The overall tone of the discussions demonstrates strong interest and cautious optimism about the study, with posts emphasizing the promising cognitive improvements observed after creatine supplementation. Words like 'encouraging' and phrases such as 'warrants further investigation' illustrate a hopeful yet measured outlook, while references to detailed study data and links reveal deep engagement and an appreciation for scientific rigor.
AgreementModerate agreement
Many discussions highlight the promising results of the pilot study, emphasizing that creatine shows potential benefits for Alzheimer's patients. Words like 'encouraging,' 'promising,' and 'definitely warrants further investigation' reflect a general cons
InterestHigh interest
The discussions feature multiple mentions of study details such as dosage (20g/day), cognitive improvements, and serum/brain creatine levels, indicating high curiosity and relevance among readers.
EngagementModerate engagement
Several posts share links to the full study, references to prior research, and comments on the significance of findings, suggesting active engagement with the scientific content.
ImpactModerate impact
While many recognize the preliminary nature of the research, some discussions suggest that these findings could influence future treatment approaches, though the overall perception remains cautious about immediate clinical impact.
Abstract in brief
A pilot trial tested the effects of creatine monohydrate (CrM) on cognition in 20 Alzheimer's disease (AD) patients over 8 weeks.
Ninety-five percent of participants were compliant, showing increased serum and brain creatine levels.
Results indicated cognitive improvements in various tests, suggesting CrM is feasible for AD treatment and warrants further investigation.
These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20 people with Alzheimer's disease (AD). https://t.co/sCd2JgQUi0 2/8 https://t.co/45f0dRpZfq
May 21, 2025 · 189 likes · 22 shares · 123,456 followersView post →
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Daniel Berglind, PhD
@DanielBerglind · X
20 g/day creatine
May 28, 2025 · 61 likes · 5 shares · 7,882 followersView post →
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Jeffrey R. Stout
@ExphysPhD · X
May 21, 2025 · 51 likes · 16 shares · 3,520 followersView post →
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Dan Go
@FitFounder · X
Here's the link to the study:
https://t.co/MlKlKWY1xz
May 21, 2025 · 34 likes · 803,175 followersView post →
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Mauricio Ambriz
@AmbrizMau · X
En este estudio piloto no aleatorizado, 20 pacientes con Alzheimer recibieron 20 g/día de creatina monohidratada por 8 semanas. Se observó alta adherencia, aumento del 11% en creatina cerebral y mejoras cognitivas modestas.
Alzheimer’s Dement 2025; DOI: https://t.co/H8M4zdAuKB https://t.co/GbGSccXwCj
Jun 4, 2025 · 31 likes · 2 shares · 71,594 followersView post →
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Sheila Macrine, Ph.D.
@MacrinePhD · X
Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCreatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition - https://t.co/UC1C51AT1G
May 21, 2025 · 23 likes · 7 shares · 4,063 followersView post →
Creatine is not just for bodybuilders; recent research highlights its benefits for women in midlife, including brain health, bone density, and hormonal support. This episode explores safe usage, myths, and…
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@hyderabaddoctor Burns JM, Swerdlow RH, Kelly E, Taylor MK. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimers Dement (N Y). 2025 May 19;11(2):e70101. doi: 10.1002/trc2.70101. PMID: 40395689; PMCID: PMC12089086
Science of clostebol doping/contamination and how inconclusive it is:
https://t.co/aLVXkPFNrG
https://t.co/WHXl62qJVw
https://t.co/E5NzbS5MJn https://t.co/BGXebeUElU
@EricBalchunas @LizSimmie Women over 50 who (in particular) have family history of dementia/alzheimers. We got my MiL on it a while ago and (combined with other interventions) she's had observable improvements in memory and cognition. It's cheap. It's easy. Why not? https://t.co/nkpDGveOy9
@igoreckert Boa Igor. Da um exposed nesses estudos aqui rapidão
Creatine as a Therapeutic Target in Alzheimer’s Disease:
https://t.co/b6J93qMenj
• Creatine monohydrate pilot in Alzheimer’s: Feasibility, safety, and preliminary efficacy:-
https://t.co/3Y18QAaQ4d
@levelsio “Cognitive decline” isn’t cured by randomly doubling creatine. Show a study in normal people needing 10 g. meanwhile we’ve got: sleep-deprivation rescue bolus (10.1038/s41598-024-54249-9) and Alzheimer’s pilot (10.1002/trc2.70101). Different problems. Fix sleep. Train. 5 g.
Seems like old people drop in muscle mass combined with low creatinine vegan balanced diets may be causing the brain malfunctions?????
https://t.co/X7usjglTmS
Like those at risk for heart attack take baby aspirin daily, I think creatine monohydrate will be the next daily supplement we take for longevity. https://t.co/BQQpeP8tiC
This was a small study but it has encouraging results. Here is the link to the full study. If anyone has family members with AD or dementia knows that hope is important.
https://t.co/50lK9zmXjq https://t.co/aJDqQ7RpqK
Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition https://t.co/LU1rC7KrgL
20 g/d in divided doses improved multiple measures of cognition
RT @GastonFRodrigu1: Monohidrato de creatina en el Alzheimer: Viabilidad, creatina cerebral y cognición - Smith - 2025 - Alzheimer y demenc…
Jun 27, 2025 · 1 share · 3,199 followersView post →
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P
@psychopharmacol · X
pilot trial: After 20 g/day creatine monohydrate for 8 weeks in 20 patients with Alzheimer's disease, brain total Cr increased by 11% (p<0.001). Cognition improved on global (p=0.02) and several tests. Efficacy of CrM in AD should be studied further https://t.co/eCRDHondme https://t.co/jO9d9gvicY
En este estudio piloto no aleatorizado, 20 pacientes con Alzheimer recibieron 20 g/día de creatina monohidratada por 8 semanas. Se observó alta adherencia, aumento del 11% en creatina cerebral y mejoras cognitivas modestas.
Alzheimer’s Dement 2025; DOI: https://t.co/H8M4zdAuKB https://t.co/GbGSccXwCj
Jun 4, 2025 · 31 likes · 2 shares · 71,594 followersView post →
JV
James McCloud / Valeriano
@vale_911 · X
Suplementación con creatina mejoraría Alzheimer.
Estudio piloto muy pequeño pero prometedor.
P.D. Sin miedo a los niveles de creatinina :)
Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition
https://t.co/9ZdmLPu8oJ
@john_reggio @johnnyxbrown The article likely refers to a 2025 pilot study, "Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition," published in Alzheimer's & Dementia: Translational Research & Clinical Interventions. It tested 20g/day creatine for 8 weeks in 20 Alzheimer’s
@jaysuvius Yes. First article on effect of creatine in Alzheimer’s was recently published actually.
Further cognitive research is continuing to be published.
https://t.co/FBWwsfIrBl
@WChrisH @JohnDParody C8 MCT
AlphaGPC
Exogenous Ketones
Creatine
There is much research on all three.
https://t.co/CXk1r69s2U
https://t.co/7h6pvmZTC5
https://t.co/S6grPVcHKw
#CreatineForHealth
This single-arm pilot study provides the first evidence in humans that CrM supplementation is feasible and may increase brain creatine and offer cognitive benefits to patients with Alzheimer's disease.
Jun 1, 2025 · 11 likes · 4 shares · 1,289 followersView post →
May 23, 2025 · 16 shares · 838 followersView post →
ES
Everett Soliz
@EverettSol82057 · X
Creatine monohydrate pilot in Alzheimer's - 20g per day can increase cognitive function in Alzheimer's Disease patients in 8 weeks!
CREATINE IS A MUST
https://t.co/AQXuXVxtKQ
A new pilot study tested creatine monohydrate in older adults with Alzheimer’s. What they found is worth your attention.
Let’s break it down.
May 22, 2025 · 6 likes · 1 share · 3,327 followersView post →
屋雄
屋敷 雄輝
@badbrainstrains · X
With no placebo group but "the CrM intervention was associated with improvement in total cognition, fluid cognition,list sorting working memory and oral reading recognition. …https://t.co/lNtPc57yvm
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 22, 2025 · 22 shares · 5,282 followersView post →
JR
J.Eagle River 1_7
@JEagleRiver2 · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 22, 2025 · 22 shares · 2,531 followersView post →
AP
Austin Prevallet
@AustinPrevallet · X
A recent pilot study conducted an 8 week trial involving 20 individuals with Alzheimer’s disease. Participants took 20g of creatine monohydrate daily.
Results showed serum creatine increased over 23-fold, and brain total creatine increased by 11 percent.
https://t.co/MJhA3Devyu
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 22, 2025 · 22 shares · 854 followersView post →
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limehoney
@truthlime · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 22, 2025 · 22 shares · 985 followersView post →
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Raul
@RaulM06 · X
RT @ExphysPhD:
May 21, 2025 · 16 shares · 849 followersView post →
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KetoMed
@KetoMed1 · X
RT @ExphysPhD:
May 21, 2025 · 16 shares · 502 followersView post →
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Javed Alam
@jalam1001 · X
Title
Creatine monohydrate pilot in Alzheimer’s: Feasibility, brain creatine, and cognition
DOI
10.1002/trc2.70101
Summary
This 2025 pilot study investigated whether 8 weeks of daily creatine monohydrate (CrM) supplementation (20 g/day) is feasible and beneficial for people https://t.co/VYXc9PZGTj
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 589 followersView post →
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Dr. Dave Nayak
@drdavenayak · X
Intersting study conducted by Smith et al. that was sponsored by the @alzassociation.
20g of daily Creatine monohydrate improves cognition in AD patients.
Definitely warrants further investigation.
Here’s the PDF link to the study: https://t.co/el6OxbzpIJ https://t.co/McBvnQMpLb
You can read the study here: https://t.co/Oq2NMX3Fpy
May 21, 2025 · 10 likes · 278,174 followersView post →
TC
The Celtic Critic
@timodonnell14 · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 17,107 followersView post →
GR
Gastón F Rodríguez
@GastonFRodrigu1 · X
Monohidrato de creatina en el Alzheimer: Viabilidad, creatina cerebral y cognición - Smith - 2025 - Alzheimer y demencia https://t.co/056EnHIChO
May 21, 2025 · 1 like · 1 share · 1,151 followersView post →
PC
Paul says Mask It or Casket
@idealust · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 1,465 followersView post →
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Legion
@dialecticalrum · X
RT @MacrinePhD: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCr…
May 21, 2025 · 7 shares · 365 followersView post →
FM
Frank Paul Mora
@InTime_49 · X
RT @MacrinePhD: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCr…
May 21, 2025 · 7 shares · 418 followersView post →
AK
Anne K.
@A161624650 · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 621 followersView post →
WB
wjmccartan-Billy
@WilliamJMcCart7 · X
RT @MacrinePhD: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCr…
May 21, 2025 · 7 shares · 2,439 followersView post →
EG
Eneelia Grace
@EneeliaGrace · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 1,187 followersView post →
DG
Dan Go
@FitFounder · X
Here's the link to the study:
https://t.co/MlKlKWY1xz
May 21, 2025 · 34 likes · 803,175 followersView post →
AK
Alex.kid
@seraphus7 · X
RT @MacrinePhD: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCr…
May 21, 2025 · 7 shares · 1,401 followersView post →
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least weasel
@leastweasel_ · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 724 followersView post →
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paengineer
@paengineer · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 2,624 followersView post →
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kuzn’
@Kuzn11shibeco · X
RT @MacrinePhD: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCr…
May 21, 2025 · 7 shares · 1,495 followersView post →
OP
Omdeep Pabla
@Omdeep_Pabla · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 296 followersView post →
SD
Sheila Macrine, Ph.D.
@MacrinePhD · X
Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. HCreatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition - https://t.co/UC1C51AT1G
May 21, 2025 · 23 likes · 7 shares · 4,063 followersView post →
SA
SunBelt Mindset (e/acc)
@SunBeltMindset · X
RT @NTFabiano: These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20…
May 21, 2025 · 22 shares · 230 followersView post →
NM
Nicholas Fabiano, MD
@NTFabiano · X
These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20 people with Alzheimer's disease (AD). https://t.co/sCd2JgQUi0 2/8 https://t.co/45f0dRpZfq
May 21, 2025 · 189 likes · 22 shares · 123,456 followersView post →
May 20, 2025 · 4 shares · 27,081 followersView post →
AR
Aaron Smith, PhD, RD
@AaronSmithRD · X
@darrencandow @EricRawsonPhD @WillBrink @DrCreatine @B_Holmer @foundmyfitness @Creatine4Health @KUALZ @LifeExtension Almost forgot the paper link:
https://t.co/Xbjdo8xGE3!
May 20, 2025 · 16 likes · 4 shares · 893 followersView post →
NP
Nutrition, Metabolism and Dementia PIA
@NutritionPIA · X
Congratulations to @AaronSmithRD and his team with their new publication on their pilot trial involving AD and creatine!
https://t.co/Xx0yraQ7Mk
RT @Vee_0111: Congratulations to @AaronSmithRD and his team on their new publication and their pilot trial involving AD and creatine!
@N…
May 20, 2025 · 3 shares · 893 followersView post →
DB
Dr. Tyler Bell
@TylerBellPhD · X
RT @Vee_0111: Congratulations to @AaronSmithRD and his team on their new publication and their pilot trial involving AD and creatine!
@N…
May 20, 2025 · 3 shares · 1,914 followersView post →
OP
Omdeep Pabla
@Omdeep_Pabla · X
RT @Vee_0111: Congratulations to @AaronSmithRD and his team on their new publication and their pilot trial involving AD and creatine!
@N…
May 20, 2025 · 3 shares · 296 followersView post →
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Fernando Gallardo
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Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's Dement (N Y). 2025;11:e70101. doi:10.1002/trc2.70101. No ...
Alzheimer et démence : recherche translationnelle et interventions cliniques, 11, e70101. https://doi. org/10.1002/trc2.70101 Points clés de cet article ...
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