PLoS Med May 2025 PMID 40392756

Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial.

Leila Abar, Eurídice Martínez Steele, Sang Kyu Lee, Lisa Kahle, Steven C Moore, Eleanor Watts, Caitlin P O'Connell, Charles E Matthews, Kirsten A Herrick, Kevin D Hall, Lauren E O'Connor, Neal D Freedman, Rashmi Sinha, Hyokyoung G Hong, Erikka Loftfield

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444

Peak: 59 in May 2025

across 5 sources since May 2025

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May 2025 – Aug 2025

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Many discussions highlight the importance of understanding how ultraprocessed food impacts health, with phrases like 'huge concern for public health' and references to 'biomarkers' suggesting urgency and relevance. Comments, such as those outlining 'distinct blood & urine metabolomic profiles' and the call for 'policy action,' indicate a serious tone emphasizing the need for change and further exploration, collectively enhancing the perception of the article's significance.

AgreementModerate agreement

Most discussions show a favorable view towards the findings and implications of the publication, suggesting general alignment with its conclusions.

InterestHigh interest

Participants express high curiosity about the study's insights into diet and health correlations, indicating that it resonates with their concerns.

EngagementModerate engagement

While some participants delved into specific methodologies and results, not all discussions displayed deep analysis, resulting in a moderate engagement score.

ImpactHigh impact

There is a strong belief that the publication could significantly influence public health conversations, especially regarding dietary habits and health markers.

Abstract in brief

Ultraprocessed foods (UPF) make up a significant portion of US calorie intake, yet their health effects are not well understood; this study aimed to identify blood and urine metabolites that can predict UPF consumption.
Out of 1,082 participants in the AARP IDATA Study, 718 provided biospecimens and dietary information, allowing for the analysis of over 1,000 metabolites using advanced chromatography techniques to establish correlations between metabolite levels and UPF intake.
Results indicated strong correlations between UPF intake and various metabolites, with further validation occurring through a randomized controlled trial involving a smaller group, confirming the relationship between diet and metabolite profiles.

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Frédéric Leroy

@fleroy1974 · X

https://t.co/4MdfXEUl4g

Aug 12, 2025 · 28,994 followers View post →

miki fern (covid 1, furious)

@miki_fern · X

Jun 10, 2025 · 719 followers View post →

DeScAI agent

@longevity_agent · X

RT @agingdoc1: Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and p…

Jun 2, 2025 · 1 share · 670 followers View post →

Agingdoc

@agingdoc1 · X

Jun 2, 2025 · 3 likes · 1 share · 41,337 followers View post →

Pon｜食と健康

@PonNutr · X

RT @NzXyZQDOCMpLgz5: 超加工食品（UPF）の摂取を反映する血中・尿中代謝物マーカーを特定し、UPF摂取量を予測する「poly-metabolite score」を開発した論文。血液・尿の代謝物データがある約1000人でスコアを開発し、UPF摂取を実施したR…

Jun 2, 2025 · 2 shares · 2,612 followers View post →

とうや@食品メーカー研究職

@NzXyZQDOCMpLgz5 · X

Jun 2, 2025 · 28 likes · 2 shares · 4,465 followers View post →

やまだ@腸活×アンチエイジング

@tarou_ymd_ · X

今後の健康診断で「食べすぎ警報」が出る時代が来るかもしれません。元論文はこちら。Natureは、論文の解説記事です。 https://t.co/EMOpIcueFO

May 31, 2025 · 3 likes · 6,185 followers View post →

Dr. Mercy Lung'aho

@MercyLungaho · X

In a breakthrough study from the National Cancer Institute, scientists have identified biological markers - specific molecules in blood and urine - that can objectively measure how much energy someone gets UPFs.

May 28, 2025 · 1,615 followers View post →

Gustavo Mora

@GustavoMor8436 · X

Consumption of ultraporcessed food is a huge concern for public health. Abar et al. (2025) identified a set of biomarkers in serum and urine. This is a huge step for prevention and early detection of related-disease #diabetes #cardiovascular https://t.co/v5gJqLgK7P https://t.co/kE8Ww7Ac5r

May 26, 2025 View post →

Seema Trivedi

@seematrivedy · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 26, 2025 · 6 shares · 211 followers View post →

Sahba Ferdowsi DO (conciergedoc)

@DrFerdowsi · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 25, 2025 · 6 shares · 9,645 followers View post →

Atanas G. Atanasov

@_atanas_ · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 25, 2025 · 6 shares · 123,606 followers View post →

Digital Health and Patient Safety Platform

@DHPSP · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 25, 2025 · 6 shares · 6,746 followers View post →

International Natural Product Sciences Taskforce

@_INPST · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 25, 2025 · 6 shares · 10,268 followers View post →

Science Communication

@ScienceCommuni2 · X

RT @EddieRDMD: Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal:…

May 25, 2025 · 6 shares · 2,873 followers View post →

Uggiee

@Uggiee1 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 25, 2025 · 28 shares · 11 followers View post →

Dr. Eddie Ramirez

@EddieRDMD · X

Journal PLoS: Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods Journal: https://t.co/oNUJBv4Img Press: https://t.co/L7RoFw1jFf @_atanas_

May 25, 2025 · 14 likes · 6 shares · 4,734 followers View post →

石部統久

@mototchen · X

RT @sarekore: UPF摂取量を予測するものでした。その後、管理された摂食研究でスコアを検証し、高度に管理された食事を摂取している入院患者20名のスコアを元に、患者の食事が高UPF食か無UPF食かを区別できました。https://t.co/oVJOSWaoOD

May 24, 2025 · 1 share · 1,080 followers View post →

サイエンスあれこれ

@sarekore · X

UPF摂取量を予測するものでした。その後、管理された摂食研究でスコアを検証し、高度に管理された食事を摂取している入院患者20名のスコアを元に、患者の食事が高UPF食か無UPF食かを区別できました。https://t.co/oVJOSWaoOD

May 24, 2025 · 1 like · 1 share · 924 followers View post →

Tim Noakes

@ProfTimNoakes · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 23, 2025 · 10 shares · 158,521 followers View post →

ValeriusX

@BioMayflower · X

@AnthropicAI Link to the study https://t.co/wAwCDr11mA https://t.co/H1Vmb1nndu

May 22, 2025 · 175 followers View post →

Dr Jen Unwin

@drjenunwin · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 29,125 followers View post →

Linda Wright

@lindawr06210728 · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 669 followers View post →

Agnes Ayton

@AgnesAyton · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 7,382 followers View post →

Dr David Unwin

@lowcarbGP · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 111,992 followers View post →

Gunter Kuhnle

@ggkuhnle · X

A fascinating aspect of this study is, that it provides the opportunity to explore a bit more the impact of UPF on metabolism. https://t.co/ZRkeOYUJ2P

May 22, 2025 · 1 like · 3,845 followers View post →

First Steps Nutrition Trust

@1stepsnutrition · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 9,594 followers View post →

Gözde Özakıncı

@Gozde786 · X

https://t.co/tsNrEiKRkF Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial

May 22, 2025 · 6,255 followers View post →

Marit Kolby

@MaritKolby · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 22, 2025 · 10 shares · 4,816 followers View post →

HerniaHerney

@HerniaHerney · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 22, 2025 · 28 shares · 27 followers View post →

Frank Paul Mora

@InTime_49 · X

May 20 Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial https://t.co/723R9BP6LY

May 21, 2025 · 386 followers View post →

Dr. Arun Gupta MD FIAP (Ped)

@Moveribfan · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 21, 2025 · 10 shares · 5,749 followers View post →

Dr Julie Woods now on Bluesky

@jwoods958 · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 21, 2025 · 10 shares · 1,239 followers View post →

Phillip Baker

@PhilBakerNZ · X

RT @CMonteiro_USP: UPF science is evolving. High-UPF diets show distinct blood & urine metabolomic profiles—matching known harms. Biomarker…

May 21, 2025 · 10 shares · 6,760 followers View post →

Carlos A. Monteiro

@CMonteiro_USP · X

May 21, 2025 · 32 likes · 10 shares · 6,185 followers View post →

Andy_Weeble_Weaver

@AndrewW66619812 · X

The paper in "PLOS Medicine" the above is based upon, & links to: “Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial” 2/2 https://t.co/UlL2EftnWb

May 21, 2025 · 4,317 followers View post →

Tahniat Afroze

@TahniatAfroze · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 9 followers View post →

BioMassSpec

@realbiomassspec.bsky.social · Bluesky

Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial #PlosMed #MassSpec journals.plos.org/plosmedicine...

May 21, 2025 View post →

JC Stanford

@JCDarnestown · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 125 followers View post →

Roberto Bertollini

@BertolliniR · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 2,621 followers View post →

Kimberley

@MollyDu127 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 286 followers View post →

Mauricio Sanhueza-Celsi⚡

@msanhuezacelsi · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 2,553 followers View post →

Jan Vopalensky

@jvopalensky · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 310 followers View post →

Wimen

@1a31551c566e43d · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 664 followers View post →

Jonas Beck

@inno_jbeck · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 12 followers View post →

Agnes Ayton

@AgnesAyton · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 7,382 followers View post →

Cardio

@PesarCardio · X

باعث یه تحول بزرگ توی طراحی آزمایش‌ها برای بررسی رژیم‌هایی غذایی روی سلامت می‌شه. https://t.co/tAGe4gdPwk

May 21, 2025 · 3 likes · 1,143 followers View post →

moonp

@eeunp44955813 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 6 followers View post →

rincondesisifo

@rincondesisifo · X

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Marcus Böhme

@BoehmeMarcus · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 4,319 followers View post →

Dr. Shashank Joshi

@AskDrShashank · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 21, 2025 · 28 shares · 32,535 followers View post →

Dzmitry Mukha

@dzmitrybio · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 110 followers View post →

Sjögrens Forum

@SjogrensForum · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 4,908 followers View post →

Rafael Gonzalez

@altairccs1 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 443 followers View post →

Nobuhiro Ariyoshi MD

@AriyoshiMd · X

https://t.co/Z3NeAhTta6

May 20, 2025 · 4,023 followers View post →

Luis Fernando Gómez Gutiérrez.

@LuisFernandoGm6 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 1,764 followers View post →

Nathan

@nathanallenwade · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 525 followers View post →

Heather McEwen

@HeatherMcEwen3 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 1,400 followers View post →

UofL's Christina Lee Brown Envirome Institute

@UofLEnvirome · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 651 followers View post →

Eldon Edwards

@eldonredwards · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 2,617 followers View post →

L♥️ve that Bl♠️b

@lovebob · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 4,163 followers View post →

@amt0407

@amt0407 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 659 followers View post →

Sarah

@SarahMya2000 · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 1,710 followers View post →

José Ríos

@jose1rt · X

RT @EricTopol: Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJ…

May 20, 2025 · 28 shares · 526 followers View post →

Eric Topol

@EricTopol · X

Tracking consumption of ultra-processed foods via metabolites in blood or urine https://t.co/psE9WCTf69 https://t.co/bo1x2OJZ8m

May 20, 2025 · 88 likes · 28 shares · 678,559 followers View post →

Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial.

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Vitamin D Effects on Telomere Length: Insights from the VITAL Trial