share · 4,584 followers View post →
Javi Ibarrondo
@jibarrondo.bsky.social · Bluesky

An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study | Science Translational Medicine www.science.org/doi/10.1126/...

May 14, 2025 · 753 likes · 169 shares View post →