J Invest Dermatol November 2025 PMID 40373957

Urocanase-Positive Skin-Resident Bacteria Metabolize cis-Urocanic Acid and in Turn Reduce the Immunosuppressive Properties of UVR.

VijayKumar Patra, Slave Trajanoski, Aaroh Joshi, Vanina Lenief, Chloe Goyet, Altan Cornu, Nicole Golob-Schwarzl, Meghana Somlapura, Amandine Mosnier, Maximilian Zarfl, Thomas Eichmann, Harald Köefeler, Mary Norval, Jean-Francois Nicolas, Peter Wolf

Mentions

60
Peak: 7 in May 2025
across 6 sources since May 2025

Extended reach

29,081
potential audience

Total likes

3

Video views

20

Mentions per month

May 2025 – Jun 2025

Where it's discussed

  • News42 articles
  • X / Twitter5 posts
  • YouTube5 videos
  • Blogs5 articles
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Discussion examples include mentions that skin bacteria such as *Staphylococcus epidermidis* can metabolize cis-urocanic acid to potentially reduce UV damage, with tone emphasizing the biological significance. Words like 'protect,' 'reduce,' and 'significance' convey curiosity and a recognition of potential health benefits, contributing to an overall positive outlook on the research's importance.

AgreementModerate agreement

Most discussions highlight the significance of skin bacteria in metabolizing cis-urocanic acid and their role in reducing UV-induced immunosuppression, showing general agreement with the research findings.

InterestHigh interest

The discussions demonstrate high interest, with multiple mentions of how this microbiome activity could influence health and sun protection strategies.

EngagementModerate engagement

Users delve into the implications of the study, referencing the protective role of skin bacteria and potential for enhancing skin health, indicating active engagement.

ImpactModerate impact

The conversations suggest that understanding this microbial process could impact future research and therapeutic approaches, reflecting moderate perceived impact.

Abstract in brief

  • The skin microbiome significantly influences health and disease, particularly in how it responds to UV radiation.
  • Recent research indicates that acute UVB exposure alters skin bacterial communities through the production of cis-urocanic acid.
  • Specific bacteria, like Staphylococcus epidermidis, metabolize this compound, impacting immune responses and tolerance to allergens; inhibiting this metabolism can restore immunosuppression and suggest new strategies for enhancing phototherapy and sun protection.

Top posts

Most liked on X and Bluesky
Biocodex Microbiota Institute
@Microbiota_Inst · X

Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis-urocanic acid and in turn reduce the immunosuppressive properties of UV radiation", a @theJIDJournal study @vijaypatra19 @aaroh_joshi @MSomlapura #Microbiota

May 21, 2025 · 3 likes · 1 share · 26,837 followers View post →
石部統久
@mototchen · X

RT @sarekore: 紫外線によって増加したシスウロカニン酸による、環境抗原に対する免疫抑制作用が、皮膚常在細菌の代謝により抑制されることがわかりました。https://t.co/okexeSEYHU

May 27, 2025 · 1 share · 1,073 followers View post →
サイエンスあれこれ
@sarekore · X

紫外線によって増加したシスウロカニン酸による、環境抗原に対する免疫抑制作用が、皮膚常在細菌の代謝により抑制されることがわかりました。https://t.co/okexeSEYHU

May 27, 2025 · 1 share · 922 followers View post →
Dr Bar MD - Stem Cell Therapy Specialist
@DrImanBarMD · X

RT @Microbiota_Inst: Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis…

May 25, 2025 · 1 share · 183 followers View post →
Dermatology Papers
@DermatologyPape · X

Urocanase-positive skin resident bacteria metabolize cis-urocanic acid and in turn reduce the immunosuppressive properties of UV radiation - https://t.co/HGhCuHD0ml

May 20, 2025 · 39 followers View post →
Biocodex Microbiota Institute
@microbiotainst.bsky.social · Bluesky

Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis-urocanic acid & in turn reduce the immunosuppressive properties of UV radiation", suggests a @thejidjournal.bsky.social study @siderm.bsky.social @esdrorg.bsky.social #Microbiota

May 21, 2025 View post →

All mentions

石部統久
@mototchen · X

RT @sarekore: 紫外線によって増加したシスウロカニン酸による、環境抗原に対する免疫抑制作用が、皮膚常在細菌の代謝により抑制されることがわかりました。https://t.co/okexeSEYHU

May 27, 2025 · 1 share · 1,073 followers View post →
サイエンスあれこれ
@sarekore · X

紫外線によって増加したシスウロカニン酸による、環境抗原に対する免疫抑制作用が、皮膚常在細菌の代謝により抑制されることがわかりました。https://t.co/okexeSEYHU

May 27, 2025 · 1 share · 922 followers View post →
Dr Bar MD - Stem Cell Therapy Specialist
@DrImanBarMD · X

RT @Microbiota_Inst: Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis…

May 25, 2025 · 1 share · 183 followers View post →
Biocodex Microbiota Institute
@microbiotainst.bsky.social · Bluesky

Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis-urocanic acid & in turn reduce the immunosuppressive properties of UV radiation", suggests a @thejidjournal.bsky.social study @siderm.bsky.social @esdrorg.bsky.social #Microbiota

May 21, 2025 View post →
Biocodex Microbiota Institute
@Microbiota_Inst · X

Skin bacteria may protect against harmful sunlight effects "Urocanase-positive #skin resident bacteria metabolize cis-urocanic acid and in turn reduce the immunosuppressive properties of UV radiation", a @theJIDJournal study @vijaypatra19 @aaroh_joshi @MSomlapura #Microbiota

May 21, 2025 · 3 likes · 1 share · 26,837 followers View post →
Dermatology Papers
@DermatologyPape · X

Urocanase-positive skin resident bacteria metabolize cis-urocanic acid and in turn reduce the immunosuppressive properties of UV radiation - https://t.co/HGhCuHD0ml

May 20, 2025 · 39 followers View post →